Pharmacokinetics, Bioequivalence, and Safety of Esomeprazole Magnesium Enteric ‐Coated Capsules in Healthy Chinese Subjects
AbstractThis bioequivalence study is critically important for drug production. Recently, a local pharmaceutical company produced esomeprazole magnesium enteric-coated capsules, a major drug to help to eradicateHelicobacter pylori, but the bioequivalence is not well known. The present study aimed to evaluate the bioequivalence of the 2 esomeprazole magnesium enteric-coated capsules and their pharmacokinetics and safety in 3 biological equivalence trials: fasting, feeding, and mixing. The fasting and mixing trials used single-centered randomized, open-label, single-dose, 2-treatment, 2-period, and 2-sequence crossover design...
Source: Clinical Pharmacology in Drug Development - June 18, 2023 Category: Drugs & Pharmacology Authors: Juan Jin,
Cuiping Huang,
Changhai Zhu,
Wanni Feng,
Ang He,
Tuo Li,
Lina Wang,
Xiaolu Wang,
Xiali Rao,
Fangliang Gan Tags: Original Article Source Type: research
Patient Preparation with Esomeprazole Is Comparable to Ranitidine in Meckel Diverticulum Scintigraphy
Conclusion: This study confirms that esomeprazole, 40 mg, when administered intravenously 30 min before a Meckel scan, enhances the scan quality comparably to ranitidine. This procedure can be incorporated into protocols.PMID:37316300 | DOI:10.2967/jnmt.123.265558 (Source: Journal of Nuclear Medicine Technology)
Source: Journal of Nuclear Medicine Technology - June 14, 2023 Category: Nuclear Medicine Authors: Tessa F Ververs Anne-Fleur H Lobbezoo Monique G Hobbelink Arthur J Braat Source Type: research
