Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice
Schizophrenia is a psychiatric disorder that affects around 1% of the population in widespread populations, with severe cases leading to long-term hospitalization and necessitation of lifelong treatment. Recen... (Source: Molecular Brain)
Source: Molecular Brain - July 12, 2023 Category: Neuroscience Authors: Siyao Li, Koki Sakurai, Masahiro Ohgidani, Takahiro A. Kato and Takatoshi Hikida Tags: Research Source Type: research
Fingolimod Modulates the Gene Expression of Proteins Engaged in Inflammation and Amyloid-Beta Metabolism and Improves Exploratory and Anxiety-Like Behavior in Obese Mice
AbstractObesity is considered a risk factor for type 2 diabetes mellitus, which has become one of the most important health problems, and is also linked with memory and executive function decline. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that regulates cell death/survival and the inflammatory response via its specific receptors (S1PRs). Since the role of S1P and S1PRs in obesity is rather obscure, we examined the effect of fingolimod (an S1PR modulator) on the expression profile of genes encoding S1PRs, sphingosine kinase 1 (Sphk1), proteins engaged in amyloid-beta (A β) generation (ADAM10, BACE1, PSEN2),...
Source: Neurotherapeutics - July 11, 2023 Category: Neurology Source Type: research
Antibody response to SARS-CoV-2 vaccination or infection in a prospective cohort of children with neuroinflammatory diseases
CONCLUSION: SARS-CoV-2 antibodies are decreased in children on CD20 monoclonal antibodies than on other treatments. Treatment duration associated with vaccination responses.PMID:37399703 | DOI:10.1016/j.ejpn.2023.06.009 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 3, 2023 Category: Neurology Authors: Charlotte Kaufmann Morgan Morris Grace Y Gombolay Source Type: research
Antibody response to SARS-CoV-2 vaccination or infection in a prospective cohort of children with neuroinflammatory diseases
CONCLUSION: SARS-CoV-2 antibodies are decreased in children on CD20 monoclonal antibodies than on other treatments. Treatment duration associated with vaccination responses.PMID:37399703 | PMC:PMC10307668 | DOI:10.1016/j.ejpn.2023.06.009 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 3, 2023 Category: Neurology Authors: Charlotte Kaufmann Morgan Morris Grace Y Gombolay Source Type: research
Antibody response to SARS-CoV-2 vaccination or infection in a prospective cohort of children with neuroinflammatory diseases
CONCLUSION: SARS-CoV-2 antibodies are decreased in children on CD20 monoclonal antibodies than on other treatments. Treatment duration associated with vaccination responses.PMID:37399703 | PMC:PMC10307668 | DOI:10.1016/j.ejpn.2023.06.009 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 3, 2023 Category: Neurology Authors: Charlotte Kaufmann Morgan Morris Grace Y Gombolay Source Type: research
Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in silico Liver-to-Plasma Partition Coefficients
In this study, two sets of in silico Kp,h values for 14 model substances were assessed using experimentally reported in vivo steady-state Kp,h data and time-dependent virtual internal exposures in the liver and plasma modeled by forward dosimetry in rats. The Kp,h values for 14 chemicals independently calculated using the primary Poulin and Theil method in this study were significantly correlated with those obtained using the updated Rodgers and Rowland method and with reported in vivo steady-state Kp,h data in rats. When pharmacokinetic parameters were derived based on individual in vivo time-dependent data for diazepam, ...
Source: Biological and Pharmaceutical Bulletin - June 28, 2023 Category: Drugs & Pharmacology Authors: Koichiro Adachi Masayoshi Utsumi Tasuku Sato Hina Nakano Makiko Shimizu Hiroshi Yamazaki Source Type: research
