Glimepiride/Insulin-glargine
(Source: Reactions Weekly)
Source: Reactions Weekly - November 1, 2023 Category: Drugs & Pharmacology Source Type: research

Study Protocol for the Pleiotropic Effects of Sodium-Glucose Cotransporter  2 Inhibitor on Organ-Specific Sympathetic Nerve Activity and Insulin Sensitivity in Participants with Type 2 Diabetes
Diabetes Ther. 2023 Oct 26. doi: 10.1007/s13300-023-01497-z. Online ahead of print.ABSTRACTINTRODUCTION: Hyperinsulinemia and hyperglycemia are associated with exaggerated systemic sympathetic nerve activity (SNA) in patients with type 2 diabetes. Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower insulin levels, whereas sulfonylureas increase insulin levels. We will test whether these two classes of antidiabetic agents have different effects on SNA.METHODS: The present study is an ongoing, 24-week, one-center (only Kanazawa University Hospital), open-label, randomized, parallel trial (jRCTs 041200035). Participants w...
Source: Atherosclerosis - October 26, 2023 Category: Cardiology Authors: Yumie Takeshita Chiaki Nomura Hisayoshi Murai Yusuke Mukai Tadayuki Hirai Takuto Hamaoka Shota Tokuno Takeo Tanaka Hisanori Goto Yujiro Nakano Soichiro Usui Kenichi Nakajima Masayuki Takamura Toshinari Takamura Source Type: research

Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids
Epoxyeicosatrienoic acids (EETs), which exert multiple endogenous protective effects, are hydrolyzed into less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). However, commercial drugs related to EETs or sEH are not yet in clinical use. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - October 21, 2023 Category: Cytology Authors: Chengcheng Zhao, Xiangrui Jiang, Liyuan Peng, Yan Zhang, Huihui Li, Qiumeng Zhang, Yinhui Wang, Feipu Yang, Junfang Wu, Zheng Wen, Zuowen He, Jingshan Shen, Chen Chen, Dao Wen Wang Source Type: research

A hospital-based assessment of glycemic control and medication adherence in type 2 diabetes mellitus in Eastern Nepal
CONCLUSION: The majority of the diabetic patients had good glycemic control and medium MA. Patients taking regular fruit, being involved in daily jogging, having a shorter duration of drug therapy, and having good diabetic knowledge were identified as factors that affect both glycemic control and MA.PMID:37636174 | PMC:PMC10451609 | DOI:10.4103/jfmpc.jfmpc_90_23 (Source: Primary Care)
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Deependra Prasad Sarraf Pramendra Prasad Gupta Source Type: research

A hospital-based assessment of glycemic control and medication adherence in type 2 diabetes mellitus in Eastern Nepal
CONCLUSION: The majority of the diabetic patients had good glycemic control and medium MA. Patients taking regular fruit, being involved in daily jogging, having a shorter duration of drug therapy, and having good diabetic knowledge were identified as factors that affect both glycemic control and MA.PMID:37636174 | PMC:PMC10451609 | DOI:10.4103/jfmpc.jfmpc_90_23 (Source: Primary Care)
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Deependra Prasad Sarraf Pramendra Prasad Gupta Source Type: research

Treatment for Type 2 Diabetes May Reduce Depressive Symptoms in Some Adults
Glucagon-like peptide-1 (GLP-1) receptor agonists —a common treatment for type 2 diabetes—may also help to reduce depressive symptoms in adults, suggests ameta-analysis published inThe American Journal of Geriatric Psychiatry.People with diabetes are known to be at greater risk of depression than those without the disease, wrote co-author Lixin Guo, M.D., of the Chinese Academy of Medical Sciences and colleagues. Though GLP-1 is a hormone produced in the gut that is released in response to food, GLP receptors are also present in the brain. Animal studies have suggested that activation of these receptors may produce ant...
Source: Psychiatr News - August 22, 2023 Category: Psychiatry Tags: antidepressant effects depression diabetes GLP-1 GLP-1 receptor agonist Parkinson ' s disease The American Journal of Geriatric Psychiatry Source Type: research

Synergistic Effect of Naringin and Glimepiride in Streptozotocin-induced Diabetic Rats
Conclusion A synergistic effect of Naringin and glimepiride was observed during the estimation of various biochemical parameters like body weight, fasting blood sugar, creatinine, urine level, TG, total cholesterol, SGOT, SGPT, ALP, Insulin, HbA1C, antioxidant parameters like SOD, GSH, and catalase in STZ-induced diabetic rats. Further, the combination of therapy improves the protective effect of the pancreas, kidney, and liver, suggesting a potential antidiabetic effect.PMID:37592777 | DOI:10.2174/1573399820666230817154835 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - August 18, 2023 Category: Endocrinology Authors: Deepankar Ratha Biswakanth Kar Gurudutta Pattnaik Pallishree Bhukta Source Type: research

Synergistic Effect of Naringin and Glimepiride in Streptozotocin-induced Diabetic Rats
Conclusion A synergistic effect of Naringin and glimepiride was observed during the estimation of various biochemical parameters like body weight, fasting blood sugar, creatinine, urine level, TG, total cholesterol, SGOT, SGPT, ALP, Insulin, HbA1C, antioxidant parameters like SOD, GSH, and catalase in STZ-induced diabetic rats. Further, the combination of therapy improves the protective effect of the pancreas, kidney, and liver, suggesting a potential antidiabetic effect.PMID:37592777 | DOI:10.2174/1573399820666230817154835 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - August 18, 2023 Category: Endocrinology Authors: Deepankar Ratha Biswakanth Kar Gurudutta Pattnaik Pallishree Bhukta Source Type: research

Synergistic Effect of Naringin and Glimepiride in Streptozotocin-induced Diabetic Rats
Conclusion A synergistic effect of Naringin and glimepiride was observed during the estimation of various biochemical parameters like body weight, fasting blood sugar, creatinine, urine level, TG, total cholesterol, SGOT, SGPT, ALP, Insulin, HbA1C, antioxidant parameters like SOD, GSH, and catalase in STZ-induced diabetic rats. Further, the combination of therapy improves the protective effect of the pancreas, kidney, and liver, suggesting a potential antidiabetic effect.PMID:37592777 | DOI:10.2174/1573399820666230817154835 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - August 18, 2023 Category: Endocrinology Authors: Deepankar Ratha Biswakanth Kar Gurudutta Pattnaik Pallishree Bhukta Source Type: research

Synergistic Effect of Naringin and Glimepiride in Streptozotocin-induced Diabetic Rats
Conclusion A synergistic effect of Naringin and glimepiride was observed during the estimation of various biochemical parameters like body weight, fasting blood sugar, creatinine, urine level, TG, total cholesterol, SGOT, SGPT, ALP, Insulin, HbA1C, antioxidant parameters like SOD, GSH, and catalase in STZ-induced diabetic rats. Further, the combination of therapy improves the protective effect of the pancreas, kidney, and liver, suggesting a potential antidiabetic effect.PMID:37592777 | DOI:10.2174/1573399820666230817154835 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - August 18, 2023 Category: Endocrinology Authors: Deepankar Rath Biswakanth Kar Gurudutta Pattnaik Pallishree Bhukta Source Type: research

Synergistic Effect of Naringin and Glimepiride in Streptozotocin-induced Diabetic Rats
Conclusion A synergistic effect of Naringin and glimepiride was observed during the estimation of various biochemical parameters like body weight, fasting blood sugar, creatinine, urine level, TG, total cholesterol, SGOT, SGPT, ALP, Insulin, HbA1C, antioxidant parameters like SOD, GSH, and catalase in STZ-induced diabetic rats. Further, the combination of therapy improves the protective effect of the pancreas, kidney, and liver, suggesting a potential antidiabetic effect.PMID:37592777 | DOI:10.2174/1573399820666230817154835 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - August 18, 2023 Category: Endocrinology Authors: Deepankar Rath Biswakanth Kar Gurudutta Pattnaik Pallishree Bhukta Source Type: research

Anti-diabetic combination therapy with pioglitazone or glimepiride added to metformin on the AGE-RAGE axis: a randomized prospective study
ConclusionThese data can help to explain the benefits of oral anti-diabetic therapy in relation to the reduction of cardiovascular risk, as suggested by variations in AGE/s-RAGE ratio as biochemical marker of endothelial function; in particular, treatment with pioglitazone seems to offer greater long-term benefit on AGE-RAGE axis. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - August 11, 2023 Category: Endocrinology Source Type: research

Long-Term Effectiveness of Quadruple Combination Therapy with Empagliflozin Versus Basal Long-Acting Insulin Therapy in Patients with Type 2 Diabetes: 3-Year Retrospective Observational Study
ConclusionEmpagliflozin was shown to perform as well as better than insulin when used as part of a quadruple drug regimen for regulating blood glucose levels in suboptimally controlled patients  with T2D.Clinical Trial NumberNCT 05103306 (ClinicalTrials.gov). (Source: Diabetes Therapy)
Source: Diabetes Therapy - July 28, 2023 Category: Endocrinology Source Type: research

The effects of early short-term insulin treatment vs. glimepiride on beta cell function in newly diagnosed type 2 diabetes with HbA1c above 9
DISCUSSION: Early short-term insulin intervention in newly diagnosed T2D improves beta cell function more than glimepiride, both added to metformin, resulting in a superior and longer lasting glycemic and lipid control.PMID:37476884 | DOI:10.55730/1300-0144.5616 (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - July 21, 2023 Category: General Medicine Authors: Jelena Stojanovic Marina Andjelic-Jelic Miljanka Vuksanovic Milica Marjanovic-Petkovic Biljana Jojic Marko Stojanovic Teodora Beljic-Zivkovic Source Type: research