Stilbenes: a journey from folklore to pharmaceutical innovation
Arch Microbiol. 2024 Apr 22;206(5):229. doi: 10.1007/s00203-024-03939-z.ABSTRACTIn modern times, medicine is predominantly based on evidence-based practices, whereas in ancient times, indigenous people relied on plant-based medicines with factual evidence documented in ancient books or folklore that demonstrated their effectiveness against specific infections. Plants and microbes account for 70% of drugs approved by the USFDA (U.S. Food and Drug Administration). Stilbenes, polyphenolic compounds synthesized by plants under stress conditions, have garnered significant attention for their therapeutic potential, bridging anci...
Source: Archives of Microbiology - April 22, 2024 Category: Microbiology Authors: Gursharan Kaur Rajinder Kaur Gurleen Kaur Sodhi Nancy George Santosh Kumar Rath Harleen Kaur Walia Vagish Dwibedi Sanjai Saxena Source Type: research
Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF- β1/Smad2 signaling pathway
In conclusion, WSLE NE markedly enhanced the permeability of plant extract constituents through the blood brain barrier to boost its neuroprotective effect against PEN-induced neurotoxicity. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 17, 2024 Category: Drugs & Pharmacology Source Type: research
Resveratrol alleviates acute lung injury in mice by promoting Pink1/Parkin-related mitophagy and inhibiting NLRP3 inflammasome activation
In conclusion, resveratrol ameliorated ALI in mice, potentially by inhibiting the activation of NLRP3 inflammasomes, activating the Pink1/Parkin pathway, and promoting mitophagy.PMID:38626830 | DOI:10.1016/j.bbagen.2024.130612 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 16, 2024 Category: Biochemistry Authors: Dongdong Wu Hui Zhang Fang Li Shuai Liu Yang Wang Zhao Zhang Jiannan Wang Qiuge Wu Source Type: research
Resveratrol alleviates acute lung injury in mice by promoting Pink1/Parkin-related mitophagy and inhibiting NLRP3 inflammasome activation
In conclusion, resveratrol ameliorated ALI in mice, potentially by inhibiting the activation of NLRP3 inflammasomes, activating the Pink1/Parkin pathway, and promoting mitophagy.PMID:38626830 | DOI:10.1016/j.bbagen.2024.130612 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 16, 2024 Category: Biochemistry Authors: Dongdong Wu Hui Zhang Fang Li Shuai Liu Yang Wang Zhao Zhang Jiannan Wang Qiuge Wu Source Type: research
Proposals for new transfer coefficient (TC) values for worker re-entry activities in grape vineyards
Regul Toxicol Pharmacol. 2024 Apr 13:105628. doi: 10.1016/j.yrtph.2024.105628. Online ahead of print.ABSTRACTNew transfer coefficient (TC) values were derived for vineyard workers handling treated grapevines during harvesting and crop maintenance activities. Re-entry exposure and dislodgeable foliar residue (DFR) studies were performed in Europe, covering hand harvesting, pruning/training, pruning/tying and pruning /shoot lifting. Foliar applications of fungicides (iprovalicarb, dimethomorph, dithianon, pyrimethanil and fenbuconazole) were made and 73 workers at 16 sites were monitored over one working day. Exposure was me...
Source: Regulatory Toxicology and Pharmacology : RTP - April 15, 2024 Category: Toxicology Authors: Udo Blaschke Edgars Felkers Nicola J Hewitt Felix M Kluxen Neil Morgan Christiane Wiemann Source Type: research
Proposals for new transfer coefficient (TC) values for worker re-entry activities in grape vineyards
Regul Toxicol Pharmacol. 2024 Apr 13:105628. doi: 10.1016/j.yrtph.2024.105628. Online ahead of print.ABSTRACTNew transfer coefficient (TC) values were derived for vineyard workers handling treated grapevines during harvesting and crop maintenance activities. Re-entry exposure and dislodgeable foliar residue (DFR) studies were performed in Europe, covering hand harvesting, pruning/training, pruning/tying and pruning /shoot lifting. Foliar applications of fungicides (iprovalicarb, dimethomorph, dithianon, pyrimethanil and fenbuconazole) were made and 73 workers at 16 sites were monitored over one working day. Exposure was me...
Source: Regulatory Toxicology and Pharmacology : RTP - April 15, 2024 Category: Toxicology Authors: Udo Blaschke Edgars Felkers Nicola J Hewitt Felix M Kluxen Neil Morgan Christiane Wiemann Source Type: research
From the grapevine to the glass: A wine metabolomics tale by FT ‐ICR‐MS
AbstractWine is one of the most consumed beverages around the world. Its unique characteristics arise from numerous processes, from the selection of grapevine varieties and grapes, the effect of the terroir and geographical origin, through the biochemical process of fermentation by microorganisms, until its aging. All molecules found in wine define its chemical fingerprint and can be used to tell the story of its origin, production, authenticity and quality. Wine's chemical composition can be characterized using an untargeted metabolomics approach based on extreme resolution mass spectrometry. Fourier transform ion cyclotr...
Source: Journal of Mass Spectrometry - April 12, 2024 Category: Chemistry Authors: Marta Sousa Silva,
M ónica Soeiro,
Carlos Cordeiro Tags: REVIEW ARTICLE Source Type: research
Use of Interfacial Interactions and Complexation of Carbon Dots to Construct Ultra ‐Robust and Efficient Photothermal Film From Micro‐Carbonized Polysaccharides
Solar energy conversion technologies, especially solar-driven photothermal conversion, are both clean and controllable. Carbonization of sodium carboxymethyl cellulose (CMC) produce just such a structure (termed CMC-g-CDs), which is used to produce an ultra-stable, robust, and efficient solar-thermal film by interfacial interactions within the CMC-g-CDs. Carbonization and complexation with Fe3+ increased the photothermal temperature and photothermal conversion efficiency by 47.95%. As a demonstration of a real-world application, the CMC-g-CDs-Fe film is used to construct a solar-driven TEG. AbstractSolar energy conversion ...
Source: Small - April 9, 2024 Category: Nanotechnology Authors: Yingying Ding,
Shouxin Liu,
Long Yang,
Guanben Du,
Jianyong Wan,
Zhijun Chen,
Shujun Li Tags: Research Article Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway
In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.PMID:38592565 | DOI:10.1007/s10522-024-10099-6 (Source: Biogerontology)
Source: Biogerontology - April 9, 2024 Category: Geriatrics Authors: Yangmin Xia Hao Zhang Xiangyi Wu Ye Xu Qian Tan Source Type: research
The grapevine miR827a regulates the synthesis of stilbenes by targeting VqMYB14 and gives rise to susceptibility in plant immunity
In this study, a microRNA (miRNA; miR827a), which negatively regulates its target gene VqMYB14, a key regulatory role in the synthesis of stilbenes, was identified in Vitis quinquangularis (V. quinquangularis) using transcriptome sequencing. Using overexpression and silencing approaches, we found that miR827a regulates the synthesis of stilbenes by targeting VqMYB14. We used flagellin N-terminal 22-amino-acid peptide (flg22), the representative elicitor in plant basal immunity, as the elicitor to verify whether miR827a is involved in the basal immunity of V. quinquangularis. Furthermore, the promoter activity of miR827a wa...
Source: TAG. Theoretical and Applied Genetics - April 6, 2024 Category: Genetics & Stem Cells Authors: Yangyang Luo Linxia Wang Jie Zhu Jingwen Tian Lin You Qin Luo Jia Li Qian Yao Dong Duan Source Type: research
