Persistent viral infections and their role in heart disease
Viral infections are the culprit of many diseases, including inflammation of the heart muscle, known as myocarditis. Acute myocarditis cases have been described in scientific literature, and viruses, such as parvovirus B19, coxsackievirus B3, or more recently, SARS-CoV-2, were the direct cause of cardiac inflammation. If not treated, myocarditis could progress to dilated cardiomyopathy, which permanently impairs the heart and limits a person’s lifespan. Accumulated evidence suggests that certain viruses may persist in cardiac tissue after the initial infection, which could open up the door to reactivation under favorable...
Source: Frontiers in Microbiology - November 24, 2022 Category: Microbiology Source Type: research

Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?
CONCLUSIONS: Our results show that the investigated pathogens are very unlikely to trigger the disease onset in CTLA-4-insufficient individuals, and their prevalence is not correlated with disease severity or expressivity.PMID:36405723 | PMC:PMC9667032 | DOI:10.3389/fimmu.2022.1011646 (Source: Herpes)
Source: Herpes - November 21, 2022 Category: Infectious Diseases Authors: M áté Krausz Noriko Mitsuiki Valeria Falcone Johanna Komp Sara Posadas-Cantera Hanns-Martin Lorenz Jiri Litzman Daniel Wolff Maria Kanariou Anita Heinkele Carsten Speckmann Georg H äcker Hartmut Hengel Laura G ámez-Díaz Bodo Grimbacher Source Type: research

Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?
CONCLUSIONS: Our results show that the investigated pathogens are very unlikely to trigger the disease onset in CTLA-4-insufficient individuals, and their prevalence is not correlated with disease severity or expressivity.PMID:36405723 | PMC:PMC9667032 | DOI:10.3389/fimmu.2022.1011646 (Source: Herpes)
Source: Herpes - November 21, 2022 Category: Infectious Diseases Authors: M áté Krausz Noriko Mitsuiki Valeria Falcone Johanna Komp Sara Posadas-Cantera Hanns-Martin Lorenz Jiri Litzman Daniel Wolff Maria Kanariou Anita Heinkele Carsten Speckmann Georg H äcker Hartmut Hengel Laura G ámez-Díaz Bodo Grimbacher Source Type: research

An atlat of the blood virome in healthy individuals
In conclusion, this study is the first comprehensive investigation of blood virome in healthy individuals by metatranscriptomic sequencing of VLP in China. Further investigation of potential false positives representing a major challenge for the identification of novel viruses in mNGS, will offer a systemic idea and means to reveal true viral infections of human.PMID:36402209 | DOI:10.1016/j.virusres.2022.199004 (Source: Cell Research)
Source: Cell Research - November 19, 2022 Category: Cytology Authors: Bo Feng Bo Liu Min Cheng Jie Dong Yongfeng Hu Fang Yang Qi Jin Source Type: research

An atlat of the blood virome in healthy individuals
In conclusion, this study is the first comprehensive investigation of blood virome in healthy individuals by metatranscriptomic sequencing of VLP in China. Further investigation of potential false positives representing a major challenge for the identification of novel viruses in mNGS, will offer a systemic idea and means to reveal true viral infections of human.PMID:36402209 | DOI:10.1016/j.virusres.2022.199004 (Source: Virus Research)
Source: Virus Research - November 19, 2022 Category: Virology Authors: Bo Feng Bo Liu Min Cheng Jie Dong Yongfeng Hu Fang Yang Qi Jin Source Type: research

An atlat of the blood virome in healthy individuals
In conclusion, this study is the first comprehensive investigation of blood virome in healthy individuals by metatranscriptomic sequencing of VLP in China. Further investigation of potential false positives representing a major challenge for the identification of novel viruses in mNGS, will offer a systemic idea and means to reveal true viral infections of human.PMID:36402209 | DOI:10.1016/j.virusres.2022.199004 (Source: Virus Research)
Source: Virus Research - November 19, 2022 Category: Virology Authors: Bo Feng Bo Liu Min Cheng Jie Dong Yongfeng Hu Fang Yang Qi Jin Source Type: research

Bilateral Conjunctivitis, Keratitis, and Anterior Uveitis in a Patient Co-infected with Parvovirus B19 and SARS-CoV-2
We report on a case of bilateral conjunctivitis, keratitis, and anterior uveitis that occurred in a patient co-infected by B19V and SARS-CoV-2. A young nurse developed, 20 days after the onset of asthenia and fever, a maculopapular rash and, in the following month, B19V-related arthritis. Shortly after a course of antibiotics and corticosteroids and the resolution of the arthritis, she began to complain of hearing loss and tinnitus. A polymerase chain reaction for SARS-CoV-2, previously negative, turned out positive; IgM for B19V decreased while IgG increased and antinuclear autoantibody and rheumatoid factor test results ...
Source: Case Reports in Ophthalmology - November 18, 2022 Category: Opthalmology Source Type: research

Case Report: Lupus Nephritis or a Mimic?
We present... [Read More] (Source: The Rheumatologist)
Source: The Rheumatologist - November 10, 2022 Category: Rheumatology Authors: Matthew J. Mandell, DO, Yishui Chen, MD, Prerna Rastogi, MD, PhD, & Rebecca Tuetken, MD, PhD Tags: Conditions SLE (Lupus) case report Fellows Fellows-in-Training Lupus nephritis parvovirus B19 SLE Resource Center syphilis Source Type: research

Pure red cell aplasia: Diagnosis, classification and treatment
Rev Med Interne. 2022 Nov 3:S0248-8663(22)01073-6. doi: 10.1016/j.revmed.2022.10.385. Online ahead of print.ABSTRACTPure red cell aplasia (PRCA) is a rare anemia characterised by profound reticulocytopenia caused by a marked reduction in bone marrow erythroblasts, without abnormalities in other blood lineages. Blackfan-Diamond anemia is an inherited ribosomopathy responsible for a hereditary form of PRCA. Acquired PRCA are separated in primary and secondary forms, including Parvovirus B19 infection, thymoma, lymphoproliferative disorders, autoimmune diseases (lupus) and drug-induced PRCA. The pathophysiology of PRCA is not...
Source: Revue de Medecine Interne - November 6, 2022 Category: Internal Medicine Authors: Herv é Lobbes Source Type: research

Characteristics and outcomes of acute hepatitis of unknown etiology in Egypt: first report of adult adenovirus-associated hepatitis
CONCLUSION: This is the first report describing etiologies and characteristics of AHUE cases in Egypt, and interestingly, adenovirus was detected in adults. Further studies are required to determine the prevalence of this newly emerging viral hepatitis pathogens.PMID:36334256 | DOI:10.1007/s15010-022-01945-1 (Source: Herpes)
Source: Herpes - November 5, 2022 Category: Infectious Diseases Authors: Haidi Karam-Allah Ramadan Ibrahim M Sayed Amal A Elkhawaga El-Zahraa M Meghezel Ashraf A Askar Abdelmajeed M Moussa Asmaa O B S Osman Azza Abo Elfadl Walaa A Khalifa Ahmed M Ashmawy Mohamed A El-Mokhtar Source Type: research

Characteristics and outcomes of acute hepatitis of unknown etiology in Egypt: first report of adult adenovirus-associated hepatitis
ConclusionThis is the first report describing etiologies and  characteristics of AHUE cases in Egypt, and interestingly, adenovirus was detected in adults. Further studies are required to determine the prevalence of this newly emerging viral hepatitis pathogens. (Source: Infection)
Source: Infection - November 5, 2022 Category: Infectious Diseases Source Type: research

Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?
ConclusionsOur results show that the investigated pathogens are very unlikely to trigger the disease onset in CTLA-4-insufficient individuals, and their prevalence is not correlated with disease severity or expressivity. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - November 2, 2022 Category: Allergy & Immunology Source Type: research

Viruses, Vol. 14, Pages 2410: Recombinant Virus-like Particles of Human Parvovirus B19 with the Internal Location of VP1 Unique Region Produced by Hansenula polymorpha
Jing Zhang Qiming Li Human parvovirus B19 (HPV B19) is pathogenic to human, which can cause fifth disease, transient aplastic crisis, arthritis, myocarditis, autoimmune disorders, hydrops fetalis, and so on. Currently, no approved vaccines or antiviral drugs are available against HPV B19, and thus the development of effective vaccines is needed. The capsid of HPV B19 is composed of two types of proteins, i.e., the major capsid protein VP2 and the minor protein VP1. Previous experimental studies have shown that the dominant immune responses against HPV B19 are elicited by VP1, especially the unique region on the N-...
Source: Viruses - October 30, 2022 Category: Virology Authors: Shuai Shao Qingqing Wang Yuqin Jin Xuefeng Zhang Zhaoming Liu Shi Chen Hailan Wu Sensen Yang Fang Tang Jiguo Su Yu Liang Jing Zhang Qiming Li Tags: Article Source Type: research