Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric ulcer in rats
CONCLUSION: The present study demonstrated that the extract from O. spinosa was able to protect gastric mucosa from ethanol injury by at least 2 mechanisms, namely the induction of COX-2 and decreasing oxidative stress in the stomach.PMID:33825407 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Abbas Manal Ahmad Kandil Yasser Ibrahim Abbas Manal Mohammad Source Type: research

Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric ulcer in rats
CONCLUSION: The present study demonstrated that the extract from O. spinosa was able to protect gastric mucosa from ethanol injury by at least 2 mechanisms, namely the induction of COX-2 and decreasing oxidative stress in the stomach.PMID:33825407 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Abbas Manal Ahmad Kandil Yasser Ibrahim Abbas Manal Mohammad Source Type: research

Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric ulcer in rats
CONCLUSION: The present study demonstrated that the extract from O. spinosa was able to protect gastric mucosa from ethanol injury by at least 2 mechanisms, namely the induction of COX-2 and decreasing oxidative stress in the stomach.PMID:33825407 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Abbas Manal Ahmad Kandil Yasser Ibrahim Abbas Manal Mohammad Source Type: research

Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric ulcer in rats
CONCLUSION: The present study demonstrated that the extract from O. spinosa was able to protect gastric mucosa from ethanol injury by at least 2 mechanisms, namely the induction of COX-2 and decreasing oxidative stress in the stomach.PMID:33825407 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Abbas Manal Ahmad Kandil Yasser Ibrahim Abbas Manal Mohammad Source Type: research

Eradication Rates for Esomeprazole and Lansoprazole-Based 7-Day Non-Bismuth Concomitant Quadruple Therapy for First-Line Anti-Helicobacter pylori Treatment in Real World Clinical Practice
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - March 25, 2021 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Is there a  correlation between hypomagnesemia linked to long-term proton pump inhibitor use and the active agent?
CONCLUSION: In light of the data obtained it was concluded that hypomagnesemia linked to PPI use is associated with the type of PPI. While patients using rabeprazole had the lowest rates, those using omeprazole had significantly higher rates of hypomagnesemia. Additionally, there was a proportional correlation between age and duration of use with the risk of development of hypomagnesemia.PMID:33751184 | DOI:10.1007/s00508-021-01834-x (Source: Wiener Klinische Wochenschrift)
Source: Wiener Klinische Wochenschrift - March 22, 2021 Category: General Medicine Authors: Şengül Aydın Yoldemir Guzin Zeren Ozturk Murat Akarsu Mustafa Ozcan Source Type: research

Is there a  correlation between hypomagnesemia linked to long-term proton pump inhibitor use and the active agent?
CONCLUSION: In light of the data obtained it was concluded that hypomagnesemia linked to PPI use is associated with the type of PPI. While patients using rabeprazole had the lowest rates, those using omeprazole had significantly higher rates of hypomagnesemia. Additionally, there was a proportional correlation between age and duration of use with the risk of development of hypomagnesemia.PMID:33751184 | DOI:10.1007/s00508-021-01834-x (Source: Wiener Klinische Wochenschrift)
Source: Wiener Klinische Wochenschrift - March 22, 2021 Category: General Medicine Authors: Şengül Aydın Yoldemir Guzin Zeren Ozturk Murat Akarsu Mustafa Ozcan Source Type: research

Proton pump inhibitors use and risk of developing spontaneous bacterial peritonitis in cirrhotic patients: A systematic review and meta-analysis
AbstractBackgroundSpontaneous bacterial peritonitis (SBP) is one of the most common infectious diseases in patients with cirrhosis and is associated with serious prognosis. A prevailing dogma posits that SBP is exacerbated by the frequent use of proton pump inhibitors (PPIs).AimsTo re-assess the association between PPIs use and SBP incidence with larger and better-quality data.MethodThe studies were identified by searching Proquest, Medline, and Embase for English language articles published between January 2008 and March 2020 using the following keywords alone or in combination: anti-ulcer agent, antacid, proton pump inhi...
Source: Gut Pathogens - March 19, 2021 Category: Microbiology Source Type: research

Antibiotic susceptibility guided reuse of levofloxacin-based therapy in a penicillin-allergic patient for Helicobacter pylori infection: A case report
Rationale: Antibiotic resistance poses a challenge for Helicobacter pylori eradication treatment. Current guidelines strongly recommend avoiding repeated treatments with the same antibiotic to prevent the emergence of drug resistance. However, for penicillin-allergic patients with recurrent H. pylori eradication failures, avoiding repeated treatments with the same antibiotic severely limits the choice of treatment. Patient concerns: A 47-year-old woman with a penicillin allergy for whom 2 previous levofloxacin and bismuth-based therapies had failed. Diagnosis: H. pylori infection. Interventions: Ag...
Source: Medicine - March 12, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Proton Pump Inhibitor Exposure and Acute Myocardial Infarction Risk: A Nested Cohort Study
CONCLUSIONS: Our study demonstrated long-term or high-dose PPI exposure associated with increased new-onset AMI risk in patients without a history of any ischemic heart disease. The underlying mechanisms of PPI-related cardiovascular effects deserve more investigation.PMID:33625647 | DOI:10.1007/s12012-021-09637-2 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - February 24, 2021 Category: Cardiology Authors: Hsiang-Jung Tseng Chih-Ming Cheng Shih-Jen Tsai Wei-Chen Lin Ya-Mei Bai Chia-Fen Tsai Tung-Ping Su Cheng-Ta Li Tzeng-Ji Chen Mu-Hong Chen Source Type: research

Proton Pump Inhibitor Exposure and Acute Myocardial Infarction Risk: A Nested Cohort Study
CONCLUSIONS: Our study demonstrated long-term or high-dose PPI exposure associated with increased new-onset AMI risk in patients without a history of any ischemic heart disease. The underlying mechanisms of PPI-related cardiovascular effects deserve more investigation.PMID:33625647 | DOI:10.1007/s12012-021-09637-2 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - February 24, 2021 Category: Cardiology Authors: Hsiang-Jung Tseng Chih-Ming Cheng Shih-Jen Tsai Wei-Chen Lin Ya-Mei Bai Chia-Fen Tsai Tung-Ping Su Cheng-Ta Li Tzeng-Ji Chen Mu-Hong Chen Source Type: research

Proton Pump Inhibitor Exposure and Acute Myocardial Infarction Risk: A Nested Cohort Study
CONCLUSIONS: Our study demonstrated long-term or high-dose PPI exposure associated with increased new-onset AMI risk in patients without a history of any ischemic heart disease. The underlying mechanisms of PPI-related cardiovascular effects deserve more investigation.PMID:33625647 | DOI:10.1007/s12012-021-09637-2 (Source: Cardiovascular Toxicology)
Source: Cardiovascular Toxicology - February 24, 2021 Category: Cardiology Authors: Hsiang-Jung Tseng Chih-Ming Cheng Shih-Jen Tsai Wei-Chen Lin Ya-Mei Bai Chia-Fen Tsai Tung-Ping Su Cheng-Ta Li Tzeng-Ji Chen Mu-Hong Chen Source Type: research

Do the types and routes of proton pump inhibitor treatments affect Clostridium difficile in ICU patients?: A retrospective cohort study.
Authors: Lee P, Fike D, Yang H, Hall RG, Pass S, Alvarez CA Abstract Background: Proton pump inhibitor (PPI) exposure is associated with Clostridium difficile infection (CDI). The impact of the route of administration is unknown. RESEARCH DESIGN AND METHODS: Patients in the Multiparameter Intelligent Monitoring in Intensive Care II database (MIMIC-II) from 2001-2008 who were>18 years old, admitted to medical, surgical, or cardiac ICUs were included. PPI exposure types were omeprazole, esomeprazole, lansoprazole, and pantoprazole. PPI administration routes were oral or intravenous. Patients who received hista...
Source: Expert Review of Clinical Pharmacology - February 14, 2021 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research

Pharmacokinetics and Pharmacodynamics of Esomeprazole/Sodium Bicarbonate Immediate-Release Capsules in Healthy Chinese Volunteers: A Cross-Over, Randomized Controlled Trial
AbstractIntroductionEsomeprazole delayed release tablets (ESO) are one of the most effective treatments for acid-related disorders. The purpose of this study is to compare the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of an immediate-release capsule formulation containing esomeprazole 20  mg and sodium bicarbonate 1100 mg (IR-ESO) compared to those of the esomeprazole delayed release tablet 20 mg (ESO). In addition, the impact ofCYP2C19 gene polymorphisms on PK and PD was evaluated.MethodsA single-center, open-label, randomized, 2-treatment, 2-sequence, and 2-period crossover study was conducte...
Source: Advances in Therapy - February 11, 2021 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of Antofloxacin-Based Triple Therapy for Helicobacter pylori Eradication Failure in China
ConclusionsThe findings showed that antofloxacin may be a promising candidate in rescue therapy forH. pylori eradication failure in China. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - February 8, 2021 Category: Gastroenterology Source Type: research

Low-dose PPI to prevent bleeding after ESD: A multicenter randomized controlled study.
CONCLUSION: The intermittent use of low-dose PPIs is sufficient to prevent post-ESD bleeding. It might be applied in clinical practice to prevent post-ESD bleeding and reduce the costs related to PPIs. PMID: 33450486 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 12, 2021 Category: Drugs & Pharmacology Authors: Yang L, Qi J, Chen W, Guo Q, Xie R, Zhao Z, Qin S, Liu A, Den M, Fan C, Bai J, Lin H, Guo H, Yang S Tags: Biomed Pharmacother Source Type: research

Pharmacokinetics of single and repeated oral doses of esomeprazole and gastrin elevation in healthy males and females.
Authors: Helgadóttir H, Lund SH, Gizurarson S, Waldum H, Björnsson ES Abstract OBJECTIVE: Gastrin elevation secondary to proton pump inhibitor (PPI) therapy is well documented. Recent studies have demonstrated a sex-related difference where females on PPIs have significantly higher baseline gastrin levels than males. The aim of the study was to analyse the pharmacokinetics of esomeprazole and short-term effect on serum gastrin levels and evaluate potential sex-related difference. MATERIALS AND METHODS: Healthy volunteers received 40 mg of esomeprazole daily for five days. After the 1st and 5t...
Source: Scandinavian Journal of Gastroenterology - December 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Protective effect of proton pump inhibitors and potassium competitive acid blockers against post-gastric endoscopic submucosal dissection bleeding: a single-center, propensity score-matched analysis.
CONCLUSIONS: The incidence of post gastric ESD bleeding is not different between patients treated with PPI and patients treated with P-CAB. Antithrombotic therapy is an independent risk factor associated with post-ESD bleeding. PMID: 33332216 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - December 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Gastroprotection in patients on antiplatelet and/or anticoagulant therapy: a position paper of National Association of Hospital Cardiologists (ANMCO) and the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO).
Abstract Aspirin and P2Y12 receptor antagonists are widely used across the spectrum of cardiovascular and cerebrovascular diseases. Gastrointestinal complications, including ulcer and bleeding, are relatively common during antiplatelet treatment and, therefore, concomitant proton pump inhibitor (PPI) treatment is often prescribed. However, potential increased risk of cardiovascular events has been suggested for PPIs, and, in recent years, it has been discussed whether these drugs may reduce the cardiovascular protection by aspirin and, even more so, clopidogrel. Indeed, pharmacodynamic and pharmacokinetic studies ...
Source: European Journal of Internal Medicine - December 2, 2020 Category: Internal Medicine Authors: Abrignani MG, Gatta L, Gabrielli D, Milazzo G, De Francesco V, De Luca L, Francese M, Imazio M, Riccio E, Rossini R, Scotto di Uccio F, Soncini M, Zullo A, Colivicchi F, Di Lenarda A, Gulizia MM, Monica F Tags: Eur J Intern Med Source Type: research

Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole —In Vitro and In Vivo Investigations
Serotonin (5-HT) is a hormone and neurotransmitter that modulates neural activity as well as a wide range of other physiological processes including cardiovascular function, bowel motility, and platelet aggregation. 5-HT synthesis is catalyzed by tryptophan hydroxylase (TPH) which exists as two distinct isoforms; TPH1 and TPH2, which are responsible for peripheral and central 5-HT, respectively. Due to the implication of 5-HT in a number of pathologies, including depression, anxiety, autism, sexual dysfunction, irritable bowel syndrome, inflammatory bowel disease, and carcinoid syndrome, there has been a growing interest i...
Source: Frontiers in Pharmacology - November 26, 2020 Category: Drugs & Pharmacology Source Type: research

Proton-pump Inhibitor Response Prediction Using Esophageal microRNAs in Children With Eosinophilic Esophagitis
Objectives: Eosinophilic esophagitis (EoE) is a chronic esophageal disease characterized by eosinophilic inflammation. Proton-pump inhibitors (PPI) induce disease remission but no predictive factors of PPI-responsiveness have been identified yet. So, a biomarker must be found to differentiate between responders (PPI-R) and nonresponder patients (PPI-NR) to PPI. Aims were to identify any molecular biomarker that could predict PPI responsiveness and to study molecular remission after PPI therapy. Methods: This prospective study enrolled 39 controls and 43 pediatric children with EoE from 2 hospitals, and they were...
Source: Journal of Pediatric Gastroenterology and Nutrition - November 21, 2020 Category: Gastroenterology Tags: Original Article: Gastroenterology: Eosinophilic GI Disease Source Type: research

Esomeprazole affects the proliferation, metastasis, apoptosis and chemosensitivity of gastric cancer cells by regulating lncRNA/circRNA-miRNA-mRNA ceRNA networks.
Authors: Xu Q, Jia X, Wu Q, Shi L, Ma Z, Ba N, Zhao H, Xia X, Zhang Z Abstract Recently, proton pump inhibitors have become a hot research topic in the field of cancer drug research. However, the specific anti-tumor effect and underlying mechanisms of esomeprazole (ESO) in gastric cancer (GC) have remained elusive. In the present study, the toxic effects of ESO on the GC cell line AGS were investigated. MTT assays confirmed that ESO inhibited the proliferation of AGS cells and significantly enhanced their chemosensitivity. Transwell assays were performed to determine the anti-metastatic effects of ESO in AGS cells....
Source: Oncology Letters - October 28, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The combination therapy with esomeprazole and flupenthixol/melitracen in symptom improvement of erosive gastritis complicated with negative feelings compared with Esomeprazole alone.
Authors: Hu L, Shen L, Li D, Huang M, Xiao X, Chen S Abstract The purpose of this study was to evaluate the co-prescription efficacy of esomeprazole and flupenthixol/melitracen relative to that of solitary esomeprazole on erosive gastritis complicated with negative feelings. 140 erosive gastritis patients complicated with negative feelings enrolled in the present study. Seventy cases in the control group took esomeprazole, and 70 cases in the observation group received esomeprazole plus flupenthixol/Melitracen, both for 4 weeks. We gastroscopically checked the clinical symptoms, mucosal erosion, PGE2 and MDA levels...
Source: Cellular and Molecular Biology - October 14, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

A comparative study of the effect of 10-day esomeprazole containing levofloxacin versus clarithromycin sequential regimens on the treatment of Iranian patients with Helicobacter pylori infection
CONCLUSIONS: Both esomeprazole containing sequential regimens including levofloxacin and clarithromycin showed good eradication rates in spite of significant differences in antimicrobial resistance patterns in vitro. The efficacy of esomeprazole in lowering gastric acidity beside its antimicrobial effect should be considered in H. pylori regimens. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Marjan Mokhtare Mehdi Nikkhah Behdad Behnam Shahram Agah Mansour Bahardoust Mohsen Masoodi Amirhosein Faghihi Source Type: research

Esomeprazole overcomes paclitaxel-resistance and enhances anticancer effects of paclitaxel by inducing autophagy in A549/Taxol cells.
This article is protected by copyright. All rights reserved. PMID: 33049093 [PubMed - as supplied by publisher] (Source: Cell Biology International)
Source: Cell Biology International - October 13, 2020 Category: Cytology Authors: Bai Z, Ding N, Ge J, Wang Y, Wang L, Wu N, Wei Q, Xu S, Liu X, Zhou G Tags: Cell Biol Int Source Type: research

Efficacy of Seven-day High-dose Esomeprazole-based Triple Therapy versus Seven-day Standard Dose Non-esomeprazole-based Triple Therapy as the First-line Treatment of Patients with Helicobacter pylori Infection.
Conclusions: The eradication rate of the 7-HEAC group was higher than that of the 7-NEAC group. Nevertheless, more effective first-line therapies may be necessary for H. pylori eradication in the near future. PMID: 32969362 [PubMed - in process] (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - September 24, 2020 Category: Gastroenterology Authors: Lee YD, Kim SE, Park SJ, Park MI, Moon W, Kim JH, Jung K, Song J Tags: Korean J Gastroenterol Source Type: research

The high-dose amoxicillin-proton pump inhibitor dual therapy in eradication of helicobacter pylori infection.
Authors: Yun J, Wu Z, Qi G, Han T, Zhang D Abstract INTRODUCTION: More attention has been paid to the eradication therapy of H. pylori with the enhancement of health awareness of patients. However, the increasing antibiotic resistance of H. pylori, due to the wide use and abuse of antibiotics, has become a critical factor affecting the efficacy of eradication. To effectively improve the eradication rate of H. pylori, high-dose amoxicillin-proton pump inhibitor (PPI) dual therapy has recently become one of the hot issues. AREAS COVERED: The authors review the schemes and efficacy of high-dose amoxicillin-PPI dua...
Source: Expert Review of Gastroenterology and Hepatology - September 24, 2020 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

Numerous white nodules during continuous administration of a potent gastric acid suppressor
A 57-year-old woman with a history of bronchial asthma received a diagnosis of eosinophilic gastroenteritis. Her treatment included administration of a steroid (prednisolone) and one of the widely used acid suppressors, esomeprazole (EPZ). To heal her gastric antral erosions, we changed EPZ (20 mg/day) to vonoprazan (VPZ) (20 mg/day). VPZ is a potassium competitive acid blocker, one of the most potent gastric acid secretion suppressors. We performed EGD 12 weeks after the start of VPZ, and diffuse small white granular nodules were observed throughout the fundic gland area of the stomach (A-C). (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - September 23, 2020 Category: Gastroenterology Authors: Yuji Kinoshita, Takuji Yamasaki, Masayuki Saruta Tags: At the focal point Source Type: research

Vonoprazan shows efficacy similar to that of proton pump inhibitors with respect to symptomatic, endoscopic, and histological responses in patients with eosinophilic esophagitis
AbstractBackgroundEosinophilic esophagitis (EoE) is a chronic allergic disease with esophageal symptoms and intraepithelial eosinophil infiltration. Effects of potassium-competitive acid blockers (P-CABs) on EoE have not been elucidated. We aimed to examine and compare the effects of P-CABs and PPIs on symptomatic, endoscopic, and histological responses of patients with EoE.MethodsWe analyzed 118 EoE patients who received PPI or P-CAB therapy with rabeprazole 10  mg (RPZ10,N = 22), rabeprazole 20 mg (RPZ20,N = 34), esomeprazole 20 mg (EPZ20,N = 25), or vonoprazan 20&...
Source: Esophagus - September 21, 2020 Category: Gastroenterology Source Type: research

Pravastatin, proton pump inhibitors, metformin, micronutrients and biologics: new horizons for the prevention or treatment of preeclampsia
There has been increasing research momentum to identify new therapeutic agents for preeclampsia. Most have adopted the pragmatic strategy of repurposing drugs. Pravastatin has been the most studied and there is significant preclinical and early phase trial evidence suggesting it may have therapeutic activity. Further large clinical trials evaluating whether pravastatin can prevent preeclampsia are planned, or ongoing. Other drugs or treatment approaches that have transitioned to human trials (ranging from single arm to phase III trials) includes esomeprazole, metformin, sulfasalazine, folate, nitric oxide donors (such as L...
Source: American Journal of Obstetrics and Gynecology - September 14, 2020 Category: OBGYN Authors: Stephen Tong, Tu ’uhevaha J. Kaitu’u-Lino, Roxanne Hastie, Fiona Brownfoot, Catherine Cluver, Natalie Hannan Tags: Expert Review Source Type: research

Esomeprazole-induced Stevens-Johnson syndrome in a patient who underwent nivolumab therapy for advanced lung adenocarcinoma
Stevens-Johnsons syndrome (SJS) is a rare but life-threatening cutaneous adverse reaction mainly elicited by exposure to certain drugs, including epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and immunotherapies [1 –3]. Nivolumab has been widely used for treating lung cancer and has been reported to cause this devastating adverse event and warrants permanent medication termination [4]. Nevertheless, immunotherapy itself may not always be the culprit medication but, rather, might simply be an enhancer of immu nologic reactions in another drug-induced SJS. (Source: Lung Cancer)
Source: Lung Cancer - September 4, 2020 Category: Cancer & Oncology Authors: Yi-Tsz Lin, James Chih-Hsin Yang, Chia-Yu Chu Source Type: research

Efficacy of tailored second-line therapy of Helicobacter pylori eradication in patients with clarithromycin-based treatment failure: a multicenter prospective study
AbstractBackgroundAfter the failure of clarithromycin- and bismuth-based quadruple therapy (CBQT), levofloxacin- and bismuth-based quadruple therapy (LBQT) is recommended forHelicobacter pylori eradication. We compared the efficacies of second-line tailored bismuth-based quadruple therapy (TBQT) and empirical LBQT.MethodsPatients with CBQT failure were randomly assigned to receive TBQT or LBQT for 14  days. All patients underwent endoscopy for culture-based antibiotic susceptibility testing. Patients in the TBQT group exhibiting levofloxacin susceptibility were randomized to receive amoxicillin, levofloxacin, esomepra...
Source: Gut Pathogens - August 28, 2020 Category: Microbiology Source Type: research

Current status of Helicobacter pylori eradication and risk factors for eradication failure.
Abstract BACKGROUND: The Helicobacter pylori (H. pylori) eradication rate is decreasing in the general population of China. AIM: To evaluate the H. pylori eradication status in real-world clinical practice and to explore factors related to eradication failure. METHODS: Patients with H. pylori infection who were treated with standard 14-d quadruple therapy and received a test of cure at a provincial medical institution between June 2018 and May 2019 were enrolled. Demographic and clinical data were recorded. Eradication rates were calculated and compared between regimens and subgroups. Multivariate analys...
Source: World Journal of Gastroenterology : WJG - August 27, 2020 Category: Gastroenterology Authors: Yan TL, Gao JG, Wang JH, Chen D, Lu C, Xu CF Tags: World J Gastroenterol Source Type: research

Esomeprazole reduces sperm motility index by targeting the spermic cholinergic machinery: A mechanistic study for the association between use of proton pump inhibitors and reduced sperm motility index.
rreh-Shori T Abstract Recent studies have linked prolonged use of the most commonly prescribed proton pump inhibitors (PPIs) with declined human sperm function and infertility. Here, we report for the first time the most plausible underlying mechanism for this unwarranted secondary mode of action. We followed up on a recent serendipitous discovery in our laboratory regarding PPIs' off-target action and performed detailed pharmacodynamic analyses by combining in silico and in vitro studies to determine the off-target effect of one of the most commonly used PPI, esomeprazole, on the key human acetylcholine biosynthe...
Source: Biochemical Pharmacology - August 27, 2020 Category: Drugs & Pharmacology Authors: Kumar A, Kumar R, Flanagan J, Långström B, Björndahl L, Darreh-Shori T Tags: Biochem Pharmacol Source Type: research

Adequacy of stress ulcer prophylaxis prescription in the intensive care unit: an observational study.
CONCLUSIONS: The adequacy of stress ulcer prophylaxis in the ICU is low. In addition, the prescription is frequently continued after ICU and many patients are even discharged home with inadequate acid-suppressive therapy.   &nbsp. PMID: 32905610 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 23, 2020 Category: General Medicine Authors: Franchitti M, Piubellini J, Sadeghipour F, Eckert P, Voirol P, Schneider AG Tags: Swiss Med Wkly Source Type: research

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia
Publication date: Available online 28 July 2020Source: Pregnancy HypertensionAuthor(s): Natalie K. Binder, Fiona C. Brownfoot, Sally Beard, Ping Cannon, Tuong V. Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J. Hannan (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 28, 2020 Category: OBGYN Source Type: research

Comparison between esomeprazole 20 mg Vs 40 mg as stress ulcer prophylaxis (SUP) in critically ill patients: A retrospective cohort study
AbstractCritically ill patients admitted to intensive care units (ICUs) are at high risk of developing upper gastrointestinal bleeding due to GI stress ulceration (SU). The major independent risk factors for the development of GI bleeding in the ICUs include mechanical ventilation (MV) and coagulopathy. There is no enough evidence regarding the most appropriate dosing of esomeprazole as stress ulcer prophylaxis (SUP) in critically ill patients. This is a retrospective cohort study conducted at King Abdulaziz Medical City ‐Riyadh between January and December 2018 to determine the efficacy and safety of two different regim...
Source: Pharmacology Research and Perspectives - July 22, 2020 Category: Drugs & Pharmacology Authors: Khalid Al Sulaiman, Kholoud Al Aamer, Alaa Al Harthi, Saud Jaser, Abdulrahman Al Anazi, Sultan Al Subaie, Ramesh Vishwakarma Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of possible pharmacokinetic interaction between methotrexate and proton pump inhibitors in rats.
CONCLUSION: Esomeprazole increases the t1/2 of MTX in rats, which may be partially attributed to the inhibition of rOAT3. PMID: 32671657 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 14, 2020 Category: Drugs & Pharmacology Authors: Ueda H, Narumi K, Sato Y, Furugen A, Kobayashi M, Iseki K Tags: Pharmacol Rep Source Type: research

Evaluation of different proton pump inhibitors combined with bismuth quadruple regimens in Helicobacter pylori eradication
AbstractTo evaluate the efficacy and economics of different proton pump inhibitors (PPIs) combined with bismuth quadruple regimens forHelicobacter pylori (Hp) eradication, a retrospective analysis method was used to collect Hp-positive patients who were treated with a bismuth-containing quadruple regimen (PPIs  + amoxicillin + furazolidone + colloid pectin bismuth) from the outpatient department of gastroenterology in our hospital from January to June 2017. A total of 1410 patients were included in the study and divided into four groups according to different PPIs: group A (pantopr...
Source: Clinical and Experimental Medicine - July 9, 2020 Category: Research Source Type: research

Esomeprazole During Pregnancy and Lactation: Esomeprazole Levels in Maternal Serum, Cord Blood, Breast Milk, and the Infant's Serum
Breastfeeding Medicine, Ahead of Print. (Source: Breastfeeding Medicine)
Source: Breastfeeding Medicine - July 6, 2020 Category: Perinatology & Neonatology Authors: Jumpei Saito Naho Yakuwa Noriko Sandaiji Hiroyo Kawasaki Kayoko Kaneko Tomo Suzuki Akimasa Yamatani Haruhiko Sago Atsuko Murashima Source Type: research

Rifabutin-Based Triple Therapy Or Bismuth-Based Quadruple Regimen As Rescue Therapies For Helicobacter pylori Infection.
CONCLUSIONS: Our data documented a decreasing trend for rifabutin-based therapy efficacy according to previous therapy failures, whilst this did not occur for Pylera®. PMID: 32646659 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - July 5, 2020 Category: Internal Medicine Authors: Saracino IM, Pavoni M, Zullo A, Fiorini G, Saccomanno L, Lazzarotto T, Antonelli G, Cavallo R, Borghi C, Vaira D Tags: Eur J Intern Med Source Type: research

[Therapeutic Response to 20 mg of Esomeprazole Twice Daily in Patients with Gastroesophageal Reflux Disease-related Non-cardiac Chest Pain: An Open-Label Randomized Pilot Study].
Conclusions: Esomeprazole BD was as effective as esomeprazole OD in improving GERD-related NCCP. Although statistically insignificant, the percentage of patients with>50% reduction in the chest pain score was higher in the esomeprazole BD group than in the esomeprazole OD group. Large-scale studies will be needed to assess these findings further. PMID: 32581204 [PubMed - in process] (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - June 24, 2020 Category: Gastroenterology Authors: Choi JK, Shim HI, Shin CM, Yoon H, Park YS, Kim N, Lee DH Tags: Korean J Gastroenterol Source Type: research

Effect of High-Dose Esomeprazole on CYP1A2, CYP2C19 and CYP3A4 Activities in Humans: Evidence for Substantial and Long-lasting Inhibition of CYP2C19.
In conclusion, high-dose esomeprazole can cause strong inhibition of CYP2C19, but only weakly inhibits CYP3A4 and leads to minor induction of CYP1A2. The enzymatic activity of CYP2C19 recovers gradually in approximately 3-4 days after discontinuation of esomeprazole treatment. PMID: 32558923 [PubMed - as supplied by publisher] (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - June 18, 2020 Category: Drugs & Pharmacology Authors: Kaartinen TJK, Tornio A, Tapaninen T, Launiainen T, Isoherranen N, Niemi M, Backman JT Tags: Clin Pharmacol Ther Source Type: research

Influence of Cow ’s Milk and Esomeprazole on the Absorption of Erlotinib: A Randomized, Crossover Pharmacokinetic Study in Lung Cancer Patients
AbstractIntroductionErlotinib ’s gastrointestinal solubility and absorption are decreased by proton pump inhibitors (PPIs). Since erlotinib is a lipophilic drug, we hypothesized that concomitant intake with the fatty beverage milk may be a feasible way to increase erlotinib uptake. We performed a two-period, randomized, crosso ver study to investigate the influence of cow’s milk with 3.9% fat on the exposure of erlotinib with and without the PPI esomeprazole in patients with non-small cell lung cancer (NSCLC). The effect of esomeprazole was studied in an additional intrapatient comparison.MethodPharmacokinetic ...
Source: Clinical Pharmacokinetics - June 16, 2020 Category: Drugs & Pharmacology Source Type: research

Y-site physical compatibility of hydrocortisone continuous infusions with admixtures used in critically ill patients.
CONCLUSION: Acetaminophen, albumin, cefepime, ciprofloxacin, cisatracurium, doripenem, epinephrine, esomeprazole, ibuprofen, levofloxacin, levothyroxine, meropenem, and norepinephrine exhibited physical compatibility with hydrocortisone via Y-site infusion. PMID: 32537625 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - June 14, 2020 Category: Drugs & Pharmacology Authors: Foushee JA, Meredith P, Fox LM, Wilder AG Tags: Am J Health Syst Pharm Source Type: research

Concomitant Treatment with Proton Pump Inhibitors and Cephalosporins Does Not Enhance QT-Associated Proarrhythmia in Isolated Rabbit Hearts.
r G Abstract Recent results from data mining analyses and reports of adverse drug events suggest a QT-prolonging drug-drug interaction resulting from the combination of distinct proton pump inhibitors and cephalosporins. Therefore, this study aimed at investigating the effect of the suspected QT-prolonging combinations of lansoprazole + ceftriaxone and esomeprazole + cefazolin, respectively. 26 hearts of New Zealand White rabbits were retrogradely perfused and paced at different cycle lengths. After generating baseline data, the hearts were assigned to two groups: In group 1, hearts wer...
Source: Cardiovascular Toxicology - June 3, 2020 Category: Cardiology Authors: Wolfes J, Ellermann C, Burde S, Leitz P, Bögeholz N, Willy K, Fehr M, Eckardt L, Frommeyer G Tags: Cardiovasc Toxicol Source Type: research

Taste disorder ’s management: a systematic review
ConclusionImproving oral hygiene may promote taste ability. Zinc may prevent and alleviate taste disorder in patients undergoing head and neck radiotherapy.Clinical relevanceThe systematic review provided evidence about the clinical efficacy of oral procedures, zinc supplementation, and palliative cares in dysgeusic patients. Further research is needed to find effective treatments with low adverse effects. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 7, 2020 Category: Dentistry Source Type: research

[ASAP] Enzymatic Preparation of the Chiral ( < italic toggle="yes" > S < /italic > )-Sulfoxide Drug Esomeprazole at Pilot-Scale Levels
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.0c00115 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - May 3, 2020 Category: Chemistry Authors: Na Xu †, Jun Zhu†, Yin-Qi Wu†, Yan Zhang†, Jian-Ye Xia†, Qian Zhao‡, Guo-Qiang Lin‡, Hui-Lei Yu*†§, and Jian-He Xu*†§ Source Type: research