Time to reposition sulfonylureas in type 2 diabetes management in Indian context: A pragmatic practical approach
AbstractSulfonylureas (SU) continue to be a vital therapeutic category of oral hypoglycemic agents (OHAs) for the management of type 2 diabetes mellitus (T2DM). Physicians consider modern SU (gliclazide and glimepiride) as “safe and smart” choices for T2DM management. The presence of multiple international guidelines and scarcity of a national guideline may contribute to the challenges faced by few physicians in choosing the right therapeutic strategy. The role of SU in diabetes management is explicit, and the pr esent consensus aims to emphasize the benefits and reposition SU in India. This pragmatic, practical appro...
Source: International Journal of Diabetes in Developing Countries - April 19, 2023 Category: Endocrinology Source Type: research
Identification and in vitro functional assessment of 10 CYP2C9 variants found in Chinese Han subjects
In this study, 1163 Chinese Han individuals were recruited to investigate their distribution pattern of CYP2C9 gene and find out the variants that may affect their drug metabolic activities. We successfully developed a multiplex PCR amplicon sequencing method and used it for the genetic screening of CYP2C9 in a large scale. Besides the wild type CYP2C9*1, totally 26 allelic variants of CYP2C9 were detected, which included 16 previously reported alleles and 10 new non-synonymous variants that had not been listed on the PharmVar website. The characteristics of these newly detected CYP2C9 variants were then evaluated after co...
Source: Frontiers in Endocrinology - March 15, 2023 Category: Endocrinology Source Type: research
Suboptimal adherence to food restrictions requirements related to drug regimens for chronic diseases
CONCLUSIONS: Patients adhered to dosing and cautionary instructions across the majority of the study period but were largely non-adherent to food intake restrictions. One quarter of patients did not receive an in-person consultation regarding their medication requirements, and patient-reported medication knowledge was low across all participants. Improved communication and increased emphasis on food intake restrictions is needed when advising patients on their medications.PMID:36912018 | DOI:10.1080/03007995.2023.2189856 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - March 13, 2023 Category: Research Authors: Robert L Boggs Samuel Engel Tongtong Wang Tracey Jean Weiss Ashley A Martin Austin Yue Nate Way Bryan Ricker Swapnil N Rajpathak Dominik Lautsch Source Type: research
Case report: Maturity-Onset Diabetes of the Young (MODY12) caused by ABCC8 gene mutations
ConclusionThis case report highlights anABCC8 gene mutation in MODY12 that responds to sulfonylurea treatment. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 24, 2023 Category: Endocrinology Source Type: research
Effect of hydroxychloroquine on beta cell function, insulin resistance, and inflammatory markers in type 2 diabetes patients uncontrolled on glimepiride and metformin therapy
ConclusionAddition of hydroxychloroquine as an add-on drug in uncontrolled diabetes significantly improves the beta cell function and the insulin resistance, along with significant improvement in adiponectin, hsCRP levels, and IL6 levels. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 4, 2023 Category: Endocrinology Source Type: research
50-Year-Old Man With Hematochezia and Fatigue
A 50-year-old man, originally from southern Mexico, presented to primary care clinic for evaluation of intermittent bright red blood per rectum (BRBPR). His medical comorbidities included type 2 diabetes, hypothyroidism, and well-controlled hypertension. He had a history of cholecystectomy in Mexico many years ago, with an unspecified complication requiring laparotomy and partial small-bowel resection. His medications included metformin, glimepiride, lisinopril, levothyroxine, atorvastatin, and low-dose aspirin. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - February 1, 2023 Category: Internal Medicine Authors: Bradley T. Busebee, Qiaonan Zhong, Joseph A. Murray Tags: Residents ’ clinic Source Type: research
GSE223538 Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes: A Randomized Controlled Trial
Contributors : Nikolai Scherbak ; Robert Kruse ; Thomas Nystr öm ; Johan JendleSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensIn the current study we evaluated the effect of glimepiride, liraglutide on the expression of the circulating miRNAs. Univariate analyses show that treatment with glimepiride altered expression of three miRNAs in patient serum, miR-206, miR-182-5p, and miR-766-3p. Both miR-182-5p and miR-766-3p were also picked up among the top contributing miRNAs with penalized regularised logistic regressions (Lasso). The highest-ranked miRNAs with respect to Lasso ...
Source: GEO: Gene Expression Omnibus - January 26, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Analysis of Medication Errors Reported by Community Pharmacists in the Republic of Korea: A Cross-Sectional Study
Conclusions: The MEs reported by community pharmacists were mainly prescribing errors, most of which were rectified before reaching patients. The prevalent medications involved in harmful errors include anti-diabetic, anti-thrombotic, and anti-inflammatory agents.PMID:36676775 | DOI:10.3390/medicina59010151 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - January 21, 2023 Category: Universities & Medical Training Authors: Ju-Hee Han Kyu-Nam Heo JiMin Han Mo-Se Lee Su-Jin Kim Sangil Min Young-Mi Ah Ju-Yeun Lee Source Type: research
Analysis of Medication Errors Reported by Community Pharmacists in the Republic of Korea: A Cross-Sectional Study
Conclusions: The MEs reported by community pharmacists were mainly prescribing errors, most of which were rectified before reaching patients. The prevalent medications involved in harmful errors include anti-diabetic, anti-thrombotic, and anti-inflammatory agents.PMID:36676775 | PMC:PMC9866739 | DOI:10.3390/medicina59010151 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - January 21, 2023 Category: Universities & Medical Training Authors: Ju-Hee Han Kyu-Nam Heo JiMin Han Mo-Se Lee Su-Jin Kim Sangil Min Young-Mi Ah Ju-Yeun Lee Source Type: research
Analysis of Medication Errors Reported by Community Pharmacists in the Republic of Korea: A Cross-Sectional Study
Conclusions: The MEs reported by community pharmacists were mainly prescribing errors, most of which were rectified before reaching patients. The prevalent medications involved in harmful errors include anti-diabetic, anti-thrombotic, and anti-inflammatory agents.PMID:36676775 | PMC:PMC9866739 | DOI:10.3390/medicina59010151 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - January 21, 2023 Category: Universities & Medical Training Authors: Ju-Hee Han Kyu-Nam Heo JiMin Han Mo-Se Lee Su-Jin Kim Sangil Min Young-Mi Ah Ju-Yeun Lee Source Type: research
