Post-Stroke Depression in Older Adults: An Overview
AbstractDetailed data on post-stroke depression (PSD) in older adults are limited in spite of the high vulnerability of this population to stroke. In fact, PSD prevalence in older adults ranges from 16.0 to 43.9%; however, timing and instruments of evaluation often differ significantly across all available studies. The etiology, genetic and inflammatory factors, as well as structural brain alterations, are claimed as part of a multifaceted mechanism of action in PSD onset. Thus, the aim of this narrative review was to further elaborate on the prevalence, etiology, diagnosis, consequences and treatment of PSD in older adult...
Source: Drugs and Aging - February 23, 2024 Category: Geriatrics Source Type: research
Identification of Potentially Repurposable Drugs for Lewy Body Dementia Using a Network-Based Approach
AbstractThe conventional method of one drug being used for one target has not yielded therapeutic solutions for Lewy body dementia (LBD), which is a leading progressive neurological disorder characterized by significant loss of neurons. The age-related disease is marked by memory loss, hallucinations, sleep disorder, mental health deterioration, palsy, and cognitive impairment, all of which have no known effective cure. The present study deploys a network medicine pipeline to repurpose drugs having considerable effect on the genes and proteins related to the diseases of interest. We utilized the novel SAveRUNNER algorithm ...
Source: Journal of Molecular Neuroscience - February 16, 2024 Category: Neuroscience Source Type: research
The Relevance of Integrating CYP2C19 Phenoconversion Effects into
Clinical Pharmacogenetics
Discussion PC of CYP2C19 changes phenotypes but does not improve
correlations with serum concentrations. However, only a limited number of
patients received perturbators of CYP2C19. Studies with large numbers of
patients are still lacking, and thus, it cannot be decided if there are minor
differences and which method of correction to use. For the time being, PC is
relevant in individual patients treated with CYP2C19-affecting drugs, for
example, esomeprazole. To ensure adequate serum concentrations in these
patients, this study suggests the use of therap...
Source: Pharmacopsychiatry - February 14, 2024 Category: Psychiatry Authors: Scherf-Clavel, Maike Weber, Heike Unterecker, Stefan Frantz, Amelie Eckert, Andreas Reif, Andreas Deckert, J ürgen Hahn, Martina Tags: Original Paper Source Type: research
The place of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depressive disorders in children and adolescents. Recommendations of the Main Board of the Polish Psychiatric Association. Part 2 - pharmacological properties and safety of use
Psychiatr Pol. 2023 Oct 31;57(5):917-940. doi: 10.12740/PP/171464. Epub 2023 Oct 31.ABSTRACTThe aim of the study was to review studies evaluating the pharmacodynamic properties of selective serotonin reuptake inhibitors (SSRIs) and their safety. SSRIs in patients <18 years of age sometimes have different pharmacokinetic parameters compared to adults, which has a significant impact on their effectiveness and tolerance. The concentration of fluoxetine, fluvoxamine or paroxetine is about 2 times higher in children compared to adolescents and adults, which should be taken into account at the stage of both drug introduction ...
Source: Psychiatria Polska - February 12, 2024 Category: Psychiatry Authors: Ma łgorzata Honorata Janas-Kozik Agnieszka S łopień Barbara Remberk Marcin Siwek Source Type: research
Molecules, Vol. 29, Pages 676: Direct Immersion & ndash;Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood disorders, including amitriptyline, citalopram, fluoxetine, paroxetine, sertraline, trazodone, duloxetine, venlafaxine, lamotrigine, quetiapine, olanzapine, and mirtazapine. The analysis is carried out using high-performance liquid chromatography coupled with mass spectroscopy. The proposed DI-SPME/LC-MS method allows for a simple and quick sc...
Source: Molecules - January 31, 2024 Category: Chemistry Authors: Magdalena Świądro-Piętoń Dominika Dudek Renata Wietecha-Pos łuszny Tags: Article Source Type: research
CYP2D6 Phenotype Influences Pharmacokinetic Parameters of Venlafaxine: Results from a Population Pharmacokinetic Model in Older Adults with Depression
In this study, we aimed to improve upon a published population pharmacokinetic (PK) model for venlafaxine (VEN) in the treatment of depression in older adults, then investigate whether CYP2D6 metabolizer status affected model-estimated PK parameters of VEN and its active metabolite O-desmethylvenlafaxine. The model included 325 participants from a clinical trial in which older adults with depression were treated with open-label VEN (maximum 300 mg/day) for 12 weeks and plasma levels of VEN and O-desmethylvenlafaxine were assessed at weeks 4 and 12. We fitted a nonlinear mixed-effect PK model using NONMEM to estimate PK par...
Source: Clinical Pharmacology and Therapeutics - January 29, 2024 Category: Drugs & Pharmacology Authors: Xiaoyu Men Zachary L Taylor Victoria S Marshe Daniel M Blumberger Jordan F Karp James L Kennedy Eric J Lenze Charles F Reynolds Cristiana Stefan Benoit H Mulsant Laura B Ramsey Daniel J M üller Source Type: research
Suicidality Emerging From Rapid Venlafaxine Discontinuation: A Challenge-Dechallenge-Rechallenge Case Report
J Clin Psychiatry. 2024 Jan 22;85(1):23cr14930. doi: 10.4088/JCP.23cr14930.NO ABSTRACTPMID:38270549 | DOI:10.4088/JCP.23cr14930 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 25, 2024 Category: Psychiatry Authors: Milutin Kostic Martin Pl öderl Michael Hengartner Jelena Buzejic Source Type: research
Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals
ConclusionThe age-related increase in C/D ratio starts in middle-aged adults and progresses up to more than twofold higher C/D ratio in the oldest old. Sertraline seems to be less prone to age-related changes in C/D ratio than the other antidepressants. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 10, 2024 Category: Drugs & Pharmacology Source Type: research
Retrospective analysis of venlafaxine-induced hypoglycemia in patients with overdose
CONCLUSIONS: The detection of hypoglycemia in a VLX overdose case is a readily available marker to suspect the severity of the patient. In any case, serum concentrations when available allow us to confirm intoxication.PMID:38182480 | DOI:10.1016/j.medcli.2023.11.002 (Source: Medicina Clinica)
Source: Medicina Clinica - January 5, 2024 Category: General Medicine Authors: Isabel Gomila Mu ñiz Lorenzo Socias Cresp í Jordi Puiguriguer Ferrando Alexandra M Guiu Marti Miguel Ángel Elorza Guerrero Bernardino Barcel ó Martín Source Type: research
