Use of sawdust for production of ligninolytic enzymes by white-rot fungi and pharmaceutical removal
Bioprocess Biosyst Eng. 2024 Mar 14. doi: 10.1007/s00449-024-02976-8. Online ahead of print.ABSTRACTUse of white-rot fungi for enzyme-based bioremediation of wastewater is of high interest. These fungi produce considerable amounts of extracellular ligninolytic enzymes during solid-state fermentation on lignocellulosic materials such as straw and sawdust. We used pure sawdust colonized by Pleurotus ostreatus, Trametes versicolor, and Ganoderma lucidum for extraction of ligninolytic enzymes in aqueous suspension. Crude enzyme suspensions of the three fungi, with laccase activity range 12-43 U/L and manganese peroxidase activ...
Source: Bioprocess and Biosystems Engineering - March 14, 2024 Category: Biomedical Engineering Authors: M Hultberg O Golovko Source Type: research
Sertraline versus venlafaxine combined with psychotherapy in trauma-affected refugees - a follow-up study on a pragmatic randomised trial
CONCLUSIONS: No conclusions could be drawn due to conflicting results between our intention-to-treat and per-protocol analyses.PMID:38451197 | DOI:10.1080/08039488.2024.2324357 (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - March 7, 2024 Category: Psychiatry Authors: Maria Barhoma Jessica Carlsson Charlotte Sonne Source Type: research
Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms
ConclusionsIn clinical practice, the impact of genotyping on thein vivo disposition process of VEN should be considered to ensure the safety and efficacy of treatment. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis
The objective of this ar ticle is to provide an overview of literature on pharmacological and non-pharmacological strategies employed in the management of neuropathic pain in multiple sclerosis. Pharmacological options include cannabinoids, muscle relaxants (tizanidine, baclofen, dantrolene), anticonvulsants (benzodiazepine s, gabapentin, phenytoin, carbamazepine, lamotrigine), antidepressants (duloxetine, venlafaxine, tricyclic antidepressants), opioids (naltrexone), and botulinum toxin variants, which have evidence from various clinical trials. Non-pharmacological approaches for trigeminal neuralgia may include neuro sur...
Source: CNS Drugs - February 29, 2024 Category: Neurology Source Type: research
The effects of drug-drug interaction on linezolid pharmacokinetics: A systematic review
ConclusionsThis systematic review found that numerous drugs have an impact on the pharmacokinetics of linezolid, and the purported main mechanism may be that linezolid is the substrate of P-glycoprotein. In clinical practice, it is prudent to pay attention to the changes in linezolid pharmacokinetics caused by interactions. Conducting therapeutic drug monitoring (TDM) is beneficial to improve efficacy and reduce adverse reactions of linezolid. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Source Type: research
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against.METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method. The evidence was then evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. Recommendations were made after conse...
Source: Annals of Internal Medicine - February 26, 2024 Category: Internal Medicine Authors: Paula P Schnurr Jessica L Hamblen Jonathan Wolf Rachael Coller Claire Collie Matthew A Fuller Paul E Holtzheimer Ursula Kelly Ariel J Lang Kate McGraw Joshua C Morganstein Sonya B Norman Katie Papke Ismene Petrakis David Riggs James A Sall Brian Shiner Il Source Type: research
Evaluation of pharmaceutical consumption between urban and suburban catchments in China by wastewater-based epidemiology
Environ Res. 2024 Feb 24:118544. doi: 10.1016/j.envres.2024.118544. Online ahead of print.ABSTRACTWastewater-based epidemiology (WBE) is amply used for estimating human consumption of chemicals, yet information on regional variation of pharmaceuticals and their environmental fate are scarce. Thus, this study aims to estimate the consumption of three cardiovascular, four non-steroidal anti-inflammatory pharmaceuticals (NSAIDs), and four psychoactive pharmaceuticals between urban and suburban catchments in China by WBE, and to explore their removal efficiencies and ecological risks. Eleven analytes were detected in both infl...
Source: Environmental Research - February 26, 2024 Category: Environmental Health Authors: Zongrui Li Jincheng Li Yongxia Hu Yile Yan Shaoyu Tang Ruixue Ma Liangzhong Li Source Type: research
Evaluation of pharmaceutical consumption between urban and suburban catchments in China by wastewater-based epidemiology
Environ Res. 2024 Feb 24:118544. doi: 10.1016/j.envres.2024.118544. Online ahead of print.ABSTRACTWastewater-based epidemiology (WBE) is amply used for estimating human consumption of chemicals, yet information on regional variation of pharmaceuticals and their environmental fate are scarce. Thus, this study aims to estimate the consumption of three cardiovascular, four non-steroidal anti-inflammatory pharmaceuticals (NSAIDs), and four psychoactive pharmaceuticals between urban and suburban catchments in China by WBE, and to explore their removal efficiencies and ecological risks. Eleven analytes were detected in both infl...
Source: Environmental Research - February 26, 2024 Category: Environmental Health Authors: Zongrui Li Jincheng Li Yongxia Hu Yile Yan Shaoyu Tang Ruixue Ma Liangzhong Li Source Type: research
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against.METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method. The evidence was then evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. Recommendations were made after conse...
Source: Annals of Internal Medicine - February 26, 2024 Category: Internal Medicine Authors: Paula P Schnurr Jessica L Hamblen Jonathan Wolf Rachael Coller Claire Collie Matthew A Fuller Paul E Holtzheimer Ursula Kelly Ariel J Lang Kate McGraw Joshua C Morganstein Sonya B Norman Katie Papke Ismene Petrakis David Riggs James A Sall Brian Shiner Il Source Type: research
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against.METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method. The evidence was then evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. Recommendations were made after conse...
Source: Annals of Internal Medicine - February 26, 2024 Category: Internal Medicine Authors: Paula P Schnurr Jessica L Hamblen Jonathan Wolf Rachael Coller Claire Collie Matthew A Fuller Paul E Holtzheimer Ursula Kelly Ariel J Lang Kate McGraw Joshua C Morganstein Sonya B Norman Katie Papke Ismene Petrakis David Riggs James A Sall Brian Shiner Il Source Type: research
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against.METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method. The evidence was then evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. Recommendations were made after conse...
Source: Annals of Internal Medicine - February 26, 2024 Category: Internal Medicine Authors: Paula P Schnurr Jessica L Hamblen Jonathan Wolf Rachael Coller Claire Collie Matthew A Fuller Paul E Holtzheimer Ursula Kelly Ariel J Lang Kate McGraw Joshua C Morganstein Sonya B Norman Katie Papke Ismene Petrakis David Riggs James A Sall Brian Shiner Il Source Type: research
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline
This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against.METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method. The evidence was then evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. Recommendations were made after conse...
Source: Annals of Internal Medicine - February 26, 2024 Category: Internal Medicine Authors: Paula P Schnurr Jessica L Hamblen Jonathan Wolf Rachael Coller Claire Collie Matthew A Fuller Paul E Holtzheimer Ursula Kelly Ariel J Lang Kate McGraw Joshua C Morganstein Sonya B Norman Katie Papke Ismene Petrakis David Riggs James A Sall Brian Shiner Il Source Type: research
