Pharmacologic heterogeneity and risk of severe hypoglycemia with concomitant use of sulfonylureas and DPP-4 inhibitors: population-based cohort study
Clin Pharmacol Ther. 2023 Jun 16. doi: 10.1002/cpt.2975. Online ahead of print.ABSTRACTDipeptidyl peptidase-4 inhibitors (DPP-4i) interact with sulfonylureas to increase their risk of hypoglycemia. Our population-based study assessed whether intra-class pharmacologic heterogeneity among sulfonylureas (long- versus short-acting) and DPP-4i (peptidomimetic versus non-peptidomimetic) modifies this interaction. We conducted a cohort study using the UK's Clinical Practice Research Datalink Aurum linked to hospitalization and vital statistics data. We assembled a cohort of patients initiating sulfonylureas (2007-2020). Using a t...
Source: Clinical Pharmacology and Therapeutics - June 16, 2023 Category: Drugs & Pharmacology Authors: Jenny Dimakos Ying Cui Robert W Platt Christel Renoux Kristian B Filion Antonios Douros Source Type: research
Pharmacologic heterogeneity and risk of severe hypoglycemia with concomitant use of sulfonylureas and DPP-4 inhibitors: population-based cohort study
Clin Pharmacol Ther. 2023 Jun 16. doi: 10.1002/cpt.2975. Online ahead of print.ABSTRACTDipeptidyl peptidase-4 inhibitors (DPP-4i) interact with sulfonylureas to increase their risk of hypoglycemia. Our population-based study assessed whether intra-class pharmacologic heterogeneity among sulfonylureas (long- versus short-acting) and DPP-4i (peptidomimetic versus non-peptidomimetic) modifies this interaction. We conducted a cohort study using the UK's Clinical Practice Research Datalink Aurum linked to hospitalization and vital statistics data. We assembled a cohort of patients initiating sulfonylureas (2007-2020). Using a t...
Source: Clinical Pharmacology and Therapeutics - June 16, 2023 Category: Drugs & Pharmacology Authors: Jenny Dimakos Ying Cui Robert W Platt Christel Renoux Kristian B Filion Antonios Douros Source Type: research
Pharmacologic heterogeneity and risk of severe hypoglycemia with concomitant use of sulfonylureas and DPP-4 inhibitors: population-based cohort study
Clin Pharmacol Ther. 2023 Jun 16. doi: 10.1002/cpt.2975. Online ahead of print.ABSTRACTDipeptidyl peptidase-4 inhibitors (DPP-4i) interact with sulfonylureas to increase their risk of hypoglycemia. Our population-based study assessed whether intra-class pharmacologic heterogeneity among sulfonylureas (long- versus short-acting) and DPP-4i (peptidomimetic versus non-peptidomimetic) modifies this interaction. We conducted a cohort study using the UK's Clinical Practice Research Datalink Aurum linked to hospitalization and vital statistics data. We assembled a cohort of patients initiating sulfonylureas (2007-2020). Using a t...
Source: Clinical Pharmacology and Therapeutics - June 16, 2023 Category: Drugs & Pharmacology Authors: Jenny Dimakos Ying Cui Robert W Platt Christel Renoux Kristian B Filion Antonios Douros Source Type: research
Evaluation of Antidiabetic Activity of Oxadiazole Derivative in Rats
In conclusion, the oxadiazole derivative showed potential antidiabetic activity and indicated its potential as a therapeutic.PMID:37143509 | PMC:PMC10154101 | DOI:10.1155/2023/1141554 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 5, 2023 Category: Complementary Medicine Authors: Adil Iqbal Qazi Bashir Ahmad Muhammad Umar Khayam Sahibzada Fareeha Anwar Ameer Khusro Fahad A Alhumaydhi Amany Abdel-Rahman Mohamed Gomaa Mostafa-Hedeab Talha Bin Emran Source Type: research
Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K+ channel subunits in cancers: role in drug –disease interactions
Conclusion: An elevated expression of the Sur2A subunit was found in proliferating cells in two animal models of cancer. Immunohistochemistry/omics/pharmacovigilance data reveal the role of the Kir6.1/2-Sur2A/B subunits as a drug target in breast/renal cancers and in C.S. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 25, 2023 Category: Drugs & Pharmacology Source Type: research
Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats
CONCLUSION: NIC has an ameliorative action against MTX-induced hepatotoxicity, most probably via its antioxidant, anti-inflammatory, and anti-apoptotic functions together with the modulation of the KATP channel, eNOS, and P-glycoprotein.PMID:37078892 | DOI:10.1080/08923973.2023.2201659 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 20, 2023 Category: Allergy & Immunology Authors: Marwa M M Refaie Maram El-Hussieny Sayed Shehata Nermeen N Welson Walaa Yehia Abdelzaher Source Type: research
