Diffuse endocapillary proliferative glomerulonephritis and parvovirus B19 infection. A causal relationship?
Med Clin (Barc). 2024 Feb 27:S0025-7753(24)00071-X. doi: 10.1016/j.medcli.2023.12.028. Online ahead of print.NO ABSTRACTPMID:38418308 | DOI:10.1016/j.medcli.2023.12.028 (Source: Medicina Clinica)
Source: Medicina Clinica - February 28, 2024 Category: General Medicine Authors: Vanesa Garc ía Chumillas Miguel Ángel González Martínez Mercedes Caba Molina Source Type: research

Viral DNAemia and DNA Virus Seropositivity and Mortality in Pediatric Sepsis
CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that DNAemia for CMV, HAdV, BKPyV, and HHV-6 and EBV seropositivity were independently associated with increased sepsis mortality. Further investigation of the underlying biology of these viral DNA infections in children with sepsis is warranted to determine whether they only reflect mortality risk or contribute to mortality.PMID:38407904 | DOI:10.1001/jamanetworkopen.2024.0383 (Source: Herpes)
Source: Herpes - February 26, 2024 Category: Infectious Diseases Authors: Stephanie S Cabler Gregory A Storch Jason B Weinberg Andrew H Walton Karen Brengel-Pesce Zachary Aldewereld Russell K Banks Valerie Cheynet Ron Reeder Richard Holubkov Robert A Berg David Wessel Murray M Pollack Kathleen Meert Mark Hall Christopher Newth Source Type: research

Viral DNAemia and DNA Virus Seropositivity and Mortality in Pediatric Sepsis
CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that DNAemia for CMV, HAdV, BKPyV, and HHV-6 and EBV seropositivity were independently associated with increased sepsis mortality. Further investigation of the underlying biology of these viral DNA infections in children with sepsis is warranted to determine whether they only reflect mortality risk or contribute to mortality.PMID:38407904 | PMC:PMC10897747 | DOI:10.1001/jamanetworkopen.2024.0383 (Source: Herpes)
Source: Herpes - February 26, 2024 Category: Infectious Diseases Authors: Stephanie S Cabler Gregory A Storch Jason B Weinberg Andrew H Walton Karen Brengel-Pesce Zachary Aldewereld Russell K Banks Valerie Cheynet Ron Reeder Richard Holubkov Robert A Berg David Wessel Murray M Pollack Kathleen Meert Mark Hall Christopher Newth Source Type: research

Antiviral alternatives against important members of the subfamily Parvovirinae: a review
AbstractParvoviruses are responsible for multiple diseases, and there is a critical need for effective antiviral therapies. Specific antiviral treatments for parvovirus infections are currently lacking, and the available options are mostly supportive and symptomatic. In recent years, significant research efforts have been directed toward understanding the molecular mechanisms of parvovirus replication and identifying potential targets for antiviral interventions. This review highlights the structure, pathogenesis, and treatment options for major viruses of the subfamilyParvovirinae, such as parvovirus B19 (B19V), canine pa...
Source: Archives of Virology - February 20, 2024 Category: Virology Source Type: research

Pure Red Cell Aplasia Secondary to Parvovirus B19 Infection as a Rare Cause of Anemia in a Dialysis Patient: A Case Report
Intern Med. 2024 Feb 19. doi: 10.2169/internalmedicine.2631-23. Online ahead of print.ABSTRACTParvovirus B19 infection can cause chronic pure red cell aplasia in immunosuppressed hosts or acute and transient aplastic crises in immunocompetent hosts. In dialysis patients, only transient aplastic crisis induced by parvovirus B19 infection has been reported. We herein report the first case of an adult dialysis patient who developed chronic pure red cell aplasia associated with parvovirus B19 infection. Repeated pneumonia and heart failure may contribute to an immunocompromised status, making the patient more vulnerable to par...
Source: Internal Medicine - February 18, 2024 Category: Internal Medicine Authors: Yuequan Shi Xiaoxiao Shi Haiyun Wang Zijuan Zhou Lei Zhang Limeng Chen Source Type: research

Fetal anaemia
is a relatively rare occurrence, but it carries a risk of significant fetal morbidity and mortality. The most common causes of fetal anaemia are haemolytic disease of fetus and newborn and parvovirus B19 infection. The only diagnostic test for fetal anaemia is fetal blood sampling, but this is an invasive test with associated risk of miscarriage, preterm membrane rupture or intrauterine fetal death. Therefore it is only performed if there is a strong suspicion of fetal anamia based on the patient's history and ultrasound findings of raised peak systolic velocity in middle cerebral artery and/or fetal hydrops. (Source: Obs...
Source: Obstetrics, Gynaecology and Reproductive Medicine - February 12, 2024 Category: OBGYN Authors: Borna Poljak, Alec McEwan Tags: Case-based learning Source Type: research

Maternal Outcomes of Parvovirus B19 Infections in Pregnancy
Parvovirus B19 (Parvo) infection during pregnancy can lead to adverse neonatal outcomes, but little is known about maternal outcomes associated with the infection. The study aims to evaluate outcomes in pregnancies complicated by clinically significant Parvovirus. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 1, 2024 Category: OBGYN Authors: Okunbor J, Watkins V, Estin M, Truong T, Unnithan S, Federspiel J, Dotters-Katz S Source Type: research

Viruses, Vol. 16, Pages 191: Parvovirus B19 and Human Parvovirus 4 Encode Similar Proteins in a Reading Frame Overlapping the VP1 Capsid Gene
n Viruses frequently contain overlapping genes, which encode functionally unrelated proteins from the same DNA or RNA region but in different reading frames. Yet, overlapping genes are often overlooked during genome annotation, in particular in DNA viruses. Here we looked for the presence of overlapping genes likely to encode a functional protein in human parvovirus B19 (genus Erythroparvovirus), using an experimentally validated software, Synplot2. Synplot2 detected an open reading frame, X, conserved in all erythroparvoviruses, which overlaps the VP1 capsid gene and is under highly significant selection pressure. In ...
Source: Viruses - January 26, 2024 Category: Virology Authors: David G. Karlin Tags: Article Source Type: research

Viruses, Vol. 16, Pages 180: Seroepidemiology of Human Parvovirus B19 Infection among the Population of Vojvodina, Serbia, over a 16-Year Period (2008 & ndash;2023)
This study aimed to estimate the serological status and dynamic changes in the prevalence of Parvovirus B19 (PVB19) antibodies within the general population residing in the northern part of the Republic of Serbia (Province of Vojvodina) during a 16-year period. Serum samples were analyzed for Human PVB19-specific IgM and IgG antibodies using enzyme-linked immunosorbent assay (ELISA). Throughout the study period, the overall seroprevalence was 49.51%. Approximately 10% of patients exhibited a serologic profile positive for PVB19 IgM antibodies. Notably, seroprevalence varied significantly, ranging from 9.12% in the pediatri...
Source: Viruses - January 25, 2024 Category: Virology Authors: Vladimir Vukovi ć Aleksandra Pati ć Mioljub Risti ć Gordana Kova čević Ivana Hrnjakovi ć Cvjetković Vladimir Petrovi ć Tags: Article Source Type: research

Feasibility of Domain Segmentation of B19V VP1u Using Intein Technology for Structural Studies
CONCLUSION: This method would allow for the selective incorporation of NMR-active isotopes into either of the VP1u domains, which can reduce signal overlap in NMR structural determination studies.PMID:38243925 | DOI:10.2174/0109298665277211231214065419 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - January 20, 2024 Category: Biochemistry Authors: Renuk Varayil Lakshmanan Mavis Agbandje-McKenna Robert McKenna Source Type: research