Preventive effect of teriparatide on medication-related osteonecrosis of the jaw in rats
In conclusion, TPD administration before tooth extraction helped reduce the occurrence of MRONJ in rats treated with zoledronic acid, confirming its preventative effects.PMID:37726385 | DOI:10.1038/s41598-023-42607-y (Source: Cancer Control)
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Kyeong-Mee Park Namkwon Lee Jaeyeon Kim Hyun Sil Kim Wonse Park Source Type: research
Exercise for optimizing bone health after hormone-induced increases in bone stiffness
Hormones and mechanical loading co-regulate bone throughout the lifespan. In this review, we posit that times of increased hormonal influence on bone provide opportunities for exercise to optimize bone strength and prevent fragility. Examples include endogenous secretion of growth hormones and sex steroids that modulate adolescent growth and exogenous administration of osteoanabolic drugs like teriparatide, which increase bone stiffness, or its resistance to external forces. We review evidence that after bone stiffness is increased due to hormonal stimuli, mechanoadaptive processes follow. Specifically, exercise provides t...
Source: Frontiers in Endocrinology - September 18, 2023 Category: Endocrinology Source Type: research
Comparative effectiveness of therapeutic interventions in pregnancy and lactation-associated osteoporosis: a systematic review and meta-analysis
CONCLUSIONS: Due to high heterogeneity and lack of robust comparative data, no safe conclusions can be made regarding the optimal therapeutic intervention in women with PLO.PMID:37708365 | DOI:10.1210/clinem/dgad548 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 14, 2023 Category: Endocrinology Authors: Panagiotis Anagnostis Kalliopi Lampropoulou-Adamidou Julia K Bosdou Georgios Trovas Petros Galanis Efstathios Chronopoulos Dimitrios G Goulis Symeon Tournis Source Type: research
Twenty-four months of follow-up in women with rebound-associated vertebral fractures after discontinuation of denosumab: a single-centre case series
ConclusionIn this series of patients with RAVFs, we did not observe any new fractures and the BMD remained stable after 24 months of RT. Future studies are needed to evaluate the most suitable treatment approach after RAVFs but these preliminary data suggest that all denosumab, zoledronate and teriparatide might be adequate options. (Source: Osteoporosis International)
Source: Osteoporosis International - September 13, 2023 Category: Orthopaedics Source Type: research
The recombinant human parathyroid hormone, teriparatide as an alternative remedy for the medication-related osteonecrosis of the jaw
This article reviews the history of the anabolic effect of the low-dose rhPTH discovery, provides evidence-based data from animal and human studies, summarizes its biological mechanisms and the clinical benefits of the anabolic therapy and also their possible role in the management of MRONJ. The majority of the clinical data indicates that, in the case of therapy-resistant osteonecrosis, it may be worthwhile to apply short-term intermittent teriparatide therapy. Notwithstanding, more randomized clinical trials are necessary in order to confirm the efficacy and the safety of the use of teriparatide in the treatment of MRONJ...
Source: Orvosi Hetilap - September 11, 2023 Category: General Medicine Authors: Istv án Gera Nikolette Sz ücs Source Type: research
Anti-sclerostin antibodies: a new frontier in fragility fractures treatment
Ther Adv Musculoskelet Dis. 2023 Sep 8;15:1759720X231197094. doi: 10.1177/1759720X231197094. eCollection 2023.ABSTRACTBone fragility is the determinant of the increased risk of minimal trauma fracture and must be treated with a multimodal approach that includes pharmacological therapy, physical exercise, and adequate nutrition. Pharmacological therapy, to date based on the administration of antiresorptive drugs, such as bisphosphonates and denosumab, or osteoanabolic drugs, such as teriparatide and abaloparatide, has shown to be effective in reducing the risk of fracture in osteoporotic patients. In the context of the cell...
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Giovanni Iolascon Sara Liguori Marco Paoletta Giuseppe Toro Antimo Moretti Source Type: research
The recombinant human parathyroid hormone, teriparatide as an alternative remedy for the medication-related osteonecrosis of the jaw
This article reviews the history of the anabolic effect of the low-dose rhPTH discovery, provides evidence-based data from animal and human studies, summarizes its biological mechanisms and the clinical benefits of the anabolic therapy and also their possible role in the management of MRONJ. The majority of the clinical data indicates that, in the case of therapy-resistant osteonecrosis, it may be worthwhile to apply short-term intermittent teriparatide therapy. Notwithstanding, more randomized clinical trials are necessary in order to confirm the efficacy and the safety of the use of teriparatide in the treatment of MRONJ...
Source: Orvosi Hetilap - September 11, 2023 Category: General Medicine Authors: Istv án Gera Nikolette Sz ücs Source Type: research
Anti-sclerostin antibodies: a new frontier in fragility fractures treatment
Ther Adv Musculoskelet Dis. 2023 Sep 8;15:1759720X231197094. doi: 10.1177/1759720X231197094. eCollection 2023.ABSTRACTBone fragility is the determinant of the increased risk of minimal trauma fracture and must be treated with a multimodal approach that includes pharmacological therapy, physical exercise, and adequate nutrition. Pharmacological therapy, to date based on the administration of antiresorptive drugs, such as bisphosphonates and denosumab, or osteoanabolic drugs, such as teriparatide and abaloparatide, has shown to be effective in reducing the risk of fracture in osteoporotic patients. In the context of the cell...
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Giovanni Iolascon Sara Liguori Marco Paoletta Giuseppe Toro Antimo Moretti Source Type: research
The recombinant human parathyroid hormone, teriparatide as an alternative remedy for the medication-related osteonecrosis of the jaw
This article reviews the history of the anabolic effect of the low-dose rhPTH discovery, provides evidence-based data from animal and human studies, summarizes its biological mechanisms and the clinical benefits of the anabolic therapy and also their possible role in the management of MRONJ. The majority of the clinical data indicates that, in the case of therapy-resistant osteonecrosis, it may be worthwhile to apply short-term intermittent teriparatide therapy. Notwithstanding, more randomized clinical trials are necessary in order to confirm the efficacy and the safety of the use of teriparatide in the treatment of MRONJ...
Source: Orvosi Hetilap - September 11, 2023 Category: General Medicine Authors: Istv án Gera Nikolette Sz ücs Source Type: research
The recombinant human parathyroid hormone, teriparatide as an alternative remedy for the medication-related osteonecrosis of the jaw
This article reviews the history of the anabolic effect of the low-dose rhPTH discovery, provides evidence-based data from animal and human studies, summarizes its biological mechanisms and the clinical benefits of the anabolic therapy and also their possible role in the management of MRONJ. The majority of the clinical data indicates that, in the case of therapy-resistant osteonecrosis, it may be worthwhile to apply short-term intermittent teriparatide therapy. Notwithstanding, more randomized clinical trials are necessary in order to confirm the efficacy and the safety of the use of teriparatide in the treatment of MRONJ...
Source: Orvosi Hetilap - September 11, 2023 Category: General Medicine Authors: Istv án Gera Nikolette Sz ücs Source Type: research
The recombinant human parathyroid hormone, teriparatide as an alternative remedy for the medication-related osteonecrosis of the jaw
This article reviews the history of the anabolic effect of the low-dose rhPTH discovery, provides evidence-based data from animal and human studies, summarizes its biological mechanisms and the clinical benefits of the anabolic therapy and also their possible role in the management of MRONJ. The majority of the clinical data indicates that, in the case of therapy-resistant osteonecrosis, it may be worthwhile to apply short-term intermittent teriparatide therapy. Notwithstanding, more randomized clinical trials are necessary in order to confirm the efficacy and the safety of the use of teriparatide in the treatment of MRONJ...
Source: Orvosi Hetilap - September 11, 2023 Category: General Medicine Authors: Istv án Gera Nikolette Sz ücs Source Type: research
