Management of Intraocular Retinoblastoma: ICMR Consensus Guidelines
AbstractRetinoblastoma (RB) is the most common childhood intraocular malignancy. Delayed presentation due to a lack of awareness and advanced intraocular tumors are a common scenario in low-middle income countries (LMICs). Remarkable treatment advances have been made in the past few decades allowing globe salvage in advanced intraocular RB (IORB) including systemic chemotherapy with focal consolidation and targeted treatments like intraarterial chemotherapy and intravitreal chemotherapy. However, a lack of availability and affordability limits the use of such advances in LMICs. External beam radiotherapy, despite risk of s...
Source: Indian Journal of Pediatrics - April 13, 2024 Category: Pediatrics Source Type: research
Troponin Elevation in Patients Undergoing Percutaneous Hepatic Perfusion for Metastatic Uveal Melanoma
CONCLUSION: Percutaneous Hepatic Perfusion is safe and associated with a transient, asymptomatic troponin elevation peri-operatively without major adverse cardiac events at 90 days. The observed troponin elevation is likely secondary to coronary demand-supply mismatch related to procedural hemodynamic shifts, hypotension, and anemia.PMID:38605434 | DOI:10.1177/10732748241246898 (Source: Cancer Control)
Source: Cancer Control - April 12, 2024 Category: Cancer & Oncology Authors: Sanjay Chandrasekhar Matthew Perez Zurain Niaz Jahanzaib Ekram Neelam Lal Sarah Koly Biwei Cao Jonathan S Zager Mohammed Alomar Source Type: research
Recent advances in tyrosine kinase inhibitors VEGFR 1-3 for the treatment of advanced metastatic melanoma
Expert Opin Pharmacother. 2024 Apr 12. doi: 10.1080/14656566.2024.2342403. Online ahead of print.ABSTRACTINTRODUCTION: Increasing evidence from preclinical and clinical studies suggests the role of vascular endothelial growth factor (VEGF) signaling in melanoma progression, response to therapy, and overall survival. Moreover, the discovery of the potential involvement of the VEGF pathway in resistance to immunotherapy has led to new clinical trials with VEGFR inhibitors.AREAS COVERED: We have reviewed recent literature, mainly published within the last 5 years, on VEGFR-targeted treatments for advanced melanoma, including ...
Source: Expert Opinion on Pharmacotherapy - April 12, 2024 Category: Drugs & Pharmacology Authors: Pawe ł Sobczuk Micha ł Cholewiński Piotr Rutkowski Source Type: research
Predictive model for iris melanoma
CONCLUSIONS: The predictive model provides direct diagnostic prediction of the lesion being iris melanoma expressed as probability (%). Use of a prediction calculator (app) can enhance decision-making and patient counselling. Further refinements can be undertaken with additional datasets, forming the basis for automated diagnosis.PMID:38609162 | DOI:10.1136/bjo-2023-324558 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - April 12, 2024 Category: Opthalmology Authors: Arun Singh Alexander Melendez-Moreno J ørgen Krohn Emily C Zabor Source Type: research
Predictive model for iris melanoma
CONCLUSIONS: The predictive model provides direct diagnostic prediction of the lesion being iris melanoma expressed as probability (%). Use of a prediction calculator (app) can enhance decision-making and patient counselling. Further refinements can be undertaken with additional datasets, forming the basis for automated diagnosis.PMID:38609162 | DOI:10.1136/bjo-2023-324558 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - April 12, 2024 Category: Opthalmology Authors: Arun Singh Alexander Melendez-Moreno J ørgen Krohn Emily C Zabor Source Type: research
Assessment of Retinal Microvasculature and Choroidal Vascularity After Intra-arterial Chemotherapy for Retinoblastoma
To evaluate changes in retinal microvascular density and choroidal vascularity in patients with retinoblastoma (RB) after intra-arterial chemotherapy (IAC). (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - April 12, 2024 Category: Opthalmology Authors: Xiuqian Yi, Xintong Lin, Chun Fang, Qiang Liu, Haifeng Chen, Jiang Qian, Kang Xue Source Type: research
Uveal melanoma cell lines Mel270 and 92.1 exhibit a mesenchymal phenotype and sensitivity to the cytostatic effects of transforming growth factor beta in vitro
CONCLUSIONS: Our findings indicate that UM cells are sensitive to the two arms of TGF-β signaling, which suggests that targeting the TGF-β pathway could be challenging in UM and would require a precise selection of patients in which only the prometastatic arm of TGF-β is activated.PMID:38601020 | PMC:PMC11006005 (Source: Molecular Vision)
Source: Molecular Vision - April 11, 2024 Category: Molecular Biology Authors: Coralie Doudnikoff Delphine Leclerc Ga ëlle Angenard David Gilot C édric Coulouarn Frederic Mouriaux Source Type: research
Quality of Life Analysis of Patients Treated with Percutaneous Hepatic Perfusion for Uveal Melanoma Liver Metastases
ConclusionM-PHP causes fatigue and a decline in physical and role functioning in the 1st weeks after treatment, but GHS returns to baseline levels within 21 days.Level of Evidence 3Cohort study.Graphical Abstract (Source: CardioVascular and Interventional Radiology)
Source: CardioVascular and Interventional Radiology - April 8, 2024 Category: Radiology Source Type: research
Apical dose versus volume dose of Ruthenium-106 brachytherapy for uveal melanoma
CONCLUSION: D99% and apex dose are affected by tumour and treatment characteristics in different ways, highlighting the complexity of radiation delivery to uveal tumours.PMID:38582499 | DOI:10.1016/j.jcjo.2024.03.007 (Source: Cancer Control)
Source: Cancer Control - April 6, 2024 Category: Cancer & Oncology Authors: Jeremy P M Flanagan Lotte S Fog Melvin A Astrahan Lachie J Talbot Daniel McKay Claire Phillips John D McKenzie Roderick O'Day Source Type: research
Apical dose versus volume dose of Ruthenium-106 brachytherapy for uveal melanoma
CONCLUSION: D99% and apex dose are affected by tumour and treatment characteristics in different ways, highlighting the complexity of radiation delivery to uveal tumours.PMID:38582499 | DOI:10.1016/j.jcjo.2024.03.007 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - April 6, 2024 Category: Opthalmology Authors: Jeremy P M Flanagan Lotte S Fog Melvin A Astrahan Lachie J Talbot Daniel McKay Claire Phillips John D McKenzie Roderick O'Day Source Type: research
Apical dose versus volume dose of Ruthenium-106 brachytherapy for uveal melanoma
CONCLUSION: D99% and apex dose are affected by tumour and treatment characteristics in different ways, highlighting the complexity of radiation delivery to uveal tumours.PMID:38582499 | DOI:10.1016/j.jcjo.2024.03.007 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - April 6, 2024 Category: Opthalmology Authors: Jeremy P M Flanagan Lotte S Fog Melvin A Astrahan Lachie J Talbot Daniel McKay Claire Phillips John D McKenzie Roderick O'Day Source Type: research
Apical dose versus volume dose of Ruthenium-106 brachytherapy for uveal melanoma
CONCLUSION: D99% and apex dose are affected by tumour and treatment characteristics in different ways, highlighting the complexity of radiation delivery to uveal tumours.PMID:38582499 | DOI:10.1016/j.jcjo.2024.03.007 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - April 6, 2024 Category: Opthalmology Authors: Jeremy P M Flanagan Lotte S Fog Melvin A Astrahan Lachie J Talbot Daniel McKay Claire Phillips John D McKenzie Roderick O'Day Source Type: research
