Fight Aging! Newsletter, April 10th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
DNA Repair Can Be Improved by Suppression of the DREAM Complex
Researchers here describe a mechanism that appears to reduce DNA repair efficiency, and which can be suppressed to improve DNA repair. This is interesting, to say the least. It might be a path to determining just how much of a contribution to the pace of aging is produced by efficiency of DNA repair. The interaction between this and the finding that repeated cycles of double strand break repair induce epigenetic changes characteristic of aging is also an intriguing question. Mammalian studies sooner rather than later are called for.
The DNA-repair capacity in somatic cells is limited compared with that in germ cel...
Source: Fight Aging! - April 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Students With Visual Impairments Empowered to Explore Chemistry Through SEPA Project
Dr. Shaw (back left) observes SEPA program students engaging with tactile graphics in his lab. Credit: Jordan Koone
Students with blindness and low vision are often excluded from chemistry labs and offered few accessible representations of the subject’s imagery, which can significantly hinder their ability to learn about and participate in chemistry. Bryan Shaw, Ph.D., a professor of chemistry and biochemistry at Baylor University in Waco, Texas, hopes to change that through a program funded by an NIGMS Science Education Partnership Award (SEPA). His inspiration to start the program came from his son, who is visually i...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 10, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology STEM Education Uncategorized Training Source Type: blogs
What's new in midwifery for International Day of the Midwife
Some things to read on International Day of the Midwife:NHS England report on test for retinoblastoma that can be carried out in utero. Guardian report of the dropping of Maternity Action from a advisory board advising the government on maternity rights in employment.NICE are consulting on areas for improvement in antenatal care - consultation closes on 10th May.A BMJ clinical review on COVID in pregnancyThanks to the Library and Knowledge Service at Rotherham General Hospital for two of those. (Source: Browsing)
Source: Browsing - May 5, 2022 Category: Databases & Libraries Tags: midwifery Source Type: blogs
Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Broadening the Taxonomy of Cellular Senescence in Aging
Cells enter a senescent state constantly throughout life, largely because they have reached the Hayflick limit on replication, but also due to molecular damage, cancerous mutations, injury to tissue, radiation, or other causes. A senescent cell stops replicating, swells in size, and begins to secrete a mix of inflammatory signals, growth factors, and other molecules. Near all senescent cells are destroyed rapidly, either by programmed cell death or by the immune system, but this stops being the case in later life. Lingering senescent cells accumulate, and signaling that is helpful in the short term, to suppress cancer or a...
Source: Fight Aging! - November 5, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice.
To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Naked Mole-Rat Senescent Cells are Unusually Vulnerable to Oxidative Stress
This open access paper expands on earlier work on cellular senescence in long-lived naked mole-rats. Individuals of this species can live as much as nine times longer than equivalently sized rodents, and are near immune to cancer. In other mammals, senescent cells accumulate with age and disrupt tissue function via their inflammatory signaling. Evidence suggests that this is an important cause of degenerative aging, given that selective destruction of these errant cells produces rejuvenation and extended life span in mice.
In naked mole-rats, senescent cells exhibit very little of the harmful signaling that occurs i...
Source: Fight Aging! - July 29, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Free App Scans Everyday Photos of Kids for Signs of Disease
Leukocoria, also known as white puppilary reflex, is a symptom of a number of diseases, including retinoblastoma, Coats’ disease, and congenital cataracts. When light enters the eye at certain angles in people with leukocoria, a white reflection from the retina can be seen. While easy to spot with ophthalmic equipment, the condition, and the underlying disease, often goes unnoticed for much too long. Retinoblastoma, for example, is detected via identification of leukocoria during general physicals in fewer than 10% of cases.
Researchers at Baylor University have now developed an app that can scan through the photo...
Source: Medgadget - October 4, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Ophthalmology Pediatrics Source Type: blogs
The new WHO Ocular Tumour “Blue Book” is now available!
Prepared by 64 contributors from 22 countriesMore than 400 tables and color photos The new edition of the WHO Classification of Tumours of the Eye isnow on sale, just in time for Christmas! The latest edition is edited by Drs. Hans E. Grossniklaus, Charles Eberhart, and Tero Kivela. There are sections on all recognized neoplasms of the eye, lacrimal apparatus, and conjuctiva. Included are substantial changes to the classification of conjunctival neoplasia and melanoma, based on the latest molecular studies. Information on clinical features in addition to prognostic and predictive factors for each tumour typ...
Source: neuropathology blog - December 20, 2018 Category: Radiology Tags: ophthalmic pathology Source Type: blogs
Choroidal Melanoma :DAMS Unplugged
Presenting an integrated case discussion on choroidal melanoma in DAMS unplugged series.Famous Radiology Blog http://www.sumerdoc.blogspot.com
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Source: Sumer's Radiology Site - November 15, 2018 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Best Post of October 2018: Young adult with an iridic mass extending into the ciliary body
The next in our " Best of the Month " series comes from October 9, 2018:Melanoma markers were negative. Smooth muscle markers were positive. This case was determined to be an epithelioid leiomyoma. I didn ' t do electron microscopy to look for mitochondia, but it may well be what Ursula Schlotzer-Schredhardt et al. have called a mitochondria-rich epithelioid leiomyoma (Arch Ophthalmol, Vol 120, January 2002). (Source: neuropathology blog)
Source: neuropathology blog - November 1, 2018 Category: Radiology Tags: Best of the Month series eye ophthalmic pathology Source Type: blogs
Young adult with an iridic mass extending into the ciliary body
Melanoma markers were negative. Smooth muscle markers were positive. This case was determined to be anepithelioid leiomyoma. I didn ' t do electron microscopy to look for mitochondia, but it may well be whatUrsula Schlotzer-Schredhardtet al. have called amitochondria-rich epithelioid leiomyoma(Arch Ophthalmol, Vol 120, January 2002). (Source: neuropathology blog)
Source: neuropathology blog - October 9, 2018 Category: Radiology Tags: eye ophthalmic pathology Source Type: blogs
Mesoectodermal Leiomyoma of the Ciliary Body
A 47-year-old woman is suspected of having a ciliary body melanoma (A). Histologic sections (B and C) show large ciliary body tumor composed of tumor cells in a fibrillar cytoplasmic matrix. Electron microscopy (D) shows a dense osmophiliic structure known as askeinoid fiber.Immunohistochemistry helped to confirm that this was a leiomyoma.(Case reported by J. Campbell et al. Ultrastruct Pathol 28:559, 1997.) (Source: neuropathology blog)
Source: neuropathology blog - October 5, 2018 Category: Radiology Tags: eye Source Type: blogs
Fight Aging! Newsletter, August 27th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
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Source: Fight Aging! - August 26, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
