Vonoprazan versus lansoprazole for healing and maintenance of healing of erosive esophagitis: a randomized trial
For decades, proton pump inhibitors (PPIs) have been the mainstay of treatment for erosive esophagitis. The potassium-competitive acid blocker vonoprazan provides more potent acid inhibition than PPIs but data on its efficacy for erosive esophagitis are limited. (Source: Gastroenterology)
Source: Gastroenterology - October 10, 2022 Category: Gastroenterology Authors: Loren Laine, Kenneth DeVault, Philip Katz, Stefan Mitev, John Lowe, Barbara Hunt, Stuart Spechler Tags: Clinical - Alimentary Tract Source Type: research
Vonoprazan vs Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial
For decades, proton pump inhibitors (PPIs) have been the mainstay of treatment for erosive esophagitis. The potassium-competitive acid blocker vonoprazan provides more potent acid inhibition than PPIs, but data on its efficacy for erosive esophagitis are limited. (Source: Gastroenterology)
Source: Gastroenterology - October 10, 2022 Category: Gastroenterology Authors: Loren Laine, Kenneth DeVault, Philip Katz, Stefan Mitev, John Lowe, Barbara Hunt, Stuart Spechler Tags: Clinical - Alimentary Tract Source Type: research
Factors Associated with Increased Severity of Erosive Esophagitis 1 Year After Laparoscopic Sleeve Gastrectomy
ConclusionThe prevalence and severity of EE increased after LSG. Male gender and post-operative hiatal hernia are independent factors for an increased severity of EE after LSG. The incidence of severe EE after LSG is low for patients without pre-operative EE or grade A EE at baseline.Graphical abstract (Source: Obesity Surgery)
Source: Obesity Surgery - October 7, 2022 Category: Surgery Source Type: research
Positive and negative impact of anti-reflux mucosal intervention on gastroesophageal reflux disease
ConclusionsARMI is generally effective and safe in PPI-dependent patients. However, possible negative effects of ARMI exist in some patients; further application of MII-pH is necessitated to evaluate the treatment response after ARMI and avoid the detrimental effect of PPI discontinuation.Graph.Graphical abstract (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - September 15, 2022 Category: Surgery Source Type: research
Clinical Endoscopic and Histologic Findings of a Long-Term Follow-Up (10.7 Years) After Roux-en-Y Laparoscopic Gastric Bypass: a Prospective Study
ConclusionLYGB is a very effective surgical procedure to control symptoms of GERD and/or endoscopic erosive esophagitis. Besides, regression of Barrett ’s mucosa to carditis occurred in 62%.Graphical abstract (Source: Obesity Surgery)
Source: Obesity Surgery - July 1, 2022 Category: Surgery Source Type: research
Laparoscopic sleeve gastrectomy with Rossetti fundoplication: long-term (5-year) follow-up
CONCLUSION: Laparoscopic sleeve gastrectomy with Rossetti fundoplication is well tolerated, feasible, and safe in patients with obesity, providing adequate weight loss results and complete resolution of clinical signs of GERD. We have recorded an improvement in esophagitis lesions present at preoperative gastroscopy and complete resolution of Barrett's esophagus within 5 years of follow-up.PMID:35760673 | DOI:10.1016/j.soard.2022.05.012 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - June 27, 2022 Category: Surgery Authors: Matteo Uccelli Giovanni Carlo Cesana Francesca Ciccarese Alberto Oldani Riccardo Giorgi Stefano Maria De Carli Roberta Villa Adelinda Angela Giulia Zanoni Ayman Ismail Francesco Di Capua Marta Bonaldi Carolina Rubicondo Davide Moioli Stefano Olmi Source Type: research
Laparoscopic sleeve gastrectomy with Rossetti fundoplication: long-term (5-year) follow-up
CONCLUSION: Laparoscopic sleeve gastrectomy with Rossetti fundoplication is well tolerated, feasible, and safe in patients with obesity, providing adequate weight loss results and complete resolution of clinical signs of GERD. We have recorded an improvement in esophagitis lesions present at preoperative gastroscopy and complete resolution of Barrett's esophagus within 5 years of follow-up.PMID:35760673 | DOI:10.1016/j.soard.2022.05.012 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - June 27, 2022 Category: Surgery Authors: Matteo Uccelli Giovanni Carlo Cesana Francesca Ciccarese Alberto Oldani Riccardo Giorgi Stefano Maria De Carli Roberta Villa Adelinda Angela Giulia Zanoni Ayman Ismail Francesco Di Capua Marta Bonaldi Carolina Rubicondo Davide Moioli Stefano Olmi Source Type: research
Network Meta-analysis Comparing Vonoprazan and Proton Pump Inhibitors for Heartburn Symptoms in Erosive Esophagitis
Conclusions:
In this study, vonoprazan 20 mg QD was equally effective in heartburn resolution on Day 1, and equally or more effective on Day 7 versus PPIs in adults with erosive esophagitis. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 17, 2022 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research
Laparoscopic Sleeve Gastrectomy with Rossetti fundoplication. Long-term (5 years) follow-up
This study presents results after five years follow-up, on morbid obese patients, of combined LSG and Rossetti fundoplication for the treatment of GERD, esophagitis and Barrett ’s esophagus in obese patients.Objectives: to evaluate long term results after sleeve gastrectomy with Rossetti fundoplication. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - May 18, 2022 Category: Surgery Authors: Matteo Uccelli, Giovanni Carlo Cesana, Francesca Ciccarese, Alberto Oldani, Riccardo Giorgi, Stefano Maria De carli, Roberta Villa, Adelinda Angela Giulia Zanoni, Ayman Ismail, Francesco DI. Capua, Marta Bonaldi, Carolina Rubicondo, Davide Moioli, Stefano Tags: Original articles Source Type: research
Laparoscopic sleeve gastrectomy with Rossetti fundoplication: long-term (5-year) follow-up
This study presents results after 5 years of follow-up of combined LSG and Rossetti fundoplication for the treatment of GERD, esophagitis, and Barrett’ s esophagus in patients with morbid obesity. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - May 18, 2022 Category: Surgery Authors: Matteo Uccelli, Giovanni Carlo Cesana, Francesca Ciccarese, Alberto Oldani, Riccardo Giorgi, Stefano Maria De Carli, Roberta Villa, Adelinda Angela Giulia Zanoni, Ayman Ismail, Francesco Di Capua, Marta Bonaldi, Carolina Rubicondo, Davide Moioli, Stefano Tags: Original article Source Type: research
Expression of VEGF, EGF, and Their Receptors in Squamous Esophageal Mucosa, with Correlations to Histological Findings and Endoscopic Minimal Changes, in Patients with Different GERD Phenotypes
CONCLUSIONS: Our findings suggest a correlation between growth factors expression and findings in conventional endoscopy, formation of endoscopic minimal changes, and histologic lesions.PMID:35564692 | DOI:10.3390/ijerph19095298 (Source: Cell Research)
Source: Cell Research - May 14, 2022 Category: Cytology Authors: Justyna Wasielica-Berger Pawe ł Rogalski Agnieszka Świdnicka-Siergiejko Anna Pryczynicz Joanna Ki śluk Jaros ław Daniluk Stefania Antonowicz Dominik Ma ślach Michalina Krzy żak Andrzej D ąbrowski Source Type: research
IJERPH, Vol. 19, Pages 5298: Expression of VEGF, EGF, and Their Receptors in Squamous Esophageal Mucosa, with Correlations to Histological Findings and Endoscopic Minimal Changes, in Patients with Different GERD Phenotypes
Conclusions: Our findings suggest a correlation between growth factors expression and findings in conventional endoscopy, formation of endoscopic minimal changes, and histologic lesions. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - April 27, 2022 Category: Environmental Health Authors: Justyna Wasielica-Berger Pawe ł Rogalski Agnieszka Świdnicka-Siergiejko Anna Pryczynicz Joanna Ki śluk Jaros ław Daniluk Stefania Antonowicz Dominik Ma ślach Michalina Krzy żak Andrzej D ąbrowski Tags: Article Source Type: research
The Discrepancy Between Subjective and Objective Clinical Endpoints in Gastroesophageal Reflux Disease
Therapeutic outcome in gastroesophageal reflux disease (GERD) is commonly determined by both subjective and objective clinical endpoints. Clinicians frequently use symptom improvement as a key benchmark of clinical success, in conjunction with normalization of objective parameters such as esophageal acid exposure and inflammation. However, GERD therapeutic trials have demonstrated that a substantial number of patients rendered asymptomatic, whether through medical, surgical, or endoscopic intervention, continue to have persistent abnormal esophageal acid exposure and erosive esophagitis. The opposite has also been demonstr...
Source: Journal of Clinical Gastroenterology - April 20, 2022 Category: Gastroenterology Tags: Clinical Reviews Source Type: research
The Hill ’s Classification Is Useful to Predict the Development of Postoperative Gastroesophageal Reflux Disease and Erosive Esophagitis After Laparoscopic Sleeve Gastrectomy
ConclusionPostoperative GERD and EE remain an important limitation following LSG. Proper preoperative assessment using the Hill ’s classification can help to accurately predict patients at risk of postoperative GERD and EE. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - April 20, 2022 Category: Surgery Source Type: research
