Acid Exposure Time > 6% Might Not Improve the Therapeutic Outcome in Chinese Gastroesophageal Reflux Disease Patients.
Conclusions: The efficacy of PPI therapy was similar in patients with AET> 6% and 4-6%. The increase of the AET threshold did not influence the clinical outcome of Chinese GERD patients. PMID: 32699186 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 25, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Practice Patterns for Eosinophilic Esophagitis Patients in Busan and Gyeongnam: A Korean Multicenter Database Study.
Conclusions: The treatment response of eosinophilic esophagitis was good in Busan city and Gyeongnam province area in Korea. Proton pump inhibitor therapy was the preferred and most effective treatment for eosinophilic esophagitis as the initial therapy. PMID: 32699187 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 25, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Quantification of Esophageal Angulation in Sigmoid Achalasia: Are We There Yet?
Authors: Nabi Z, Reddy DN PMID: 32699188 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 25, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Depression and Structural Factors Are Associated With Symptoms in Patients of Irritable Bowel Syndrome With Diarrhea.
Conclusions: Comorbid depression and higher scores of structural factors might aggravate GI and extra-GI symptoms other than bowel movements and stool form. Structural factors of Hamilton Depression Rating Scale correlated with efficacy of paroxetine and mirtazapine in patients with IBS-D. PMID: 32675388 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 18, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Comparison of Short Versus Long Esophageal Myotomy in Cases With Idiopathic Achalasia: A Randomized Controlled Trial.
In this study, we aim to compare the outcomes of short (3 cm) versus long (6 cm and above) esophageal myotomy in patients undergoing POEM for achalasia cardia. Methods: Consecutive patients with idiopathic achalasia (type I and II) were randomized to receive short (3 cm) or long esophageal myotomy (≥ 6 cm). Both groups were compared for clinical success, operative time, adverse events, and gastroesophageal reflux disease (GERD). Results: Seventy-one consecutive patients with type I and II achalasia underwent POEM with short (n = 34) or long (n = 37) esophageal myotomy techniques. Mean length of esophageal myotom...
Source: Journal of Neurogastroenterology and Motility - July 18, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Disaccharidase Deficiency as a Cause of Unexplained Functional Gastrointestinal Disorder.
Authors: Kwon YH PMID: 32606251 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Toward an Improved Treatment for Gastroparesis.
Authors: Kim TH PMID: 32606252 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Practice of Gastrointestinal Motility Laboratory During COVID-19 Pandemic: Position Statements of the Asian Neurogastroenterology and Motility Association (ANMA-GML-COVID-19 Position Statements).
Authors: Siah KTH, Rahman MM, Ong AML, Soh AYS, Lee YY, Xiao Y, Sachdeva S, Jung KW, Wang YP, Oshima T, Patcharatrakul T, Tseng PH, Goyal O, Pang J, Lai CKC, Park JH, Mahadeva S, Cho YK, Wu JCY, Ghoshal UC, Miwa H Abstract During the Coronavirus Disease 2019 (COVID-19) pandemic, practices of gastrointestinal procedures within the digestive tract require special precautions due to the risk of contraction of severe acute respiratoy syndrome coronavirus-2 (SARS-CoV-2) infection. Many procedures in the gastrointestinal motility laboratory may be considered moderate to high-risk for viral transmission. Healthcare staff ...
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Lyon Consensus: Does It Differ From the Previous Ones?
Authors: Ghisa M, Barberio B, Savarino V, Marabotto E, Ribolsi M, Bodini G, Zingone F, Frazzoni M, Savarino E Abstract Gastroesophageal reflux disease (GERD) is a complex disorder with heterogeneous symptoms and a multifaceted pathogenetic basis, which prevent a simple diagnostic algorithm or any categorical classification. Clinical history, questionnaires and response to proton pump inhibitor (PPI) therapy are insufficient tools to make a conclusive diagnosis of GERD and further investigations are frequently required. The Lyon Consensus goes beyond the previous classifications and defines endoscopic and functional...
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Functional Dyspepsia: A Narrative Review With a Focus on Sex-Gender Differences.
In conclusion, an individualized and multicomponent approach that considers sex and gender issues might improve FD treatment and improve patient Qol, especially for women. PMID: 32606255 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Effect of Body Position on High-resolution Esophageal Manometry Variables and Final Manometric Diagnosis.
Authors: Riva CG, Siboni S, Ferrari D, Sozzi M, Capuzzo M, Asti E, Ogliari C, Bonavina L Abstract Background/Aims: According to the Chicago classification version 3.0, high-resolution manometry (HRM) should be performed in the supine position. However, with the patient in the upright/sitting position, the test could more closely simulate real-life behavior and may be better tolerated. We performed a systematic review of the literature to search whether the manometric variables and the final diagnosis are affected by positional changes. Methods: A literature search was conducted according to the Preferred Report...
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Performing High-resolution Impedance Manometry After Endoscopy With Conscious Sedation Has Negligible Effects on Esophageal Motility Results.
Conclusions: Performing HRIM after endoscopy with conscious sedation had minimal clinical impact on the motility diagnosis or motility parameters. Thus, this approach may be a viable alternative for patients who cannot tolerate unsedated catheter placement. PMID: 32606257 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Multichannel Intraluminal Impedance and pH Monitoring: A Step Towards Pediatric Reference Values.
Authors: Cresi F, Cester EA, Salvatore S, De Rose DU, Ripepi A, Magistà AM, Fontana C, Maggiora E, Coscia A, Francavilla R, Cristofori F Abstract Background/Aims: Combined multichannel intraluminal impedance and pH monitoring (MII/pH) is considered the most accurate test to detect gastroesophageal reflux (GER), however lacking reference values. We aim to determine reference values for the pediatric population and to correlate these values with age and postprandial/fasting period. Methods: We evaluated MII/pH traces from patients (newborns, infants, and children) admitted to 3 Italian hospitals and who un...
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Assessment of Pyloric Sphincter Physiology Using Functional Luminal Imaging Probe in Healthy Volunteers.
Authors: Jagtap N, Kalapala R, Reddy DN Abstract Background/Aims: The functional luminal imaging probe (FLIP) can measure tissue distensibility and geometric changes through volumetric distention. The esophagogastric junction has been well studied using EndoFLIP, studies on pylorus are lacking. We aim to study biomechanical properties of pylorus using EndoFLIP to create normative data. Methods: We performed a prospective study of 20 healthy volunteers (ages, 18-54 years; 10 men) who underwent pylorus evaluation using 12- cm FLIP placed across the pyloric sphincter. FLIP data were analyzed using FLIP planimetry ...
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

EphrinA1/EphA2 Promotes Epithelial Hyperpermeability Involving in Lipopolysaccharide-induced Intestinal Barrier Dysfunction.
Conclusion: EphrinA1/ephA2 promotes epithelial hyperpermeability with an ERK1/2-dependent pathway, which involves in LPS-induced intestinal barrier dysfunction. PMID: 32606260 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Minimally Invasive Gastric Electrical Stimulation Using a Newly Developed Wireless Gastrostimulator: A Pilot Animal Study.
Conclusions: GES is feasible with our minimally invasive wireless device. This technique has the potential to increase utilization of GES as a treatment alternative. PMID: 32606261 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Can We Apply the Salivary Pepsin Test for Patients With Gastroesophageal Reflux Disease in Primary Practice?
Authors: Lee TH PMID: 32606262 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 2, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Usefulness of Esophageal Baseline Impedance Levels for the Diagnosis of Nonerosive Reflux Disease and the Proper Time for Measurement in Endoscopy-negative Korean Patients With Esophageal or Supraesophageal Symptoms.
Conclusion: The BILs of the distal esophagus measured at time points before or after night bedtime appear to be useful for the diagnosis of NERD, but not for the diagnosis of RH, in endoscopy-negative Korean patients with esophageal or supraesophageal symptoms. PMID: 32595173 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 1, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Spontaneous Internal Anal Sphincter Relaxation During High-resolution Anorectal Manometry Is Associated With Peripheral Neuropathy and Higher Charlson Comorbidity Scores in Patients With Defecatory Disorders.
Authors: Lee TH, Lee JS, Kim J, Kim JO, Kim HG, Jeon SR, Hong SJ, Cho YS, Park S Abstract Background/Aims: We aim to evaluate associations between comorbidities, peripheral neuropathy, and spontaneous internal anal sphincter relaxation (SAR) in patients with defecatory disorders. Methods: A patient is considered to exhibit SAR during high-resolution anorectal manometry (HR-ARM) when the nadir pressure is
Source: Journal of Neurogastroenterology and Motility - May 16, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pHimpedance Monitoring.
Authors: Horton A, Sullivan B, Charles K, McIntosh T, Davis A, Gellad Z, Shimpi R, Gyawali CP, Patel A Abstract Background/Aims: Esophageal baseline impedance (BI) can be extracted from pH-impedance tracings as mean nocturnal baseline impedance (MNBI), and from high-resolution impedance manometry (HRIM), but it is unknown if values are similar between acquisition methods across HRIM manufacturers. We aim to assess correlations between MNBI and BI from HRIM (BI-HRIM) from 2 HRIM manufacturers in the setting of physiologic acid exposure time (AET). Methods: HRIM and pH-impedance monitoring demonstrating physiologic AET (
Source: Journal of Neurogastroenterology and Motility - May 12, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Prevalence of Disaccharidase Deficiency in Adults With Unexplained Gastrointestinal Symptoms.
Conclusions: Isolated disaccharidase deficiency occurs in adults, usually lactase and rarely maltase. Pandisaccharidase deficiency is rare. Baseline symptoms or its severity did not predict enzyme deficiency. LBT has good specificity and diagnostic agreement with lactase assay and may be more cost-effective. In adults with refractory gastrointestinal symptoms, disaccharidase testing detects enzyme deficiency in approximately one-half of patients and can aid diagnosis and management. PMID: 32380581 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - May 9, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Factors of Reflux Episodes with Post-reflux Swallow-induced Peristaltic Wave in Gastroesophageal Reflux Disease.
Conclusions: The role of acid seems to be less important in a reflux episode inducing a PSPW. Proximal reflux episodes are more likely to induce a PSPW. The depression of volume clearance may also be an important factor in eliciting a PSPW. PMID: 32344502 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - May 1, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Distal Esophageal Impedance Measured by High-resolution Esophageal Manometry With Impedance Suggests the Presence Barrett's Esophagus.
Authors: Kataria R, Rosenfeld B, Malik Z, Harrison M, Smith MS, Schey R, Parkman HP Abstract Background/Aims: Barrett's esophagus (BE) is characterized by intestinal metaplasia in the distal esophagus. The aims of this study are to: (1) Compare baseline distal esophageal impedance (DEI) using high-resolution esophageal manometry with impedance (HREMI) in patients with BE, esophagitis, and healthy volunteers, and (2) Correlate length of low impedance on HREMI in patients with BE to the length of endoscopic BE. Methods: Patients with BE or esophagitis who underwent HREMI were included. Ten volunteers had HREMI. B...
Source: Journal of Neurogastroenterology and Motility - April 25, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Transient Receptor Potential Canonical 4 and 5 Channel Antagonist ML204 Depolarized Pacemaker Potentials of Interstitial Cells of Cajal.
Conclusions: The results implied that ML204 could not inhibit the pacemaker activity but depolarized the membrane potential of ICCs by regulating intracellular Ca2+ oscillations and anoctamin 1 channels. PMID: 32321198 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 23, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Role of the Rapid Drink Challenge Test in Esophageal Motility Disorder Diagnosis.
Authors: Hsing LC, Jung KW PMID: 32235024 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Cost-effective Management of Severe Gastroesophageal Reflux Disease: Toward an Improved Understanding of Anti-reflux Surgery.
Authors: Park CH PMID: 32235025 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Exploring Esophageal Microbiomes in Esophageal Diseases: A Systematic Review.
Authors: Park CH, Lee SK Abstract Studies that investigated esophageal microbiomes are limited when compared to those on intestinal microbiomes. Nevertheless, several studies have investigated the relationship between esophageal microbiomes and various esophageal diseases, owing to the advancement of next-generation sequencing techniques. Streptococcus is the most common bacterial taxon in a normal esophagus. Additionally, Haemophilus, Neisseria, Prevotella, and Veillonella are also found. However, gram-negative bacteria, including Prevotella, are more abundant in a diseased esophagus, such as in gastroesophageal r...
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

2019 Seoul Consensus on Esophageal Achalasia Guidelines.
Authors: Jung HK, Hong SJ, Lee OY, Pandolfino J, Park H, Miwa H, Ghoshal UC, Mahadeva S, Oshima T, Chen M, Chua ASB, Cho YK, Lee TH, Min YW, Park CH, Kwon JG, Park MI, Jung K, Park JK, Jung KW, Lim HC, Jung DH, Kim DH, Lim CH, Moon HS, Park JH, Choi SC, Suzuki H, Patcharatrakul T, Wu JCY, Lee KJ, Tanaka S, Siah KTH, Park KS, Kim SE, Korean Society of Neurogastroenterology and Motility Abstract Esophageal achalasia is a primary motility disorder characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis. Achalasia is a chronic disease that causes progressive irreversible l...
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Anti-reflux Surgery Versus Proton Pump Inhibitors for Severe Gastroesophageal Reflux Disease: A Cost-Effectiveness Study in Korea.
Conclusions: This study showed anti-reflux surgery was less expensive and more effective therapy over the PPI medication after 9 years of follow-up. This suggests the surgical strategy is a cost-effective alternative to PPI medication among patients who need long-term management for GERD in Korea. PMID: 32235028 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Gastroesophageal Reflux Disease Is Not Associated With Jackhammer Esophagus: A Case-control Study.
Conclusions: Pathologic acid exposure does not appear to be associated with JE. JE patients had increased CCB and LABA use. The unexpected finding of increased LABA use warrants more investigation and may provide support for a cholinergic etiology of JE. PMID: 32235029 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Mosapride Improves Lower Esophageal Sphincter and Esophageal Body Function in Patients With Minor Disorders of Esophageal Peristalsis.
This study evaluates the effect of mosapride in patients with minor peristaltic disorders. Methods: This study prospectively enrolled 21 patients with esophageal symptoms who were diagnosed with minor peristaltic disorders by gastroscopy and HRM using the Chicago classification version 3.0. Patients received mosapride 30 mg daily for 2 weeks. Symptoms were assessed using the abbreviated World Health Organization quality of life scale (WHOQOL-BREF) and a HRM study was performed before and after 2 weeks of treatment. Results: HRM metrics of lower esophageal sphincter (LES) respiratory mean pressure (median 14.6 mmHg ...
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Measurement of Esophageal Nocturnal Baseline Impedance: A Simplified Method.
Authors: Hoshikawa Y, Sawada A, Sonmez S, Nikaki K, Woodland P, Yazaki E, Sifrim D Abstract Background/Aims: Mean nocturnal baseline impedance (MNBI) during multichannel intraluminal impedance pH-monitoring (MII-pH) reflects the status of esophageal mucosal integrity. MNBI is suggested as an adjunctive method to distinguish patients with true gastroesophageal reflux disease (GERD) from functional heartburn (FH) and might predict outcomes for anti-reflux treatment. However, current methodology for calculation of MNBI is time-consuming and subject to operator-dependent selection bias. We aim to simplify and provide a...
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex.
Conclusions: H. pylori can affect a variety of TJPs, particularly claudin-4 and occludin. Claudin-2 is thought to be involved in FD irrespective of H. pylori status, especially in the pathophysiology of male FD. PMID: 32235032 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Efficacy and Safety of Clidinium/Chlordiazepoxide as an Add-on Therapy in Functional Dyspepsia: A Randomized, Controlled, Trial.
Authors: Puasripun S, Thinrungroj N, Pinyopornpanish K, Kijdamrongthum P, Leerapun A, Chitapanarux T, Thongsawat S, Praisontarangkul OA Abstract Background/Aims: The treatment of refractory functional dyspepsia (FD) is a challenge. Clidinium/chlordiazepoxide is a combination of antispasmodic and anxiolytic drugs that has been used as an adjunct treatment for FD in clinical practice with limited supporting evidence of efficacy. The aim of the study is to assess the efficacy and safety of clidinium/chlordiazepoxide as an adjunct treatment to a proton pump inhibitor (PPI) in refractory dyspepsia. Methods: We perfo...
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Atopic Patients Who Fulfilled Rome III Criteria for Irritable Bowel Syndrome Had Higher Animal Danders Sensitization.
Authors: Siah KTH, Santosa A, Cheung CKY, Soh AYS, Bigliardi PL Abstract Background/Aims: The relationship between animal exposure and irritable bowel syndrome (IBS) is debated. Epidemiological studies have shown that atopy is more prevalent in IBS patients and vice versa. We set out to examine the association between animal danders sensitization and IBS-like symptoms in atopic patients. Methods: We recruited 69 consecutive atopic patients from the allergy clinic of a tertiary hospital. Subjects completed validated bowel questionnaires, underwent skin prick test, blood was collected for serum total immunoglobul...
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Psychosocial Factors Linked and Associated to Irritable Bowel Syndrome.
Authors: Chen M, Ye X PMID: 32235035 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Injury of Partial Colon Obstruction in Colonic Interstitial Cells With/Without Interstitial Cells of Cajal.
Authors: Lv J, Xia M, Zhou Z, Hu Z PMID: 32235036 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 4, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

High-resolution Manometry Determinants of Refractoriness of Reflux Symptoms to Proton Pump Inhibitor Therapy.
Authors: Ribolsi M, Savarino E, Rogers B, Rengarajan A, Coletta M, Ghisa M, Cicala M, Gyawali CP Abstract Background/Aims: Impaired esophageal motility and disrupted esophagogastric junction (EGJ) on highresolution manometry (HRM) have been associated with increased reflux severity in gastroesophageal reflux disease (GERD) patients. However, there are limited data evaluating HRM parameters in proton pump inhibitors (PPI) non-responders. Methods: Clinical and endoscopic data, HRM and multichannel intraluminal impedance-pH studies performed of PPI therapy in patients with typical GERD symptoms were reviewed from ...
Source: Journal of Neurogastroenterology and Motility - March 5, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Characteristics of a Subset of Achalasia With Normal Integrated Relaxation Pressure.
Conclusions: Patients with achalasia of normal IRP value were older and had longer disease duration and higher distensibility index and cross-sectional area than patients with achalasia with abnormal relaxation of lower esophageal sphincter. Therapeutic outcomes were not different between the 2 groups. PMID: 32102139 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - February 29, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Role of Rapid Drink Challenge During Esophageal High-resolution Manometry in Predicting Outcome of Peroral Endoscopic Myotomy in Patients With Achalasia.
Authors: Foisy H, Pioche M, Chabrun E, Ponchon T, Zerbib F, Rivory J, Mion F, Roman S Abstract Background/Aims: Peroral endoscopy myotomy (POEM) is effective to treat achalasia. We aim to determine POEM effect on esophageal function and search for predictive factors of response to POEM and co-occurrence of gastroesophageal reflux disease (GERD). Methods: A total of 64 untreated achalasia patients who underwent high-resolution manometry (HRM) before and 3 months after POEM were retrospectively included. Response to treatment was defined as an Eckardt score
Source: Journal of Neurogastroenterology and Motility - February 8, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Can Ultrasonographic Measurements of Gastric Motility Identify Pathophysiological Abnormalities of Functional Dyspepsia and Irritable Bowel Syndrome?
Authors: Lee HS PMID: 31917911 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 10, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Find Out the Differences by Types of Hiatal Hernia!
Authors: Cha RR PMID: 31917912 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 10, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Clinical Practice Guidelines for Functional Dyspepsia in Korea.
Authors: Oh JH, Kwon JG, Jung HK, Tae CH, Song KH, Kang SJ, Kim SE, Jung K, Kim JS, Park JK, Bang KB, Baeg MK, Shin JE, Shin CM, Lee JY, Lim HC, Functional Dyspepsia Research Group and Clinical Practice Guidelines Group Under the Korean Society of Neurogastroenterology and Motility Abstract Functional dyspepsia (FD) is a chronic upper gastrointestinal (GI) symptom complex that routine diagnostic work-up, such as endoscopy, blood laboratory analysis, or radiological examination, fails to identify a cause. It is highly prevalent in the World population, and its response to the various available therapeutic strategies...
Source: Journal of Neurogastroenterology and Motility - January 10, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Normative Values for Esophageal Motility Assessed in the Physiological Seated Position for 16-Channel Water Perfused High-resolution Esophageal Manometry System and Postural Variations in Healthy Volunteers.
Authors: Srinivas M, Jain M, Bawane P, Jayanthi V Abstract Background/Aims: Consensus guidelines for performance and analysis of high-resolution esophageal manometry (HREM) recommend use of equipment, population and posture specific normative values. To provide normative values for Chicago classification (CC) metrics in the physiological seated position for a 16-channel water perfused system (Dentsleeve HREM catheter, Advanced Manometry Systems, Melbourne, Australia) widely used in India and other countries with limited access to solid-state equipment. The results are compared with published CC metrics in supine po...
Source: Journal of Neurogastroenterology and Motility - January 10, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Postprandial Symptoms in Patients With Functional Dyspepsia and Irritable Bowel Syndrome: Relations to Ultrasound Measurements and Psychological Factors.
Authors: Steinsvik EK, Valeur J, Hausken T, Gilja OH Abstract Background/Aims: Dyspeptic symptoms are common in patients with functional gastrointestinal (GI) disorders, and may be related to visceral hypersensitivity. We aim to explore the relation between visceral hypersensitivity by using an ultrasonographic meal test and questionnaires in patients with irritable bowel syndrome (IBS) and/or functional dyspepsia (FD). Methods: Patients (FD, n = 94; IBS, n = 88; IBS + FD, n = 66, healthy controls [HC], n = 30) were recruited consecutively and examined with ultrasound of the proximal and distal stomach after dr...
Source: Journal of Neurogastroenterology and Motility - January 10, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Effect of Phloroglucinol in Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled Trial.
Conclusions: Phloroglucinol could be a safe and beneficial option for the management of overall IBS symptoms in patients with IBS-D. Further large scaled studies are warranted. PMID: 31917916 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 10, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

A Novel Approach in Spinal Cord Stimulation for Enhancing Gastric Motility: A Preliminary Study on Canines.
Conclusions: SCS with optimized stimulation location and parameters improves gastric motility in healthy-dogs and accelerates gastric emptying impaired by glucagon via enhancing vagal activity. PMID: 31917917 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 10, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Progression of Jackhammer Esophagus to Type III Achalasia and Improvement After Extended Myotomy.
Authors: Vázquez García P, Ciriza de Los Ríos C, Canga Rodríguez-Valcárcel F, Hernández García-Gallardo D PMID: 31917918 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 10, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Morphologic Restoration After Peroral Endoscopic Myotomy in Sigmoid-type Achalasia.
Authors: Yoon HJ, Lee JE, Jung DH, Park JC, Youn YH, Park H Abstract Background/Aims: Achalasia is a chronic, progressive motility disorder of the esophagus. The sigmoid-type achalasia is an advanced stage of achalasia characterized by severe dilatation and tortuous angulation of the esophageal body. Peroral endoscopic myotomy (POEM) has been reported to provide excellent clinical outcomes for achalasia, including the sigmoid type, but the restoration of esophageal morphology and function remain poorly described. The aim of our study is to investigate esophageal restoration after POEM for sigmoid-type achalasia. ...
Source: Journal of Neurogastroenterology and Motility - December 24, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

A Unique Case of Non-Cardiac Chest Pain Caused by Mepolizumab: Case Report and Review of the Literature.
Authors: Korbitz PM, Gallagher JP, Md NB, Md WM PMID: 31760716 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - November 27, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research