Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to Irritable Bowel Syndrome Subtype and Sex.
Authors: Lee JY, Kim N, Park JH, Nam RH, Lee SM, Song CH, Kim G, Na HY, Choi YJ, Kim JJ, Lee DH Abstract Background/Aims: Emerging evidence shows that the mechanism of irritable bowel syndrome (IBS) is associated with neurotrophic factors and tight junction proteins (TJPs) It is known that there are sex differences in the pathophysiology of IBS. The aim of the present study is to determine expression levels of neurotrophic factors, TJPs, and cytokines according to IBS subtype and sex. Methods: From 59 IBS (33 IBS-constipation, 21 IBS-diarrhea, and 5 IBS-mixed) and 36 control patients, colonic mucosa mRNA expres...
Source: Journal of Neurogastroenterology and Motility - October 18, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Phase 4 Study in Patients From Asia With Gastroesophageal Reflux Disease Treated With Dexlansoprazole.
Conclusions: In Asian patients with GERD, treatment with dexlansoprazole modified-release indicates a favorable efficacy and safety profile in relieving heartburn and acid regurgitation symptoms. PMID: 31597230 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 11, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Does Elevated Intrabolus Pressure Predict Esophageal Stasis in Dysphagia Patients?
Authors: Cho YK PMID: 31587537 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Associations Among Symptoms, Quality of Life, and Gastric Emptying: An Unresolved Issue.
Authors: Lee TH PMID: 31587538 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Diagnosis and Management of Functional Chest Pain in the Rome IV Era.
Authors: Fass R, Shibli F, Tawil J Abstract Functional chest pain accounts for about a third of the patients with noncardiac chest pain. It is a very common functional esophageal disorder that remains even today a management challenge to the practicing physician. Based on the definition offered by the Rome IV criteria, diagnosis of functional chest pain requires a negative workup of noncardiac chest pain patients that includes, proton pump inhibitor test or empirical proton pump inhibitor trial, endoscopy with esophageal mucosal biopsies, reflux testing, and esophageal manometry. The mainstay of treatment are neuro...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives.
Authors: Lin S, Li H, Fang X Abstract Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophageal sphincter, frequent transient lower esophageal sphincter relaxation, esophageal hypersensitivity, reduced resistance of the esophageal mucosa against the refluxed contents, ineffective esophageal motility, abnormal bolus transport, deficits initiating secondary p...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Pyridostigmine in Pediatric Intestinal Pseudo-obstruction: Case Report of a 2-year Old Girl and Literature Review.
Authors: Nardo GD, Viscogliosi F, Esposito F, Stanghellini V, Villa MP, Parisi P, Morlando A, Cal G, Giorgio R Abstract Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes. The diagnosis is usually clinical and diagnostic work is usually aimed to rule out mechanical obstruction and to identify any underlying diseases. Treatment is challenging and requires a multidisciplinary effort. In this manuscript we describe the youngest child successfully treated with ...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Role of Esophageal Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Discriminating Chinese Patients With Heartburn.
Authors: Sun YM, Gao Y, Gao F Abstract Background/Aims: Recently, esophageal mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index have been proposed, which can increase the diagnostic role of multichannel intraluminal impedance and pH recording (MII/pH) for differentiating patients with heartburn. Therefore, our aim is to investigate the role of esophageal proximal MNBI, distal MNBI, and PSPW index in differentiating Chinese patients with heartburn. Methods: Patients with heartburn from the Beijing Anzhen Hospital, who underwent upper gastrointestinal endoscopy ...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Elevated Intrabolus Pressure Predicts Abnormal Timed Barium Esophagram in Esophagogastric Junction Outflow Obstruction.
Conclusions: In our study, we found significant differences in IBP between these patient groups. These findings suggest that patients with EGJOO and elevated IBP may prompt further clinical evaluation with TBE in order to clarify clinical diagnosis and guide therapeutic intervention. PMID: 31587543 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

An Increasing Trend of Eosinophilic Esophagitis in Korea and the Clinical Implication of the Biomarkers to Determine Disease Activity and Treatment Response in Eosinophilic Esophagitis.
Authors: Kim GH, Park YS, Jung KW, Kim M, Na HK, Ahn JY, Lee JH, Kim DH, Choi KD, Song HJ, Lee GH, Dellon ES, Jung HY Abstract Background/Aims: The epidemiology and pathogenesis of eosinophilic esophagitis (EoE) remain unclear in Asian countries. We investigated clinicopathological characteristics and diagnostic trends of EoE, and evaluated 3 tissue biomarkers for correlation with disease activity and treatment response in Korean patients with EoE. Methods: We retrospectively reviewed 25 271 esophageal biopsies performed during upper endoscopies between 2006 and 2017. We diagnosed EoE based on ≥ 15 eosinophi...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Association Between Symptoms, Quality of Life, and Gastric Emptying in Dyspeptic Patients.
Conclusions: There is no association between symptoms, quality of life and gastric emptying in an overall dyspeptic population. However, there is an association between symptoms, quality of life of delayed gastric emptying in the subgroup of patients with severely delayed gastric emptying. An 8-hour measurement of gastric emptying should be recommended. PMID: 31587545 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

What Is Appropriate Upper Endoscopic Interval Among Dyspeptic Patients With Previously Normal Endoscopy? A Multicenter Study With Bayesian Change Point Analysis.
Conclusion: To rule out dysplastic lesions among dyspeptic patients who had previously normal endoscopy, a 2-year interval could be offered as follow-up interval for repeat upper endoscopy. PMID: 31587546 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study.
Conclusion: Nighttime Trp metabolites may provide clues to poor sleep and stress with IBS. Further study of the mechanism of metabolite action is warranted. PMID: 31587547 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
Authors: Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa H Abstract Background/Aims: Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients. Methods: We conducted a randomized, double-blind placebo-controlled study. Thirty-four female patients with mild to moderate constipation were randomly assigned to either placebo (n = 17) or MgO group (n = 17) 0.5 g × 3/day for 28 da...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Prevalence and Severity of Fecal Incontinence in Veterans.
Authors: Hosmer AE, Saini SD, Menees SB Abstract Background/Aims: Fecal incontinence (FI) is a common complaint that increases in prevalence with age. Our aim was to determine the prevalence of FI and assess its severity by self-report in a male-predominant Veteran outpatient clinic setting. Methods: An anonymous 28 item questionnaire was administered to a convenience sample of veterans awaiting appointments. FI was defined as a loss of liquid or solid stool at least monthly. Multivariable logistic and linear models were used to identify predictors of FI prevalence and severity. Results: One hundred thirty-...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Colonic Dysmotility in Murine Partial Colonic Obstruction Due to Functional Changes in Interstitial Cells.
Conclusion: Colonic transit disorder may be due to the downregulation of the Kit and Ano1 channels and the upregulation of SK3 channels in platelet-derived growth factor receptor-α positive (PDGFRα+) cells. The imbalance between interstitial cells of Cajal-Ano1 and PDGFRαSK3 distribution might be a potential reason for the colonic dysmotility. PMID: 31587550 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Effects of Naloxegol on Gastrointestinal Transit and Colonic Fecal Volume in Healthy Participants Receiving Oxycodone.
Authors: Olesen AE, Grønlund D, Mark EB, Krogh K, Frøkjær JB, Drewes AM Abstract Background/Aims: Opioids cause gastrointestinal (GI) dysmotility, decrease gut secretion, and affect gut sphincters. Symptoms of opioid-induced bowel dysfunction may be alleviated by peripherally acting opioid antagonists like naloxegol, but detailed knowledge on GI effects of this drug is lacking. We hypothesized that naloxegol, compared to placebo, would reduce GI transit time and colonic fecal volume in opioid-treated healthy participants. Methods: We conducted a randomized, double-blinded, single-center, 2-w...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Intranasal Administration of Oxytocin Attenuates Stress Responses Following Chronic Complicated Stress in Rats.
Conclusion: Intranasal administration of OXT has an anxiolytic effect and attenuates the hypothalamus-pituitary-adrenal axis in response to CCS, and gave effects which helped to restore GI dysmotility, and might be a new approach for the treatment of stress-induced GI motility disorders. PMID: 31587552 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Stool Consistency: Looking Beyond the Bristol Stool Form Scale.
Authors: Vork L, Wilms E, Penders J, Jonkers DMAE PMID: 31587553 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Gallbladder Nerve Fiber Degeneration: Reactive Drug-induced Change?
Authors: Handra-Luca A PMID: 31416300 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - August 18, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Surgical Treatment for Gastroesophageal Reflux Disease: Is It Effective Even for Asians?
Authors: Park CH PMID: 31327216 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Evaluation of Anorectal Afferent Pathway: Does It Help Overcome Unmet Diagnostic Needs in the Management of Fecal Incontinence?
Authors: Lee TH PMID: 31327217 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Second Asian Consensus on Irritable Bowel Syndrome.
Conclusions: Our consensus is that all patients with functional gastrointestinal disorders should be evaluated comprehensively with a view to holistic management. Physicians should be encouraged to take a positive attitude to the treatment outcomes for IBS patients. PMID: 31327218 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Parkinson's Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation.
Authors: Dutta SK, Verma S, Jain V, Surapaneni BK, Vinayek R, Phillips L, Nair PP Abstract The role of the microbiome in health and human disease has emerged at the forefront of medicine in the 21st century. Over the last 2 decades evidence has emerged to suggest that inflammation-derived oxidative damage and cytokine induced toxicity may play a significant role in the neuronal damage associated with Parkinson's disease (PD). Presence of pro-inflammatory cytokines and T cell infiltration has been observed in the brain parenchyma of patients with PD. Furthermore, evidence for inflammatory changes has been reported i...
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Role of DNA Methylation in the Development and Differentiation of Intestinal Epithelial Cells and Smooth Muscle Cells.
Authors: Jorgensen BG, Ro S Abstract The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has revealed that various alterations to the DNA methylation apparatus within both of these cell types can result in a variety of cellular phenotypes including modified differentiation status, apoptosis, and uncontrolled growth. Methyl groups added to cytosines in regulatory genomic regions typically act to repress associated gene transcription. Aberrant DNA methylation patterns are often found in cells w...
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Multicenter Prospective Study of Laparoscopic Nissen Fundoplication for Gastroesophageal Reflux Disease in Korea.
Authors: Park S, Park JM, Kim JJ, Lee IS, Han SU, Seo KW, Kwon JW Abstract Backgrounds/Aims: This multicenter study aims to evaluate the effect and feasibility of anti-reflux surgery compared with medical treatment for gastroesophageal reflux disease (GERD). Methods: Patients with GERD who were undergoing medical treatment with proton pump inhibitors for more than 8 weeks and those who were scheduled to undergo anti-reflux surgery were enrolled. Efficacy of pre-operative medical treatment was evaluated retrospectively and effect of anti-reflux surgery was prospectively evaluated at 1 week and 3 months after sur...
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Efficacy and Safety of AlbisD Compared With Omeprazole 20 mg in Patients With Non-erosive Reflux Disease: A Randomized, Open-label, Active-controlled, Pilot Study.
Conclusions: The efficacy and safety of AlibsD in treating NERD patients are not inferior to those of omeprazole. Therefore, AlbisD can be an alternative to PPIs for NERD. PMID: 31327222 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Vagal Transient Receptor Potential Ankyrin 1 Mediates Stress-exacerbated Visceral Mechanonociception After Antral Cold Exposure.
Conclusions: Stress-exaggerated visceral mechanonociception after antral cold exposure may involve up-regulation of TRPA1 expression and function on vagal afferents. Our findings reveal a novel mechanism for abnormal gastrointestinal cold sensing in IBS. PMID: 31327223 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Modulatory Effects of Gut Microbiota on Constipation: The Commercial Beverage Yakult Shapes Stool Consistency.
Authors: Chen M, Ye X, Shen D, Ma C PMID: 31327224 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

On Functional Connectivity and Symptom Relief After Gut-directed Hypnotherapy in Irritable Bowel Syndrome: A Preliminary Study.
Authors: Simon RA, Engström M, Icenhour A, Lowén M, Ström M, Tillisch K, Mayer E, Elsenbruch S, Walter S PMID: 31327225 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Defective Conduction of Anorectal Afferents Is a Very Prevalent Pathophysiological Factor Associated to Fecal Incontinence in Women.
Conclusions: Pathophysiology of FI in women is mainly associated with mechanical sphincter dysfunctions related to either muscle damage or, to a lesser extent, impaired efferent conduction at pudendal nerves. Impaired conduction through afferent anorectal pathways is also very prevalent in women with FI and may play an important role as a pathophysiological factor and as a potential therapeutic target. PMID: 31177647 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - June 12, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Gastroesophageal Reflux Events Occurring During a Meal Can Still Be Temporally Associated With a Symptom Even When Analysis Settings Are Set to Exclude Meals.
Authors: Woodley FW PMID: 31177648 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - June 12, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Effect of Trimebutine and/or Helicobacter pylori Eradication on the Gastroesophageal Reflux Disease, Irritable Bowel Syndrome, and Functional Dyspepsia Overlapping Disorders.
Authors: Kountouras J, Gavalas E, Doulberis M, Polyzos SA, Papaefthimiou A, Touloumtsi M, Vardaka E, Kountouras K, Papanikolopoulou K, Katsinelos P PMID: 31177649 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - June 12, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Effects of Intraduodenal Infusion of the Bitter Tastant, Quinine, on Antropyloroduodenal Motility, Plasma Cholecystokinin, and Energy Intake in Healthy Men.
Conclusion: Quinine, administered intraduodenally over 60 minutes, even at moderately high doses, but low infusion rates, does not modulate appetite-related gastrointestinal functions or energy intake. PMID: 31177650 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - June 12, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Association Between Gastric Emptying Time and Incidence of Cardiovascular Diseases in Subjects With Diabetes.
Conclusion: A delay of GE was associated with an increased incidence of cardiovascular events in diabetic subjects with chronic UGI symptoms. PMID: 31177651 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - June 12, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Five-fold Gastrointestinal Electrical Stimulation With Electromyography-based Activity Analysis: Towards Multilocular Theranostic Intestinal Implants.
Conclusions: Multilocular ES with variable ES parameters is feasible and may significantly modulate GI electrical activity. Automated electromyography analysis revealed complex reaction patterns in the 5 examined GI segments. PMID: 31177652 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - June 12, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Polymorphisms of the BARX1 and ADAMTS17 locus genes in individuals with gastroesophageal reflux disease.
Conclusion: : This is a study investigating the potential correlation between 2 BARX1 and ADAMTS17 polymorphisms and the development of GERD, showing a considerable association between both polymorphisms and the disease. This finding suggests that esophageal differentiation or altered regulation on microfibrils in the cell environment could be implicated as possible mechanisms in the pathogenesis of GERD. PMID: 31048564 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - May 4, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Role of Opioids and Alcohol in the Development of Achalasia Type III and Esophagogastric Junction Outflow Obstruction.
Authors: Kim GH, Jung KW PMID: 30982237 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Can Certain Foods Cause Gastrointestinal Symptoms in Korean Patients With Irritable Bowel Syndrome?
Authors: Nam K, Shin JE PMID: 30982238 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Opioid Treatment and Excessive Alcohol Consumption Are Associated With Esophagogastric Junction Disorders.
Authors: Schindler V, Runggaldier D, Bianca A, Becker AS, Murray F, Savarino E, Pohl D Abstract Background/Aims: The influence of external factors such as opioids and alcohol has been extensively investigated for various segments of the gastrointestinal tract. However, the association between their use and the development of esophagogastric junction outflow obstruction disorders (EGJOODs) is unknown. Therefore, the aim of this study is to analyze prevalence and clinical relevance of opioids and alcohol intake in patients with EGJOODs. Methods: In this single-center, retrospective study, we reviewed clinical and...
Source: Journal of Neurogastroenterology and Motility - April 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Is Long-term Ambient Air Pollutant Exposure a Risk Factor for Irritable Bowel Syndrome in Children? A 12-year Longitudinal Cohort Study.
Authors: Tan TK, Saps M, Lin CL, Wei CC Abstract Background/Aims: Recent studies suggest that air pollution may play a role in gastrointestinal disorders. However, the effect of long-term exposure to air pollution on childhood irritable bowel syndrome (IBS) is unclear. Hence, we conducted a nationwide cohort study to investigate the association between long-term air pollution exposure and the incidence and risk of IBS in Taiwanese children during 2000-2012. Methods: We collected data from the Taiwan National Health Insurance Research Database, linked to the Taiwan Air Quality-Monitoring Database according to th...
Source: Journal of Neurogastroenterology and Motility - April 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

High-resolution Anorectal Manometry in the Diagnosis of Functional Defecation Disorder in Patients With Functional Constipation: A Retrospective Cohort Study.
Conclusion: HRAM could be used as a test for the diagnosis of functional defecation disorder and functional defecation disorder is common in Chinese patients with functional constipation. PMID: 30982241 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Influence of Age and Body Mass Index on Total and Segmental Colonic Transit Times in Constipated Subjects.
Authors: Bouchoucha M, Fysekidis M, Rompteaux P, Airinei G, Sabate JM, Benamouzig R Abstract Background/Aims: Discordant data are found in the literature for the relationships between total and segmental colonic transit time (CTT) and demographic parameters. The aim of this study is to examine the influence of age, and body mass index (BMI) on total and segmental CTT in constipated subjects. Methods: We included 354 constipated patients on this cross-sectional study. According to the Rome III criteria, patients were classified as having irritable bowel syndrome with constipation, or functional constipation. All...
Source: Journal of Neurogastroenterology and Motility - April 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Colonic Transit Disorder Mediated by Downregulation of Interstitial Cells of Cajal/Anoctamin-1 in Dextran Sodium Sulfate-induced Colitis Mice.
Conclusion: The results suggest that colonic transit disorder is mediated via downregulation of the nitric oxide/ICC/ANO1 signalling pathway in DSS-colitis mice. PMID: 30982243 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Effect of Mizagliflozin on Postprandial Plasma Glucose in Patients With Functional Constipation.
Authors: Fukudo S, Kaku K PMID: 30982244 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Esophagogastric Junction Outflow Obstruction Caused by Gabapentin.
Authors: Barret M, Guillaumot MA, Léandri C, Gaillard R, Chaussade S PMID: 30982245 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Fluoroscopic Characterization of Colonic Dysmotility Associated to Opioid and Cannabinoid Agonists in Conscious Rats.
Conclusions: Fluoroscopy allows studying colonic propulsion of endogenous fecal pellets in conscious rats. Our method may be applied to the non-invasive study of the effect of different drug treatments and pathologies. PMID: 30870877 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - March 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Psychosocial Factors Associated With Irritable Bowel Syndrome Development in Chinese College Freshmen.
Conclusions: The prevalence of IBS in college freshmen is 4.0%, and to the freshmen, psychosocial factors such as experience of abuse, depression, and suicidal intention were associated with high risk of developing IBS. PMID: 30870878 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - March 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias.
This study aims to investigate the relationship between hyperglycemia and the patterns of dysrhythmias by employing high-resolution (multi-electrode) mapping simultaneously at the anterior and posterior gastric serosa. Methods: High-resolution mapping (8 × 16 electrodes per serosal) was performed in 4 anesthetized hounds. Baseline recordings (21 ± 8 minutes) were followed by intravenous injection of glucagon (0.5 mg per dose) and further recordings (59 ± 15 minutes). Blood glucose levels were monitored manually using a glucose sensing kit at regular 5-minute intervals. Slow wave activation maps, amp...
Source: Journal of Neurogastroenterology and Motility - March 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

High Prevalence of Slow Transit Constipation in Patients With Gastroparesis.
Conclusions: Patients with gastroparesis had a higher rate of slow transit constipation, but equal rates of dyssynergic defecation compared to patients with normal gastric emptying. These findings argue for investigation of possible delayed colonic transit in patients with gastroparesis and vice versa. PMID: 30870880 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - March 16, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research