Overlap Between Constipation and Gastroesophageal Reflux Disease in Japan: Results from an Internet Survey
J Neurogastroenterol Motil. 2021 Nov 19. doi: 10.5056/jnm21065. Online ahead of print.ABSTRACTBACKGROUND/AIMS: Detailed evaluations of overlapping constipation and gastroesophageal reflux disease (GERD) have not been conducted in Japan. The REACTION-J2 study examined the overlap of these diseases in Japan.METHODS: This internet-based survey recruited participants from general public survey panels. Questions included demographic and medical data and assessments based on validated measures for constipation and GERD. Associations between background factors affecting constipation/GERD overlap, disease measures, and treatment w...
Source: Journal of Neurogastroenterology and Motility - November 21, 2021 Category: Gastroenterology Authors: Naotaka Ogasawara Yasushi Funaki Kunio Kasugai Masahide Ebi Yasuhiro Tamura Shinya Izawa Makoto Sasaki Source Type: research

Is There a Way to Differentiate Esophageal Motility Disorders in Patients With Heartburn?
J Neurogastroenterol Motil. 2021 Oct 30;27(4):445-447. doi: 10.5056/jnm21173.NO ABSTRACTPMID:34642264 | PMC:PMC8521468 | DOI:10.5056/jnm21173 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Sung Eun Kim Source Type: research

Risk of Pyogenic Liver Abscess in Proton Pump Inhibitor Users: New Inventory of Proton Pump Inhibitor Induced Complications?
J Neurogastroenterol Motil. 2021 Oct 30;27(4):448-450. doi: 10.5056/jnm21177.NO ABSTRACTPMID:34642265 | PMC:PMC8521461 | DOI:10.5056/jnm21177 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Ki Bae Bang Source Type: research

Are Peri-operative Inflammatory Markers Useful in Predicting Post-operative Ileus?
J Neurogastroenterol Motil. 2021 Oct 30;27(4):451-452. doi: 10.5056/jnm21174.NO ABSTRACTPMID:34642266 | PMC:PMC8521474 | DOI:10.5056/jnm21174 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Jung Ho Park Source Type: research

2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease
J Neurogastroenterol Motil. 2021 Oct 30;27(4):453-481. doi: 10.5056/jnm21077.ABSTRACTGastroesophageal reflux disease (GERD) is a condition in which gastric contents regurgitate into the esophagus or beyond, resulting in either troublesome symptoms or complications. GERD is heterogeneous in terms of varied manifestations, test findings, and treatment responsiveness. GERD diagnosis can be established with symptomatology, pathology, or physiology. Recently the Lyon consensus defined the "proven GERD" with concrete evidence for reflux, including advanced grade erosive esophagitis (Los Angeles classification grades C ...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Hye-Kyung Jung Chung Hyun Tae Kyung Ho Song Seung Joo Kang Jong Kyu Park Eun Jeong Gong Jeong Eun Shin Hyun Chul Lim Sang Kil Lee Da Hyun Jung Yoon Jin Choi Seung In Seo Joon Sung Kim Jung Min Lee Beom Jin Kim Sun Hyung Kang Chan Hyuk Park Suck Chei Choi Source Type: research

Brain to Belly: Abdominal Variants of Migraine and Functional Abdominal Pain Disorders Associated With Migraine
This article considers the so-called abdominal variants of migraine, which are more commonly seen in children rather than adults: abdominal migraine, cyclic vomiting syndrome, and infantile colic. Other functional abdominal pain disorders such as irritable bowel syndrome and functional dyspepsia have also been linked to migraine in clinical studies. The common pathophysiological root of these diseases seems to be the gut-brain axis mechanism. Abdominal variants of migraine are considered pediatric precursors of migraine whereas the functional abdominal pain disorders related to migraine seem to share a pathophysiological r...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: L éa LenglarT Caroline Caula Thomas Moulding Annabel Lyles Delphine Wohrer Luigi Titomanlio Source Type: research

Medical Management of Constipation in Elderly Patients: Systematic Review
CONCLUSIONS: Bulk laxative, osmotic laxative, stimulant laxative with or without fiber, and other medications can be used in elderly patients in short-term within 3 months with reasonable safety. However, the quality of included studies was not high and most of studies was conducted in a small number of patients. Among these laxatives, polyethylene glycol seems to be safe and effective in long-term use of about 6 months in elderly patients.PMID:34642269 | PMC:PMC8521458 | DOI:10.5056/jnm20210 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Seung Joo Kang Young Sin Cho Tae Hee Lee Seong-Eun Kim Han Seung Ryu Jung-Wook Kim Seon-Young Park Yoo Jin Lee Jeong Eun Shin Constipation Research Group of the Korean Society of Neurogastroenterology and Motility Source Type: research

Pitfalls in the Interpretation of Chicago Classification for Esophageal Motility Disorders
J Neurogastroenterol Motil. 2021 Oct 30;27(4):513-517. doi: 10.5056/jnm20058.ABSTRACTHigh-resolution manometry permitted the creation of the Chicago classification, that is the categorization for esophageal motility disorders most currently used. Despite its wide acceptance, there are few pitfalls for the correct interpretation of the tests. This technique review illustrates some difficult cases that may lead to misinterpretation of the results. Difficult cases are analyzed, such as the distinction of: (1) esophagogastric junction morphology and lower esophageal sphincter excursion, (2) intrabolus pressure pattern or commo...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Fernando A M Herbella Francisco Schlottmann Marco G Patti Source Type: research

Comparative Analysis of Relaxation Time Interval and Integrated Relaxation Pressure as Risk Factors for Aspiration in Patients With Oropharyngeal Dysphagia
J Neurogastroenterol Motil. 2021 Oct 30;27(4):518-524. doi: 10.5056/jnm20049.ABSTRACTBACKGROUND/AIMS: Integrated relaxation pressure (IRP) is an important metric for functional evaluation of the lower esophageal sphincter. However, the effectiveness of IRP for evaluation of upper esophageal sphincter (UES) function has not yet been clarified.METHODS: High-resolution manometry (HRM) was performed in 180 patients with dysphagia. For comparison, 26 asymptomatic subjects were also recruited. IRP of the UES was defined as means of 0.2, 0.25, or 0.3 seconds (sIRPs) of maximal deglutitive relaxation in a 0.4-second window (a new ...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Jung Ho Park Chong-Il Sohn Kyung Jae Yoon Jung Hwan Park Source Type: research

Esophageal Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Identifying Proton Pump Inhibitor-refractory Non-erosive Reflux Disease
This study aims to compare the MNBI and PSPW index in patients with no evidence of erosive reflux disease.METHODS: Impedance-pH monitoring tracings from 70 patients, 50 with non-erosive reflux disease (NERD) and 20 with functional heartburn (FH), were reviewed. According to proton pump inhibitors (PPI) treatment response, NERD patients were divided into NERD/PPI responders and NERD/PPI nonresponders. MNBI, PSPW index, and intercellular spaces were measured and compared among each group.RESULTS: MNBI values and PSPW index were lower in NERD patients than in FH (P
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Yan Wang Bixing Ye Meifeng Wang Lin Lin Liuqin Jiang Source Type: research

Diagnostic Yield of High-resolution Esophageal Manometry With Chicago Classification Version 3.0 in Thai Patients
CONCLUSION: Esophageal manometry provided the highest yield in dysphagia; it was not a strongly beneficial test in patients presenting with nondysphagia to identify clinically relevant esophageal motor disorders.PMID:34642273 | PMC:PMC8521467 | DOI:10.5056/jnm20088 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Sawangpong Jandee Kasemsak Jandee Source Type: research

Symptom Severity Related With Contraction Peaks in Patients With Jackhammer Esophagus
CONCLUSIONS: Repetitive contractions akin to a jackhammer were common amongst patients with hypercontractile esophagus. Patients with the jackhammer pattern also presented with more severe symptoms. Further distinction of hypercontractile esophagus into a jackhammer dominant subtype may be warranted.PMID:34642274 | PMC:PMC8521457 | DOI:10.5056/jnm20229 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Yinglian Xiao Dustin A Carlson John E Pandolfino Source Type: research

Clinical Characteristics of Esophageal Motility Disorders in Patients With Heartburn
This study aims to elucidate clinical features associated with various types of EMDs in patients with heartburn symptoms.METHODS: Of the 511 patients who underwent high-resolution manometry, 394 who were evaluated for heartburn symptoms were examined. Patients subjected to high-resolution manometry were classified into 4 groups: outflow obstruction group, hypermotility group, hypomotility group, and normal motility group. Symptoms were evaluated using 3 questionnaires. Patient characteristics and symptoms for each EMD type were compared with those of the normal motility group.RESULTS: Of the 394 patients, 193 (48.9%) were ...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Satsuki Takahashi Tomoaki Matsumura Tatsuya Kaneko Mamoru Tokunaga Hirotaka Oura Tsubasa Ishikawa Ariki Nagashima Wataru Shiratori Naoki Akizue Yuki Ohta Atsuko Kikuchi Mai Fujie Keiko Saito Kenichiro Okimoto Daisuke Maruoka Tomoo Nakagawa Makoto Arai Jun Source Type: research

Proton Pump Inhibitor Use Increases Pyogenic Liver Abscess Risk: A Nationwide Cohort Study
CONCLUSION: The present data indicate that PPI use is associated with an increased PLA risk. Therefore, it is necessary to prescribe PPIs with clear indication and to avoid improper use of PPIs.PMID:34642276 | PMC:PMC8521470 | DOI:10.5056/jnm20221 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Joo Hyun Oh Danbee Kang Wonseok Kang Eliseo Guallar Juhee Cho Yang Won Min Source Type: research

Perceived Gastrointestinal Symptoms and Association With Meals in a French Cohort of Patients With Irritable Bowel Syndrome
CONCLUSIONS: This study has confirmed the important link between gastrointestinal symptoms and food. Gastrointestinal symptoms induced by meals are frequent and associated with severity and IBS-diarrhea subtype. Our study also underlines patients' interest in food and diet. More knowledge is needed on food that triggers IBS symptoms but also on diet conditions in order to improve this condition.PMID:34642277 | PMC:PMC8521472 | DOI:10.5056/jnm20201 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Chlo é Melchior Simon Fremaux Pauline Jou ët Gilles Macaigne Jean-Jacques Raynaud Suzelle Facon Franck Iglicki Yannick Taes Jean-Marc Sabate Source Type: research

Heartburn, Functional Dyspepsia, Anxiety/Depression, and Sleep Disturbances Are Associated With Clinically Significant Belching
CONCLUSION: The detailed epidemiology of belching in the general adult population was clarified.PMID:34642278 | PMC:PMC8521483 | DOI:10.5056/jnm20225 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Yasuhiro Fujiwara Masatsugu Okuyama Yasuaki Nagami Koichi Taira Hirotaka Ishizu Osamu Takaishi Hiroshi Sato Toshio Watanabe Source Type: research

Peri-operative Inflammatory Marker as a Predictive Factor for Prolonged Post-operative Ileus After Gastrectomy for Gastric Cancer
CONCLUSIONS: Peri-operative inflammatory markers, such as CRP level and NLR, are useful predictive factors for PPOI who received gastrectomy for gastric cancer. Moreover, prophylactic antibiotics and anti-inflammatory drugs can be preventive and therapeutic agents for PPOI.PMID:34642279 | PMC:PMC8521482 | DOI:10.5056/jnm20203 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Yonsoo Kim Young Min Kim Jie-Hyun Kim Young Hoon Youn Jong Won Kim Hyojin Park Source Type: research

Self-reported Wheat Sensitivity in Irritable Bowel Syndrome and Healthy Subjects: Prevalence of Celiac Markers and Response to Wheat-free Diet
CONCLUSIONS: Eleven percent of patients with IBS self-reported wheat sensitivity. None of them had positive celiac serology; 60.9% were positive for HLA DQ2 and DQ8, suggesting a possible genetic basis. All of them improved symptomatically on a wheat-free diet.PMID:34642280 | PMC:PMC8521475 | DOI:10.5056/jnm20086 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Pavan Dhoble Philip Abraham Devendra Desai Anand Joshi Tarun Gupta Shachish Doctor Anand Deshpande Rajeshwari Basavanna Source Type: research

Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life
J Neurogastroenterol Motil. 2021 Oct 30;27(4):602-611. doi: 10.5056/jnm20135.ABSTRACTBACKGROUND/AIMS: Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population.METHODS: This cross-sectional internet-based survey included 3000 subjects with constipation, classified according to sleep status (good/poor). Primary endpoints were Bristol stool form scale (BSFS) score and correlations between sleep disorder criteria of the Pittsburgh Sleep Quality Index (PSQI) and sleep status (good/poor sleep). Secondary endpoints included...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Sayuri Yamamoto Yurika Kawamura Kazuhiro Yamamoto Yoshiharu Yamaguchi Yasuhiro Tamura Shinya Izawa Hiroaki Nakagawa Yoshinori Wakita Yasutaka Hijikata Masahide Ebi Yasushi Funaki Wataru Ohashi Naotaka Ogasawara Makoto Sasaki Masato Maekawa Kunio Kasugai Source Type: research

A Pilot Study of Clinical Evaluation and Formation Mechanism of Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease Patients in Remission
CONCLUSION: IBD-IBS patients may have low QOL and psychological abnormalities, as wells as visceral hypersensitivity which may be related to increased 5-HT and NGF levels released from activated mast cells.PMID:34642282 | PMC:PMC8521459 | DOI:10.5056/jnm20151 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Haiyang Wang Xiaojing Zhao Xiufang Cui Meifeng Wang Chunhua Jiao Jiajia Li Yan Yang Yi Li Hongjie Zhang Source Type: research

Can We Rely on the Rome IV Questionnaire to Diagnose Children With Functional Gastrointestinal Disorders?
CONCLUSIONS: Our study shows that a large proportion of children cannot adequately complete the QPGS-IV and that the intra-rater reliability among those who did adequately follow the instructions is moderate. We advise to test the children's understanding of the instructions prior to completion of questionnaires and recommend to not rely exclusively on a self-reported questionnaire to select, recruit, or evaluate pediatric patients for FGIDs for research purposes.PMID:34642283 | PMC:PMC8521469 | DOI:10.5056/jnm20179 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Desiree F Baaleman Carlos A Velasco-Ben ítez Laura M M éndez-Guzmán Marc A Benninga Miguel Saps Source Type: research

Paradoxical Stimulatory Response of Remanent Sphincter of Oddi to Buscapina After Endoscopic Sphincterotomy
CONCLUSIONS: EST destroys not only the smooth muscle of OS, also alters the innervation interrupting the duodeno-sphincteric nerve circuit. This finding questions the use of Buscapina or other anticholinergic agent as spasmolytic in patients after EST.PMID:34642284 | PMC:PMC8521478 | DOI:10.5056/jnm20180 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Zolt án Berger Ana Mar ía Madrid S Source Type: research

Altered Intestinal Permeability and Drug Repositioning in a Post-operative Ileus Guinea Pig Model
CONCLUSIONS: The alteration in intestinal permeability is one of the factors involved in the pathogenesis of POI. We repositioned 3 drugs (mosapride, glutamine, and ketotifen) as novel therapeutic agents for POI.PMID:34642285 | PMC:PMC8521477 | DOI:10.5056/jnm21018 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Young Min Kim Zahid Hussain Young Ju Lee Hyojin Park Source Type: research

Cognitive Deficits Associated With Dysphagia in Patients With Dementia
J Neurogastroenterol Motil. 2021 Oct 30;27(4):650-652. doi: 10.5056/jnm21027.NO ABSTRACTPMID:34642286 | PMC:PMC8521476 | DOI:10.5056/jnm21027 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Sun-Wung Hsieh Hui-Yu Chuang Chih-Hsing Hung Chun-Hung Chen Source Type: research

Impact of < em > Helicobacter pylori < /em > -related Microbial Dysbiosis in the Pathogenesis of Metabolic Syndrome and Gastrointestinal Dysmotility Disorders
J Neurogastroenterol Motil. 2021 Oct 30;27(4):653-654. doi: 10.5056/jnm21059.NO ABSTRACTPMID:34642287 | PMC:PMC8521481 | DOI:10.5056/jnm21059 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Jannis Kountouras Apostolis Papaefthymiou Stergios A Polyzos Elisabeth Vardaka Marina Boziki Anthony Kyriakopoulos Fotios Sampsonas George Agrotis Kyriaki Karafyllidou Michael Doulberis Source Type: research

Association Between Visceral Hypersensitivity in Irritable Bowel Syndrome, Intestinal Microbiota, and Mast Cells: How to Detect Mast Cells Using Confocal Microscopy
J Neurogastroenterol Motil. 2021 Oct 30;27(4):657-659. doi: 10.5056/jnm21132.NO ABSTRACTPMID:34642288 | PMC:PMC8521466 | DOI:10.5056/jnm21132 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Kang Nyeong Lee Jiwon Lee Juil Hwang Chungha Lee Ji Sook Kim Seok Ho Song Oh Young Lee Kwang-Geol Lee Source Type: research

Is There a Way to Differentiate Esophageal Motility Disorders in Patients With Heartburn?
J Neurogastroenterol Motil. 2021 Oct 30;27(4):445-447. doi: 10.5056/jnm21173.NO ABSTRACTPMID:34642264 | PMC:PMC8521468 | DOI:10.5056/jnm21173 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Sung Eun Kim Source Type: research

Risk of Pyogenic Liver Abscess in Proton Pump Inhibitor Users: New Inventory of Proton Pump Inhibitor Induced Complications?
J Neurogastroenterol Motil. 2021 Oct 30;27(4):448-450. doi: 10.5056/jnm21177.NO ABSTRACTPMID:34642265 | PMC:PMC8521461 | DOI:10.5056/jnm21177 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Ki Bae Bang Source Type: research

Are Peri-operative Inflammatory Markers Useful in Predicting Post-operative Ileus?
J Neurogastroenterol Motil. 2021 Oct 30;27(4):451-452. doi: 10.5056/jnm21174.NO ABSTRACTPMID:34642266 | PMC:PMC8521474 | DOI:10.5056/jnm21174 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Jung Ho Park Source Type: research

2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease
J Neurogastroenterol Motil. 2021 Oct 30;27(4):453-481. doi: 10.5056/jnm21077.ABSTRACTGastroesophageal reflux disease (GERD) is a condition in which gastric contents regurgitate into the esophagus or beyond, resulting in either troublesome symptoms or complications. GERD is heterogeneous in terms of varied manifestations, test findings, and treatment responsiveness. GERD diagnosis can be established with symptomatology, pathology, or physiology. Recently the Lyon consensus defined the "proven GERD" with concrete evidence for reflux, including advanced grade erosive esophagitis (Los Angeles classification grades C ...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Hye-Kyung Jung Chung Hyun Tae Kyung Ho Song Seung Joo Kang Jong Kyu Park Eun Jeong Gong Jeong Eun Shin Hyun Chul Lim Sang Kil Lee Da Hyun Jung Yoon Jin Choi Seung In Seo Joon Sung Kim Jung Min Lee Beom Jin Kim Sun Hyung Kang Chan Hyuk Park Suck Chei Choi Source Type: research

Brain to Belly: Abdominal Variants of Migraine and Functional Abdominal Pain Disorders Associated With Migraine
This article considers the so-called abdominal variants of migraine, which are more commonly seen in children rather than adults: abdominal migraine, cyclic vomiting syndrome, and infantile colic. Other functional abdominal pain disorders such as irritable bowel syndrome and functional dyspepsia have also been linked to migraine in clinical studies. The common pathophysiological root of these diseases seems to be the gut-brain axis mechanism. Abdominal variants of migraine are considered pediatric precursors of migraine whereas the functional abdominal pain disorders related to migraine seem to share a pathophysiological r...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: L éa LenglarT Caroline Caula Thomas Moulding Annabel Lyles Delphine Wohrer Luigi Titomanlio Source Type: research

Medical Management of Constipation in Elderly Patients: Systematic Review
CONCLUSIONS: Bulk laxative, osmotic laxative, stimulant laxative with or without fiber, and other medications can be used in elderly patients in short-term within 3 months with reasonable safety. However, the quality of included studies was not high and most of studies was conducted in a small number of patients. Among these laxatives, polyethylene glycol seems to be safe and effective in long-term use of about 6 months in elderly patients.PMID:34642269 | PMC:PMC8521458 | DOI:10.5056/jnm20210 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Seung Joo Kang Young Sin Cho Tae Hee Lee Seong-Eun Kim Han Seung Ryu Jung-Wook Kim Seon-Young Park Yoo Jin Lee Jeong Eun Shin Constipation Research Group of the Korean Society of Neurogastroenterology and Motility Source Type: research

Pitfalls in the Interpretation of Chicago Classification for Esophageal Motility Disorders
J Neurogastroenterol Motil. 2021 Oct 30;27(4):513-517. doi: 10.5056/jnm20058.ABSTRACTHigh-resolution manometry permitted the creation of the Chicago classification, that is the categorization for esophageal motility disorders most currently used. Despite its wide acceptance, there are few pitfalls for the correct interpretation of the tests. This technique review illustrates some difficult cases that may lead to misinterpretation of the results. Difficult cases are analyzed, such as the distinction of: (1) esophagogastric junction morphology and lower esophageal sphincter excursion, (2) intrabolus pressure pattern or commo...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Fernando A M Herbella Francisco Schlottmann Marco G Patti Source Type: research

Comparative Analysis of Relaxation Time Interval and Integrated Relaxation Pressure as Risk Factors for Aspiration in Patients With Oropharyngeal Dysphagia
J Neurogastroenterol Motil. 2021 Oct 30;27(4):518-524. doi: 10.5056/jnm20049.ABSTRACTBACKGROUND/AIMS: Integrated relaxation pressure (IRP) is an important metric for functional evaluation of the lower esophageal sphincter. However, the effectiveness of IRP for evaluation of upper esophageal sphincter (UES) function has not yet been clarified.METHODS: High-resolution manometry (HRM) was performed in 180 patients with dysphagia. For comparison, 26 asymptomatic subjects were also recruited. IRP of the UES was defined as means of 0.2, 0.25, or 0.3 seconds (sIRPs) of maximal deglutitive relaxation in a 0.4-second window (a new ...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Jung Ho Park Chong-Il Sohn Kyung Jae Yoon Jung Hwan Park Source Type: research

Esophageal Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Identifying Proton Pump Inhibitor-refractory Non-erosive Reflux Disease
This study aims to compare the MNBI and PSPW index in patients with no evidence of erosive reflux disease.METHODS: Impedance-pH monitoring tracings from 70 patients, 50 with non-erosive reflux disease (NERD) and 20 with functional heartburn (FH), were reviewed. According to proton pump inhibitors (PPI) treatment response, NERD patients were divided into NERD/PPI responders and NERD/PPI nonresponders. MNBI, PSPW index, and intercellular spaces were measured and compared among each group.RESULTS: MNBI values and PSPW index were lower in NERD patients than in FH (P
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Yan Wang Bixing Ye Meifeng Wang Lin Lin Liuqin Jiang Source Type: research

Diagnostic Yield of High-resolution Esophageal Manometry With Chicago Classification Version 3.0 in Thai Patients
CONCLUSION: Esophageal manometry provided the highest yield in dysphagia; it was not a strongly beneficial test in patients presenting with nondysphagia to identify clinically relevant esophageal motor disorders.PMID:34642273 | PMC:PMC8521467 | DOI:10.5056/jnm20088 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Sawangpong Jandee Kasemsak Jandee Source Type: research

Symptom Severity Related With Contraction Peaks in Patients With Jackhammer Esophagus
CONCLUSIONS: Repetitive contractions akin to a jackhammer were common amongst patients with hypercontractile esophagus. Patients with the jackhammer pattern also presented with more severe symptoms. Further distinction of hypercontractile esophagus into a jackhammer dominant subtype may be warranted.PMID:34642274 | PMC:PMC8521457 | DOI:10.5056/jnm20229 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Yinglian Xiao Dustin A Carlson John E Pandolfino Source Type: research

Clinical Characteristics of Esophageal Motility Disorders in Patients With Heartburn
This study aims to elucidate clinical features associated with various types of EMDs in patients with heartburn symptoms.METHODS: Of the 511 patients who underwent high-resolution manometry, 394 who were evaluated for heartburn symptoms were examined. Patients subjected to high-resolution manometry were classified into 4 groups: outflow obstruction group, hypermotility group, hypomotility group, and normal motility group. Symptoms were evaluated using 3 questionnaires. Patient characteristics and symptoms for each EMD type were compared with those of the normal motility group.RESULTS: Of the 394 patients, 193 (48.9%) were ...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Satsuki Takahashi Tomoaki Matsumura Tatsuya Kaneko Mamoru Tokunaga Hirotaka Oura Tsubasa Ishikawa Ariki Nagashima Wataru Shiratori Naoki Akizue Yuki Ohta Atsuko Kikuchi Mai Fujie Keiko Saito Kenichiro Okimoto Daisuke Maruoka Tomoo Nakagawa Makoto Arai Jun Source Type: research

Proton Pump Inhibitor Use Increases Pyogenic Liver Abscess Risk: A Nationwide Cohort Study
CONCLUSION: The present data indicate that PPI use is associated with an increased PLA risk. Therefore, it is necessary to prescribe PPIs with clear indication and to avoid improper use of PPIs.PMID:34642276 | PMC:PMC8521470 | DOI:10.5056/jnm20221 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Joo Hyun Oh Danbee Kang Wonseok Kang Eliseo Guallar Juhee Cho Yang Won Min Source Type: research

Perceived Gastrointestinal Symptoms and Association With Meals in a French Cohort of Patients With Irritable Bowel Syndrome
CONCLUSIONS: This study has confirmed the important link between gastrointestinal symptoms and food. Gastrointestinal symptoms induced by meals are frequent and associated with severity and IBS-diarrhea subtype. Our study also underlines patients' interest in food and diet. More knowledge is needed on food that triggers IBS symptoms but also on diet conditions in order to improve this condition.PMID:34642277 | PMC:PMC8521472 | DOI:10.5056/jnm20201 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Chlo é Melchior Simon Fremaux Pauline Jou ët Gilles Macaigne Jean-Jacques Raynaud Suzelle Facon Franck Iglicki Yannick Taes Jean-Marc Sabate Source Type: research

Heartburn, Functional Dyspepsia, Anxiety/Depression, and Sleep Disturbances Are Associated With Clinically Significant Belching
CONCLUSION: The detailed epidemiology of belching in the general adult population was clarified.PMID:34642278 | PMC:PMC8521483 | DOI:10.5056/jnm20225 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Yasuhiro Fujiwara Masatsugu Okuyama Yasuaki Nagami Koichi Taira Hirotaka Ishizu Osamu Takaishi Hiroshi Sato Toshio Watanabe Source Type: research

Peri-operative Inflammatory Marker as a Predictive Factor for Prolonged Post-operative Ileus After Gastrectomy for Gastric Cancer
CONCLUSIONS: Peri-operative inflammatory markers, such as CRP level and NLR, are useful predictive factors for PPOI who received gastrectomy for gastric cancer. Moreover, prophylactic antibiotics and anti-inflammatory drugs can be preventive and therapeutic agents for PPOI.PMID:34642279 | PMC:PMC8521482 | DOI:10.5056/jnm20203 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Yonsoo Kim Young Min Kim Jie-Hyun Kim Young Hoon Youn Jong Won Kim Hyojin Park Source Type: research

Self-reported Wheat Sensitivity in Irritable Bowel Syndrome and Healthy Subjects: Prevalence of Celiac Markers and Response to Wheat-free Diet
CONCLUSIONS: Eleven percent of patients with IBS self-reported wheat sensitivity. None of them had positive celiac serology; 60.9% were positive for HLA DQ2 and DQ8, suggesting a possible genetic basis. All of them improved symptomatically on a wheat-free diet.PMID:34642280 | PMC:PMC8521475 | DOI:10.5056/jnm20086 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Pavan Dhoble Philip Abraham Devendra Desai Anand Joshi Tarun Gupta Shachish Doctor Anand Deshpande Rajeshwari Basavanna Source Type: research

Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life
J Neurogastroenterol Motil. 2021 Oct 30;27(4):602-611. doi: 10.5056/jnm20135.ABSTRACTBACKGROUND/AIMS: Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population.METHODS: This cross-sectional internet-based survey included 3000 subjects with constipation, classified according to sleep status (good/poor). Primary endpoints were Bristol stool form scale (BSFS) score and correlations between sleep disorder criteria of the Pittsburgh Sleep Quality Index (PSQI) and sleep status (good/poor sleep). Secondary endpoints included...
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Sayuri Yamamoto Yurika Kawamura Kazuhiro Yamamoto Yoshiharu Yamaguchi Yasuhiro Tamura Shinya Izawa Hiroaki Nakagawa Yoshinori Wakita Yasutaka Hijikata Masahide Ebi Yasushi Funaki Wataru Ohashi Naotaka Ogasawara Makoto Sasaki Masato Maekawa Kunio Kasugai Source Type: research

A Pilot Study of Clinical Evaluation and Formation Mechanism of Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease Patients in Remission
CONCLUSION: IBD-IBS patients may have low QOL and psychological abnormalities, as wells as visceral hypersensitivity which may be related to increased 5-HT and NGF levels released from activated mast cells.PMID:34642282 | PMC:PMC8521459 | DOI:10.5056/jnm20151 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Haiyang Wang Xiaojing Zhao Xiufang Cui Meifeng Wang Chunhua Jiao Jiajia Li Yan Yang Yi Li Hongjie Zhang Source Type: research

Can We Rely on the Rome IV Questionnaire to Diagnose Children With Functional Gastrointestinal Disorders?
CONCLUSIONS: Our study shows that a large proportion of children cannot adequately complete the QPGS-IV and that the intra-rater reliability among those who did adequately follow the instructions is moderate. We advise to test the children's understanding of the instructions prior to completion of questionnaires and recommend to not rely exclusively on a self-reported questionnaire to select, recruit, or evaluate pediatric patients for FGIDs for research purposes.PMID:34642283 | PMC:PMC8521469 | DOI:10.5056/jnm20179 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 13, 2021 Category: Gastroenterology Authors: Desiree F Baaleman Carlos A Velasco-Ben ítez Laura M M éndez-Guzmán Marc A Benninga Miguel Saps Source Type: research