Interstitial pneumonia and venlafaxine use
We describe a 71-year-old woman who developed interstitial pneumonia within a complex somatic state. Diagnostic clearance suggested venlafaxine-induced interstitial pneumonia. In the literature, we found 13 cases of venlafaxine-induced interstitial pneumonia. Case reports were also described for other antidepressants. Based on these case reports, there is consensus in the literature that antidepressants may in rare cases give rise to (sub)acute or chronic interstitial pneumonia. Although a rare side effect, it seems important to be aware of this as a psychiatrist.PMID:37756030 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - September 27, 2023 Category: Psychiatry Authors: V Claerhout J De Fruyt H van den Ameele C Depuydt K Demyttenaere Source Type: research
Interstitial pneumonia and venlafaxine use
We describe a 71-year-old woman who developed interstitial pneumonia within a complex somatic state. Diagnostic clearance suggested venlafaxine-induced interstitial pneumonia. In the literature, we found 13 cases of venlafaxine-induced interstitial pneumonia. Case reports were also described for other antidepressants. Based on these case reports, there is consensus in the literature that antidepressants may in rare cases give rise to (sub)acute or chronic interstitial pneumonia. Although a rare side effect, it seems important to be aware of this as a psychiatrist.PMID:37756030 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - September 27, 2023 Category: Psychiatry Authors: V Claerhout J De Fruyt H van den Ameele C Depuydt K Demyttenaere Source Type: research
Interstitial pneumonia and venlafaxine use
We describe a 71-year-old woman who developed interstitial pneumonia within a complex somatic state. Diagnostic clearance suggested venlafaxine-induced interstitial pneumonia. In the literature, we found 13 cases of venlafaxine-induced interstitial pneumonia. Case reports were also described for other antidepressants. Based on these case reports, there is consensus in the literature that antidepressants may in rare cases give rise to (sub)acute or chronic interstitial pneumonia. Although a rare side effect, it seems important to be aware of this as a psychiatrist.PMID:37756030 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - September 27, 2023 Category: Psychiatry Authors: V Claerhout J De Fruyt H van den Ameele C Depuydt K Demyttenaere Source Type: research
Interstitial pneumonia and venlafaxine use
We describe a 71-year-old woman who developed interstitial pneumonia within a complex somatic state. Diagnostic clearance suggested venlafaxine-induced interstitial pneumonia. In the literature, we found 13 cases of venlafaxine-induced interstitial pneumonia. Case reports were also described for other antidepressants. Based on these case reports, there is consensus in the literature that antidepressants may in rare cases give rise to (sub)acute or chronic interstitial pneumonia. Although a rare side effect, it seems important to be aware of this as a psychiatrist.PMID:37756030 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - September 27, 2023 Category: Psychiatry Authors: V Claerhout J De Fruyt H van den Ameele C Depuydt K Demyttenaere Source Type: research
Interstitial pneumonia and venlafaxine use
We describe a 71-year-old woman who developed interstitial pneumonia within a complex somatic state. Diagnostic clearance suggested venlafaxine-induced interstitial pneumonia. In the literature, we found 13 cases of venlafaxine-induced interstitial pneumonia. Case reports were also described for other antidepressants. Based on these case reports, there is consensus in the literature that antidepressants may in rare cases give rise to (sub)acute or chronic interstitial pneumonia. Although a rare side effect, it seems important to be aware of this as a psychiatrist.PMID:37756030 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - September 27, 2023 Category: Psychiatry Authors: V Claerhout J De Fruyt H van den Ameele C Depuydt K Demyttenaere Source Type: research
Interstitial pneumonia and venlafaxine use
We describe a 71-year-old woman who developed interstitial pneumonia within a complex somatic state. Diagnostic clearance suggested venlafaxine-induced interstitial pneumonia. In the literature, we found 13 cases of venlafaxine-induced interstitial pneumonia. Case reports were also described for other antidepressants. Based on these case reports, there is consensus in the literature that antidepressants may in rare cases give rise to (sub)acute or chronic interstitial pneumonia. Although a rare side effect, it seems important to be aware of this as a psychiatrist.PMID:37756030 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - September 27, 2023 Category: Psychiatry Authors: V Claerhout J De Fruyt H van den Ameele C Depuydt K Demyttenaere Source Type: research
Interstitial pneumonia and venlafaxine use
We describe a 71-year-old woman who developed interstitial pneumonia within a complex somatic state. Diagnostic clearance suggested venlafaxine-induced interstitial pneumonia. In the literature, we found 13 cases of venlafaxine-induced interstitial pneumonia. Case reports were also described for other antidepressants. Based on these case reports, there is consensus in the literature that antidepressants may in rare cases give rise to (sub)acute or chronic interstitial pneumonia. Although a rare side effect, it seems important to be aware of this as a psychiatrist.PMID:37756030 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - September 27, 2023 Category: Psychiatry Authors: V Claerhout J De Fruyt H van den Ameele C Depuydt K Demyttenaere Source Type: research
Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs
Conclusion: Clinicians should monitor the adverse events associated with the concomitant use of adaptogens and antidepressant drugs in patients with mental disorders. Aggregation of side effects and pharmacokinetic interactions (inhibition of CYP and p-glycoprotein) between those medicines may result in clinically significant adverse events. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 27, 2023 Category: Drugs & Pharmacology Source Type: research
Revisiting the pK < sub > a < /sub > -Flux method for determining intrinsic membrane permeability
Eur J Pharm Sci. 2023 Sep 24:106592. doi: 10.1016/j.ejps.2023.106592. Online ahead of print.ABSTRACTIntrinsic membrane permeability is one of several factors that critically determine the intestinal absorption of a chemical. The intrinsic membrane permeability of a chemical is usually extracted from transwell experiments with Caco-2 or MDCK cells, preferably by the pKa-Flux method, which is considered the method of choice when aqueous boundary layer effects need to be excluded. The pKa-Flux method has two variants, the iso-pH method, where apical and basolateral pH are equal, and the gradient-pH method, where apical and ba...
Source: European Journal of Pharmaceutical Sciences - September 26, 2023 Category: Drugs & Pharmacology Authors: Carolin Dahley Kai-Uwe Goss Andrea Ebert Source Type: research
Revisiting the pK < sub > a < /sub > -Flux method for determining intrinsic membrane permeability
Eur J Pharm Sci. 2023 Sep 24:106592. doi: 10.1016/j.ejps.2023.106592. Online ahead of print.ABSTRACTIntrinsic membrane permeability is one of several factors that critically determine the intestinal absorption of a chemical. The intrinsic membrane permeability of a chemical is usually extracted from transwell experiments with Caco-2 or MDCK cells, preferably by the pKa-Flux method, which is considered the method of choice when aqueous boundary layer effects need to be excluded. The pKa-Flux method has two variants, the iso-pH method, where apical and basolateral pH are equal, and the gradient-pH method, where apical and ba...
Source: European Journal of Pharmaceutical Sciences - September 26, 2023 Category: Drugs & Pharmacology Authors: Carolin Dahley Kai-Uwe Goss Andrea Ebert Source Type: research
Revisiting the pK < sub > a < /sub > -Flux method for determining intrinsic membrane permeability
Eur J Pharm Sci. 2023 Sep 24:106592. doi: 10.1016/j.ejps.2023.106592. Online ahead of print.ABSTRACTIntrinsic membrane permeability is one of several factors that critically determine the intestinal absorption of a chemical. The intrinsic membrane permeability of a chemical is usually extracted from transwell experiments with Caco-2 or MDCK cells, preferably by the pKa-Flux method, which is considered the method of choice when aqueous boundary layer effects need to be excluded. The pKa-Flux method has two variants, the iso-pH method, where apical and basolateral pH are equal, and the gradient-pH method, where apical and ba...
Source: European Journal of Pharmaceutical Sciences - September 26, 2023 Category: Drugs & Pharmacology Authors: Carolin Dahley Kai-Uwe Goss Andrea Ebert Source Type: research
Effect of vortioxetine versus venlafaxine on cognitive functions in adults with major depressive disorder: A randomized-controlled trial
CONCLUSION: Our study findings suggest that improvement in cognitive scores is significantly higher with vortioxetine than venlafaxine over the eight weeks of monotherapy.CLINICAL TRIAL REGISTRATION NUMBER: CTRI/2020/07/026819 (Registered with Clinical Trials Registry- India).PMID:37736222 | PMC:PMC10510634 | DOI:10.4103/indianjpsychiatry.indianjpsychiatry_160_23 (Source: Indian Journal of Psychiatry)
Source: Indian Journal of Psychiatry - September 22, 2023 Category: Psychiatry Authors: Chayan K Manna Rajeev Ranjan Pankaj Kumar Shamshad Ahmad Santanu Nath Source Type: research
