Different dosages of vonoprazan for gastroesophageal reflux disease: study protocol for a pragmatic, crossover-cluster, randomized controlled trial with patient preference arms
This study aims to investigate whether vonoprazan could relieve the symptoms of Chinese patients with non-erosive reflux disease (NERD) and whether increased dosage or different times of dosing could increase t he response rate of GERD.MethodsThis study is a pragmatic, open-label, crossover-cluster, randomized controlled trial with patient preference arms. Two thousand eight hundred eighty patients with GERD from 48 hospitals in China will be enrolled. These hospitals will be divided into a compulsory randomization cluster (24 hospitals) and a patient preference cluster (24 hospitals). Patients in the compulsory randomizat...
Source: Trials - December 1, 2023 Category: Research Source Type: clinical trials

A Phase 3, Double-Blind, Randomized, Two-Phase, Active-Controlled Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Erosive Esophagitis
Condition:   Erosive Esophagitis Interventions:   Drug: BLI5100;   Drug: PPI Control Sponsor:   Braintree Laboratories Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 20, 2022 Category: Research Source Type: clinical trials

JP-1366 20mg Versus Esomeprazole 40mg in Patients With Erosive Esophagitis
Condition:   Erosive Esophagitis Interventions:   Drug: Experimental drug;   Drug: Active comparative drug Sponsor:   Onconic Therapeutics Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 5, 2022 Category: Research Source Type: clinical trials