Age-specific causes of upper gastrointestinal bleeding in children
World J Gastroenterol. 2023 Dec 21;29(47):6095-6110. doi: 10.3748/wjg.v29.i47.6095.ABSTRACTThe etiology of upper gastrointestinal bleeding (UGIB) varies by age, from newborns to adolescents, with some of the causes overlapping between age groups. While particular causes such as vitamin K deficiency and cow's milk protein allergy are limited to specific age groups, occurring only in neonates and infants, others such as erosive esophagitis and gastritis may be identified at all ages. Furthermore, the incidence of UGIB is variable throughout the world and in different hospital settings. In North America and Europe, most UGIBs...
Source: World Journal of Gastroenterology : WJG - January 8, 2024 Category: Gastroenterology Authors: Marija Kocic Petar Rasic Vuk Marusic Dragan Prokic Djordje Savic Maja Milickovic Ivana Kitic Tanja Mijovic Adrijan Sarajlija Source Type: research
Age-specific causes of upper gastrointestinal bleeding in children
World J Gastroenterol. 2023 Dec 21;29(47):6095-6110. doi: 10.3748/wjg.v29.i47.6095.ABSTRACTThe etiology of upper gastrointestinal bleeding (UGIB) varies by age, from newborns to adolescents, with some of the causes overlapping between age groups. While particular causes such as vitamin K deficiency and cow's milk protein allergy are limited to specific age groups, occurring only in neonates and infants, others such as erosive esophagitis and gastritis may be identified at all ages. Furthermore, the incidence of UGIB is variable throughout the world and in different hospital settings. In North America and Europe, most UGIBs...
Source: World Journal of Gastroenterology - January 8, 2024 Category: Gastroenterology Authors: Marija Kocic Petar Rasic Vuk Marusic Dragan Prokic Djordje Savic Maja Milickovic Ivana Kitic Tanja Mijovic Adrijan Sarajlija Source Type: research
Age-specific causes of upper gastrointestinal bleeding in children
World J Gastroenterol. 2023 Dec 21;29(47):6095-6110. doi: 10.3748/wjg.v29.i47.6095.ABSTRACTThe etiology of upper gastrointestinal bleeding (UGIB) varies by age, from newborns to adolescents, with some of the causes overlapping between age groups. While particular causes such as vitamin K deficiency and cow's milk protein allergy are limited to specific age groups, occurring only in neonates and infants, others such as erosive esophagitis and gastritis may be identified at all ages. Furthermore, the incidence of UGIB is variable throughout the world and in different hospital settings. In North America and Europe, most UGIBs...
Source: World Journal of Gastroenterology : WJG - January 8, 2024 Category: Gastroenterology Authors: Marija Kocic Petar Rasic Vuk Marusic Dragan Prokic Djordje Savic Maja Milickovic Ivana Kitic Tanja Mijovic Adrijan Sarajlija Source Type: research
Age-specific causes of upper gastrointestinal bleeding in children
World J Gastroenterol. 2023 Dec 21;29(47):6095-6110. doi: 10.3748/wjg.v29.i47.6095.ABSTRACTThe etiology of upper gastrointestinal bleeding (UGIB) varies by age, from newborns to adolescents, with some of the causes overlapping between age groups. While particular causes such as vitamin K deficiency and cow's milk protein allergy are limited to specific age groups, occurring only in neonates and infants, others such as erosive esophagitis and gastritis may be identified at all ages. Furthermore, the incidence of UGIB is variable throughout the world and in different hospital settings. In North America and Europe, most UGIBs...
Source: World Journal of Gastroenterology - January 8, 2024 Category: Gastroenterology Authors: Marija Kocic Petar Rasic Vuk Marusic Dragan Prokic Djordje Savic Maja Milickovic Ivana Kitic Tanja Mijovic Adrijan Sarajlija Source Type: research
Numerous gastric nodules in a leukaemia patient
Clinical presentation An 81-year-old white man presented with 2 weeks of odynophagia and dysphagia to solids and liquids limiting his oral intake and leading to 5 lb weight loss. He has a history of chronic myelomonocytic leukaemia with recent transition to myelofibrosis, uncontrolled gastro-oesophageal reflux disease (GORD) and chronic obstructive pulmonary disease on home oxygen. He denied fever, chills, nausea, vomiting, early satiety, abdominal pain, melena or haematemesis. The physical examination was unremarkable, and he had no oral thrush. His laboratory tests showed pancytopenia (absolute neutrophils count 62 cells...
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Bahdi, F., Alkassis, S., Lewis, M. S., El-Masry, M., Bejjani, A., Kolb, J. M. Tags: GUT Snapshot, Gut Editor ' s quiz: GI snapshot Source Type: research
Refractory Gastroesophageal Reflux Disease: Diagnosis and Management
J Neurogastroenterol Motil. 2024 Jan 30;30(1):17-28. doi: 10.5056/jnm23145.ABSTRACTGastroesophageal reflux disease (GERD) is common, with increasing worldwide disease prevalence and high economic burden. A significant number of patients will remain symptomatic following an empiric proton pump inhibitor (PPI) trial. Persistent symptoms despite PPI therapy are often mislabeled as refractory GERD. For patients with no prior GERD evidence (unproven GERD), testing is performed off antisecretory therapy to identify objective evidence of pathologic reflux using criteria outlined by the Lyon consensus. In proven GERD, differentiat...
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Trevor A Davis C Prakash Gyawali Source Type: research
Refractory Gastroesophageal Reflux Disease: Diagnosis and Management
J Neurogastroenterol Motil. 2024 Jan 30;30(1):17-28. doi: 10.5056/jnm23145.ABSTRACTGastroesophageal reflux disease (GERD) is common, with increasing worldwide disease prevalence and high economic burden. A significant number of patients will remain symptomatic following an empiric proton pump inhibitor (PPI) trial. Persistent symptoms despite PPI therapy are often mislabeled as refractory GERD. For patients with no prior GERD evidence (unproven GERD), testing is performed off antisecretory therapy to identify objective evidence of pathologic reflux using criteria outlined by the Lyon consensus. In proven GERD, differentiat...
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Trevor A Davis C Prakash Gyawali Source Type: research
PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes
In this study, we aimed to establish the physiologically based pharmacokinetic (PBPK) model to predict the pharmacokinetics of pantoprazole in populations with various CYP2C19 metabolic activities. A comprehensive investigation of previous reports and drug databases was conducted to collect the clinical pharmacogenomic data, physicochemical data, and disposition properties of pantoprazole, and the collected data were used for model establishment. The model was evaluated by comparing the predicted plasma concentration-time profiles and/or pharmacokinetic parameters (AUC and Cmax) with the clinical observation results. The p...
Source: Archives of Pharmacal Research - December 27, 2023 Category: Drugs & Pharmacology Authors: Chang-Keun Cho Eunvin Ko Ju Yeon Mo Pureum Kang Choon-Gon Jang Seok-Yong Lee Yun Jeong Lee Jung-Woo Bae Chang-Ik Choi Source Type: research
PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes
In this study, we aimed to establish the physiologically based pharmacokinetic (PBPK) model to predict the pharmacokinetics of pantoprazole in populations with various CYP2C19 metabolic activities. A comprehensive investigation of previous reports and drug databases was conducted to collect the clinical pharmacogenomic data, physicochemical data, and disposition properties of pantoprazole, and the collected data were used for model establishment. The model was evaluated by comparing the predicted plasma concentration-time profiles and/or pharmacokinetic parameters (AUC and Cmax) with the clinical observation results. The p...
Source: Archives of Pharmacal Research - December 27, 2023 Category: Drugs & Pharmacology Authors: Chang-Keun Cho Eunvin Ko Ju Yeon Mo Pureum Kang Choon-Gon Jang Seok-Yong Lee Yun Jeong Lee Jung-Woo Bae Chang-Ik Choi Source Type: research
Efficacy and safety of HIP1601 (dual delayed-release esomeprazole) 40 mg in erosive esophagitis compared to HGP1705 (delayed-release esomeprazole) 40 mg: a multicenter, randomized, double-blind, non-inferiority study
This study aime... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - December 18, 2023 Category: Gastroenterology Authors: Hyun Lim, Jong Kyu Park, Hyunsoo Chung, Si Hyung Lee, Jae Myung Park, Jung Ho Park, Gwang Ha Kim, Sung Kwan Shin, Su Jin Hong, Kwang Jae Lee, Moo In Park, Hye-Kyung Jung, Hyun-Soo Kim, Jae Kyu Sung, Seong Woo Jeon, Suck Chei Choi & hellip; Tags: Research Source Type: research
National trends in utilization and safety of gastric bypass, sleeve gastrectomy and conversion surgery in patients with GERD
ConclusionsThis data suggests that a strategy of performing a primary SG and subsequent SG-RYGB conversion for those with recalcitrant GERD symptoms is not riskier than a primary RYGB. Thus, it may be reasonable to perform SG in patients who are well informed of the risk of worsening GERD requiring additional surgical interventions. However, the impact of such stage d approach (SG followed by conversion to RYGB) on long-term outcomes remains unknown.Graphical abstract (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - December 14, 2023 Category: Surgery Source Type: research
