Inhibition of CDK4 Reverses Measures of Aging in the Liver
Today, I'll point out an open access commentary in which the authors survey a number of lines of research into age-related dysfunction in the liver, all of which lead back to elevated levels of cyclin-dependent kinase 4 (CDK4). Some of this work involves investigation of the mechanisms of fatty liver disease, more properly known as hepatic steatosis. This is most commonly caused by being overweight in this age of cheap calories, but, setting aside the morbidly obese, the condition nonetheless tends to emerge later rather than earlier in life. Other research programs look at more directly age-associated measures of liver fu...
Source: Fight Aging! - August 20, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 4th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 3, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Commentary on Senolytic Gene Therapies to Target p16 Overexpression
This short commentary discusses the utility of Oisin Biotechnologies' initial strategy for destroying senescent cells, which is to use p16 expression as the determining sign of senescence. Oisin's implementation involves delivering dormant DNA machinery indiscriminately to all cells, and then triggering it only in cells with high levels of p16. This particular implementation is one of many possibilities in the gene therapy space, and thus various other groups are working on their own p16-based approaches as senolytic development as a treatment for aging grows in funding and popularity.
It isn't just senescence and a...
Source: Fight Aging! - May 28, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Uveal Melanoma: The Basics
The uvea of the eye is a vascular tunic comprised of the iris, ciliary body, and choroid. Located between the sclera and the retina, the uvea contains dendritic pigmented melanocytes which have the potential to give rise to malignant melanoma. Patients with choroidal melanoma typically present as adults with painless monocular vision loss, while a cataract or glaucoma may be the presenting feature of an anterior segment melanoma.Approximately half of patients with choroidal and ciliochoroidal melanomas eventually die from their tumors. Prognosis is better in cases localized to the iris, presumably because they are recogniz...
Source: neuropathology blog - February 1, 2018 Category: Radiology Tags: eye Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Fight Aging! Newsletter, June 19th 2017
This study is the first to show that downregulation of PAPP-A expression in adult mice can significantly extend life span.
Importantly, this beneficial longevity phenotype is distinct from the dwarfism of long-lived PAPP-A KO, Ames dwarf, Snell dwarf and growth hormone receptor (GHR) KO mice with germ-line mutations. Thus, downregulation of PAPP-A expression joins other treatment regimens, such as resveratrol, rapamycin and dietary restriction, which can extend life span when started in mice as adults. In a recent study, inducible knockdown of the GHR in young adult female mice increased maximal, but not median, lif...
Source: Fight Aging! - June 18, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Recent Research into the Details of Cellular Senescence
Today's papers are representative of present investigations that aim primarily to expand our knowledge of the details of cellular senescence. This is as opposed to efforts to immediately produce treatments that can address the impact of senescent cells on health. Senescent cells accumulate with age, and their presence is one of the root causes of degenerative aging. The most important work on cellular senescence at the moment is that aimed at selective destruction of these cells. The vast majority of cells that become senescent in our bodies, countless numbers day in and day out, are in fact already efficiently destroyed, ...
Source: Fight Aging! - June 14, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 22nd 2017
In this study, researchers analysed data of millions of British patients between 1995 and 2015 to see if this claim held true. They tracked people who were obese at the start of the study, defined as people with a body mass index (BMI) of 30 or more, who had no evidence of heart disease, high blood pressure, high cholesterol or diabetes at this point. They found these people who were obese but "metabolically healthy" were at higher risk of developing heart disease, strokes and heart failure than people of normal weight.
No such thing as 'fat but fit', major study finds
Several studies in the past have sug...
Source: Fight Aging! - May 21, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Comparing Regeneration of Fingertips Between Species
As a sidebar to yesterday's post on regeneration in mammals, here is a review paper that just considers fingertip regeneration in various species. This can occur in mammals, and even on rare occasions in adult humans, though it isn't well understood as to why it happens at all given the inability to regenerate most other lost appendages. It is possible that this is a useful point of investigation in order to better understand why mammals do not regenerate like salamanders, and how that state of affairs might be changed for the better.
Mammalian fingertips and toes can partially regrow under certain conditions; how...
Source: Fight Aging! - May 17, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Can Cellular Senescence be Reversed in the Near Future, and is Reversal Desirable?
Cellular senescence is one of the causes of degenerative aging. Normal somatic cells in adults become senescent at the end of their replicative life span, when they reach the Hayflick limit on cell divisions, or in response to damage or a toxic environment. Most such cells self-destruct or are destroyed by the immune system, but some linger to cause problems, ever more of them over the years. A senescent cell generates a mix of signals known as the senescence-associated secretory phenotype (SASP) that promotes inflammation, damages surrounding tissue structures, and alters the behavior of nearby cells for the worse. Senesc...
Source: Fight Aging! - December 14, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Vestige of a choroidal melanoma
Only melanin and melanophages remain in an enucleation specimen from a patient successfully treated with brachytherapy for choroidal melanoma. The eye was enucleated not because of the tumor, but because it was blind and intractably painful in the aftermath of treatment. (Source: neuropathology blog)
Source: neuropathology blog - November 29, 2016 Category: Radiology Tags: ophthalmic pathology Source Type: blogs
Neuropathology Maintenance of Certification Topics
For those taking the maintenance of certification (MOC) examination at some point in the next few years, the American Board of Pathology (ABP) has published topics that may be covered in the examination. The examination consists of 150 multiple-choice questions, 50 of which are required to be in the a category designated " general neuropathology I " . The remaining 100 questions can be from various categories which the examinee chooses (general neuropathology II, degenerative I& II, developmental/pediatric/congenital I& II, neoplastic I& II, and neuromuscular I& II). The ABP provides an MOC examination...
Source: neuropathology blog - November 2, 2016 Category: Radiology Tags: MOC Source Type: blogs
Scleral invasion by uveal melanoma
Circled cells represent superficial invasion of sclera (I don ' t think those cells are in a vessel) (Source: neuropathology blog)
Source: neuropathology blog - August 10, 2016 Category: Radiology Tags: neoplasms ophthalmic pathology Source Type: blogs
Choroidal Involvement by Retinoblastoma
(Source: neuropathology blog)
Source: neuropathology blog - June 6, 2016 Category: Radiology Tags: neoplasms ophthalmic pathology Source Type: blogs
Uveal melanoma at iris root
Neoplasm is extending into and blocking anterior chamber angle (Source: neuropathology blog)
Source: neuropathology blog - May 28, 2016 Category: Radiology Tags: neoplasms ophthalmic pathology Source Type: blogs
