Acute parvovirus B19 infection: analysis of 46 patients.
CONCLUSIONS: Although there is a variable clinical spectrum, polyarthralgias and generalized maculopapular rash with fever and anaemia are the typical and most frequent manifestations of primary infection by PVB19 and are usually self-limiting. PMID: 32143947 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - March 8, 2020 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Parvovirus B19 infection in a patient with multiple sclerosis treated with rituximab.
Authors: Ruiz Molina I, Chic Acevedo C, Solís García E PMID: 32143942 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - March 8, 2020 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Exanthematous Eruptions in Children.
Abstract Childhood exanthems are commonly encountered by pediatricians in the hospital and the office. In the last several decades, we have seen a shift in the epidemiology of many of these diseases. After being deemed eliminated at the turn of 21st century, measles has experienced a resurgence secondary to falling vaccination rates, raising public health concerns. A new variant of hand, foot, and mouth disease caused by coxsackievirus A6 has been associated with more widespread and atypical disease, which can present diagnostic challenges to clinicians. Parvovirus B19, which is traditionally associated with fifth...
Source: Pediatric Annals - March 1, 2020 Category: Pediatrics Authors: Young TK, Oza VS Tags: Pediatr Ann Source Type: research

Acute Necrotizing Encephalopathy of Childhood Associated with Human Parvovirus B19 Infection
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - February 8, 2020 Category: Pediatrics Source Type: research

[CME Rheumatology 20/Answers: Parvovirus B19-Induced Tenosynovitis?]
r V PMID: 32019454 [PubMed - in process] (Source: Praxis)
Source: Praxis - February 1, 2020 Category: General Medicine Authors: Tamborrini G, Schwab M, Hebert T, Köhler V Tags: Praxis (Bern 1994) Source Type: research

Parvovirus B19-Associated Graft Failure after Allogeneic Hematopoietic Stem Cell Transplantation
Parvovirus B19 (PVB19) is a single-stranded DNA virus that infects erythroid progenitor cells, classically causing a pure red cell aplasia, but sometimes causing fulminant pancytopenia. PVB19 has been implicated in solid organ allograft failure, but no such literature exists for allogeneic hematopoietic stem cell transplantation (allo-HSCT). PVB19 may be an underappreciated complication in allo-HSCT. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Nabila Rattani, Christina Matheny, Erica Garcia-Frausto, Michael J. Eckrich, Lisa Madden, Troy C. Quigg Tags: 527 Source Type: research

Effects of antibodies against human parvovirus B19 on angiogenic signaling.
Authors: Su CC, Hsu TC, Hsiao CH, Chiu CC, Tzang BS Abstract Human parvovirus B19 (B19V) infection has symptoms similar to those of anti‑phospholipid syndrome (APS). Antibodies against B19V‑VP1 unique region (VP1u) exhibit activity similar to that of anti‑phospholipid antibodies (aPLs) by inducing vascular endothelial cell adhesion factors and APS‑like syndrome. Previous studies have identified an effect of aPLs on angiogenesis. However, little is understood regarding the effect of anti‑B19V‑VP1u antibodies on angiogenesis. The present study investigated the effects of anti‑B19V‑VP1u ...
Source: Molecular Medicine Reports - January 12, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Parvovirus B19 DNAemia in pregnant women in relation to perinatal death: a nested case ‐control study within a large population‐based pregnancy cohort
ConclusionsB19V ‐PCR positivity was high and similar in both cases and controls. In our study B19V‐DNAemia was thus not seen to be associated with fatal outcome of pregnancy. The clinical significance of B19V‐DNA detection during pregnancy is uncertain. Caution is needed when diagnosing a B19V‐infection bas ed only on B19V‐DNAemia. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 11, 2020 Category: OBGYN Authors: Regine Barlinn, Lill Trogstad, Halvor Rollag, Fredrik Fr øen, Per Magnus, Susanne G. Dudman Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Parvovirus B19 infection: A challenging cause of fulminant hepatitis
Publication date: Available online 6 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Nicolas Gille, Anne-Marie Roque-Afonso, Mylène Sebagh, Marika Rudler, Dominique Thabut, Jean-Charles Duclos-Vallée, Didier Samuel, Audrey Coilly (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - January 7, 2020 Category: Gastroenterology Source Type: research

Viral serology in “infarct-like” acute myocarditis: Useful or useless?
ConclusionCardiotropic viruses (HHV6, Parvovirus B19 and Coxsackie virus) were found in almost 50% of cases in “infarct like” acute myocarditis. According the presence or absence of cardiotropic viruses, CMR parameters were different. Furthermore, use of quantitative PCR (detection of viral genomes) or detection of viral DNA and RNA via in situ hybridization would be a challenge for the future identification of viruses in myocarditis. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - January 7, 2020 Category: Cardiology Source Type: research

Viruses, Vol. 12, Pages 69: Evaluation of the LIAISON XL Zika Capture IgM II for the Diagnosis of Zika Virus Infections
nte Murillo Minguito de Ory The aim of this study is to evaluate the performance characteristics of the LIAISON XL Zika Capture IgM II. For this purpose we tested 128 samples obtained from recent infections caused by the Zika (ZIKV; 74 samples), dengue (DENV; 10 samples), chikungunya (CHIK V; 11 samples), rubella (RUBV; 10 samples) and measles (MeV; 10 samples) viruses, as well as human parvovirus B19 (HPVB19; 13 samples). The results of the assay under evaluation are compared with those obtained from an indirect immunofluorescence (IIF) assay, and the discrepancies are resolved by considering other laborator...
Source: Viruses - January 7, 2020 Category: Virology Authors: P érez-Olmeda S ánchez-Seco V ázquez Balfag ón de la Fuente Murillo Minguito de Ory Tags: Article Source Type: research

Epidemiology of TORCH Infections and Understanding the Serology in Their Diagnosis
AbstractTORCH, as coined by Nahmias et al. consists of Toxoplasmosis, other infections (includes, syphilis, HIV, Hepatitis viruses, varicella virus and Parvovirus B19), Rubella, Cytomegalovirus (CMV) and Herpes simplex virus. These infections are transmitted prenatally, perinatally, and postnatally through transplacental passage, contact with blood and vaginal secretions or from exposure to breast milk for CMV, HIV and HSV and infection generally manifests at birth, in infancy or in later years of life. The disease burden is maximum in low to middle-income countries. As treatment and prevention strategies are available for...
Source: Journal of Fetal Medicine - January 2, 2020 Category: Perinatology & Neonatology Source Type: research

CME-Rheumatologie 20: Parvovirus-B19-induzierte Tenosynovitis? CME-Fragen.
We present a case of a patient with chronic tenosynovitis in the 4th extensor tendon compartment. With unremarkable anamnesis and due to normal laboratory results a «seronegative (RF), ACPA (CCP)-negative tenosynovitis without arthritis» had been reported. Diagnostic and therapeutic tenosynovectomy was performed. Histologic processing revealed a positive PCR for parvovirus B19. We discuss articular and extraarticular manifestations. A parvovirus B19-associated manifestation in the musculoskeletal system is usually self-limiting. The therapy should be carried out symptomatically. In our patient there was a marke...
Source: Praxis - January 1, 2020 Category: General Medicine Authors: Tamborrini G, Schwab M, Hebert T, Köhler V Tags: Praxis (Bern 1994) Source Type: research

Key Infections in the Placenta
Congenital infections are an important cause of morbidity and mortality worldwide, especially in low-income settings. This review discusses the main pathways of infections and associated adverse maternal and fetal outcomes, considering the TORCH pathogens, including Zika virus; the acronym stands for Toxoplasma gondii infection, other (Listeria monocytogenes, Treponema pallidum, and parvovirus B19, among others, including Zika virus), rubella virus, cytomegalovirus, and herpes simplex viruses type 1 and type 2. (Source: Obstetrics and Gynecology Clinics)
Source: Obstetrics and Gynecology Clinics - December 19, 2019 Category: OBGYN Authors: Maria Laura Costa, Guilherme de Moraes Nobrega, Arthur Antolini-Tavares Source Type: research

Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays.
Abstract SUMMARYInfections during pregnancy that may cause congenital abnormalities have been recognized for decades, but their diagnosis is challenging. This was again illustrated with the emergence of Zika virus (ZIKV), highlighting the inherent difficulties in estimating the extent of pre- and postnatal ZIKV complications because of the difficulties in establishing definitive diagnoses. We reviewed the epidemiology, infection kinetics, and diagnostic methods used for Toxoplasma gondii, parvovirus B19, rubella virus, and cytomegalovirus (TORCH) infections and compared the results with current knowledge of ZIKV d...
Source: Clinical Microbiology Reviews - December 14, 2019 Category: Microbiology Authors: Voordouw B, Rockx B, Jaenisch T, Fraaij P, Mayaud P, Vossen A, Koopmans M Tags: Clin Microbiol Rev Source Type: research

The Role of Emerging and Neglected Viruses in the Etiology of Hepatitis
AbstractPurpose of ReviewIn this review, we present the overview of emerging and neglected viruses associated with liver involvement.Recent FindingsHepatitis E virus (HEV) emerged in the last two decades, causing hepatitis in many parts of the world. Moreover, liver involvement was also described in some emerging arboviral infections. Many reports showed dengue-associated liver injury; however, chikungunya, West Nile, tick-borne encephalitis, and Zika virus are rarely associated with clinically manifest liver disease. In addition, some neglected highly prevalent viruses such as adenoviruses and parvovirus B19 are capable o...
Source: Current Infectious Disease Reports - November 21, 2019 Category: Infectious Diseases Source Type: research

Parvovirus B19 Infection with Positive Rumpel-Leede Sign
A 49-year-old Japanese female nursery teacher with no known medical history presented with fever, myalgia, and rash. Six days previously, fever, chill, and moderate pain in the bilateral thighs and lower back had developed, followed 3 days later by exanthema containing urticaria-like wheal, maculopapular rash, and lace-like rash at the bilateral lower limbs and left upper limb. Two days before presentation, the rash expanded to the abdomen. By the next day the rash and fever had alleviated but bilateral swelling of the fingers developed, and pain in the lower limbs and back persisted. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - November 9, 2019 Category: General Medicine Authors: Junki Mizumoto Tags: Clinical Communications to the Editor Source Type: research

Parvovirus B19 infection in a patient with multiple sclerosis treated with ocrelizumab
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - October 25, 2019 Category: Neurology Source Type: research

Quantitative PCR evaluation of parvovirus B19 removal via nanofiltration.
Abstract When human parvovirus B19 (B19) is removed from plasma-derived products by nanofiltration, non-infectious fragmented B19 DNA in filtrate prevents quantitative real time PCR (qPCR) from accurately evaluating reduction of the virus particles. To determine optimal target sequence length for detection of full-length B19 genome in the viral particles by qPCR, we analyzed 4 different sequences ranging from 372 to 1,980 bp and found that a 989 bp sequence shows a well-balanced performance for the sensitivity and the run time. Nuclease treatment of filtrates prior to qPCR is also expected to decrease the influenc...
Source: Journal of Virological Methods - October 21, 2019 Category: Virology Authors: Ideno S, Takahashi K, Yusa K, Sakai K Tags: J Virol Methods Source Type: research

Parvovirus B19 ‐induced hemophagocytic lymphohistiocytosis: Case report and review of the literature
HLH is a catastrophic and likely underdiagnosed pathology with multiple triggers including infection. PVB19 can cause persistent marrow infection leading to HLH despite negative acute serologic markers making timely diagnosis difficult. Increased awareness of PVB19 ‐HLH is warranted given its potentially lethal nature and the careful interpretation required with serologic markers. AbstractHLH is a catastrophic and likely underdiagnosed pathology with multiple triggers including infection. PVB19 can cause persistent marrow infection leading to HLH despite negative acute serologic markers making timely diagnosis difficult....
Source: Clinical Case Reports - September 27, 2019 Category: General Medicine Authors: James Kalmuk, Sara Matar, Gong Feng, Edward Kilb, Ming Y. Lim Tags: CASE REPORT Source Type: research

Human parvovirus B19 genotype 1 in suspected dengue patients of Tefé, Amazonas State, Brazil
Abstract INTRODUCTION: Human parvovirus B19 (B19V) is a common pathogen, which on infection causes variety of clinical conditions from benign self-limiting exanthematous disease and other similar pathologies to fetal death. METHODS: We collected 341 serum samples between the first and fourth day after the onset of symptoms from all patients suspected of dengue fever who were attended at Regional Hospital of Tef é. Initially, patients were screened for malaria by blood smear test and negative samples were sent to Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD) situated in Manaus (AM...
Source: Revista da Sociedade Brasileira de Medicina Tropical - September 6, 2019 Category: Tropical Medicine Source Type: research

Viruses, Vol. 11, Pages 820: Establishment of a Parvovirus B19 NS1-Expressing Recombinant Adenoviral Vector for Killing Megakaryocytic Leukemia Cells
In this study, we aimed to generate a recombinant adenovirus serotype 5 (rAd5) vector that has a high efficiency in gene transfer to megakaryocytic leukemic cells with anticancer potential. We first modified the rAd5 backbone vector with a chimeric fiber gene of Ad5 and Ad11p (rAd5F11p) to increase the gene delivery efficiency. Then, the nonstructural protein NS1 of human parvovirus B19 (B19V), which induces cell cycle arrest at the G2/M phase and apoptosis, was cloned into the adenoviral shuttle vector. As the expression of parvoviral NS1 protein inhibited Ad replication and production, we engineered the cytomegalovirus (...
Source: Viruses - September 4, 2019 Category: Virology Authors: Xu Wang Li Qiu Tags: Article Source Type: research

Viruses, Vol. 11, Pages 820: Establishment of a Parvovirus B19 NS1-Expressing Recombinant Adenoviral Vector for Killing Megakaryocytic Leukemia Cells
In this study, we aimed to generate a recombinant adenovirus serotype 5 (rAd5) vector that has a high efficiency in gene transfer to megakaryocytic leukemic cells with anticancer potential. We first modified the rAd5 backbone vector with a chimeric fiber gene of Ad5 and Ad11p (rAd5F11p) to increase the gene delivery efficiency. Then, the nonstructural protein NS1 of human parvovirus B19 (B19V), which induces cell cycle arrest at the G2/M phase and apoptosis, was cloned into the adenoviral shuttle vector. As the expression of parvoviral NS1 protein inhibited Ad replication and production, we engineered the cytomegalovirus (...
Source: Viruses - September 4, 2019 Category: Virology Authors: Peng Xu Xiaomei Wang Yi Li Jianming Qiu Tags: Article Source Type: research

Immunosuppression in inflammatory cardiomyopathy and parvovirus B19 persistence
European Journal of Heart Failure, EarlyView. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - September 2, 2019 Category: Cardiology Authors: Carsten Tsch öpe, Ahmed Elsanhoury, Saskia Schlieker, Sophie Van Linthout, Uwe Kühl Tags: Research Letter Source Type: research

Syphilis and parvovirus B19 co-infection imitating a lupus nephropathy: A case report
We present a unique presentation of a co-infection by syphilis and parvovirus B19 sharing all the biological and histological features of proliferative lupus nephritis (LN). Patient concerns: We present a case of a 71-year-old Caucasian male returning from a trip to Asia presenting with nephrotic syndrome with antinuclear antibodies (ANA) positivity. Diagnoses: Because of nephrotic syndrome a kidney biopsy was performed. It demonstrated a membranous nephropathy with extracapillary proliferation and a full house pattern (presence of IgA, IgG, IgM and C1Q deposits) on immunofluorescence (IF), highly suggestive of LN cl...
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Perinatal outcomes of intrauterine transfusion for foetal anaemia due to red blood cell alloimmunisation.
Authors: Şavkli AÖ, Çetin BA, Acar Z, Özköse Z, Behram M, Çaypinar SS, Tayyar A, Yüksel MA Abstract The aim of this study was to evaluate the maternal and neonatal outcomes of patients who underwent intrauterine transfusion (IUT) for foetal anaemia due to red blood cell alloimmunisation and to determine the factors that affected the outcomes. All pregnancies that were treated with IUT due to Rh immunisation between January 2015 and June 2018 in the Kanuni Sultan Süleyman Training and Research Hospital, Department of Obstetrics and Gynaecology, were evaluated retrospectively. ...
Source: Journal of Obstetrics and Gynaecology - August 31, 2019 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

Prevalence and factors associated with human parvovirus b19 infection in sickle cell patients hospitalized in tanzania
Conclusion: The prevalence of HPV B19 among hospitalized SCD patients at MNH was high. SCD patients with HPV B19 were more likely to present with pain, low neutrophils levels and MCH. HIV infection might be associated with high risk of HPV infection in SCD patients, however this requires further investigation. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - August 29, 2019 Category: Hematology Source Type: research

Prevalence and disease association of human parvovirus B19 in Iran: a Systematic Review
Future Virology, Ahead of Print. (Source: Future Virology)
Source: Future Virology - August 27, 2019 Category: Virology Authors: Mohammadmahdi Sabahi Arash Salehipour Azin Kazemi Mohammadreza Sadeghi Nicola Decaro Sayed-Hamidreza Mozhgani Farid Azizi Jalilian Mojtaba Hedayat Yaghoobi Source Type: research

Parvovirus B19 infection presenting with neutropenia and thrombocytopenia: Three case reports
Rationale: Parvovirus B19 (PV) infection is usually symptomless and can cause benign, short-lived conditions. Anemia associated with PRCA is the most representative hematologic manifestation, but neutropenia and thrombocytopenia have been rarely reported. Patient concerns: Three patients were admitted to the hospital with neutropenia and thrombocytopenia. The accompanying symptoms were fever, myalgia, rash, or arthralgia, and all patients were previously healthy. Diagnosis: Patients were positive for PV PCR and diagnosed with PV infection. Before the diagnosis of PV infection, 2 patients underwent BM study and almo...
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Primary Human Parvovirus B19 infection in an HIV patient on Antiretroviral Therapy.
Authors: Mirgh SP, Mishra VA, Sorabjee JS PMID: 31324102 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - July 22, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Viruses, Vol. 11, Pages 659: Advances in the Development of Antiviral Strategies against Parvovirus B19
ella Parvovirus B19 (B19V) is a human pathogenic virus, responsible for an ample range of clinical manifestations. Infections are usually mild, self-limiting, and controlled by the development of a specific immune response, but in many cases clinical situations can be more complex and require therapy. Presently available treatments are only supportive, symptomatic, or unspecific, such as administration of intravenous immunoglobulins, and often of limited efficacy. The development of antiviral strategies against B19V should be considered of highest relevance for increasing the available options for more specific and eff...
Source: Viruses - July 18, 2019 Category: Virology Authors: Manaresi Gallinella Tags: Review Source Type: research

Infections in pregnancy.
Authors: Keighley CL, Skrzypek HJ, Wilson A, Bonning MA, Gilbert GL Abstract Infections in pregnancy represent a challenging and often underappreciated area of concern for many specialists and general practitioners and can cause serious sequelae. Antenatal status should be highlighted on pathology request forms, as this serves to alert the laboratory of the need to store serum for an extended period. Prior antenatal specimens can be forwarded to other laboratories to enable testing in parallel with the more recent sample. Women with a confirmed, potentially vertically transmissible infection should be referred to a...
Source: Medical Journal of Australia - July 5, 2019 Category: General Medicine Tags: Med J Aust Source Type: research

Upregulation of Pro-inflammatory Cytokine Genes by Parvovirus B19 in Human Bone Marrow Mesenchymal Stem Cells.
In this study, we hypothesized that BM-MSCs as the main cellular component of bone marrow niche may be induced to secret pro-inflammatory cytokines after B19V infection. BM-MSCs were cultured up to passage 3. The cells were then subjected to nucleofection to transfer a plasmid containing B19V genome. After 36 h, total RNA was extracted and the expression levels of IL-1β, IL-6, TNF-α and NF-κB genes were examined using qRT-PCR. Data analysis showed the significant increase in expression levels of all studied genes in the B19V-transfected cells (P 
Source: Biochemical Genetics - June 27, 2019 Category: Genetics & Stem Cells Authors: Amiri S, Atashi A, Azad M, Elmi A, Abbaszade Dibavar M, Ajami M, Ajami M, Rassaei N, Mohammadihaji R, Gheibi N Tags: Biochem Genet Source Type: research

Microscopic visualization of virus removal by dedicated filters used in biopharmaceutical processing: Impact of membrane structure and localization of captured virus particles
This article is protected by copyright. All rights reserved. (Source: Biotechnology Progress)
Source: Biotechnology Progress - June 22, 2019 Category: Biotechnology Authors: Jun Adan ‐Kubo, Muneo Tsujikawa, Kadue Takahashi, Tomoko Hongo‐Hirasaki, Kaoru Sakai Tags: RESEARCH ARTICLE Source Type: research

Human Parvovirus B19 Infection in Patients with or without Underlying Diseases
ConclusionThe classical parvovirus B19 manifestations were less frequently observed in patients with a preexisting disease compared with previously healthy patients. Depending on host factors, the symptoms of parvovirus B19 infection can be multifaceted. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - June 20, 2019 Category: Microbiology Source Type: research

Performance of a Multiplex Nested Polymerase Chain Reaction in Detecting 7 Pathogens Containing DNA in Their Genomes Associated With Congenital Infections.
Abstract CONTEXT.—: Infections are the leading cause of perinatal and infant mortality in low-income and low-resource countries, which have a higher prevalence of infections. Definitive diagnosis of congenital and perinatal infections is largely dependent upon the results of laboratory tests. OBJECTIVE.—: To develop a multiplex nested polymerase chain reaction (PCR) for the simultaneous detection of 7 pathogens containing DNA in their genomes in suspected cases of congenital infection. DESIGN.—: Eligible participants were pregnant women with positive immunoglobulin M antibodies raised t...
Source: Archives of Pathology and Laboratory Medicine - June 20, 2019 Category: Laboratory Medicine Authors: Yamamoto L, Filho AGA, Queiroz JA, de Carvalho MHB, Rodrigues JC, Kanunfre KA, Francisco RPV, Okay TS Tags: Arch Pathol Lab Med Source Type: research

Current mechanistic insights into the role of infection in systemic lupus erythematosus
Publication date: September 2019Source: Biomedicine & Pharmacotherapy, Volume 117Author(s): Qingjun Pan, Zejian Liu, Shuzhen Liao, Lin Ye, Xing Lu, Xiaoqun Chen, Zhihang Li, Xinxin Li, Yong-Zhi Xu, Huafeng LiuAbstractSystemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by inflammation and abnormal production of autoantibody, but the mechanisms of the aberrant immune responses are currently unknown. Recently, growing evidence has suggested that infection plays a pivotal role in SLE. Here, we investigate the role of infectious agents (e.g., Epstein-Barr virus, parvovirus B19, human T-lymphotr...
Source: Biomedicine and Pharmacotherapy - June 19, 2019 Category: Drugs & Pharmacology Source Type: research

Human parvovirus B19 infection in patients with or without underlying diseases.
CONCLUSION: The classical parvovirus B19 manifestations were less frequently observed in patients with a preexisting disease compared with previously healthy patients. Depending on host factors, the symptoms of parvovirus B19 infection can be multifaceted. PMID: 31257106 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - June 19, 2019 Category: Microbiology Authors: Sim JY, Chang LY, Chen JM, Lee PI, Huang LM, Lu CY Tags: J Microbiol Immunol Infect Source Type: research

Viruses, Vol. 11, Pages 566: Systematic Review of PCR Proof of Parvovirus B19 Genomes in Endomyocardial Biopsies of Patients Presenting with Myocarditis or Dilated Cardiomyopathy
Conclusions: This systematic review reveals that the mean rate of PCR detected B19V genomes in patients presenting with MC/DCM does not differ significantly from the findings in control myocardial tissues. These data imply pathogenetically insignificant latency of B19V genomes in a proportion of myocardial tissues, both in MC-/DCM-patients and in controls. More information (i.e., replicative status, viral protein expression) is pertinent to achieve a comprehensive workup of myocardial B19V infection. (Source: Viruses)
Source: Viruses - June 18, 2019 Category: Virology Authors: Angelos G. Rigopoulos Bianca Klutt Marios Matiakis Athanasios Apostolou Sophie Mavrogeni Michel Noutsias Tags: Review Source Type: research

Current mechanistic insights into the role of infection in systemic lupus erythematosus.
Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by inflammation and abnormal production of autoantibody, but the mechanisms of the aberrant immune responses are currently unknown. Recently, growing evidence has suggested that infection plays a pivotal role in SLE. Here, we investigate the role of infectious agents (e.g., Epstein-Barr virus, parvovirus B19, human T-lymphotropic virus type 1, human immunodeficiency virus type 1, and endogenous retroviruses) in the pathogenesis of SLE. More importantly, we explore the known mechanisms underlying the involvement of infectious...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 18, 2019 Category: Drugs & Pharmacology Authors: Pan Q, Liu Z, Liao S, Ye L, Lu X, Chen X, Li Z, Li X, Xu YZ, Liu H Tags: Biomed Pharmacother Source Type: research

Kidney Diseases Associated With Parvovirus B19, Hanta, Ebola, and Dengue Virus Infection: A Brief Review
Publication date: May 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 3Author(s): Narayan Prasad, James E. Novak, Manas R. PatelViral infection-associated kidney diseases are an emerging public health issue in both developing and developed countries. Many new viruses have emerged with new paradigms of kidney injury, either directly through their cytopathic effect or indirectly through immune-mediated glomerulopathy, tubulointerstitial disease, and acute kidney injury as part of multiorgan failure. Herein, we will discuss Parvovirus, which causes glomerulopathy, and Hanta, Ebola, and Dengue viruses, which c...
Source: Advances in Chronic Kidney Disease - June 13, 2019 Category: Urology & Nephrology Source Type: research

Role of Viral Infections in Testicular Cancer Etiology: Evidence From a Systematic Review and Meta-Analysis
The most represented histotype of testicular cancer is the Testicular germ-cell tumor (TGCTs), both seminoma and non.seminoma. The pathogenesis of this cancer is poorly known. A possible causal relationship between viral infections and TGCTs was firstly evoked almost forty years ago and is still a subject of debate. In the recent past, different authors have argued about a possible role of specific viruses in the development of TGCTs including human papillomavirus (HPV), Epstein Barr virus (EBV), cytomegalovirus (CMV), Parvovirus B-19 and human immunodeficiency virus (HIV). The aim of this present review was to summarize, ...
Source: Frontiers in Endocrinology - June 12, 2019 Category: Endocrinology Source Type: research

Early Intraperitoneal Transfusion for Fetal Hydrops Caused by Parvovirus B19 Infection
Fetal Diagn Ther (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - June 11, 2019 Category: Perinatology & Neonatology Source Type: research

Acute exanthemas: a prospective study of 98 adult patients with emphasis of cytokinic and metagenomic investigation.
CONCLUSION: Routine investigations revealed HHV6 as the most frequent. Histology did not discriminate MPEs. In idiopathic MPE, the alarmin IL-33 could suggest an environmental factor as a trigger. Results of metagenomic analysis in skin samples question the interest of routine PCR and viral serologies. This article is protected by copyright. All rights reserved. PMID: 31127953 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 25, 2019 Category: Dermatology Authors: Deschamps O, Ortonne N, Hüe S, Rodriguez C, Deschodt C, Hirsch G, Colin A, Grégoire L, Delfau-Larue MH, Chosidow O, Wolkenstein P, Ingen-Housz-Oro S Tags: Br J Dermatol Source Type: research

Viruses, Vol. 11, Pages 430: Parvovirus B19 Uncoating Occurs in the Cytoplasm without Capsid Disassembly and It Is Facilitated by Depletion of Capsid-Associated Divalent Cations
This study reveals an uncoating strategy of B19V based on a limited capsid rearrangement prior to nuclear entry, a process that can be mimicked in vitro by depletion of divalent cations. (Source: Viruses)
Source: Viruses - May 10, 2019 Category: Virology Authors: Oliver Caliaro Andrea Marti Nico Ruprecht Remo Leisi Suriyasri Subramanian Susan Hafenstein Carlos Ros Tags: Article Source Type: research

[Erythrovirus B19 infections. Six years of follow-up in adults and children].
CONCLUSIONS: The characteristic clinical presentation in childhood was rash and fever, whereas in adults it was arthralgia. Anaemia is also frequent, but only severe in previous haematological disease. It should be pointed out that Erythrovirus B19 infection during pregnancy could severely affect the foetus. PMID: 31056091 [PubMed - in process] (Source: Anales de Pediatria)
Source: Anales de Pediatria - May 1, 2019 Category: Pediatrics Authors: Claver Belver N, Sanfeliu Sala I, Merino Asensio MJ, Monterde Pedra C, Pineda Solas V, Capilla Rubio S, Fontanals Aymerich D Tags: An Pediatr (Barc) Source Type: research

An assessment of the risk, cost-effectiveness, and perceived benefits of anti-parvovirus B19 tested blood products.
CONCLUSION: The estimated mortality and morbidity caused by B19V infection was low in the risk groups. The cost-effectiveness ratio is similar to other blood safety screening measures. No guidance exists to evaluate the acceptability of this ratio. The explicit overview of costs and effects may further guide the discussion of the desirability of B19V safe blood products. PMID: 31032994 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - April 29, 2019 Category: Hematology Authors: van Hoeven LR, Janssen MP, Lieshout-Krikke RW, Molenaar-de Backer MW Tags: Transfusion Source Type: research