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Comparative Study of the Efficacy and Side Effects of Brand-Name and Generic Clozapine for Long-Term Maintenance Treatment Among Korean Patients With Schizophrenia: A Retrospective Naturalistic Mirror-Image Study
CONCLUSION: Clinical efficacy and tolerability appear comparable when switching to Clzapine during clozapine maintenance treatment. This study offers descriptive real-world clinical insights into clozapine maintenance treatment in Korea, thereby providing patients with more treatment options and contributing to the development of maintenance guidelines tailored to the Korean population.PMID:38569589 | PMC:PMC10990625 | DOI:10.30773/pi.2023.0413 (Source: Psychiatry Investigation)
Source: Psychiatry Investigation - April 3, 2024 Category: Psychiatry Authors: Nuree Kang Hee-Soo Yoon Se Hyun Kim Jae Hoon Jeong Minah Kim Jun Soo Kwon Source Type: research

Colorectal cancer disease profile and treatment patterns at an urban tertiary hospital in Rwanda
CONCLUSION: CRC patients presented at an advanced stage and required complex treatment regimens at KFH. Further epidemiologic and molecular research is needed to characterise CRC incidence and presentation at a national level in Rwanda as increasing westernisation continues to change the face of CRC in urban areas of SSA.PMID:38566760 | PMC:PMC10984839 | DOI:10.3332/ecancer.2024.1687 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - April 3, 2024 Category: Cancer & Oncology Authors: Margaret Baldwin Brandon A Niyibizi Daniella Rangira Benita Rangira Madeleine K Kazindu Daniel Seifu Cristina Daniela Stefan Eulade Rugengamanzi Achille V C Manirakiza Source Type: research

Intertrochanteric (Reverse Oblique) Fracture Subclassifications AO/OTA 31-A3 Have No Effect on Outcomes or Postoperative Complications
CONCLUSIONS: Based on the findings of this study, no significant differences were observed between the groups, indicating that the subclassifications of AO/OTA 31-A3 fractures do not have a significant impact on surgical outcomes or the occurrence of postoperative complications.PMID:38562635 | PMC:PMC10973612 | DOI:10.4055/cios23204 (Source: Clinics in Orthopedic Surgery)
Source: Clinics in Orthopedic Surgery - April 2, 2024 Category: Orthopaedics Authors: Shai Factor Etay Elbaz Efi Kazum Itay Pardo Samuel Morgan Tomer Ben-Tov Amal Khoury Yaniv Warschawski Source Type: research

Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in Type 2 Diabetes
CONCLUSIONS HbA1c and NLR emerge as noteworthy risk indicators associated with the manifestation of DPN in patients with type 2 diabetes. The combined detection of HbA1c and NLR exhibits a heightened predictive value for the development of DPN.PMID:38561932 | DOI:10.12659/MSM.942509 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 2, 2024 Category: Research Authors: Bo Lou Yu-Lan Hu Zhong-Hua Jiang Source Type: research

Health Disparities in Patients With Musculoskeletal Injuries: Food Insecurity Is a Common and Clinically Challenging Problem
CONCLUSION: Food insecurity is common among patients who have experienced orthopaedic trauma, and patients who have it may be at increased risk of superficial infections after surgery. Future research in this area should focus on defining these health disparities further and interventions that could address them.LEVEL OF EVIDENCE: Level III, therapeutic study.PMID:38564799 | DOI:10.1097/CORR.0000000000003055 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - April 2, 2024 Category: Orthopaedics Authors: Loc-Uyen T Vo Luke Verlinsky Sohan Jakkaraju Ana S Guerra Boris A Zelle Source Type: research

Comparing the Effect of Early Versus Delayed Metformin Treatment on Glycaemic Parameters Among Australian Adults With Incident Diabetes: Evidence Using a National General Practice Database
Clin Ther. 2024 Apr 1:S0149-2918(24)00067-5. doi: 10.1016/j.clinthera.2024.03.001. Online ahead of print.ABSTRACTPURPOSE: To compare the effect of early vs delayed metformin treatment for glycaemic management among patients with incident diabetes.METHODS: Cohort study using electronic health records of regular patients (1+ visits per year in 3 consecutive years) aged 40+ years with 'incident' diabetes attending Australian general practices (MedicineInsight, 2011-2018). Patients with incident diabetes were defined as those who had a) 12+ months of medical data before the first recording of a diabetes diagnosis AND b) a diag...
Source: Clinical Therapeutics - April 2, 2024 Category: Drugs & Pharmacology Authors: Mingyue Zheng Mumtaz Begum Carla De Oliveira Bernardo Nigel Stocks David Gonzalez-Chica Source Type: research