Cryptococcal meningoencephalitis in multiple sclerosis treated with fingolimod
Pract Neurol. 2023 Oct 6:pn-2023-003691. doi: 10.1136/pn-2023-003691. Online ahead of print.ABSTRACTA 21-year-old woman with multiple sclerosis (taking regular fingolimod) developed sudden-onset severe headache with nausea and malaise. Neurological examination was normal and she was afebrile. Blood results showed lymphocytes 0.53 x 109/L and C reactive protein 19 mg/L. CT scan of head and venogram were normal. CSF showed an opening pressure of 33 cm H2O and an incidental light growth of Cryptococcus neoformans, confirmed with positive India Ink stain and a positive cryptococcal antigen (1:100). She was treated for cryptoco...
Source: Practical Neurology - October 6, 2023 Category: Neurology Authors: Moneeb Nasir Ian Galea Aidan Neligan Karen Chung Source Type: research
Cryptococcal meningoencephalitis in multiple sclerosis treated with fingolimod
Pract Neurol. 2023 Oct 6:pn-2023-003691. doi: 10.1136/pn-2023-003691. Online ahead of print.ABSTRACTA 21-year-old woman with multiple sclerosis (taking regular fingolimod) developed sudden-onset severe headache with nausea and malaise. Neurological examination was normal and she was afebrile. Blood results showed lymphocytes 0.53 x 109/L and C reactive protein 19 mg/L. CT scan of head and venogram were normal. CSF showed an opening pressure of 33 cm H2O and an incidental light growth of Cryptococcus neoformans, confirmed with positive India Ink stain and a positive cryptococcal antigen (1:100). She was treated for cryptoco...
Source: Practical Neurology - October 6, 2023 Category: Neurology Authors: Moneeb Nasir Ian Galea Aidan Neligan Karen Chung Source Type: research
Cryptococcal meningoencephalitis in multiple sclerosis treated with fingolimod
Pract Neurol. 2023 Oct 6:pn-2023-003691. doi: 10.1136/pn-2023-003691. Online ahead of print.ABSTRACTA 21-year-old woman with multiple sclerosis (taking regular fingolimod) developed sudden-onset severe headache with nausea and malaise. Neurological examination was normal and she was afebrile. Blood results showed lymphocytes 0.53 x 109/L and C reactive protein 19 mg/L. CT scan of head and venogram were normal. CSF showed an opening pressure of 33 cm H2O and an incidental light growth of Cryptococcus neoformans, confirmed with positive India Ink stain and a positive cryptococcal antigen (1:100). She was treated for cryptoco...
Source: Practical Neurology - October 6, 2023 Category: Neurology Authors: Moneeb Nasir Ian Galea Aidan Neligan Karen Chung Source Type: research
Enhanced selective capture of phosphomonoester lipids enabling highly sensitive detection of sphingosine 1-phosphate
Anal Bioanal Chem. 2023 Sep 22. doi: 10.1007/s00216-023-04937-8. Online ahead of print.ABSTRACTSphingolipids play crucial roles in cellular membranes, myelin stability, and signalling responses to physiological cues and stress. Among them, sphingosine 1-phosphate (S1P) has been recognized as a relevant biomarker for neurodegenerative diseases, and its analogue FTY-720 has been approved by the FDA for the treatment of relapsing-remitting multiple sclerosis. Focusing on these targets, we here report three novel polymeric capture phases for the selective extraction of the natural biomarker and its analogue drug. To enhance an...
Source: Analytical and Bioanalytical Chemistry - September 22, 2023 Category: Chemistry Authors: Giuliana Grasso Eduardo M Sommella Fabrizio Merciai Rahma Abouhany Sudhirkumar A Shinde Pietro Campiglia B örje Sellergren Carlo Crescenzi Source Type: research
Enhanced selective capture of phosphomonoester lipids enabling highly sensitive detection of sphingosine 1-phosphate
Anal Bioanal Chem. 2023 Sep 22. doi: 10.1007/s00216-023-04937-8. Online ahead of print.ABSTRACTSphingolipids play crucial roles in cellular membranes, myelin stability, and signalling responses to physiological cues and stress. Among them, sphingosine 1-phosphate (S1P) has been recognized as a relevant biomarker for neurodegenerative diseases, and its analogue FTY-720 has been approved by the FDA for the treatment of relapsing-remitting multiple sclerosis. Focusing on these targets, we here report three novel polymeric capture phases for the selective extraction of the natural biomarker and its analogue drug. To enhance an...
Source: Analytical and Bioanalytical Chemistry - September 22, 2023 Category: Chemistry Authors: Giuliana Grasso Eduardo M Sommella Fabrizio Merciai Rahma Abouhany Sudhirkumar A Shinde Pietro Campiglia B örje Sellergren Carlo Crescenzi Source Type: research
Inhibitory Effect of Fingolimod on Head and Neck Squamous Cell Carcinoma and Its Mechanism: Gene Set Enrichment Analysis
This study aimed to clarify the therapeutic effect of Fingolimod on head and neck squamous cell carcinoma (HNSC) and initially explore its mechanism through data mining, clinical sample analysis and basic experiments. The normalized Enrichment Score (NES) of Fingolimod in tumor tissues was obtained by SwissTargetPrediction and The Cancer Genome Atlas (TCGA) database. IC50 (50% inhibitory concentration) of Fingolimod for HNSC was verified based on the Genomics of Drug Sensitivity in Cancer (GDSC) database. SCC9 cells were cultured in vitro for the application of Fingolimod. Cell proliferation was determined by the Cell Coun...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Lemeng Chang Chunhua Xie Kaiping Chou Qingnan Meng Lihui Zhao Source Type: research
Inhibitory Effect of Fingolimod on Head and Neck Squamous Cell Carcinoma and Its Mechanism: Gene Set Enrichment Analysis
This study aimed to clarify the therapeutic effect of Fingolimod on head and neck squamous cell carcinoma (HNSC) and initially explore its mechanism through data mining, clinical sample analysis and basic experiments. The normalized Enrichment Score (NES) of Fingolimod in tumor tissues was obtained by SwissTargetPrediction and The Cancer Genome Atlas (TCGA) database. IC50 (50% inhibitory concentration) of Fingolimod for HNSC was verified based on the Genomics of Drug Sensitivity in Cancer (GDSC) database. SCC9 cells were cultured in vitro for the application of Fingolimod. Cell proliferation was determined by the Cell Coun...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Lemeng Chang Chunhua Xie Kaiping Chou Qingnan Meng Lihui Zhao Source Type: research
