Esophageal Motility Patterns After Peroral Endoscopic Myotomy in Patients With Achalasia.
Conclusions: More than 20% of achalasia patients have signs of partial recovery of esophageal peristalsis after POEM. It occurs predominantly in type II achalasia but the clinical relevance seems to be negligible. PMID: 33462158 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 21, 2021 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Characteristics of symptomatic belching in patients with belching disorder and patients who exhibit gastroesophageal reflux disease with belching.
This study investigates belch characteristics in association with reflux, compared between patients with BD and those who had GERD with belching. Methods: Impedance pH monitoring data from 10 patients with BD and 10 patients with GERD who exhibited belching were retrospectively analyzed. Belches were considered "isolated" or "reflux-related" and acidic/non-acidic. Belch characteristics were compared between patients with BD and those with GERD. Results: Symptomatic belches were more frequent in patients with BD than in patients with GERD (median, 160.5 vs 56.0, P
Source: Journal of Neurogastroenterology and Motility - January 13, 2021 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Lactose sensitivity and lactose malabsorption. The two faces of lactose intolerance.
Conclusions: Thirty percent of LI patients have normal lactose absorption and normal LS. In the other 70% of patients, LI could be associated with LM and/or LS. PMID: 33361550 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - December 29, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders.
Authors: Singh R, Zogg H, Wei L, Bartlett A, Ghoshal UC, Rajender S, Ro S Abstract Of all microorganisms in the human body, the largest and most complex population resides in the gastrointestinal (GI) tract. The gut microbiota continuously adapts to the host environment and serves multiple critical functions for their hosts, including regulating host immunity, procuring energy from food, and preventing the colonization of pathogens. Mounting evidence has suggested gut microbial imbalance (dysbiosis) as a core pathophysiology in the development of GI motility and metabolic disorders, such as irritable bowel syndrome...
Source: Journal of Neurogastroenterology and Motility - November 12, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Knowledge, Attitude, and Practice Survey of Gastroparesis in Asia by Asian Neurogastroenterology and Motility Association.
Conclusions: Gastroparesis can be challenging to diagnose due to the lack of instrument, standardized method, and paucity of research data on normative value, risk factors, and treatment studies in Asian patients. Future strategies should concentrate on how to disseminate the latest knowledge of gastroparesis in Asia. In particular, there is an urgent need to estimate the magnitude of the problems in high risk and idiopathic patients as well as a standardized diagnostic procedure in Asia. PMID: 33106443 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 29, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Kegel Exercises, Biofeedback, Electrostimulation, and Peripheral Neuromodulation Improve Clinical Symptoms of Fecal Incontinence and Affect Specific Physiological Targets: An Randomized Controlled Trial.
Authors: Mundet L, Rofes L, Ortega O, Cabib C, Clavé P Abstract Background/Aims: Fecal incontinence (FI) is a prevalent condition among community-dwelling women, and has a major impact on quality of life (QoL). Research on treatments commonly used in clinical practice-Kegel exercises, biofeedback, electrostimulation, and transcutaneous neuromodulation-give discordant results and some lack methodological rigor, making scientific evidence weak. The aim is to assess the clinical efficacy of these 4 treatments on community-dwelling women with FI and their impact on severity, QoL and anorectal physiology. Met...
Source: Journal of Neurogastroenterology and Motility - October 29, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Whether the Role of Esophageal Baseline Impedance Is Complementary to or Alternative to the 24-Hour Esophageal pH Monitoring for the Diagnosis of Gastroesophageal Reflux Disease?
Authors: Cho YK PMID: 32989180 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Is Gastroesophageal Reflux Disease Really a Risk Factor for Acute Myocardial Infarction?
Authors: Kim SY PMID: 32989181 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Clinical Evaluation of a Patient With Symptoms of Colonic or Anorectal Motility Disorders.
We describe how to take a detailed history, perform meticulous digital rectal examination, and use validated tools to supplement clinical evaluation, including assessments of quality of life and scoring systems for disease severity and digital Apps. These tools could facilitate a comprehensive plan for clinical management including diagnostic tests, and translate the patients' complaints into definable, diagnostic categories. PMID: 32989182 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Parental, Perinatal, and Childhood Risk Factors for Development of Irritable Bowel Syndrome: A Systematic Review.
Conclusions: More effort is needed to identify what fetal and maternal factors are associated with low birth weight and IBS. A well-executed prospective birth cohort with a collection of bio-samples and functional data will provide a better understanding of how adversity and the interplay between genetics, epigenetics, and numerous risk factors affect the development of IBS. PMID: 32989183 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Risk of Acute Myocardial Infarction in Patients With Gastroesophageal Reflux Disease.
Authors: Eisa M, Sandhu A, Prakash R, Ganocy SJ, Fass R Abstract Background/Aims: A number of inflammatory mediators have been documented to be elevated in gastroesophageal reflux disease (GERD). Similar inflammatory mediators are involved in coronary artery disease. Thus, the aim of the study is to determine if GERD is a risk factor for developing acute myocardial infarction (AMI). Methods: We used Explorys, a private cloud-based data store to which a number of health care systems feed information. We identified a cohort of GERD patients who have undergone an esophagogastroduodenoscopy compared to those withou...
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Esophageal Involvement and Determinants of Perception of Esophageal Symptoms Among South Koreans With Systemic Sclerosis.
Conclusions: Esophageal involvement among South Koreans with SSc was characterized by heterogeneous motility patterns, with a higher prevalence of normal motility and lower prevalence of erosive esophagitis. Reflux hypersensitivity or functional heartburn might be partly attributed to the perception of esophageal symptoms in SSc patients who have neither gastroesophageal reflux disease nor esophageal dysmotility. PMID: 32989185 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Effects of a Psychobiotic Supplement on Serum Brain-derived Neurotrophic Factor Levels in Depressive Patients: A Post Hoc Analysis of a Randomized Clinical Trial.
Authors: Heidarzadeh-Rad N, Gökmen-Özel H, Kazemi A, Almasi N, Djafarian K Abstract Background/Aims: Psychobiotics are probiotics or prebiotics that, upon ingestion in adequate amounts, yield positive influence on mental health via microbiota-gut-brain axis regulation to modulate the circulating cytokines, chemokines, neurotransmitters, or neurotrophins levels. We have recently shown that a psychobiotic combination (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175; CEREBIOME) significantly improved depression symptoms in patients with depression. Recent animal data suggest the influence of ...
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Nutrient Challenge Testing Is Not Equivalent to Scintigraphy-Lactulose Hydrogen Breath Testing in Diagnosing Small Intestinal Bacterial Overgrowth.
Conclusions: This study could not show an equivalence of NCT and ScLHBT in diagnosing SIBO. A possible explanation might be the different transit times owing to unequal testing substances. The effect of this deviation in relation to consecutive therapy regimens should be tested in further prospective studies. PMID: 32989187 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Role of Intestinal Microbiota and Mast Cell in a Rat Model of Visceral Hypersensitivity.
Conclusions: Probiotic VSL#3 decreases visceral sensitivity in VH rats. The mechanism may be related to mast cell and intestinal flora. Change of Clostridium sensu stricto 1 abundance may be a basis for VH observed in irritable bowel syndrome and may be prevented by specific probiotic administration. PMID: 32989188 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Fecal Microbiota Alterations and Small Intestinal Bacterial Overgrowth in Functional Abdominal Bloating/Distention.
Conclusion: The fecal microbiota profiles in FABD patients are different from those in healthy controls, particularly in SIBO (+) patients, suggesting a role of gut microbiota in the pathogenesis of FABD. PMID: 32989189 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Transient Anal Sphincter Relaxations Are a Normal Phenomenon in Healthy Subjects.
Authors: Huizinga JD, Milkova N, Chen JH PMID: 32989190 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Transient Anal Sphincter Relaxations Are a Normal Phenomenon in Healthy Subjects: Author's Reply.
Authors: Lee TH PMID: 32989191 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Calcium/Calmodulin-dependent Serine Protein Kinase-associated Neuro-gastrointestinal Disorder: First Report of a Patient With Hirschsprung's Disease.
Authors: Tian M, Pan H, Lei W, Chen J, Li J, Lang C, Shu X PMID: 32989192 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

CSP01, a Novel Superabsorbent Hydrogel, Reduces Colonic Transit Time in Patients With Chronic Idiopathic Constipation in a Randomized, Doubleblind, Controlled Pilot Clinical Trial.
Conclusion: CSP01 significantly decreased CTT compared to placebo among patients with CIC, but not IBSC. PMID: 32807749 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - August 20, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Efficacy and safety of DWJ1252 compared with Gasmotin ® in the treatment of functional dyspepsia: a multicenter, randomized, double-blind, active-controlled study.
This study aimed to evaluate the efficacy and safety of once-a-day DWJ1252, a sustained-release formulation of Gasmotin®, compared with Gasmotin® three times a day, in patients with FD. Methods: In this multicentre, randomized, double-blind, active-controlled, non-inferiority study, 119 patients with FD (by the Rome III criteria, 60 for DWJ1252 and 59 for Gasmotin®) were randomly allocated to DWJ1252 once daily or Gasmotin® thrice daily for 4 weeks in 16 medical institutions. Primary end point was the change in gastrointestinal symptom (GIS) score from baseline, assessed by GIS questionnaires on 5-point...
Source: Journal of Neurogastroenterology and Motility - August 15, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Influence of Gastroesophageal Reflux Disease on Daytime Sleepiness and Depressive Symptom in Patients With Obstructive Sleep Apnea.
Authors: Kang HH, Lim CH, Oh JH, Cho MJ, Lee SH Abstract Background/Aims: As there is insufficient evidence for a relationship between gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA), we investigated whether OSA diagnosed by polysomnography (PSG) is related to GERD. Methods: A total of 402 subjects was evaluated. Overnight PSG was performed and a few questionnaires on GERD, anxiety, depression, and daytime sleepiness were administered. An apnea-hypopnea index
Source: Journal of Neurogastroenterology and Motility - August 13, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Acid Exposure Time > 6% Might Not Improve the Therapeutic Outcome in Chinese Gastroesophageal Reflux Disease Patients.
Conclusions: The efficacy of PPI therapy was similar in patients with AET> 6% and 4-6%. The increase of the AET threshold did not influence the clinical outcome of Chinese GERD patients. PMID: 32699186 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 25, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Practice Patterns for Eosinophilic Esophagitis Patients in Busan and Gyeongnam: A Korean Multicenter Database Study.
Conclusions: The treatment response of eosinophilic esophagitis was good in Busan city and Gyeongnam province area in Korea. Proton pump inhibitor therapy was the preferred and most effective treatment for eosinophilic esophagitis as the initial therapy. PMID: 32699187 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 25, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Quantification of Esophageal Angulation in Sigmoid Achalasia: Are We There Yet?
Authors: Nabi Z, Reddy DN PMID: 32699188 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 25, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Depression and Structural Factors Are Associated With Symptoms in Patients of Irritable Bowel Syndrome With Diarrhea.
Conclusions: Comorbid depression and higher scores of structural factors might aggravate GI and extra-GI symptoms other than bowel movements and stool form. Structural factors of Hamilton Depression Rating Scale correlated with efficacy of paroxetine and mirtazapine in patients with IBS-D. PMID: 32675388 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 18, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Comparison of Short Versus Long Esophageal Myotomy in Cases With Idiopathic Achalasia: A Randomized Controlled Trial.
In this study, we aim to compare the outcomes of short (3 cm) versus long (6 cm and above) esophageal myotomy in patients undergoing POEM for achalasia cardia. Methods: Consecutive patients with idiopathic achalasia (type I and II) were randomized to receive short (3 cm) or long esophageal myotomy (≥ 6 cm). Both groups were compared for clinical success, operative time, adverse events, and gastroesophageal reflux disease (GERD). Results: Seventy-one consecutive patients with type I and II achalasia underwent POEM with short (n = 34) or long (n = 37) esophageal myotomy techniques. Mean length of esophageal myotom...
Source: Journal of Neurogastroenterology and Motility - July 18, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Disaccharidase Deficiency as a Cause of Unexplained Functional Gastrointestinal Disorder.
Authors: Kwon YH PMID: 32606251 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Toward an Improved Treatment for Gastroparesis.
Authors: Kim TH PMID: 32606252 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Practice of Gastrointestinal Motility Laboratory During COVID-19 Pandemic: Position Statements of the Asian Neurogastroenterology and Motility Association (ANMA-GML-COVID-19 Position Statements).
Authors: Siah KTH, Rahman MM, Ong AML, Soh AYS, Lee YY, Xiao Y, Sachdeva S, Jung KW, Wang YP, Oshima T, Patcharatrakul T, Tseng PH, Goyal O, Pang J, Lai CKC, Park JH, Mahadeva S, Cho YK, Wu JCY, Ghoshal UC, Miwa H Abstract During the Coronavirus Disease 2019 (COVID-19) pandemic, practices of gastrointestinal procedures within the digestive tract require special precautions due to the risk of contraction of severe acute respiratoy syndrome coronavirus-2 (SARS-CoV-2) infection. Many procedures in the gastrointestinal motility laboratory may be considered moderate to high-risk for viral transmission. Healthcare staff ...
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Lyon Consensus: Does It Differ From the Previous Ones?
Authors: Ghisa M, Barberio B, Savarino V, Marabotto E, Ribolsi M, Bodini G, Zingone F, Frazzoni M, Savarino E Abstract Gastroesophageal reflux disease (GERD) is a complex disorder with heterogeneous symptoms and a multifaceted pathogenetic basis, which prevent a simple diagnostic algorithm or any categorical classification. Clinical history, questionnaires and response to proton pump inhibitor (PPI) therapy are insufficient tools to make a conclusive diagnosis of GERD and further investigations are frequently required. The Lyon Consensus goes beyond the previous classifications and defines endoscopic and functional...
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Functional Dyspepsia: A Narrative Review With a Focus on Sex-Gender Differences.
In conclusion, an individualized and multicomponent approach that considers sex and gender issues might improve FD treatment and improve patient Qol, especially for women. PMID: 32606255 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Effect of Body Position on High-resolution Esophageal Manometry Variables and Final Manometric Diagnosis.
Authors: Riva CG, Siboni S, Ferrari D, Sozzi M, Capuzzo M, Asti E, Ogliari C, Bonavina L Abstract Background/Aims: According to the Chicago classification version 3.0, high-resolution manometry (HRM) should be performed in the supine position. However, with the patient in the upright/sitting position, the test could more closely simulate real-life behavior and may be better tolerated. We performed a systematic review of the literature to search whether the manometric variables and the final diagnosis are affected by positional changes. Methods: A literature search was conducted according to the Preferred Report...
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Performing High-resolution Impedance Manometry After Endoscopy With Conscious Sedation Has Negligible Effects on Esophageal Motility Results.
Conclusions: Performing HRIM after endoscopy with conscious sedation had minimal clinical impact on the motility diagnosis or motility parameters. Thus, this approach may be a viable alternative for patients who cannot tolerate unsedated catheter placement. PMID: 32606257 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Multichannel Intraluminal Impedance and pH Monitoring: A Step Towards Pediatric Reference Values.
Authors: Cresi F, Cester EA, Salvatore S, De Rose DU, Ripepi A, Magistà AM, Fontana C, Maggiora E, Coscia A, Francavilla R, Cristofori F Abstract Background/Aims: Combined multichannel intraluminal impedance and pH monitoring (MII/pH) is considered the most accurate test to detect gastroesophageal reflux (GER), however lacking reference values. We aim to determine reference values for the pediatric population and to correlate these values with age and postprandial/fasting period. Methods: We evaluated MII/pH traces from patients (newborns, infants, and children) admitted to 3 Italian hospitals and who un...
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers.
Authors: Jagtap N, Kalapala R, Reddy DN Abstract Background/Aims: The functional luminal imaging probe (FLIP) can measure tissue distensibility and geometric changes through volumetric distention. The esophagogastric junction has been well studied using EndoFLIP, studies on pylorus are lacking. We aim to study biomechanical properties of pylorus using EndoFLIP to create normative data. Methods: We performed a prospective study of 20 healthy volunteers (ages, 18-54 years; 10 men) who underwent pylorus evaluation using 12- cm FLIP placed across the pyloric sphincter. FLIP data were analyzed using FLIP planimetry ...
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

EphrinA1/EphA2 Promotes Epithelial Hyperpermeability Involving in Lipopolysaccharide-induced Intestinal Barrier Dysfunction.
Conclusion: EphrinA1/ephA2 promotes epithelial hyperpermeability with an ERK1/2-dependent pathway, which involves in LPS-induced intestinal barrier dysfunction. PMID: 32606260 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Minimally Invasive Gastric Electrical Stimulation Using a Newly Developed Wireless Gastrostimulator: A Pilot Animal Study.
Conclusions: GES is feasible with our minimally invasive wireless device. This technique has the potential to increase utilization of GES as a treatment alternative. PMID: 32606261 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Can We Apply the Salivary Pepsin Test for Patients With Gastroesophageal Reflux Disease in Primary Practice?
Authors: Lee TH PMID: 32606262 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Usefulness of Esophageal Baseline Impedance Levels for the Diagnosis of Nonerosive Reflux Disease and the Proper Time for Measurement in Endoscopy-negative Korean Patients With Esophageal or Supraesophageal Symptoms.
Conclusion: The BILs of the distal esophagus measured at time points before or after night bedtime appear to be useful for the diagnosis of NERD, but not for the diagnosis of RH, in endoscopy-negative Korean patients with esophageal or supraesophageal symptoms. PMID: 32595173 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 1, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Spontaneous Internal Anal Sphincter Relaxation During High-resolution Anorectal Manometry Is Associated With Peripheral Neuropathy and Higher Charlson Comorbidity Scores in Patients With Defecatory Disorders.
Authors: Lee TH, Lee JS, Kim J, Kim JO, Kim HG, Jeon SR, Hong SJ, Cho YS, Park S Abstract Background/Aims: We aim to evaluate associations between comorbidities, peripheral neuropathy, and spontaneous internal anal sphincter relaxation (SAR) in patients with defecatory disorders. Methods: A patient is considered to exhibit SAR during high-resolution anorectal manometry (HR-ARM) when the nadir pressure is
Source: Journal of Neurogastroenterology and Motility - May 16, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pHimpedance Monitoring.
Authors: Horton A, Sullivan B, Charles K, McIntosh T, Davis A, Gellad Z, Shimpi R, Gyawali CP, Patel A Abstract Background/Aims: Esophageal baseline impedance (BI) can be extracted from pH-impedance tracings as mean nocturnal baseline impedance (MNBI), and from high-resolution impedance manometry (HRIM), but it is unknown if values are similar between acquisition methods across HRIM manufacturers. We aim to assess correlations between MNBI and BI from HRIM (BI-HRIM) from 2 HRIM manufacturers in the setting of physiologic acid exposure time (AET). Methods: HRIM and pH-impedance monitoring demonstrating physiologic AET (
Source: Journal of Neurogastroenterology and Motility - May 12, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Prevalence of Disaccharidase Deficiency in Adults With Unexplained Gastrointestinal Symptoms.
Conclusions: Isolated disaccharidase deficiency occurs in adults, usually lactase and rarely maltase. Pandisaccharidase deficiency is rare. Baseline symptoms or its severity did not predict enzyme deficiency. LBT has good specificity and diagnostic agreement with lactase assay and may be more cost-effective. In adults with refractory gastrointestinal symptoms, disaccharidase testing detects enzyme deficiency in approximately one-half of patients and can aid diagnosis and management. PMID: 32380581 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - May 9, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Factors of Reflux Episodes with Post-reflux Swallow-induced Peristaltic Wave in Gastroesophageal Reflux Disease.
Conclusions: The role of acid seems to be less important in a reflux episode inducing a PSPW. Proximal reflux episodes are more likely to induce a PSPW. The depression of volume clearance may also be an important factor in eliciting a PSPW. PMID: 32344502 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - May 1, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Distal Esophageal Impedance Measured by High-resolution Esophageal Manometry With Impedance Suggests the Presence Barrett's Esophagus.
Authors: Kataria R, Rosenfeld B, Malik Z, Harrison M, Smith MS, Schey R, Parkman HP Abstract Background/Aims: Barrett's esophagus (BE) is characterized by intestinal metaplasia in the distal esophagus. The aims of this study are to: (1) Compare baseline distal esophageal impedance (DEI) using high-resolution esophageal manometry with impedance (HREMI) in patients with BE, esophagitis, and healthy volunteers, and (2) Correlate length of low impedance on HREMI in patients with BE to the length of endoscopic BE. Methods: Patients with BE or esophagitis who underwent HREMI were included. Ten volunteers had HREMI. B...
Source: Journal of Neurogastroenterology and Motility - April 25, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Transient Receptor Potential Canonical 4 and 5 Channel Antagonist ML204 Depolarized Pacemaker Potentials of Interstitial Cells of Cajal.
Conclusions: The results implied that ML204 could not inhibit the pacemaker activity but depolarized the membrane potential of ICCs by regulating intracellular Ca2+ oscillations and anoctamin 1 channels. PMID: 32321198 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 23, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Role of the Rapid Drink Challenge Test in Esophageal Motility Disorder Diagnosis.
Authors: Hsing LC, Jung KW PMID: 32235024 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 3, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Cost-effective Management of Severe Gastroesophageal Reflux Disease: Toward an Improved Understanding of Anti-reflux Surgery.
Authors: Park CH PMID: 32235025 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 3, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Exploring Esophageal Microbiomes in Esophageal Diseases: A Systematic Review.
Authors: Park CH, Lee SK Abstract Studies that investigated esophageal microbiomes are limited when compared to those on intestinal microbiomes. Nevertheless, several studies have investigated the relationship between esophageal microbiomes and various esophageal diseases, owing to the advancement of next-generation sequencing techniques. Streptococcus is the most common bacterial taxon in a normal esophagus. Additionally, Haemophilus, Neisseria, Prevotella, and Veillonella are also found. However, gram-negative bacteria, including Prevotella, are more abundant in a diseased esophagus, such as in gastroesophageal r...
Source: Journal of Neurogastroenterology and Motility - April 3, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

2019 Seoul Consensus on Esophageal Achalasia Guidelines.
Authors: Jung HK, Hong SJ, Lee OY, Pandolfino J, Park H, Miwa H, Ghoshal UC, Mahadeva S, Oshima T, Chen M, Chua ASB, Cho YK, Lee TH, Min YW, Park CH, Kwon JG, Park MI, Jung K, Park JK, Jung KW, Lim HC, Jung DH, Kim DH, Lim CH, Moon HS, Park JH, Choi SC, Suzuki H, Patcharatrakul T, Wu JCY, Lee KJ, Tanaka S, Siah KTH, Park KS, Kim SE, Korean Society of Neurogastroenterology and Motility Abstract Esophageal achalasia is a primary motility disorder characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis. Achalasia is a chronic disease that causes progressive irreversible l...
Source: Journal of Neurogastroenterology and Motility - April 3, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research