Parvovirus B19 Myocarditis in a Covid19 MIS-C Syndrome: Cause or Causality?
Myocarditis has been recognized as one of major complication during COVID 19 infections and vaccination. Few data are currently available on viral detection during myocardial damage in pediatric population. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2023 Category: Transplant Surgery Authors: E. Bellettini, E. Mencarelli, M. Rebonato, P. Francalanci, N. Cantarutti, S. Alfieri, L. Galletti, R. Kirk, A. Amodeo, R. Adorisio Tags: (577) Source Type: research

Importin α/β-dependent nuclear transport of human parvovirus B19 nonstructural protein 1 is essential for viral replication
In this study we undertake structural, biophysical, and cellular approaches to characterize this process. Quantitative confocal laser scanning microscopy (CLSM), gel mobility shift, fluorescence polarization and crystallographic analysis identified a short sequence of amino acids (GACHAKKPRIT-182) as the classical nuclear localization signal (cNLS) responsible for nuclear import, mediated in an energy and importin (IMP) α/β-dependent fashion. Structure-guided mutagenesis of key residue K177 strongly impaired IMPα binding, nuclear import, and viral gene expression in a minigenome system. Further, treatment with ivermecti...
Source: Antiviral Research - March 29, 2023 Category: Virology Authors: Gualtiero Alvisi Elisabetta Manaresi Emily M Cross Mikayla Hoad Nasim Akbari Silvia Pavan Daryl Ariawan Gloria Bua Gayle F Petersen Jade Forwood Giorgio Gallinella Source Type: research

Skin and SARS-CoV-2 in pediatrics
Rev Alerg Mex. 2022 May 27;69(1):14-20. doi: 10.29262/ram.v69i1.1000.ABSTRACTThe clinical presentation, disease course, and outcome of SARS-CoV-2 infection in pediatrics differ from the presentation in adults. In a review by Hoang et al., the prevalence of dermatological manifestations was estimated in 0.25% of a total of 2,445 children with confirmed COVID-19. Similarly, the prevalence of skin manifestations was reported in 3% of 100 children in the Parri's study. A systematic review by Shah et al. analyzed 13 studies with 149 children who met eligibility criteria. The acral erythematous maculopapular lesion was the most ...
Source: Herpes - March 17, 2023 Category: Infectious Diseases Authors: Mar ía Claudia Ortega-López Source Type: research

An adagio for viruses, played out on ancient DNA
Genome Biol Evol. 2023 Mar 17:evad047. doi: 10.1093/gbe/evad047. Online ahead of print.ABSTRACTStudies of ancient DNA have transformed our understanding of human evolution. Palaeogenomics can also reveal historic and prehistoric agents of disease, including endemic, epidemic and pandemic pathogens. Viruses - and in particular those with single or double-stranded DNA genomes - are an important part of the palaeogenomic revolution, preserving within some remains or environmental samples for tens of thousands of years. The results of these studies capture the public imagination, as well as giving scientists a unique perspecti...
Source: Herpes - March 17, 2023 Category: Infectious Diseases Authors: Toni de-Dios Christiana L Scheib Charlotte J Houldcroft Source Type: research

Skin and SARS-CoV-2 in pediatrics
Rev Alerg Mex. 2022 May 27;69(1):14-20. doi: 10.29262/ram.v69i1.1000.ABSTRACTThe clinical presentation, disease course, and outcome of SARS-CoV-2 infection in pediatrics differ from the presentation in adults. In a review by Hoang et al., the prevalence of dermatological manifestations was estimated in 0.25% of a total of 2,445 children with confirmed COVID-19. Similarly, the prevalence of skin manifestations was reported in 3% of 100 children in the Parri's study. A systematic review by Shah et al. analyzed 13 studies with 149 children who met eligibility criteria. The acral erythematous maculopapular lesion was the most ...
Source: Herpes - March 17, 2023 Category: Infectious Diseases Authors: Mar ía Claudia Ortega-López Source Type: research

Viruses, Vol. 15, Pages 595: Novel Nucleic Acid Detection for Human Parvovirus B19 Based on Pyrococcus furiosus Argonaute Protein
Wang Yanming Dong Parvovirus B19 (B19V) is pathogenic to humans and causes various human diseases. However, no antiviral agents or vaccines currently exist for the treatment or prevention of B19V infection. Therefore, developing sensitive and specific methods for B19V infection diagnosis is essential for accurate diagnoses. Previously, a Clustered Regularly Interspaced Palindromic Repeats (CRISPR)-Cas12a (cpf1)-based electrochemical biosensor (E-CRISPR) with a picomole sensitivity for B19V detection was established. Herein, we set up a novel nucleic acid detection system based on Pyrococcus furiosus Argonaute (PfAgo)...
Source: Viruses - February 21, 2023 Category: Virology Authors: Weiran Chen Liyang Qiu Ting Luo Zhongqin Lu Xueying Wang Qi Hong Jingwen Luo Lixin Ma Yuan Wang Yanming Dong Tags: Brief Report Source Type: research

Correction: Human Parvovirus B19 May Be a Risk Factor in Myasthenia Gravis with Thymoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 8, 2023 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: A Possible New Etiology of Thymoma-Associated Myasthenia Gravis —Human Parvovirus B19
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 8, 2023 Category: Cancer & Oncology Source Type: research

Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient
Immunosuppressed patients can contract parvovirus B19, and some may experience hemophagocytic lymphohistiocytosis (HLH). Herein, we describe the first report of hemophagocytic lymphohistiocytosis in a heart-lung transplant patient with concomitant parvovirus B19 infection. The patient was treated with intravenous immune globulin (IVIG) and the features of HLH were remission. This instance emphasizes the significance of parvovirus B19 monitoring in transplant patients with anemia; if HLH complicates the situation, IVIG may be an adequate remedy. Finally, a summary of the development in diagnosing and managing parvovirus B19...
Source: Frontiers in Immunology - February 7, 2023 Category: Allergy & Immunology Source Type: research

Prevalence and genotypic characterization of human parvovirus B19 in hemophilia patients
CONCLUSION: Since hemophilia patients receive large amounts of blood factors, prevalence of B19V in these patients might be higher than normal subjects.PMID:36721508 | PMC:PMC9867637 | DOI:10.18502/ijm.v14i4.10244 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - February 1, 2023 Category: Microbiology Authors: Mohsen Keshavarz Nahid Janati-Namin Yaser Arjeini Talat Mokhtari-Azad Farhad Rezaei Source Type: research