Viruses, Vol. 16, Pages 191: Parvovirus B19 and Human Parvovirus 4 Encode Similar Proteins in a Reading Frame Overlapping the VP1 Capsid Gene
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Viruses frequently contain overlapping genes, which encode functionally unrelated proteins from the same DNA or RNA region but in different reading frames. Yet, overlapping genes are often overlooked during genome annotation, in particular in DNA viruses. Here we looked for the presence of overlapping genes likely to encode a functional protein in human parvovirus B19 (genus Erythroparvovirus), using an experimentally validated software, Synplot2. Synplot2 detected an open reading frame, X, conserved in all erythroparvoviruses, which overlaps the VP1 capsid gene and is under highly significant selection pressure. In ...
Source: Viruses - January 26, 2024 Category: Virology Authors: David G. Karlin Tags: Article Source Type: research
Viruses, Vol. 16, Pages 180: Seroepidemiology of Human Parvovirus B19 Infection among the Population of Vojvodina, Serbia, over a 16-Year Period (2008 & ndash;2023)
This study aimed to estimate the serological status and dynamic changes in the prevalence of Parvovirus B19 (PVB19) antibodies within the general population residing in the northern part of the Republic of Serbia (Province of Vojvodina) during a 16-year period. Serum samples were analyzed for Human PVB19-specific IgM and IgG antibodies using enzyme-linked immunosorbent assay (ELISA). Throughout the study period, the overall seroprevalence was 49.51%. Approximately 10% of patients exhibited a serologic profile positive for PVB19 IgM antibodies. Notably, seroprevalence varied significantly, ranging from 9.12% in the pediatri...
Source: Viruses - January 25, 2024 Category: Virology Authors: Vladimir Vukovi ć Aleksandra Pati ć Mioljub Risti ć Gordana Kova čević Ivana Hrnjakovi ć Cvjetković Vladimir Petrovi ć Tags: Article Source Type: research
Feasibility of Domain Segmentation of B19V VP1u Using Intein Technology for Structural Studies
CONCLUSION: This method would allow for the selective incorporation of NMR-active isotopes into either of the VP1u domains, which can reduce signal overlap in NMR structural determination studies.PMID:38243925 | DOI:10.2174/0109298665277211231214065419 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - January 20, 2024 Category: Biochemistry Authors: Renuk Varayil Lakshmanan Mavis Agbandje-McKenna Robert McKenna Source Type: research
Parvovirus in Kidney Transplant Recipients: A Single-Center Experience
CONCLUSIONS: Parvovirus B19 is a relatively underreported disease in renal transplant recipients, with patients presenting with anemia and the disease causing transient graft dysfunction. Parvovirus B19 infection responds well to a decrease in immunosuppression and intravenous immunoglobulin therapy.PMID:38140930 | DOI:10.6002/ect.2023.0127 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - December 23, 2023 Category: Transplant Surgery Authors: Priyash Tambi Ruchir Dave Vivek Kute Himanshu V Patel Shivam Shah Rahul Yadav Source Type: research
Parvovirus in Kidney Transplant Recipients: A Single-Center Experience
CONCLUSIONS: Parvovirus B19 is a relatively underreported disease in renal transplant recipients, with patients presenting with anemia and the disease causing transient graft dysfunction. Parvovirus B19 infection responds well to a decrease in immunosuppression and intravenous immunoglobulin therapy.PMID:38140930 | DOI:10.6002/ect.2023.0127 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - December 23, 2023 Category: Transplant Surgery Authors: Priyash Tambi Ruchir Dave Vivek Kute Himanshu V Patel Shivam Shah Rahul Yadav Source Type: research
Parvovirus in Kidney Transplant Recipients: A Single-Center Experience
CONCLUSIONS: Parvovirus B19 is a relatively underreported disease in renal transplant recipients, with patients presenting with anemia and the disease causing transient graft dysfunction. Parvovirus B19 infection responds well to a decrease in immunosuppression and intravenous immunoglobulin therapy.PMID:38140930 | DOI:10.6002/ect.2023.0127 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - December 23, 2023 Category: Transplant Surgery Authors: Priyash Tambi Ruchir Dave Vivek Kute Himanshu V Patel Shivam Shah Rahul Yadav Source Type: research
Parvovirus in Kidney Transplant Recipients: A Single-Center Experience
CONCLUSIONS: Parvovirus B19 is a relatively underreported disease in renal transplant recipients, with patients presenting with anemia and the disease causing transient graft dysfunction. Parvovirus B19 infection responds well to a decrease in immunosuppression and intravenous immunoglobulin therapy.PMID:38140930 | DOI:10.6002/ect.2023.0127 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - December 23, 2023 Category: Transplant Surgery Authors: Priyash Tambi Ruchir Dave Vivek Kute Himanshu V Patel Shivam Shah Rahul Yadav Source Type: research
Structural Shifts of the Parvovirus B19 Capsid Receptor-binding Domain: A Peptide Study
CONCLUSION: Loss of function Y20W substitution in VP1 capsid protein prevents the shift into the beta-structural state by way of alpha helix stabilization and the decrease of its ability to turn into the disordered state.PMID:38053353 | DOI:10.2174/0109298665272845231121064717 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - December 6, 2023 Category: Biochemistry Authors: Vladislav Victorovich Khrustalev Aleksander Nicolaevich Stojarov Anastasia Aleksandrovna Akunevich Oleg Evgenyevich Baranov Anna Vladimirovna Popinako Elena Olegovna Samoylovich Marina Anatolyevna Yermolovich Galina Valeryevna Semeiko Egor Gennadyevich Sa Source Type: research
Structural Shifts of the Parvovirus B19 Capsid Receptor-binding Domain: A Peptide Study
CONCLUSION: Loss of function Y20W substitution in VP1 capsid protein prevents the shift into the beta-structural state by way of alpha helix stabilization and the decrease of its ability to turn into the disordered state.PMID:38053353 | DOI:10.2174/0109298665272845231121064717 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - December 6, 2023 Category: Biochemistry Authors: Vladislav Victorovich Khrustalev Aleksander Nicolaevich Stojarov Anastasia Aleksandrovna Akunevich Oleg Evgenyevich Baranov Anna Vladimirovna Popinako Elena Olegovna Samoylovich Marina Anatolyevna Yermolovich Galina Valeryevna Semeiko Egor Gennadyevich Sa Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities
Ann Biol Clin (Paris). 2023 Nov 29;81(5). doi: 10.1684/abc.2023.1843. Online ahead of print.ABSTRACTThe discovery of hemolytic anemia requires a meticulous investigation to determine its etiology. Among patients of African origin, it is not uncommon to find multiple constitutional red blood cell abnormalities, which can complicate diagnosis. We herein describe the case of a two-year-old child presenting with acute hemolytic anemia. A G6PD deficiency, hereditary spherocytosis, and a sickle cell trait A/S were simultaneously identified, all within the context of a primary infection with Parvovirus B19. This virus commonly tr...
Source: Annales de Biologie Clinique - November 29, 2023 Category: Biochemistry Authors: Romain Ravel-Chapuis L éo Mottin Ma ïssa Souissi Agn ès Lahary Victor Bob ée Source Type: research
