Molecules, Vol. 28, Pages 4911: Implications of Pharmacokinetic Potentials of Pioglitazone Enantiomers in Rat Plasma Mediated through Glucose Uptake Assay
imath Gurupadayya
Pioglitazone, a PPAR-gamma activator used to diagnose hyperglycemia, was studied for its stereoselective deposition and active enantiomers in female albino Wistar rats. In accordance with USFDA recommendations, a bioanalytical technique was employed to assess the segregation of pioglitazone enantiomers in rat plasma with glimepiride as an internal standard. A Phenomenox i-Amylose-3 column (150 mm × 4.6 mm) of 5 µm was used for high-performance liquid chromatography (HPLC) with a mobile phase of 10 mM ammonium acetate buffer in Millipore water and acetonitrile in 60:40 (v/v)...
Source: Molecules - June 22, 2023 Category: Chemistry Authors: Tatineni Spandana Veera Venkata Nishanth Goli Mohamed Rahamathulla Sirajunisa Talath Riyaz Ali M. Osmani Mohammed Muqtader Ahmed Syeda Ayesha Farhana Shalam Mohamed Hussain Bannimath Gurupadayya Tags: Article Source Type: research
Neuroprotective Effects of Anti-diabetic Drugs in the Treatment of Patients with Diabetes and Glaucoma or at High Risk for Glaucoma
Klin Monbl Augenheilkd. 2023 Jun 19. doi: 10.1055/a-2066-3389. Online ahead of print.ABSTRACTThere is an association between glaucoma and several risk factors and metabolic diseases, such as type 2 diabetes mellitus. Diabetes mellitus leads to neurodegenerative changes, both peripherally and in the brain. This might be a shared pathophysiology and etiology for both glaucoma and diabetes. It is interesting that drugs for the treatment of diabetes seem to have neuroprotective properties independent of their blood sugar reduction. Although prospective, randomized, clinical studies are still missing, particularly metformin and...
Source: Klinische Monatsblatter fur Augenheilkunde - June 19, 2023 Category: Opthalmology Authors: Burkhard Weisser Carl Erb Source Type: research
