Report of a collaborative study to establish the first Indian Pharmacopoeia reference standard for teriparatide
This study involved four laboratories from India and the candidate standard was calibrated against the WHO IS by each participant laboratory using high-performance liquid chromatography (HPLC) assay method per IP monograph. Direct calibration of the candidate standard resulted in an assigned content of 1.02 mg per vial. Based on the study results the candidate standard was judged suitable to serve as the first IPRS for teriparatide for identification and assay by HPLC.PMID:38479212 | DOI:10.1016/j.biologicals.2024.101755 (Source: Biologicals : Journal of the International Association of Biological Standardization)
Source: Biologicals : Journal of the International Association of Biological Standardization - March 13, 2024 Category: Biotechnology Authors: Gaurav Pratap Singh Jadaun M Kalaivani Mukesh Kumar Gyanendra Nath Singh Rajeev Singh Raghuvanshi Parveen Jain Participants of the Study Source Type: research
Report of a collaborative study to establish the first Indian Pharmacopoeia reference standard for teriparatide
This study involved four laboratories from India and the candidate standard was calibrated against the WHO IS by each participant laboratory using high-performance liquid chromatography (HPLC) assay method per IP monograph. Direct calibration of the candidate standard resulted in an assigned content of 1.02 mg per vial. Based on the study results the candidate standard was judged suitable to serve as the first IPRS for teriparatide for identification and assay by HPLC.PMID:38479212 | DOI:10.1016/j.biologicals.2024.101755 (Source: Biologicals : Journal of the International Association of Biological Standardization)
Source: Biologicals : Journal of the International Association of Biological Standardization - March 13, 2024 Category: Biotechnology Authors: Gaurav Pratap Singh Jadaun M Kalaivani Mukesh Kumar Gyanendra Nath Singh Rajeev Singh Raghuvanshi Parveen Jain Participants of the Study Source Type: research
Report of a collaborative study to establish the first Indian Pharmacopoeia reference standard for teriparatide
This study involved four laboratories from India and the candidate standard was calibrated against the WHO IS by each participant laboratory using high-performance liquid chromatography (HPLC) assay method per IP monograph. Direct calibration of the candidate standard resulted in an assigned content of 1.02 mg per vial. Based on the study results the candidate standard was judged suitable to serve as the first IPRS for teriparatide for identification and assay by HPLC.PMID:38479212 | DOI:10.1016/j.biologicals.2024.101755 (Source: Biologicals : Journal of the International Association of Biological Standardization)
Source: Biologicals : Journal of the International Association of Biological Standardization - March 13, 2024 Category: Biotechnology Authors: Gaurav Pratap Singh Jadaun M Kalaivani Mukesh Kumar Gyanendra Nath Singh Rajeev Singh Raghuvanshi Parveen Jain Participants of the Study Source Type: research
Current and Developing Pharmacologic Agents for Improving Skeletal Health in Adults with Osteogenesis Imperfecta
AbstractOsteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility largely caused by defects in structure, synthesis, or post-translational processing of type I collagen. Drugs currently used to improve skeletal health in OI were initially developed to treat osteoporosis and clinical trials are ongoing to study their effectiveness in OI adults. Additionally, novel bone-protective agents are in preclinical studies and various phases of OI clinical trials. This review summarizes current knowledge on available pharmacologic agents and current drug trials involving OI participants. A PubMed on...
Source: Calcified Tissue International - March 12, 2024 Category: Orthopaedics Source Type: research
Teriparatide and clodronate combination as a potential treatment for complex regional pain syndrome type I in delayed consolidation after foot surgery: a case report and review of the literature
ConclusionTeriparatide cannot be considered the primary treatment for complex regional pain syndrome due to insufficient solid clinical data. However, when complex regional pain syndrome is associated with or caused by delayed union, teriparatide can be used to address the underlying cause of complex regional pain syndrome. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 8, 2024 Category: General Medicine Source Type: research
Exploring epigenetic strategies for the treatment of osteoporosis
Mol Biol Rep. 2024 Mar 8;51(1):398. doi: 10.1007/s11033-024-09353-4.ABSTRACTThe worldwide trend toward an aging population has resulted in a higher incidence of chronic conditions, such as osteoporosis. Osteoporosis, a prevalent skeletal disorder characterized by decreased bone mass and increased fracture risk, encompasses primary and secondary forms, each with distinct etiologies. Mechanistically, osteoporosis involves an imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Current pharmacological interventions for osteoporosis, such as bisphosphonates, denosumab, and teriparatide, aim to mo...
Source: Molecular Biology Reports - March 7, 2024 Category: Molecular Biology Authors: Sun-Ju Yi Jaeho Lim Kyunghwan Kim Source Type: research
Medication-related osteonecrosis of the jaw: evolving research for multimodality medical management
DiscussionWhile several adjuvant treatment modalities exhibit promising results in facilitating the healing process, current clinical practice guidelines predominantly recommend antibiotic therapy as a non-surgical approach, primarily addressing secondary infections in necrotic areas. However, this mainly addresses the potential infectious complication of MRONJ. Medical approaches including PENT-E, teriparatide, PBM, and PDT can result in successful management and should be considered prior to taking a surgical approach. Combined medical management for both preventing and managing MRONJ holds potential for achieving optima...
Source: Supportive Care in Cancer - March 5, 2024 Category: Cancer & Oncology Source Type: research
Analyzing the factors associated with efficacy among teriparatide treatment in postmenopausal women with osteoporosis
Teriparatide (TPTD) is a widely used anabolic agent for the treatment of osteoporosis. Several factors have been identified to be related to bone mineral density (BMD) increase in anti-osteoporosis treatment w... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - February 3, 2024 Category: Orthopaedics Authors: Meng Kong, Changtong Gao, Xiaona Luan, Cuiying Fan, Meng Hao, Canghai Jin, Jiangning Zhao, Hongyan Li, Jindong Zhao, Jian Luan, Yong Lin and Qiang Li Tags: Research Source Type: research
Comparison of the cost-effectiveness of sequential treatment with abaloparatide in US men and women at very high risk of fractures
CONCLUSIONS: Sequential therapy with ABL/ALN was cost-effective in US men and women at very high risk of fractures.PMID:38289413 | PMC:PMC10827834 | DOI:10.1007/s40520-023-02682-7 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 30, 2024 Category: Geriatrics Authors: Mickael Hiligsmann Stuart L Silverman Andrea J Singer Leny Pearman Yamei Wang John Caminis Jean-Yves Reginster Source Type: research
Comparison of radiological and functional outcomes of conservative treatment with teriparatide and denosumab in thoracolumbar osteoporotic vertebral fracture
ConclusionsTeriparatide and denosumab, despite of their different pharmacological mechanisms, showed similar radiological deformation and functional outcomes in the conservative treatment of TL-OVF. However, teriparatide showed a significantly higher incidence of fracture union with paravertebral bone bridge formation. (Source: Osteoporosis International)
Source: Osteoporosis International - January 23, 2024 Category: Orthopaedics Source Type: research
Denosumab, teriparatide and bisphosphonates for glucocorticoid-induced osteoporosis: a Bayesian network meta-analysis
Conclusion: Teriparatide denosumab and the bisphosphonates are all effective in improving BMD for GIO patients. Based on this network meta-analysis, teriparatide and denosumab have higher efficiency in improving lumbar spine and femur neck BMD, and reducing vertebrae fracture.Systematic Review Registration:10.17605/OSF.IO/2G8YA, identifier CRD42023456305. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 19, 2024 Category: Drugs & Pharmacology Source Type: research
Intraoperative complications during total hip arthroplasty: a very uncommon intraoperative femur fracture occurred in a malnourished osteoporotic patient
Acta Biomed. 2023 Jun 23;94(S2):e2023171. doi: 10.23750/abm.v94iS2.13811.ABSTRACTIntraoperative femoral fracture is a rare but growing complication of primary total hip arthroplasty. We aimed to present an uncommon related case, assessing also the role of malnutrition and osteoporosis. We discuss the case of a 49 years old male patient, malnourished and osteoporotic, with an intertrochanteric, multifragmentary, inveterate fracture, that happened three months before. During the prosthetic surgery, a supracondylar fracture occurred. We synthesized it with a 13 holes LISS plate, 7 distal screws and 3 proximal cerclage wires. ...
Source: Acta Bio-Medica : Atenei Parmensis - January 9, 2024 Category: General Medicine Authors: Alessandro Zanzi Corrado Ciatti Chiara Asti Gianfilippo Caggiari Umberto Cardinale Carlo Doria Francesco Pisanu Source Type: research
Intraoperative complications during total hip arthroplasty: a very uncommon intraoperative femur fracture occurred in a malnourished osteoporotic patient
Acta Biomed. 2023 Jun 23;94(S2):e2023171. doi: 10.23750/abm.v94iS2.13811.ABSTRACTIntraoperative femoral fracture is a rare but growing complication of primary total hip arthroplasty. We aimed to present an uncommon related case, assessing also the role of malnutrition and osteoporosis. We discuss the case of a 49 years old male patient, malnourished and osteoporotic, with an intertrochanteric, multifragmentary, inveterate fracture, that happened three months before. During the prosthetic surgery, a supracondylar fracture occurred. We synthesized it with a 13 holes LISS plate, 7 distal screws and 3 proximal cerclage wires. ...
Source: Acta Bio-Medica : Atenei Parmensis - January 9, 2024 Category: General Medicine Authors: Alessandro Zanzi Corrado Ciatti Chiara Asti Gianfilippo Caggiari Umberto Cardinale Carlo Doria Francesco Pisanu Source Type: research
Intraoperative complications during total hip arthroplasty: a very uncommon intraoperative femur fracture occurred in a malnourished osteoporotic patient
Acta Biomed. 2023 Jun 23;94(S2):e2023171. doi: 10.23750/abm.v94iS2.13811.ABSTRACTIntraoperative femoral fracture is a rare but growing complication of primary total hip arthroplasty. We aimed to present an uncommon related case, assessing also the role of malnutrition and osteoporosis. We discuss the case of a 49 years old male patient, malnourished and osteoporotic, with an intertrochanteric, multifragmentary, inveterate fracture, that happened three months before. During the prosthetic surgery, a supracondylar fracture occurred. We synthesized it with a 13 holes LISS plate, 7 distal screws and 3 proximal cerclage wires. ...
Source: Acta Bio-Medica : Atenei Parmensis - January 9, 2024 Category: General Medicine Authors: Alessandro Zanzi Corrado Ciatti Chiara Asti Gianfilippo Caggiari Umberto Cardinale Carlo Doria Francesco Pisanu Source Type: research
