Response to letter to the editor regarding, “MRI-based endplate Bone Quality score independently predicts cage subsidence following transforaminal lumbar interbody fusion”
We would like to express our gratitude to Mochizuki et al. [1] for their critical review and valuable comments on our study entitled, “MRI-based Endplate Bone Quality score independently predicts cage subsidence following transforaminal lumbar interbody fusion.” Concern was raised regarding variables that can be potential confounding factors for cage subsidence, such as details of the surgical techniques, cage surface coating (eg, titanium-coated), cage shape (eg, boomerang versus bullet), cage's position, and the use of antiosteoporosis drugs (eg, bisphosphonate and teriparatide). (Source: The Spine Journal)
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Authors: Youwei Ai, Qian Chen, Ce Zhu, Limin Liu Tags: Letters to the Editor Source Type: research
Pre-implantation teriparatide administration improves initial implant stability and accelerates the osseointegration process in osteoporotic rats
Osteoporotic individuals who have dental implants usually require a prolonged healing time for osseointegration due to the shortage of bone mass and the lack of initial stability. Although studies have shown t... (Source: International Journal of Implant Dentistry)
Source: International Journal of Implant Dentistry - April 16, 2024 Category: Dentistry Authors: Boyu Cui, Tianyi Bai, Qiyou Wu, Yibo Hu and Yihong Liu Tags: Research Source Type: research
The cost-effectiveness of osteoporosis medications for preventing periprosthetic fractures following femoral neck fracture indicated hip arthroplasty: a break-even analysis
ConclusionThe utilization of lower cost osteoporosis medications such as oral bisphosphonates and estrogen hormonal therapy as PPF prophylaxis in this patient population would be economically viable if they reduce the PPF rate by 1.8% and 1.5%, respectively. For IV bisphosphonates and newer agents to be economically viable as PPF prophylaxis in the USA, their costs need to be significantly reduced. (Source: Osteoporosis International)
Source: Osteoporosis International - April 15, 2024 Category: Orthopaedics Source Type: research
Therapeutic advantage of teriparatide in very elderly patients with proximal femoral fractures: a functional and BMD analysis
This study investigates its efficacy in functional recovery post... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - April 13, 2024 Category: Orthopaedics Authors: Ooi Chin Sheng, Wen-Tien Wu, Cheng-Huan Peng, Ting-Kuo Yao, Ing-Ho Chen, Jen-Hung Wang and Kuang-Ting Yeh Tags: Research Source Type: research
Delayed and significant hypercalcaemia due to teriparatide therapy: a case report and review
We report the case of a female who developed significant delayed hypercalcaemia after teriparatide treatment for osteoporosis and review other cases in the literature to date.Case reportA 72-year-old female on teriparatide for the treatment of osteoporosis was found to have hypercalcaemia (3.30 mmol/l) on routine testing approximately 3 months after starting therapy. Serum calcium pretreatment was normal at 2.39 mmol/l. She was admitted to the hospital for investigations which identified a serum 25-hydroxyvitamin D of 94 nmol/l, a low parathyroid hormone of 6.0 pg/ml, and normal test results for 1,25 dihydroxyvitamin D (11...
Source: Osteoporosis International - April 13, 2024 Category: Orthopaedics Source Type: research
Bisphosphonates Maintain BMD after Sequential Teriparatide and Denosumab in Premenopausal Women with Idiopathic Osteoporosis
CONCLUSION: BMD remained stable in women with PremenIOP who received bisphosphonates after sequential teriparatide-denosumab therapy.PMID:38605469 | DOI:10.1210/clinem/dgae240 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Mafo Kamanda-Kosseh Stephanie Shiau Sanchita Agarwal Ananya Kondapalli Ivelisse Colon Nayoung Kil Mariana Bucovsky Joan M Lappe Julie Stubby Elizabeth Shane Adi Cohen Source Type: research
Bisphosphonates Maintain BMD after Sequential Teriparatide and Denosumab in Premenopausal Women with Idiopathic Osteoporosis
CONCLUSION: BMD remained stable in women with PremenIOP who received bisphosphonates after sequential teriparatide-denosumab therapy.PMID:38605469 | DOI:10.1210/clinem/dgae240 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Mafo Kamanda-Kosseh Stephanie Shiau Sanchita Agarwal Ananya Kondapalli Ivelisse Colon Nayoung Kil Mariana Bucovsky Joan M Lappe Julie Stubby Elizabeth Shane Adi Cohen Source Type: research
Bisphosphonates Maintain BMD after Sequential Teriparatide and Denosumab in Premenopausal Women with Idiopathic Osteoporosis
CONCLUSION: BMD remained stable in women with PremenIOP who received bisphosphonates after sequential teriparatide-denosumab therapy.PMID:38605469 | DOI:10.1210/clinem/dgae240 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Mafo Kamanda-Kosseh Stephanie Shiau Sanchita Agarwal Ananya Kondapalli Ivelisse Colon Nayoung Kil Mariana Bucovsky Joan M Lappe Julie Stubby Elizabeth Shane Adi Cohen Source Type: research
Bisphosphonates Maintain BMD after Sequential Teriparatide and Denosumab in Premenopausal Women with Idiopathic Osteoporosis
CONCLUSION: BMD remained stable in women with PremenIOP who received bisphosphonates after sequential teriparatide-denosumab therapy.PMID:38605469 | DOI:10.1210/clinem/dgae240 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Mafo Kamanda-Kosseh Stephanie Shiau Sanchita Agarwal Ananya Kondapalli Ivelisse Colon Nayoung Kil Mariana Bucovsky Joan M Lappe Julie Stubby Elizabeth Shane Adi Cohen Source Type: research
Impact of osteoporosis and osteoporosis medications on fracture healing: a narrative review
ConclusionOverall, there appears to be no deleterious effect of osteoporosis medications on fracture healing. The benefit of treating osteoporosis and the urgent necessity to mitigate imminent refracture risk after a fracture should be given prime consideration. It is imperative that new radiological and biological markers of fracture healing be identified. It is also important to synthesize clinical and basic science methodologies to assess fracture healing, so that a convergence of the two frameworks can be achieved. (Source: Osteoporosis International)
Source: Osteoporosis International - April 8, 2024 Category: Orthopaedics Source Type: research
Systematical mutational analysis of teriparatide on anti-osteoporosis activity by alanine scanning
Bioorg Med Chem Lett. 2024 Apr 5:129732. doi: 10.1016/j.bmcl.2024.129732. Online ahead of print.ABSTRACTOsteoporosis is a progressive systemic skeletal disease that decreases bone density and bone quality, making them fragile and easy to break. In spite of effective anti-osteoporosis potency, teriparatide, the first anabolic medications approved for the treatment of osteoporosis, was proven to exhibit various side effects. And the relevant structure-activity relationship (SAR) of teriparatide was in need. In this work, we performed a systematical alanine scanning against teriparatide and synthesized 34 teriparatide derivat...
Source: Bioorganic and Medicinal Chemistry Letters - April 7, 2024 Category: Chemistry Authors: Haiyan Liang Huaxing Shen Mengjun Zheng Yejiao Shi Xiang Li Source Type: research
Systematical mutational analysis of teriparatide on anti-osteoporosis activity by alanine scanning
Bioorg Med Chem Lett. 2024 Apr 5;104:129732. doi: 10.1016/j.bmcl.2024.129732. Online ahead of print.ABSTRACTOsteoporosis is a progressive systemic skeletal disease that decreases bone density and bone quality, making them fragile and easy to break. In spite of effective anti-osteoporosis potency, teriparatide, the first anabolic medications approved for the treatment of osteoporosis, was proven to exhibit various side effects. And the relevant structure-activity relationship (SAR) of teriparatide was in need. In this work, we performed a systematical alanine scanning against teriparatide and synthesized 34 teriparatide der...
Source: Bioorganic and Medicinal Chemistry Letters - April 7, 2024 Category: Chemistry Authors: Haiyan Liang Huaxing Shen Mengjun Zheng Yejiao Shi Xiang Li Source Type: research
The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena
ConclusionIn our new multidisciplinary guideline osteoporosis and fracture prevention, we developed 5 “relatively new statements” that are all a crucial step forward in the optimization of diagnosis and treatment for fracture prevention. We also developed 5 flowcharts, and we suppose that this may be helpful for individual doctors and their patients in daily practice and may facilitate implement ation. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - April 2, 2024 Category: Orthopaedics Source Type: research
