Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Growing controversy over role of FDA and Medicare in promoting anti-amyloid drugs given limited benefit, high cost, severe side-effects
The War Over Whether Medicare Should Pay For The New Anti-Alzheimer’s Drugs (Forbers):
The powerful Alzheimer’s Disease lobby is fighting a multi-billion-dollar battle on two fronts. It is quietly trying to limit restrictions the Food and Drug Administration puts on the use of new drugs aimed at slowing the progression of the brain disease. And it is publicly pressing Medicare to pay for the widespread use of the monoclonal antibodies FDA already has conditionally approved as well as others in the pipeline.
While the FDA approves drugs for use, it doesn’t decide who pays for them. And, for now, the Centers for Medica...
Source: SharpBrains - June 21, 2023 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Alzheimer's experts Alzheimer’s Disease Anti-Alzheimer’s Drugs Biogen brain swelling Eisai europe FDA lecanemab Medicare Source Type: blogs
Will Success in Reversing Aging Shape the Regulatory System to Accommodate It?
A sizable fraction of the therapies produced by the medical industry are, not to put too fine a point on it, garbage. The benefit is not worth the cost of diverting the resources into the full scale production of the drug, versus those resources going towards some better form of medical research and development. Giving a cancer patient an extra month or two of life, reducing fibrosis in the liver by 10% over a year of treatment, incrementally improving mitophagy to half the degree that exercise achieves, and so forth. Small molecule development in particular excels at producing this sort out outcome, as the effects on gene...
Source: Fight Aging! - June 19, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT.
Age-Related Dysfunction of Water Homeostasis
https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/
Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes from the 2023 Age-Related Disease Therapeutics Summit
The former Longevity Therapeutics conference series was renamed to the Age-Related Disease Therapeutics Summit and held its fifth event recently in San Francisco. It was a smaller meeting than in past years, perhaps a result of the recent downturn in the global financial and investment environment. Few investors were present. Nonetheless, one can usually learn something interesting from the presenting biotech founders and executives. I took a few notes while I was there to present on progress at Repair Biotechnologies, and they follow in the order of the conference program.
Birget Schilling from the Buck Institute f...
Source: Fight Aging! - June 16, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
The Republican Study Committee Budget on the Key Drivers of Spending and Debt
Romina BocciaThe House and Senate both have budget committees. And yet, neither chamber has released a budget this year. Against this backdrop, it’s refreshing to see the Republican Study Committee (RSC) continue its nearly 30‐year tradition of producing an alternative conservative budget proposal. Titled “Protecting America ’s Economic Security, ” the RSC under chairman Kevin Hern (R‑OK) and Budget and Spending Task Force chairman Ben Cline (R‑VA) proposes to balance the federal budget, cut taxes, slash red tape, and boost work.The growth in the federal debt is directly tied to increases in spending for...
Source: Cato-at-liberty - June 16, 2023 Category: American Health Authors: Romina Boccia Source Type: blogs
In An Ironic Twist, the AMA Seeks Alternatives to the Residency Matching Program
Jeffrey A. SingerLast weekend the American Medical Association House of Delegates passed a resolution tacitly claiming that the National Residency Matching Program (NRMP) is likely anti ‐competitive and a violation of the Sherman Antitrust Act of 1890. The resolution concluded:RESOLVED, That our American Medical Association study alternatives to the current residency and fellowship Match process which would be less restrictive on free market competition for applicants. (Directive to Take Action)This is quite surprising, given that the AMA was a co‐defendant, along with the Association of American Medical Col...
Source: Cato-at-liberty - June 14, 2023 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
Career Conversations: Q & A With Physiologist Elimelda Moige Ongeri
Credit: Courtesy of Dr. Elimelda Moige Ongeri.
A career path in science is rarely clear cut and linear, which Elimelda Moige Ongeri, Ph.D., can attest adds to its excitement. She went from working in animal reproductive biology to studying proteins involved in inflammation and tissue injury. Dr. Ongeri is also currently dean of the Hairston College of Health and Human Sciences and professor of physiology at North Carolina Agricultural and Technical State University (NC A&T) in Greensboro. In this interview, she shares details of her career, including a change in research focus to human physiology; her goals for the f...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Proteins Source Type: blogs
Trump Earns a Failing Grade in Civics (K-12) in North Carolina.
BY Mike Magee MD
Events over the past year clearly have confirmed that we are a “work in progress” even as we stubbornly affirm our good intentions to create a society committed to “life, liberty, and the pursuit of happiness.”
With the Dobbs’ decision, our Supreme Court has unleashed long-abandoned regressive state laws designed to reinforce selective patriarchy and undermine the stability and confidence of America’s women and families. As a result, our nation’s health professionals, and the patients they care for, potentially find themselves “on the wrong side of the law.”
It calls to mind ...
Source: The Health Care Blog - June 13, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Donald Trump Mike Magee North Carolina Republican Supreme Court Source Type: blogs
What ’s in the Republican Economic Tax Package?
Adam N. MichelWays and Means Committee Republicans recently introduced theAmerican Families and Jobs Act, an economic tax package that addresses significant ongoing tax increases on domestic investment built into the 2017Tax Cuts and Jobs Act. Most of the Republicans ’ major proposed changes in theAmericanFamilies and Jobs Act expire after 2025, worsening current tax uncertainty and obscuring the necessary reforms ’ fiscal cost.Other than permanence, theAmerican Families and Jobs Act could be significantly improved by adding Universal Savings Accounts for family savings flexibility and neutral cost recovery for current...
Source: Cato-at-liberty - June 12, 2023 Category: American Health Authors: Adam N. Michel Source Type: blogs
Landed Gentry and Health
BY MIKE MAGEE
“The title of our lands is free, clear, and absolute, and every proprietor of the land is a princess his own domains, and lord paramount of the fee.”
Jesse Root, 1798, Chief Justice of the Connecticut Supreme Court
When it came to social hierarchy and family position, land was the ultimate measure of success and influence in Great Britain. But by the time of the American Revolution, our Founders were already fast at work dismantling Primogeniture (“the right of succession belonging to the firstborn child, especially the feudal rule by which the whole real estate of an intestate passed to...
Source: The Health Care Blog - June 7, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Landed Gentry Mike Magee Source Type: blogs
Webinar for the Maximizing Investigators ’ Research Award (MIRA) Program for Early Stage Investigators
I’m pleased to announce that the Maximizing Investigators’ Research Award (MIRA) notice of funding opportunity for early stage investigators (ESIs) (PAR-23-145) has been reissued. MIRA funding provides support for an area of research in an ESI’s laboratory that falls within the NIGMS mission. The next application due date is October 3, 2023.
We’re hosting a webinar to discuss the key features of the ESI MIRA program and to answer your questions:
Wednesday, July 26, 1:00-2:30 p.m. ET
Zoom meeting link
Join by phone
Meeting ID: 160 696 7912
Passcode: 796551
Participants requiring sign language int...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - June 7, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Funding Opportunities Meetings/Events Early Stage Investigator MIRA Webinars Source Type: blogs
poem
Write What You KnowAnytime you ' re stuck or sounding derivative that ’s what they always say. Write what you know. For the longest time I ignored it. Deluded by the arrogance of the overlooked. For fruitless years I wrote about rivers even though I’m clueless. Landlocked and sea sick. I hate to fish. All my rivers just wind and shimmer, wind and shimmer. They bec ome chlorinated lazy rivers lily padded with sunburnt bodies wafting along in blow up rafts. Meanwhile I ' m just using them to skip a stone to the other side. Do you know how long it takes to really know if you know anything? I know a little bit, I ' l...
Source: Buckeye Surgeon - June 6, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Investigating Bacteria ’ s CRISPR Defense System to Improve Human Health
Credit: Adrian Sanchez Gonzales.
The earliest Andrew Santiago-Frangos, Ph.D., remembers being interested in science was when he was about 8 years old. He was home sick and became engrossed in a children’s book that explained how some bacteria and viruses cause illness. To this day, his curiosity about bacteria persists, and he’s making discoveries about CRISPR—a system that helps bacteria defend against viruses—as a postdoctoral researcher and NIGMS-funded Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) scholar at Montana State University (MSU) in Bozeman.
Becoming a Biologist...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 31, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Bacteria Cellular Processes COVID-19 DNA Profiles Source Type: blogs
Affirmative Action in College Admissions
This article appeared onSubstack on May 30, 2023, and an earlier version appeared under Jacob Winter ’s byline in theHarvard Undergraduate Law Review.In a few weeks, the Supreme Court will announce its decision in two cases it heard last fall, one against Harvard and the other against the University of North Carolina. Both suits challenge race‐based affirmative action in college admissions. In each case, a group called Students for Fair Admiss ions (SFFA) argues that the universities’ admissions policies unlawfully discriminate against Asian Americans.The case against UNC rests on two issues. Under the Fourteen...
Source: Cato-at-liberty - May 30, 2023 Category: American Health Authors: Jeffrey Miron, Jacob Winter Source Type: blogs
