Comparative efficacy and safety of glucose-lowering drugs in children and adolescents with type 2 diabetes: A systematic review and network meta-analysis
ConclusionsThe top 10 treatments of type 2 diabetes in children and adolescents aged 10–17 years were saxagliptin+metformin, liraglutide+metformin, liraglutide, dapagliflozin, exenatide–2 mcg, sitagliptin+metformin, linagliptin–5 mg, linagliptin–1 mg, metformin, and exenatide–5/10 mcg.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=284897, identifier CRD42021284897. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - August 11, 2022 Category: Endocrinology Source Type: research
Precision therapy for three Chinese families with maturity-onset diabetes of the young (MODY12)
In this study, we aimed to investigate the pathogenic gene for diabetes and provide precise treatment for diabetes patients in three families. Three families with suspected MODY were enrolled and screened for germline mutations using Whole exome sequencing (WES). Candidate pathogenic variants were validated in other family members and non-related healthy controls. Three heterozygous missense mutations in the ABCC8 gene (NM_001287174), c.1555 C>T (p.R519C), c.3706 A>G (p.I1236V), and c.2885 C>T (p.S962L) were found in families A, B, and C, respectively. All mutation sites cosegregated with diabetes, were predicted ...
Source: Frontiers in Endocrinology - August 3, 2022 Category: Endocrinology Source Type: research
Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3 β signaling
ConclusionThe current data suggests that GPD exerts a protective effect against tauopathy, behavioural consequences, neurodegeneration, neuroinflammation and apoptosis. GPD is therefore a promising agent for the treatment of neurodegenerative diseases associated with tauopathy.Graphical abstract (Source: Inflammopharmacology)
Source: Inflammopharmacology - August 3, 2022 Category: Drugs & Pharmacology Source Type: research
A Clinical Decision Support System for Diabetes Patients with Deep Learning: Experience of a Taiwan Medical Center
Conclusion: This study found that Bi-LSTM models is a well kernel in a CDSS which help physicians' decision-making, and the increasing the number of seasons will negative impact the performance. In addition, this study found that the most important drug is metformin, which is recommended as first-line treatment OHA in various situations for DM patients.PMID:35813300 | PMC:PMC9254376 | DOI:10.7150/ijms.71341 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 11, 2022 Category: Biomedical Science Authors: Ting-Ying Chien Hsien-Wei Ting Chih-Fang Chen Cheng-Zen Yang Chong-Yi Chen Source Type: research
