Fingolimod improves diffuse brain injury by promoting AQP4 polarization and functional recovery of the glymphatic system
CONCLUSIONS: In brief, these findings suggest that fingolimod alleviates whole-brain inflammation and GS system damage after DBI and that inhibiting the GS could weaken the positive effect of fingolimod on nerve function in rats with DBI. Thus, inhibiting inflammation and regulating the GS may be critical for the therapeutic effect of fingolimod on DBI.PMID:38459666 | DOI:10.1111/cns.14669 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2024 Category: Neuroscience Authors: Dongyi Feng Tao Liu Xinjie Zhang Tangtang Xiang Wanqiang Su Wei Quan Rongcai Jiang Source Type: research
Fingolimod improves diffuse brain injury by promoting AQP4 polarization and functional recovery of the glymphatic system
CONCLUSIONS: In brief, these findings suggest that fingolimod alleviates whole-brain inflammation and GS system damage after DBI and that inhibiting the GS could weaken the positive effect of fingolimod on nerve function in rats with DBI. Thus, inhibiting inflammation and regulating the GS may be critical for the therapeutic effect of fingolimod on DBI.PMID:38459666 | PMC:PMC10924110 | DOI:10.1111/cns.14669 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 9, 2024 Category: Neuroscience Authors: Dongyi Feng Tao Liu Xinjie Zhang Tangtang Xiang Wanqiang Su Wei Quan Rongcai Jiang Source Type: research
Early intensive versus escalation treatment in patients with relapsing –remitting multiple sclerosis in Austria
ConclusionsESC treatment after DMF and TERI revealed a higher relapse and EDSS progression probability compared to EIT in Austrian RRMS patients. Therefore, an early intensive treatment should be started in patients with an active or highly active disease course. (Source: Journal of Neurology)
Source: Journal of Neurology - March 2, 2024 Category: Neurology Source Type: research
An integrative mechanistic model of thymocyte dynamics
ConclusionsIn summary, the proposed model accurately describes, in mechanistic terms, thymic output as a function of age. It may be further used to perform predictive simulations of clinically relevant scenarios which combine specific patho-physiological conditions and pharmacological interventions of interest. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 26, 2024 Category: Allergy & Immunology Source Type: research
Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy
CONCLUSIONS: Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling post-ischemia in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.PMID:38357819 | DOI:10.1161/ATVBAHA.123.320339 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Dirk M Hermann Source Type: research
Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy
CONCLUSIONS: Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling post-ischemia in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.PMID:38357819 | DOI:10.1161/ATVBAHA.123.320339 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Dirk M Hermann Source Type: research
Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy
CONCLUSIONS: Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling post-ischemia in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.PMID:38357819 | DOI:10.1161/ATVBAHA.123.320339 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Dirk M Hermann Source Type: research
Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy
CONCLUSIONS: Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling post-ischemia in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.PMID:38357819 | DOI:10.1161/ATVBAHA.123.320339 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Dirk M Hermann Source Type: research
Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy
CONCLUSIONS: Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling post-ischemia in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.PMID:38357819 | DOI:10.1161/ATVBAHA.123.320339 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Dirk M Hermann Source Type: research
The sphingosine 1 ‐phosphate analogue, FTY720, modulates the lipidomic signature of the mouse hippocampus
FTY720 is a synthetic analogue of sphingosine 1-phosphate. It is currently used to treat multiple sclerosis and has recently been approved for use in adolescents. The aim of this study was to investigate how FTY720 alters the lipid composition of the brain of adolescent mice. Three weeks of chronic FTY720 treatment caused an up-regulation of 99 lipid species in the mouse hippocampus, including several oxidised phosphatidylcholines, whereas only 3 lipid species of the phosphatidic acid class were down-regulated. Our study presents novel insight into FTY720's molecular mechanism of action in the central nervous system. FST, ...
Source: Journal of Neurochemistry - February 10, 2024 Category: Neuroscience Authors: Daniela M. Magalh ães,
Nicolas A. Stewart,
Myrthe Mampay,
Sara O. Rolle,
Chloe M. Hall,
Emad Moeendarbary,
Melanie S. Flint,
Ana M. Sebastião,
Cláudia A. Valente,
Marcus K. Dymond,
Graham K. Sheridan Tags: ORIGINAL ARTICLE Source Type: research
Drug-Induced Progressive Multifocal Leukoencephalopathy (PML): A Systematic Review and Meta-Analysis
ConclusionsA higher risk of drug-related PML in patients whose immune system is not additionally depressed by means of neoplasms, HIV or concomitant medications is found in the neurological field. This risk is higher in MS treatment, and specifically during long-term natalizumab therapy. While this drug is still routinely prescribed in this field, considering the efficacy in reducing MS relapses, in other areas it could play a smaller role, and be gradually replaced by other safer and more recently approved agents. (Source: Drug Safety)
Source: Drug Safety - February 7, 2024 Category: Drugs & Pharmacology Source Type: research
Risk of skin cancer associated with disease-modifying therapies in multiple sclerosis: a modern comprehensive evidence review
Actas Dermosifiliogr. 2024 Jan 31:S0001-7310(24)00055-3. doi: 10.1016/j.ad.2024.01.022. Online ahead of print.ABSTRACTThe use of disease-modifying therapies (DMT) has led to a paradigm shift in the management of multiple sclerosis. A comprehensive narrative review was conducted through an extensive literature search including Medline and Google Scholar to elucidate the link between DMT and the propensity of cutaneous malignancies. Sphingosine-1-phosphate receptor modulators, such as fingolimod and siponimod are associated with a higher risk of basal cell carcinoma (BCC), but not squamous cell carcinoma, or melanoma. The as...
Source: Actas Dermo-Sifiliograficas - February 2, 2024 Category: Dermatology Authors: M Brufau-Cochs M Mansilla-Polo D Morgado-Carrasco Source Type: research
Therapeutic Potential of Fingolimod in Diabetes Mellitus and Its Chronic Complications
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - February 1, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
GSE250453 Transcriptomic profile of multiple sclerosis patients treated with fingolimod
Contributors : Alicia S ánchez-Sanz ; Antonio García-Merino ; Antonio J Sánchez-López ; Rafael Muñoz-VianaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFingolimod is an immunomodulatory sphingosine-1-phosphate (S1P) analogue approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). The identification of biomarkers of clinical response to fingolimod is a major necessity in MS to identify optimal responders and avoid the risk of disease progression in non-responders. With this aim, we used RNA-sequencing to study the transcriptomic changes induced by fingoli...
Source: GEO: Gene Expression Omnibus - January 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
