Regulatory T cells Are Increased and Correlate With Mast Cells in Eosinophilic Esophagitis
CONCLUSIONS: Tregs were increased in esophageal epithelium of patients with EoE, and correlated with mast cell infiltration.PMID:38173156 | DOI:10.5056/jnm23040 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Junji Chen Tadayuki Oshima Toshihiko Tomita Hirokazu Fukui Shinichiro Shinzaki Source Type: research

Effects of Codeine on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility: Studies Using High-resolution Manometry
CONCLUSIONS: In IEM patients, acute administration of codeine increases contraction vigor and reduces distal latency of primary esophageal peristalsis, but has no effect on secondary peristalsis. Future studies are required to further elucidate clinical relevance of these findings, especially in the setting of gastroesophageal reflux disease with IEM.PMID:38173157 | DOI:10.5056/jnm22131 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Wei-Yi Lei Tso-Tsai Liu Wei-Chuan Chang Chih-Hsun Yi Jui-Sheng Hung Ming-Wun Wong Shu-Wei Liang Lin Lin Chien-Lin Chen Source Type: research

Interpretation of Impedance Data on High-resolution Impedance Manometry Studies-A Worldwide Survey
CONCLUSIONS: There is no consensus on interpreting HRIM data. Providers' approaches to studies with inconsistencies between manometry and impedance data vary. There is an unmet need for guidelines on interpreting impedance data in HRIM studies.PMID:38173158 | DOI:10.5056/jnm23057 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Lev Dorfman Sherief Mansi Khalil El-Chammas Chunyan Liu Ajay Kaul Source Type: research

The Disease Spectrum and Natural History of Patients With Abdominal Bloating or Distension: A Longitudinal Study
CONCLUSIONS: FGIDs are the most common diagnosis in patients with AB/D. Symptoms were especially hard to be improved. Classification diagnoses of FGIDs in AB/D patients fluctuated significantly over time.PMID:38173159 | DOI:10.5056/jnm22197 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Fangfei Chen Niandi Tan Songfeng Chen Qianjun Zhuang Mengyu Zhang Yinglian Xiao Source Type: research

Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study
CONCLUSIONS: gQlab administration can improve the overall IBS symptoms, especially in female and constipation-predominant IBS patients. Further research is necessary to clarify the pathophysiology behind sex-related treatment responses in IBS patients.PMID:38173160 | DOI:10.5056/jnm23036 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Young Hoon Chang Yoon Jin Choi Cheol Min Shin Jin Seok Moon Tae-Yoon Kim Hyuk Yoon Young Soo Park Nayoung Kim Dong Ho Lee Source Type: research

Relationship Between Colonic Transit Response to Eating With Self-reported Constipation Severity in Constipated Patients According to the Phenotype
CONCLUSION: Colonic transit response to eating was not associated to CS in IBS-C patients, but left CTRE was associated with constipation severity in FC and DD patients.PMID:38173161 | DOI:10.5056/jnm21091 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: David Deutsch Michel Bouchoucha Julien Uzan Gheorghe Airinei Jean-Marc Sabate Robert Benamouzig Source Type: research

Clinical Trial: Efficacy of Mosapride Controlled-release and Nortriptyline in Patients With Functional Dyspepsia: A Multicenter, Double-placebo, Double-blinded, Randomized Controlled, Parallel Clinical Study
CONCLUSION: Mosapride CR and nortriptyline showed similar efficacy in patients with FD regardless of the subtype. Both treatments could be equally helpful for improving quality of life and psychological well-being while also relieving dyspepsia.PMID:38173162 | DOI:10.5056/jnm23147 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Chung Hyun Tae Ra Ri Cha Jung-Hwan Oh Tae-Guen Gweon Jong Kyu Park Ki Bae Bang Kyung Ho Song Cheal Wung Huh Ju Yup Lee Cheol Min Shin Jong Wook Kim Young Hoon Youn Joong Goo Kwon Functional Dyspepsia Research Group under the Korean Society of Neurogastroe Source Type: research

Can Small Fiber Neuropathy Explain the Overlap Gastrointestinal and Non-gastrointestinal Symptoms in Some Irritable Bowel Syndrome Patients?
J Neurogastroenterol Motil. 2024 Jan 30;30(1):116-118. doi: 10.5056/jnm23039.NO ABSTRACTPMID:38173163 | DOI:10.5056/jnm23039 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Amanda C Y Chan Kewin T H Siah Source Type: research

Tagging an Air Swallow From the Bottom →Up Is More Efficient Than From the Top→Down
J Neurogastroenterol Motil. 2024 Jan 30;30(1):119-120. doi: 10.5056/jnm23163.NO ABSTRACTPMID:38173164 | DOI:10.5056/jnm23163 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Frederick W Woodley Source Type: research

Editing Multichannel Intraluminal Impedance-pH Tracings to Reduce Non-reflux-related Esophageal Acidification
J Neurogastroenterol Motil. 2024 Jan 30;30(1):121-122. doi: 10.5056/jnm23164.NO ABSTRACTPMID:38173165 | DOI:10.5056/jnm23164 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Frederick W Woodley Source Type: research

The Need for Updated Classification of Esophageal Motility Disorders Using High-resolution Impedance Manometry
J Neurogastroenterol Motil. 2024 Jan 30;30(1):1-3. doi: 10.5056/jnm23185.NO ABSTRACTPMID:38173152 | DOI:10.5056/jnm23185 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Sung Eun Kim Source Type: research

Mind the Gap: The Realities of Novel Irritable Bowel Syndrome Drug Access in Asian Clinical Practice
J Neurogastroenterol Motil. 2024 Jan 30;30(1):4-6. doi: 10.5056/jnm23183.NO ABSTRACTPMID:38173153 | DOI:10.5056/jnm23183 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Yong Sung Kim Tadayuki Oshima Kewin T H Siah Suck Chei Choi Source Type: research

Symptomatic Response to Antibiotics in Patients With Small Intestinal Bacterial Overgrowth: A Systematic Review and Meta-analysis
CONCLUSIONS: Antibiotics appear to be efficacious in treating SIBO, although small sample sizes and poor data quality limit this interpretation. Symptomatic response rates also appear to be higher in IBS patients with SIBO. This may be the first example of precision medicine in IBS as opposed to our current empiric treatment approach. Large-multicenter studies are needed to verify the results.PMID:38173154 | DOI:10.5056/jnm22187 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Will Takakura Ali Rezaie William D Chey Jiajing Wang Mark Pimentel Source Type: research

Refractory Gastroesophageal Reflux Disease: Diagnosis and Management
J Neurogastroenterol Motil. 2024 Jan 30;30(1):17-28. doi: 10.5056/jnm23145.ABSTRACTGastroesophageal reflux disease (GERD) is common, with increasing worldwide disease prevalence and high economic burden. A significant number of patients will remain symptomatic following an empiric proton pump inhibitor (PPI) trial. Persistent symptoms despite PPI therapy are often mislabeled as refractory GERD. For patients with no prior GERD evidence (unproven GERD), testing is performed off antisecretory therapy to identify objective evidence of pathologic reflux using criteria outlined by the Lyon consensus. In proven GERD, differentiat...
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Trevor A Davis C Prakash Gyawali Source Type: research

Regulatory T cells Are Increased and Correlate With Mast Cells in Eosinophilic Esophagitis
CONCLUSIONS: Tregs were increased in esophageal epithelium of patients with EoE, and correlated with mast cell infiltration.PMID:38173156 | DOI:10.5056/jnm23040 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - January 4, 2024 Category: Gastroenterology Authors: Junji Chen Tadayuki Oshima Toshihiko Tomita Hirokazu Fukui Shinichiro Shinzaki Source Type: research