Esomeprazole-induced Stevens-Johnson syndrome in a patient who underwent nivolumab therapy for advanced lung adenocarcinoma
Stevens-Johnsons syndrome (SJS) is a rare but life-threatening cutaneous adverse reaction mainly elicited by exposure to certain drugs, including epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and immunotherapies [1 –3]. Nivolumab has been widely used for treating lung cancer and has been reported to cause this devastating adverse event and warrants permanent medication termination [4]. Nevertheless, immunotherapy itself may not always be the culprit medication but, rather, might simply be an enhancer of immu nologic reactions in another drug-induced SJS. (Source: Lung Cancer)
Source: Lung Cancer - September 5, 2020 Category: Cancer & Oncology Authors: Yi-Tsz Lin, James Chih-Hsin Yang, Chia-Yu Chu Source Type: research

Efficacy of tailored second-line therapy of Helicobacter pylori eradication in patients with clarithromycin-based treatment failure: a multicenter prospective study
AbstractBackgroundAfter the failure of clarithromycin- and bismuth-based quadruple therapy (CBQT), levofloxacin- and bismuth-based quadruple therapy (LBQT) is recommended forHelicobacter pylori eradication. We compared the efficacies of second-line tailored bismuth-based quadruple therapy (TBQT) and empirical LBQT.MethodsPatients with CBQT failure were randomly assigned to receive TBQT or LBQT for 14  days. All patients underwent endoscopy for culture-based antibiotic susceptibility testing. Patients in the TBQT group exhibiting levofloxacin susceptibility were randomized to receive amoxicillin, levofloxacin, esomepra...
Source: Gut Pathogens - August 29, 2020 Category: Microbiology Source Type: research

Esomeprazole reduces sperm motility index by targeting the spermic cholinergic machinery: A mechanistic study for the association between use of proton pump inhibitors and reduced sperm motility index.
rreh-Shori T Abstract Recent studies have linked prolonged use of the most commonly prescribed proton pump inhibitors (PPIs) with declined human sperm function and infertility. Here, we report for the first time the most plausible underlying mechanism for this unwarranted secondary mode of action. We followed up on a recent serendipitous discovery in our laboratory regarding PPIs' off-target action and performed detailed pharmacodynamic analyses by combining in silico and in vitro studies to determine the off-target effect of one of the most commonly used PPI, esomeprazole, on the key human acetylcholine biosynthe...
Source: Biochemical Pharmacology - August 28, 2020 Category: Drugs & Pharmacology Authors: Kumar A, Kumar R, Flanagan J, Långström B, Björndahl L, Darreh-Shori T Tags: Biochem Pharmacol Source Type: research

Current status of Helicobacter pylori eradication and risk factors for eradication failure.
Abstract BACKGROUND: The Helicobacter pylori (H. pylori) eradication rate is decreasing in the general population of China. AIM: To evaluate the H. pylori eradication status in real-world clinical practice and to explore factors related to eradication failure. METHODS: Patients with H. pylori infection who were treated with standard 14-d quadruple therapy and received a test of cure at a provincial medical institution between June 2018 and May 2019 were enrolled. Demographic and clinical data were recorded. Eradication rates were calculated and compared between regimens and subgroups. Multivariate analys...
Source: World Journal of Gastroenterology : WJG - August 28, 2020 Category: Gastroenterology Authors: Yan TL, Gao JG, Wang JH, Chen D, Lu C, Xu CF Tags: World J Gastroenterol Source Type: research

Adequacy of stress ulcer prophylaxis prescription in the intensive care unit: an observational study.
CONCLUSIONS: The adequacy of stress ulcer prophylaxis in the ICU is low. In addition, the prescription is frequently continued after ICU and many patients are even discharged home with inadequate acid-suppressive therapy.   &nbsp. PMID: 32905610 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 24, 2020 Category: General Medicine Authors: Franchitti M, Piubellini J, Sadeghipour F, Eckert P, Voirol P, Schneider AG Tags: Swiss Med Wkly Source Type: research

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia
Publication date: Available online 28 July 2020Source: Pregnancy HypertensionAuthor(s): Natalie K. Binder, Fiona C. Brownfoot, Sally Beard, Ping Cannon, Tuong V. Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J. Hannan (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 28, 2020 Category: OBGYN Source Type: research

Comparison between esomeprazole 20 mg Vs 40 mg as stress ulcer prophylaxis (SUP) in critically ill patients: A retrospective cohort study
AbstractCritically ill patients admitted to intensive care units (ICUs) are at high risk of developing upper gastrointestinal bleeding due to GI stress ulceration (SU). The major independent risk factors for the development of GI bleeding in the ICUs include mechanical ventilation (MV) and coagulopathy. There is no enough evidence regarding the most appropriate dosing of esomeprazole as stress ulcer prophylaxis (SUP) in critically ill patients. This is a retrospective cohort study conducted at King Abdulaziz Medical City ‐Riyadh between January and December 2018 to determine the efficacy and safety of two different regim...
Source: Pharmacology Research and Perspectives - July 23, 2020 Category: Drugs & Pharmacology Authors: Khalid Al Sulaiman, Kholoud Al Aamer, Alaa Al Harthi, Saud Jaser, Abdulrahman Al Anazi, Sultan Al Subaie, Ramesh Vishwakarma Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of possible pharmacokinetic interaction between methotrexate and proton pump inhibitors in rats.
CONCLUSION: Esomeprazole increases the t1/2 of MTX in rats, which may be partially attributed to the inhibition of rOAT3. PMID: 32671657 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 15, 2020 Category: Drugs & Pharmacology Authors: Ueda H, Narumi K, Sato Y, Furugen A, Kobayashi M, Iseki K Tags: Pharmacol Rep Source Type: research

Evaluation of different proton pump inhibitors combined with bismuth quadruple regimens in Helicobacter pylori eradication
AbstractTo evaluate the efficacy and economics of different proton pump inhibitors (PPIs) combined with bismuth quadruple regimens forHelicobacter pylori (Hp) eradication, a retrospective analysis method was used to collect Hp-positive patients who were treated with a bismuth-containing quadruple regimen (PPIs  + amoxicillin + furazolidone + colloid pectin bismuth) from the outpatient department of gastroenterology in our hospital from January to June 2017. A total of 1410 patients were included in the study and divided into four groups according to different PPIs: group A (pantopr...
Source: Clinical and Experimental Medicine - July 10, 2020 Category: Research Source Type: research

Esomeprazole During Pregnancy and Lactation: Esomeprazole Levels in Maternal Serum, Cord Blood, Breast Milk, and the Infant's Serum
Breastfeeding Medicine, Ahead of Print. (Source: Breastfeeding Medicine)
Source: Breastfeeding Medicine - July 7, 2020 Category: Perinatology & Neonatology Authors: Jumpei Saito Naho Yakuwa Noriko Sandaiji Hiroyo Kawasaki Kayoko Kaneko Tomo Suzuki Akimasa Yamatani Haruhiko Sago Atsuko Murashima Source Type: research

Rifabutin-Based Triple Therapy Or Bismuth-Based Quadruple Regimen As Rescue Therapies For Helicobacter pylori Infection.
CONCLUSIONS: Our data documented a decreasing trend for rifabutin-based therapy efficacy according to previous therapy failures, whilst this did not occur for Pylera®. PMID: 32646659 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - July 6, 2020 Category: Internal Medicine Authors: Saracino IM, Pavoni M, Zullo A, Fiorini G, Saccomanno L, Lazzarotto T, Antonelli G, Cavallo R, Borghi C, Vaira D Tags: Eur J Intern Med Source Type: research

[Therapeutic Response to 20 mg of Esomeprazole Twice Daily in Patients with Gastroesophageal Reflux Disease-related Non-cardiac Chest Pain: An Open-Label Randomized Pilot Study].
Conclusions: Esomeprazole BD was as effective as esomeprazole OD in improving GERD-related NCCP. Although statistically insignificant, the percentage of patients with>50% reduction in the chest pain score was higher in the esomeprazole BD group than in the esomeprazole OD group. Large-scale studies will be needed to assess these findings further. PMID: 32581204 [PubMed - in process] (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - June 25, 2020 Category: Gastroenterology Authors: Choi JK, Shim HI, Shin CM, Yoon H, Park YS, Kim N, Lee DH Tags: Korean J Gastroenterol Source Type: research

Effect of High-Dose Esomeprazole on CYP1A2, CYP2C19 and CYP3A4 Activities in Humans: Evidence for Substantial and Long-lasting Inhibition of CYP2C19.
In conclusion, high-dose esomeprazole can cause strong inhibition of CYP2C19, but only weakly inhibits CYP3A4 and leads to minor induction of CYP1A2. The enzymatic activity of CYP2C19 recovers gradually in approximately 3-4 days after discontinuation of esomeprazole treatment. PMID: 32558923 [PubMed - as supplied by publisher] (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - June 19, 2020 Category: Drugs & Pharmacology Authors: Kaartinen TJK, Tornio A, Tapaninen T, Launiainen T, Isoherranen N, Niemi M, Backman JT Tags: Clin Pharmacol Ther Source Type: research

Influence of Cow ’s Milk and Esomeprazole on the Absorption of Erlotinib: A Randomized, Crossover Pharmacokinetic Study in Lung Cancer Patients
AbstractIntroductionErlotinib ’s gastrointestinal solubility and absorption are decreased by proton pump inhibitors (PPIs). Since erlotinib is a lipophilic drug, we hypothesized that concomitant intake with the fatty beverage milk may be a feasible way to increase erlotinib uptake. We performed a two-period, randomized, crosso ver study to investigate the influence of cow’s milk with 3.9% fat on the exposure of erlotinib with and without the PPI esomeprazole in patients with non-small cell lung cancer (NSCLC). The effect of esomeprazole was studied in an additional intrapatient comparison.MethodPharmacokinetic ...
Source: Clinical Pharmacokinetics - June 17, 2020 Category: Drugs & Pharmacology Source Type: research

Y-site physical compatibility of hydrocortisone continuous infusions with admixtures used in critically ill patients.
CONCLUSION: Acetaminophen, albumin, cefepime, ciprofloxacin, cisatracurium, doripenem, epinephrine, esomeprazole, ibuprofen, levofloxacin, levothyroxine, meropenem, and norepinephrine exhibited physical compatibility with hydrocortisone via Y-site infusion. PMID: 32537625 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - June 15, 2020 Category: Drugs & Pharmacology Authors: Foushee JA, Meredith P, Fox LM, Wilder AG Tags: Am J Health Syst Pharm Source Type: research

Concomitant Treatment with Proton Pump Inhibitors and Cephalosporins Does Not Enhance QT-Associated Proarrhythmia in Isolated Rabbit Hearts.
r G Abstract Recent results from data mining analyses and reports of adverse drug events suggest a QT-prolonging drug-drug interaction resulting from the combination of distinct proton pump inhibitors and cephalosporins. Therefore, this study aimed at investigating the effect of the suspected QT-prolonging combinations of lansoprazole + ceftriaxone and esomeprazole + cefazolin, respectively. 26 hearts of New Zealand White rabbits were retrogradely perfused and paced at different cycle lengths. After generating baseline data, the hearts were assigned to two groups: In group 1, hearts wer...
Source: Cardiovascular Toxicology - June 4, 2020 Category: Cardiology Authors: Wolfes J, Ellermann C, Burde S, Leitz P, Bögeholz N, Willy K, Fehr M, Eckardt L, Frommeyer G Tags: Cardiovasc Toxicol Source Type: research

Taste disorder ’s management: a systematic review
ConclusionImproving oral hygiene may promote taste ability. Zinc may prevent and alleviate taste disorder in patients undergoing head and neck radiotherapy.Clinical relevanceThe systematic review provided evidence about the clinical efficacy of oral procedures, zinc supplementation, and palliative cares in dysgeusic patients. Further research is needed to find effective treatments with low adverse effects. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - May 8, 2020 Category: Dentistry Source Type: research

[ASAP] Enzymatic Preparation of the Chiral ( < italic toggle="yes" > S < /italic > )-Sulfoxide Drug Esomeprazole at Pilot-Scale Levels
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.0c00115 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - May 3, 2020 Category: Chemistry Authors: Na Xu †, Jun Zhu†, Yin-Qi Wu†, Yan Zhang†, Jian-Ye Xia†, Qian Zhao‡, Guo-Qiang Lin‡, Hui-Lei Yu*†§, and Jian-He Xu*†§ Source Type: research

Enhanced performance of a novel superparamagnetic g-C3N4/NiO/ZnO/Fe3O4 nanohybrid photocatalyst for removal of esomeprazole: Effects of reaction parameters, co-existing substances and water matrices
Publication date: 1 September 2020Source: Chemical Engineering Journal, Volume 395Author(s): Sauvik Raha, M. Ahmaruzzaman (Source: Chemical Engineering Journal)
Source: Chemical Engineering Journal - April 30, 2020 Category: Chemistry Source Type: research

Treatment with compound Lactobacillus acidophilus followed by a tetracycline- and furazolidone-containing quadruple regimen as a rescue therapy for Helicobacter pylori infection
Conclusions: Patients who failed multiple attempts at H. pylori eradication may benefit from a treatment with probiotics followed by a tetracycline- and furazolidone-containing quadruple regimen. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - April 21, 2020 Category: Gastroenterology Authors: Airu Liu Yuxin Wang Yingxiao Song Yiqi Du Source Type: research

Efficacy of modified esomeprazole-amoxicillin dual therapies for Helicobacter pylori infection: an open-label, randomized trial
Conclusion The eradication rate of 10-day q.i.d. dual therapy was unacceptable, while that of the 14-day t.i.d. dual therapy was borderline acceptable for first-line therapy. The two dual therapies were well tolerated with few adverse effects. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - April 8, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients.
In this study, we have clarified the factors causing aggregate formation, focusing on the role of pharmaceutical additives and electrostatic interaction. Co-suspension of enteric-coated proton pump inhibitor (PPI) esomeprazole magnesium hydrate with levofloxacin resulted in aggregate formation, whereas the non-enteric-coated PPI vonoprazan fumarate did not. A comparison of pharmaceutical additive in the two PPIs highlighted polysorbate 80 and methacrylic acid copolymer LD as candidates causing aggregation. When these pharmaceutical additives were added to levofloxacin, only methacrylic acid copolymer LD induced aggregate f...
Source: Biological and Pharmaceutical Bulletin - April 4, 2020 Category: Drugs & Pharmacology Authors: Nakagawa Y, Suzuki T, Suga Y, Shimada T, Sai Y Tags: Biol Pharm Bull Source Type: research

State pharmaceutical importation programmes: an analysis of the cost ‐effectiveness
ConclusionsWhile pharmaceutical importation plans are politically attractive, the numbers demonstrate that they fail to deliver cost savings when implemented safely. These schemes can be cheap, or they can be safe, but not both. (Source: Journal of Pharmaceutical Health Services Research)
Source: Journal of Pharmaceutical Health Services Research - March 19, 2020 Category: Drugs & Pharmacology Authors: Kristina M. L. Acri n ée Lybecker Tags: Research Paper Source Type: research

Factors Affecting Quality of Life and Satisfaction in Patients with Arthritis after Change to a Fixed-Dose Naproxen/Esomeprazole Combination Drug.
Authors: Park D, Kwon Y Abstract Background: In drug therapy for patients with arthritis, a naproxen/esomeprazole combination drug may be a tolerable choice because it can minimize gastrointestinal and cardiovascular adverse effects. The aim of this study was to investigate the changes in quality of life (QOL), medication adherence, and satisfaction after switch from the existing drug to the combination drug. In addition, we analyzed the correlation between the above-mentioned variables and the stratified demographic and medical data of the patients. Methods: A prospective, noninterventional, observational stud...
Source: Clinics in Orthopedic Surgery - March 4, 2020 Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research

Multicellular vacuoles in hypokalemic nephropathy
A 61-year-old morbidly obese Caucasian woman with hypertension, hyperlipidemia, and 6-month history of hypokalemia presented with generalized muscle weakness and nonoliguric acute kidney injury. After cholecystectomy in 2006, she underwent lysis of adhesions, partial ileal and rectosigmoid resection, and permanent end colostomy in 2011. Outpatient medications included Nexium (AstraZeneca, Wilmington, DE), pravastatin, furosemide (20 mg daily), and potassium chloride (10 mEq daily). She presented in July 2019 with serum creatinine 9.8 mg/dL (increased from baseline 1.0 mg/dL 1 year prior), serum sodium 133 mmol/l, chloride ...
Source: Kidney International - February 19, 2020 Category: Urology & Nephrology Authors: Satoru Kudose, Harry Dounis, Vivette D. D ’Agati Tags: Nephrology Image Source Type: research

Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway.
Conclusions: Our data demonstrate that LZD protects the duodenal mucosa from IND-caused lesions, which is at least partially attributable to the interaction of its potential cytoprotective and anti-inflammatory mechanisms together with enhancement of the mucosal immunity through TLR-2/MyD88 signaling pathway. PMID: 32063985 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - February 19, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Clinical Impact of Co-Medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study.
CONCLUSION: The effect of comedication with PPIs on the plasma concentration of clobazam is more pronounced for pantoprazole in greater extent when compared to esomeprazole and rabeprazole. When pantoprazole is used in combination with clobazam, dose reduction of clobazam should be considered or significance of PPIs is seen to avoid adverse effects. PMID: 32067615 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 18, 2020 Category: Drugs & Pharmacology Authors: Pasupuleti B, Gone V, Baddam R, Venisetty RK, Prasad OP Tags: Curr Drug Metab Source Type: research

Novel Interventions for the Prevention of Preeclampsia
AbstractPurpose of ReviewTo review the rationale and biological plausibility and discuss the current research on novel interventions for the prevention of preeclampsia.Recent FindingsPreeclampsia affects up to 8% of pregnancies worldwide and remains a major cause of maternal and neonatal morbidity and mortality. Multiple medications have been investigated or repurposed as potential effective interventions for preeclampsia prevention. Aspirin is currently the only drug for which there is some evidence of benefit for preeclampsia prevention, and its use is recommended by professional societies for pregnancies at risk. Statin...
Source: Current Hypertension Reports - February 12, 2020 Category: Primary Care Source Type: research

Development and Validation of a RPHPLC Method to Quantify Amoxicillin Tinidazole Esomeprazole and Lansoprazole in a Mixture
M. Smerikarova*, S. Bozhanov and V. Maslarska (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - February 8, 2020 Category: Drugs & Pharmacology Source Type: research

14-Day High-Dose Amoxicillin- and Metronidazole-Containing Triple Therapy With or Without Bismuth as First-Line Helicobacter pylori Treatment
ConclusionNeither the presence nor absence of bismuth or metronidazole resistance reduced the effectiveness of triple therapy containing esomeprazole 20  mg twice a day, amoxicillin 1 g, and metronidazole 400 mg thrice daily in this population. The clinical trial was registered with ClinicalTrials.gov, NCT03557437. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - February 4, 2020 Category: Gastroenterology Source Type: research

Short-term Effect of Hypergastrinemia Following Esomeprazole Treatment On Well-Controlled Type 2 Diabetes Mellitus: A Prospective Study.
Authors: Bozkuş Y, Mousa U, İyidir ÖT, Kırnap N, Demir CÇ, Nar A, Tütüncü NB Abstract OBJECTIVE: Proton pump inhibitor (PPI) drugs, reduce gastric acid secretion and lead to an increase in serum gastrin levels. Many preclinical and some clinical researches established some positive effects of gastrin or PPI therapy on glucose regulation. The aim of this study was to prospectively investigate the short term effects of esomeprazole on glycaemic control in patients with type 2 diabetes mellitus. In addition, the presence of an association between this effect and gastrin levels was evaluat...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 30, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Development and Validation of a RPHPLC Method to Quantify Amoxicillin Tinidazole Esomeprazole and Lansoprazole in a Mixture
M. Smerikarova*, S. Bozhanov and V. Maslarska (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - January 21, 2020 Category: Drugs & Pharmacology Source Type: research

A Randomized Placebo-Controlled N-of-1 Trial: The Effect of Proton Pump Inhibitor in the Management of Gastroesophageal Reflux Disease.
Conclusion: There was no significant improvement in the patient GERD symptoms increasing the dose of oral esomeprazole during the 6 months of study. N-of-1 trials in chronic pathologies including GERD are recommended due to their potential value as systematic methods that evaluate therapies without strong scientific evidence. PMID: 31929980 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - January 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Comparison of Utilization Trends between Biosimilars and Generics: Lessons from the Nationwide Claims Data in South Korea
ConclusionBiosimilars captured the market rapidly, despite a heterogeneous uptake rate by product in South Korea. However, expansion of biosimilar use in the market and consequent expenditure savings need to be supported by pre-emptive policy measures to encourage price competition and boost utilization. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - January 13, 2020 Category: Health Management Source Type: research

Is tailored therapy based on antibiotic susceptibility effective ? a multicenter, open-label, randomized trial
In this study, we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy. We also evaluated the factors that cause treatment failure in high-resistance areas. For this multicenter trial, we recruited 467H. pylori-positive patients. The patients were randomly assigned to receive tailored triple therapy (TATT), tailored bismuth-containing quadruple therapy (TABQT), or traditional bismuth-containing quadruple therapy (TRBQT). For the TATT and TABQT groups, antibiotic selection proceeded via susceptibility testing using an agar-dilution test. The patients in the ...
Source: Frontiers of Medicine - January 3, 2020 Category: General Medicine Source Type: research

Investigation the relaxant effects of proton pump & #305;nhibitors and their relaxation mechanism on sheep sphincter of Oddi
Conclusions: The present study suggests that PPIs create relaxation on SO partially via Ca+2-activated potassium channels. PPIs, especially esomeprazole, may be beneficial during the ERCP procedure. Further clinical studies are needed to confirm our results. (Source: Nigerian Journal of Clinical Practice)
Source: Nigerian Journal of Clinical Practice - December 3, 2019 Category: Rural Health Authors: S Soylu B Sarac A Kurt A Altun E Cakmak HH Pence YE Kahramanoglu I Bagcivan Source Type: research

Reversed-phase HPLC enantioseparation of pantoprazole using a teicoplanin aglycone stationary phase-Determination of the enantiomer elution order using HPLC-CD analyses.
l B, Szabó ZI, Tóth G Abstract A direct HPLC method was developed for the enantioseparation of pantoprazole using macrocyclic glycopeptide-based chiral stationary phases, along with various methods to determine the elution order without isolation of the individual enantiomers. In the preliminary screening, four macrocyclic glycopeptide-based chiral stationary phases containing vancomycin (Chirobiotic V), ristocetin A (Chirobiotic R), teicoplanin (Chirobiotic T), and teicoplanin-aglycone (Chirobiotic TAG) were screened in polar organic and reversed-phase mode. Best results were achieved by using Chiro...
Source: Chirality - December 3, 2019 Category: Molecular Biology Authors: Papp LA, Foroughbakhshfasaei M, Fiser B, Horváth P, Kiss E, Sekkoum K, Gyéresi Á, Hancu G, Noszál B, Szabó ZI, Tóth G Tags: Chirality Source Type: research

Concomitant use of drugs known to cause interactions with oral antiplatelets —polypharmacy in acute coronary syndrome outpatients in Finland
AbstractPurposeUse of oral antiplatelets (OAPs) is essential for preventing thrombotic events in patients with acute coronary syndrome (ACS). Effects of clopidogrel, prasugrel, and ticagrelor may be enhanced due to pharmacodynamic interactions, but as CYP substrates, they are prone to pharmacokinetic interactions too. The aim was to study polypharmacy in ACS patients following hospital discharge.MethodsThis observational drug utilization study linked patient-level data from nationwide registers. The study population consisted of adult ACS patients discharged from Finnish hospitals in 2009 –2013. Logistic regression w...
Source: European Journal of Clinical Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Source Type: research

Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub-types of Gastroesophageal Reflux Disease and Gastroesophageal Reflux Disease-related Disorders.
Authors: Wang YJ, Lang XQ, Wu D, He YQ, Lan CH, Xiao X, Wang B, Zou DW, Wu JM, Zhao YB, Dettmar PW, Chen DF, Yang M Abstract Background/Aims: To determine the value of salivary pepsin in discriminating sub-types of gastroesophageal refluxdisease (GERD) and GERD-related disorders. Methods: Overall, 322 patients with different sub-types of GERD and 45 healthy controls (HC) werestudied. All patients took Gastroesophageal Reflux Disease Questionnaire (GerdQ) andunderwent endoscopy and 24-hour esophageal pH monitoring and manometry. Salivary pepsinconcentration (SPC) was detected by using colloidal gold double-antib...
Source: Journal of Neurogastroenterology and Motility - October 30, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Physiologically based pharmacokinetic modeling to predict exposures in healthy Japanese subjects with different CYP2C19 phenotypes: Esomeprazole case study 
.
CONCLUSION: By adjusting CYP2C19 enzyme abundances levels in the Japanese population, the systemic exposure of esomeprazole in Japanese subjects can be reasonably extrapolated using a PBPK model developed in Caucasian subjects. This analysis serves as a case application for assessing the predictive performance of CYP2C19 substrate in Japanese subjects by using PBPK modeling approach.
. PMID: 31657713 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - October 29, 2019 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

[ASAP] Going Green in Process Chemistry: Optimizing an Asymmetric Oxidation Reaction To Synthesize the Antiulcer Drug Esomeprazole
Journal of Chemical EducationDOI: 10.1021/acs.jchemed.9b00350 (Source: Journal of Chemical Education)
Source: Journal of Chemical Education - October 7, 2019 Category: Chemistry Authors: Graeme D. McAllister and Andrew F. Parsons* Source Type: research

Evaluation of psoriasis treatment with esomeprazole - a pilot study
CONCLUSION: The use of esomeprazole for psoriasis resulted in excellent clinical results with a significant reduction of PASI score.RESUMO CONTEXTO: A psor íase é uma doença inflamatória da pele que afeta 1%-3% das populações caucasianas e pode ser persistente, desfigurante e estigmatizante. Inibidores da bomba de prótons (IBP) são potentes bloqueadores da secreção de ácido no estômago. Eles são considerados como os agentes de escolha para o tratamento de doenças ácido-pépticas. No entanto, além dos efeitos...
Source: Arquivos de Gastroenterologia - October 1, 2019 Category: Gastroenterology Source Type: research

Optimizing proton pump inhibitors in Helicobacter pylori treatment: Old and new tricks to improve effectiveness.
Abstract The survival and replication cycle of Helicobacter pylori (H. pylori) is strictly dependant on intragastric pH, since H. pylori enters replicative phase at an almost neutral pH (6-7), while at acid pH (3-6) it turns into its coccoid form, which is resistant to antibiotics. On these bases, it is crucial to increase intragastric pH by proton pump inhibitors (PPIs) when an antibiotic-based eradicating therapy needs to be administered. Therefore, several tricks need to be used to optimize eradication rate of different regimens. The administration of the highest dose as possible of PPI, by doubling or increasi...
Source: World Journal of Gastroenterology : WJG - September 14, 2019 Category: Gastroenterology Authors: Ierardi E, Losurdo G, Fortezza RF, Principi M, Barone M, Leo AD Tags: World J Gastroenterol Source Type: research

Experimental study and thermodynamic modeling of Esomeprazole (proton-pump inhibitor drug for stomach acid reduction) solubility in supercritical carbon dioxide
Publication date: Available online 28 August 2019Source: The Journal of Supercritical FluidsAuthor(s): Gholamhossein Sodeifian, Reza Drakhsheshpoor, Seyed Ali SajadianAbstractProduction of micro- and nano-sized particles trough supercritical fluid (SCF) technology needs substantial measurements of solubility data. In this work, for the first time, solubility of Esomeprazole (ESM) in supercritical carbon dioxide (SC-CO2) was determined at pressures and temperatures ranging within 12-27 MPa and 308.2-338.2 K, respectively. Under the applied conditions, mole fractions were obtained in the range of 1.11 &t...
Source: The Journal of Supercritical Fluids - August 29, 2019 Category: Chemistry Source Type: research

Topical Esomeprazole Mitigates Radiation-Induced Dermal Inflammation and Fibrosis.
In conclusion, topical formulation of the FDA-approved drug esomeprazole is highly effective in attenuating dermal inflammation and fibrosis. PMID: 31415221 [PubMed - as supplied by publisher] (Source: Radiation Research)
Source: Radiation Research - August 15, 2019 Category: Physics Authors: Pham N, Ludwig MS, Wang M, Ebrahimpour A, Bonnen MD, Diwan AH, Kim SJ, Bryan J, Newton JM, Sikora AG, Donovan DT, Sandulache V, Ghebre YT Tags: Radiat Res Source Type: research

Cost-utility analysis of a ‘vonoprazan-first’ strategy versus ‘esomeprazole- or rabeprazole-first’ strategy in GERD
ConclusionsVonoprazan-first strategy increased QALYs and appeared to be cost-effective for GERD patients compared with the esomeprazole- or rabeprazole-first strategies. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 8, 2019 Category: Gastroenterology Source Type: research

Efficacy of Jianpi Liqi therapy for functional dyspepsia: A meta-analysis of randomized, positive medicine-controlled trials
Background: We performed this meta-analysis to assess the efficacy and safety of Jianpi Liqi therapy (JLT), a traditional Chinese medicine therapy, in treating functional dyspepsia (FD). Methods: We systematically searched 13 databases from their inception to 15th, May 2019. Eligible studies were randomized controlled trials (RCTs) that compared JLT medicine with conventional pharmacotherapy (CP) in treating patients with FD. Cochrane Collaboration tool, Review Manager 5.3 and STATA 11.0, GRADE profiler 3.6 were used for evaluating risk of bias, analyzing, and assessing quality of evidence respectively. Results: Af...
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

A potential risk factor for paraoxonase 1: in silico and in ‐vitro analysis of the biological activity of proton‐pump inhibitors
ConclusionsWe observed that the drugs decreased PON1 activity at low concentrations. The results show that adjusting the dosages of these medications is a crucial case for each patient. The physicians should more carefully interpret whether there is an essential indication before prescribing PPIs and, if there is, to approve the proper dosing for the situation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 29, 2019 Category: Drugs & Pharmacology Authors: C üneyt Türkeş Tags: Research Paper Source Type: research