NIH Halts Drug Making Operations after FDA Inspection
Discussion
This event is reminiscent of the FDA's New England Compounding Center inspection controversy. FDA's inspectors observed problems with NECC's ability to maintain its clean room, which is the enclosed space that is designed and maintained to have a controlled environment with low levels of airborne particles and surface contamination. In that case The U.S. Centers for Disease Control and Prevention (CDC) reported that 751 patients in 20 states were diagnosed with a fungal infection after receiving injections from the NECC. Of those 751 patients, the CDC reported that 64 patients in nine states died.
The closure is...
Source: Policy and Medicine - June 5, 2015 Category: American Health Authors: Thomas Sullivan Source Type: blogs
Nitric oxide synthase – NOS1, NOS2, NOS3
Nitric oxide synthase
Three important varieties of nitric oxide synthase involved in the synthesis of nitric oxide can be seen in the human system. They are neuronal, inducible and endothelial varieties.
nNOS: neuronal nitric oxide synthase (NOS1): Neuronal nitric oxide synthase is involved in the production of nitric oxide in both central and peripheral nervous system.
iNOS: inducible nitric oxide synthase (NOS2): Inducible nitric oxide synthase also generates nitric oxide from L-arginine. Nitric oxide has an important role in blood pressure regulation and is also thought to have roles in infectious and malignant pr...
Source: Cardiophile MD - July 30, 2014 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology endothelial nitric oxide synthase eNOS eNOS substrate L-arginine inducible nitric oxide synthase iNOS neuronal nitric oxide synthase nNOS NOS1 NOS2 NOS3 Source Type: blogs
Microbial Contributions to Alzheimer's Disease
There are a lot of papers on Alzheimer's disease that fall outside the mainstream focus on the formation of amyloid in the brain. This is perhaps in part a consequence of the challenges and delays that have beset efforts to produce practical treatments based on the amyloid view of the progression of Alzheimer's. As soon as any consensus in medical research and development fails to keep up its momentum, there are factions nibbling at its heels and trying out other ideas. The past few decades of the broader field of medical science are littered with promising approaches discarded in favor of others in the course of a few sho...
Source: Fight Aging! - July 4, 2014 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Microbiology Conferences July 2014
July 01 - 02, 2014 Biophysical Techniques for Probing Metals in BiologyNorwich, UK Further informationBiochemical Society Conference.Suggested reading: Bioremediation of Mercury July 04 - 06, 2014 Bringing PK and PD in Fungal Infections into the ClinicNijmegen, The Netherlands Further informationESCMID courses and workshops. Suggested reading: Human Pathogenic Fungi Molecular Diagnostics July 04 - 11, 2014 4th Central European Summer Course on MycologySzeged, Hungary Further informationBiology of Pathogenic Fungi and the 1st Rising Stars in Myco...
Source: Microbiology Blog: The weblog for microbiologists. - June 14, 2014 Category: Microbiology Source Type: blogs
Finally a homemade mayonnaise worth writing about! MCT mayo!
I have a love-hate relationship with homemade mayonnaise. I have known about the horrors of conventional mayo, (rancid soybean oil anyone?), not to mention the sugar and poor quality eggs used to make it. I knew I could do better than Hellman's. Until I couldn't do better. I love my Hellman's, (cue 'bring out the Hellman's and bring out the best!), and each time I made homemade mayo it just tasted bad in comparison. Smart me knew that what I had made was greatly superior to the store bought stuff, but man, it was not palatable. Mayo debacle after mayo debacle came in rapid succession. All olive oil? too bitter....
Source: the beautiful diabetic - February 19, 2014 Category: Diabetes Authors: Kathryn Source Type: blogs
Going Bananas: Another Climate Change Hustle
Paul C. "Chip" Knappenberger and Patrick J. Michaels
Global Science Report is a feature from the Center for the Study of Science, where we highlight one or two important new items in the scientific literature or the popular media. For broader and more technical perspectives, consult our monthly “Current Wisdom.”
We hear that there is looming banana crisis in Costa Rica—the world’s 2nd leading exporter of the fruit—as this year’s crop is being threatened by an infestation of mealybugs, scale insects, and fungal infection.
Petulance, plagues, disease? It must be climate change, of course!
The Director ...
Source: Cato-at-liberty - December 17, 2013 Category: Health Medicine and Bioethics Commentators Authors: Paul C. "Chip" Knappenberger, Patrick J. Michaels Source Type: blogs
Cryptococcus gattii Causing New Deadly Fungal Infection
Cryptococcus gattii is a deadly fungal infection that has now been found in several states outside of the Pacific Northwest in a development that is perplexing to infectious disease physicians and public health officials.
Unlike the more common Cryptococcus neoformans which infects mostly immunocompromised patients, C. gattii, while still very rare, can infect and kill the young and healthy, including a recent case of a healthy 18 year old woman in Georgia. The fungus causes severe brain and lung infections.
Julie Harris, MD, of the CDC comments in the article.
Unencapsulated (left) and encapsulated forms of C. gattii
&nbs...
Source: Inside Surgery - September 11, 2013 Category: Surgeons Authors: Editor Tags: Infectious Disease Medical News Wire brain infection CDC Cryptococcus fungal infection gatti Julie Harris lung infection neoformans Source Type: blogs
The saga of my pancreas..feet..microbiome ..blood.. liver - part 1
Well, this just keeps going - on and on and on. I thought I would be able to write a post when it was all done. But clearly not. So below is part 1 of an ongoing tale about me - my microbiome - my pancreas - my feet - my liver - my blood - and more.
Medical Record from my being admitted to
the hospital in 1984.
This particular saga started - I guess - in 1984. That was when, at 15 years old, I came pretty close to dying before being diagnosed with type I diabetes.
My immune system had betrayed me by killing the beta cells in my pancreas. Thanks a lot immune system. Anyway - this is ...
Source: The Tree of Life - August 30, 2013 Category: Medical Scientists Authors: Jonathan Eisen Source Type: blogs
Six ways Big Pharma manipulates consumers - Salon
This article originally appeared on AlterNet.
The blockbuster pill profit party is over for Big Pharma. Bestselling pills like Lipitor, Seroquel, Zyprexa, Singular and Concerta have gone off patent and sites which their ads sustained are withering on the vine. WebMD, for example, the voice of Pharma on the Web, with a former Pfizer exec serving as CEO, announced it would cut 250 positions in December.
But don’t worry, Wall Street. Pharma isn’t going to deliver disappointing earnings just because it has little or no new drugs coming online and has failed at the very reason for its existence. Here are six new Pharma ma...
Source: PharmaGossip - April 28, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs
What Your Nails Tell About You
Did you know that cracked or split nails have been linked to thyroid disease? If there is a combination of yellowish hue there may be a possibility of fungal infection.Contributor: Betty AsphyPublished: Apr 21, 2013 (Source: Most Recent Health Wellness - Associated Content)
Source: Most Recent Health Wellness - Associated Content - April 22, 2013 Category: Other Conditions Source Type: blogs
The LITFL Review 101
Conclusion: Imaging and repeat imaging in sciatic doesn’t really change the management..So why do it then!
Focus Article: Early Imaging After Arrest Often Finds the Culprit. Bottom line from this study: The use of an early diagnosis protocol with immediate coronary angiography and/or CT scan provided the etiology of nearly two thirds of OHCA cases.
ECG of the Week
ECG of the Week – It looks bad and wide – whats going on!
Ultrasound Podcast
ULTRASOUND OF RADIUS FRACTURE! What? That’s right. Diagnose it and guide your reduction with US!
TJdogma
ICE 007 – another great ICE case, simple, s...
Source: Life in the Fast Lane - April 8, 2013 Category: Emergency Medicine Doctors Authors: Kane Guthrie Tags: Education eLearning Emergency Medicine Featured Intensive Care LITFL review LITFL R/V Source Type: blogs
The LITFL Review 101
Conclusion: Imaging and repeat imaging in sciatic doesn’t really change the management..So why do it then!Focus Article: Early Imaging After Arrest Often Finds the Culprit. Bottom line from this study: The use of an early diagnosis protocol with immediate coronary angiography and/or CT scan provided the etiology of nearly two thirds of OHCA cases.ECG of the WeekECG of the Week – It looks bad and wide – whats going on!Ultrasound PodcastULTRASOUND OF RADIUS FRACTURE! What? That’s right. Diagnose it and guide your reduction with US!TJdogmaICE 007 – another great ICE case, simple, short and infor...
Source: Life in the Fast Lane - April 8, 2013 Category: Emergency Medicine Doctors Authors: Kane Guthrie Tags: Education eLearning Emergency Medicine Featured Intensive Care LITFL review LITFL R/V Source Type: blogs
Ulcerative colitis tamed
Traci posted this wonderful story of her dramatic relief from years of ulcerative colitis:
Dr. Davis,
For 24+ years I have suffered from Ulcerative Colitis (UC). This past Christmas, my stepmother recommend that I read your Wheat Belly book. I did because I had decided to remove carbs from my diet at the beginning of the year. She said your book would be a great supplement to my carb reduction. I had no idea that by reading your book my symptoms of UC would disappear!!!
Normally, I am treated with a medicine called Remicade which is administered via IV. Usually I receive this medicine every 2 months. Guess what??? It’s ...
Source: Wheat Belly Blog - March 6, 2013 Category: Cardiology Authors: Dr. Davis Tags: Ulcerative colitis Source Type: blogs
Oral Thrush: A Pain in the Mouth
Thrush is a fungal infection that can affect the mouth and genital areas. Find out more about this condition and ways to combat it.Contributor: Tania CowlingPublished: Feb 21, 2013 (Source: Most Recent Health Wellness - Associated Content)
Source: Most Recent Health Wellness - Associated Content - February 21, 2013 Category: Other Conditions Source Type: blogs
Does my Dog Need Skin Lotion?
Betty says…My mom told me to put lotion on my dog to stop her from scratching behind her ears. Is it really safe to put lotion on dogs?
The Beauty Brains respond:
We’ll take a crack at this one even though we’re not the Beauty Bitches (as in female dogs…get your mind out of the gutter!)
Canine cosmetics
Dogs have a pretty good life except when it comes to skin care. Their skin doesn’t produce sebum the way ours does and certain breeds are prone to dry skin conditions. Regular skin lotions don’t work so well through all that hair but there is a special “lotion” for dogs that...
Source: thebeautybrains.com - January 25, 2013 Category: Consumer Health News Authors: thebeautybrains Tags: Questions Source Type: blogs
