Patients With Definite and Inconclusive Evidence of Reflux According to Lyon Consensus Display Similar Motility and Esophagogastric Junction Characteristics
CONCLUSION: Esophageal motor parameters on HRM are similar between pathologic and inconclusive GERD according to the Lyon consensus.PMID:34045366 | DOI:10.5056/jnm20158 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - May 28, 2021 Category: Gastroenterology Authors: Mentore Ribolsi Edoardo Savarino Benjamin Rogers Arvind Rengarajan Marco Della Coletta Matteo Ghisa Michele Cicala Chandra Prakash Gyawali Source Type: research

Emergence of Celiac disease and Gluten-related disorders in Asia
J Neurogastroenterol Motil. 2021 May 6. doi: 10.5056/jnm20140. Online ahead of print.ABSTRACTCeliac disease (CeD) is a systemic, immune-mediated enteropathy, which is triggered by gluten protein in genetically susceptible individuals. CeD, once thought to be an uncommon disease, is now recognized to affect approximately 40-60 million people globally. While CeD is now well reported from a few Asian countries such as India, China, Pakistan, and Middle Eastern countries; it is still believed to be uncommon in the rest of Asia. Gluten-related diseases other than CeD, like non-celiac gluten sensitivity (NCGS) are also emerging ...
Source: Journal of Neurogastroenterology and Motility - May 10, 2021 Category: Gastroenterology Authors: Srikant Mohta Mahendra S Rajput Vineet Ahuja Govind K Makharia Source Type: research

What Is the Difference in Characteristics Between Belching Disorder and Gastroesophageal Reflux Disease With Belching? Centering Around Supragastric Belching
J Neurogastroenterol Motil. 2021 Apr 30;27(2):149-150. doi: 10.5056/jnm21032.NO ABSTRACTPMID:33795536 | PMC:PMC8026372 | DOI:10.5056/jnm21032 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Sung Eun Kim Source Type: research

Integrated Relaxation Pressure During Swallowing: An Ever-changing Metric
J Neurogastroenterol Motil. 2021 Apr 30;27(2):151-152. doi: 10.5056/jnm21033.NO ABSTRACTPMID:33795537 | PMC:PMC8026369 | DOI:10.5056/jnm21033 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Eun Jeong Gong Source Type: research

Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia
J Neurogastroenterol Motil. 2021 Apr 30;27(2):153-164. doi: 10.5056/jnm20175.ABSTRACTIrritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional gastrointestinal disorders (FGIDs) and account for a large proportion of consulting patients. These 2 disorders overlap with each other frequently. The pathogenesis of IBS or FD is complicated and multi-factors related, in which infectious or non-infectious inflammation and local or systemic immune response play significant roles. There are few studies focusing on the mechanism of inflammation in patients with overlap syndrome of irritable bowel syndrome and...
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Congzhen Wang Xiucai Fang Source Type: research

A Systematic Review and Meta-analysis of Randomized Control Trials: Combination Treatment With Proton Pump Inhibitor Plus Prokinetic for Gastroesophageal Reflux Disease
CONCLUSIONS: Combination of prokinetics with PPI treatment is more effective than PPI alone in GERD patients. Further high-quality trials with large sample sizes are needed to verify the effects based on prokinetic type.PMID:33795539 | PMC:PMC8026378 | DOI:10.5056/jnm20161 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Da Hyun Jung Cheal Wung Huh Sang Kil Lee Jun Chul Park Sung Kwan Shin Yong Chan Lee Source Type: research

Impact of Overlapping Functional Gastrointestinal Disorders on the Quality of Life in Patients With Gastroesophageal Reflux Disease
J Neurogastroenterol Motil. 2021 Apr 30;27(2):176-184. doi: 10.5056/jnm19006.ABSTRACTGastroesophageal reflux disease (GERD) and functional gastrointestinal disorders (FGIDs), including irritable bowel syndrome and functional dyspepsia, are common afflictions within the general population. Both conditions have a considerable impact on the daily health related quality of life (HRQoL) of affected individuals. Risk factors surrounding any impaired HRQoL in patients with GERD involve those of younger age, obesity, an increase in reflux symptom frequency, and overlapping FGIDs. The risk factors for subjects experiencing an overl...
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Shou-Wu Lee Chi-Sen Chang Source Type: research

Simultaneous Evaluation of Laryngopharyngeal Reflux and Swallowing Function Using Hypopharyngeal Multichannel Intraluminal Impedance Measurements in Neurologically Impaired Patients
This study aims to evaluate the presence of laryngopharyngeal reflux (LPR) and to investigate the use of hypopharyngeal baseline impedance (BI) for assessing swallowing dysfunction and gastroesophageal reflux disease (GERD) using hypopharyngeal multichannel intraluminal impedance and pH (HMII-pH) monitoring in neurologically impaired patients (NIPs).METHODS: The study population in this retrospective study comprised 20 NIPs (mean age, 36.1 ± 15.0 years; age range, 13-64 years) who underwent multichannel intraluminal impedance and pH (MII-pH), HMII-pH, and laryngoscopy using the Hyodo scoring method from December 201...
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Daisuke Masui Suguru Fukahori Naoki Hashizume Shinji Ishii Naruki Higashidate Saki Sakamoto Shiori Tsuruhisa Hirotomo Nakahara Nobuyuki Saikusa Yoshiaki Tanaka Minoru Yagi Source Type: research

Efficacy of S-pantoprazole 10 mg in the Symptom Control of Non-erosive Reflux Disease: A Phase III Placebo-controlled Trial
CONCLUSIONS: Low dose of S-pantoprazole (10 mg) for 4 weeks was more efficacious than placebo in providing reflux symptom relief in patients with NERD, especially acid regurgitation. More doses or longer periods of treatment with S-pantoprazole would be needed to completely eliminate symptoms.PMID:33795542 | PMC:PMC8026380 | DOI:10.5056/jnm19053 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Yu Kyung Cho Myung-Gyu Choi Hyojin Park Ji Won Kim Dong Ho Lee Kwang Hyun Ko Sang Gyun Kim Hwoon-Yong Jung Su Jin Hong Yong Chan Lee Si Hyung Lee Source Type: research

A Resting-state Functional Magnetic Resonance Imaging Study of Whole-brain Functional Connectivity of Voxel Levels in Patients With Irritable Bowel Syndrome With Depressive Symptoms
CONCLUSIONS: DEP-IBS patients have abnormal FC in brain regions associated with the fronto-limbic and sensorimotor networks, especially insula and SMA, which explains the vicious circle between negative emotion and gastrointestinal symptoms in IBS. Identification of such alterations may facilitate earlier and more accurate diagnosis of depression in IBS, and development of effective treatment strategies.PMID:33795543 | PMC:PMC8026363 | DOI:10.5056/jnm20209 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Jie Li Ping He Xingqi Lu Yun Guo Min Liu Guoxiong Li Jianping Ding Source Type: research

High-fat Diet Enhances Gastric Contractility, but Abolishes Nesfatin-1-induced Inhibition of Gastric Emptying
CONCLUSIONS: HFD caused mild systemic inflammation, disrupted enteric innervation, enhanced gastric contractility, inhibited ileal contractility, and eliminated inhibitory effect of NES-1 on gastric motility.PMID:33795544 | PMC:PMC8026381 | DOI:10.5056/jnm20206 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Zarife N Özdemir-Kumral T ürkan Koyuncuoğlu Sevil Arabac ı-Tamer Özlem T Çilingir-Kaya Ay ça K Köroğlu Meral Y üksel Berrak Ç Yeğen Source Type: research

Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome: Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine
CONCLUSIONS: Biopsies from a well-characterized IBS-D cohort showed no substantial inflammation. Mesalazine has little effect on gene expression and its previous reported effect on fecal microbiota associated with much greater inflammation found in inflammatory bowel diseases is likely secondary to reduced inflammation. Increased expression of TLR4 and correlated receptors in IBS may mediate a general increase in sensitivity to external stimuli, particularly those that signal via the TLR system.PMID:33795545 | PMC:PMC8026366 | DOI:10.5056/jnm20205 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Jonna Jalanka Ching Lam Andrew Bennett Anna Hartikainen Fiona Crispie Laura A Finnegan Paul D Cotter Robin Spiller Source Type: research

Transient Receptor Potential Canonical 4 Channel in Interstitial Cells of Cajal as a Target for Control of Gastrointestinal Motility
J Neurogastroenterol Motil. 2021 Apr 30;27(2):302-304. doi: 10.5056/jnm20267.NO ABSTRACTPMID:33795546 | PMC:PMC8026375 | DOI:10.5056/jnm20267 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Zengzi Zhou Meng Xia Jianlin Lv Source Type: research

There Is Something More Important Than Proximal Reflux Episode in the Development of Post-reflux Swallow-induced Peristaltic Wave
J Neurogastroenterol Motil. 2021 Apr 30;27(2):305-306. doi: 10.5056/jnm20276.NO ABSTRACTPMID:33795547 | PMC:PMC8026371 | DOI:10.5056/jnm20276 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Tae Hee Lee Source Type: research

What Is the Difference in Characteristics Between Belching Disorder and Gastroesophageal Reflux Disease With Belching? Centering Around Supragastric Belching
J Neurogastroenterol Motil. 2021 Apr 30;27(2):149-150. doi: 10.5056/jnm21032.NO ABSTRACTPMID:33795536 | PMC:PMC8026372 | DOI:10.5056/jnm21032 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Sung Eun Kim Source Type: research

Integrated Relaxation Pressure During Swallowing: An Ever-changing Metric
J Neurogastroenterol Motil. 2021 Apr 30;27(2):151-152. doi: 10.5056/jnm21033.NO ABSTRACTPMID:33795537 | PMC:PMC8026369 | DOI:10.5056/jnm21033 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Eun Jeong Gong Source Type: research

Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia
J Neurogastroenterol Motil. 2021 Apr 30;27(2):153-164. doi: 10.5056/jnm20175.ABSTRACTIrritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional gastrointestinal disorders (FGIDs) and account for a large proportion of consulting patients. These 2 disorders overlap with each other frequently. The pathogenesis of IBS or FD is complicated and multi-factors related, in which infectious or non-infectious inflammation and local or systemic immune response play significant roles. There are few studies focusing on the mechanism of inflammation in patients with overlap syndrome of irritable bowel syndrome and...
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Congzhen Wang Xiucai Fang Source Type: research

A Systematic Review and Meta-analysis of Randomized Control Trials: Combination Treatment With Proton Pump Inhibitor Plus Prokinetic for Gastroesophageal Reflux Disease
CONCLUSIONS: Combination of prokinetics with PPI treatment is more effective than PPI alone in GERD patients. Further high-quality trials with large sample sizes are needed to verify the effects based on prokinetic type.PMID:33795539 | PMC:PMC8026378 | DOI:10.5056/jnm20161 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Da Hyun Jung Cheal Wung Huh Sang Kil Lee Jun Chul Park Sung Kwan Shin Yong Chan Lee Source Type: research

Impact of Overlapping Functional Gastrointestinal Disorders on the Quality of Life in Patients With Gastroesophageal Reflux Disease
J Neurogastroenterol Motil. 2021 Apr 30;27(2):176-184. doi: 10.5056/jnm19006.ABSTRACTGastroesophageal reflux disease (GERD) and functional gastrointestinal disorders (FGIDs), including irritable bowel syndrome and functional dyspepsia, are common afflictions within the general population. Both conditions have a considerable impact on the daily health related quality of life (HRQoL) of affected individuals. Risk factors surrounding any impaired HRQoL in patients with GERD involve those of younger age, obesity, an increase in reflux symptom frequency, and overlapping FGIDs. The risk factors for subjects experiencing an overl...
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Shou-Wu Lee Chi-Sen Chang Source Type: research

Simultaneous Evaluation of Laryngopharyngeal Reflux and Swallowing Function Using Hypopharyngeal Multichannel Intraluminal Impedance Measurements in Neurologically Impaired Patients
This study aims to evaluate the presence of laryngopharyngeal reflux (LPR) and to investigate the use of hypopharyngeal baseline impedance (BI) for assessing swallowing dysfunction and gastroesophageal reflux disease (GERD) using hypopharyngeal multichannel intraluminal impedance and pH (HMII-pH) monitoring in neurologically impaired patients (NIPs).METHODS: The study population in this retrospective study comprised 20 NIPs (mean age, 36.1 ± 15.0 years; age range, 13-64 years) who underwent multichannel intraluminal impedance and pH (MII-pH), HMII-pH, and laryngoscopy using the Hyodo scoring method from December 201...
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Daisuke Masui Suguru Fukahori Naoki Hashizume Shinji Ishii Naruki Higashidate Saki Sakamoto Shiori Tsuruhisa Hirotomo Nakahara Nobuyuki Saikusa Yoshiaki Tanaka Minoru Yagi Source Type: research

Efficacy of S-pantoprazole 10 mg in the Symptom Control of Non-erosive Reflux Disease: A Phase III Placebo-controlled Trial
CONCLUSIONS: Low dose of S-pantoprazole (10 mg) for 4 weeks was more efficacious than placebo in providing reflux symptom relief in patients with NERD, especially acid regurgitation. More doses or longer periods of treatment with S-pantoprazole would be needed to completely eliminate symptoms.PMID:33795542 | PMC:PMC8026380 | DOI:10.5056/jnm19053 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Yu Kyung Cho Myung-Gyu Choi Hyojin Park Ji Won Kim Dong Ho Lee Kwang Hyun Ko Sang Gyun Kim Hwoon-Yong Jung Su Jin Hong Yong Chan Lee Si Hyung Lee Source Type: research

A Resting-state Functional Magnetic Resonance Imaging Study of Whole-brain Functional Connectivity of Voxel Levels in Patients With Irritable Bowel Syndrome With Depressive Symptoms
CONCLUSIONS: DEP-IBS patients have abnormal FC in brain regions associated with the fronto-limbic and sensorimotor networks, especially insula and SMA, which explains the vicious circle between negative emotion and gastrointestinal symptoms in IBS. Identification of such alterations may facilitate earlier and more accurate diagnosis of depression in IBS, and development of effective treatment strategies.PMID:33795543 | PMC:PMC8026363 | DOI:10.5056/jnm20209 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Jie Li Ping He Xingqi Lu Yun Guo Min Liu Guoxiong Li Jianping Ding Source Type: research

High-fat Diet Enhances Gastric Contractility, but Abolishes Nesfatin-1-induced Inhibition of Gastric Emptying
CONCLUSIONS: HFD caused mild systemic inflammation, disrupted enteric innervation, enhanced gastric contractility, inhibited ileal contractility, and eliminated inhibitory effect of NES-1 on gastric motility.PMID:33795544 | PMC:PMC8026381 | DOI:10.5056/jnm20206 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Zarife N Özdemir-Kumral T ürkan Koyuncuoğlu Sevil Arabac ı-Tamer Özlem T Çilingir-Kaya Ay ça K Köroğlu Meral Y üksel Berrak Ç Yeğen Source Type: research

Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome: Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine
CONCLUSIONS: Biopsies from a well-characterized IBS-D cohort showed no substantial inflammation. Mesalazine has little effect on gene expression and its previous reported effect on fecal microbiota associated with much greater inflammation found in inflammatory bowel diseases is likely secondary to reduced inflammation. Increased expression of TLR4 and correlated receptors in IBS may mediate a general increase in sensitivity to external stimuli, particularly those that signal via the TLR system.PMID:33795545 | PMC:PMC8026366 | DOI:10.5056/jnm20205 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Jonna Jalanka Ching Lam Andrew Bennett Anna Hartikainen Fiona Crispie Laura A Finnegan Paul D Cotter Robin Spiller Source Type: research

Transient Receptor Potential Canonical 4 Channel in Interstitial Cells of Cajal as a Target for Control of Gastrointestinal Motility
J Neurogastroenterol Motil. 2021 Apr 30;27(2):302-304. doi: 10.5056/jnm20267.NO ABSTRACTPMID:33795546 | PMC:PMC8026375 | DOI:10.5056/jnm20267 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Zengzi Zhou Meng Xia Jianlin Lv Source Type: research

There Is Something More Important Than Proximal Reflux Episode in the Development of Post-reflux Swallow-induced Peristaltic Wave
J Neurogastroenterol Motil. 2021 Apr 30;27(2):305-306. doi: 10.5056/jnm20276.NO ABSTRACTPMID:33795547 | PMC:PMC8026371 | DOI:10.5056/jnm20276 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Tae Hee Lee Source Type: research

What Is the Difference in Characteristics Between Belching Disorder and Gastroesophageal Reflux Disease With Belching? Centering Around Supragastric Belching
J Neurogastroenterol Motil. 2021 Apr 30;27(2):149-150. doi: 10.5056/jnm21032.NO ABSTRACTPMID:33795536 | PMC:PMC8026372 | DOI:10.5056/jnm21032 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Sung Eun Kim Source Type: research

Integrated Relaxation Pressure During Swallowing: An Ever-changing Metric
J Neurogastroenterol Motil. 2021 Apr 30;27(2):151-152. doi: 10.5056/jnm21033.NO ABSTRACTPMID:33795537 | PMC:PMC8026369 | DOI:10.5056/jnm21033 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 2, 2021 Category: Gastroenterology Authors: Eun Jeong Gong Source Type: research