Abnormal functional connectivity of the reward circuit associated with early satiety in patients with postprandial distress syndrome
This study indicated that the altered FC of reward circuit regions may play a role in the pathophysiology of patients with PDS, and some of the aberrant NAc-based FC within the reward circuit were more related to the early satiety of patients with PDS. These findings improve our symptom-based understanding of the central pathophysiology of FD, lay the groundwork for an objective diagnosis of FD, and shed light on the precise prescription for treating FD based on symptoms.PMID:38552365 | DOI:10.1016/j.appet.2024.107317 (Source: Appetite)
Source: Appetite - March 29, 2024 Category: Nutrition Authors: Pan Zhang Yangke Mao Liangchao Gao Zilei Tian Ruirui Sun Yuqi He Peihong Ma Beihong Dou Yuan Chen Xiabing Zhang Zhaoxuan He Tao Yin Fang Zeng Source Type: research
Impact of < em > Saussurea lappa < /em > against foodborne parasite < em > Trichinella spiralis < /em > experimental infections induced variation in DNA damage, oxidative stress and PCNA expression in rat skeletal muscles
Toxicol Res (Camb). 2024 Mar 23;13(2):tfae047. doi: 10.1093/toxres/tfae047. eCollection 2024 Apr.ABSTRACTTrichinellosis is a parasite zoonosis that is spread through ingesting raw or undercooked meat that contains the Trichinella spiralis (T. spiralis) infective larvae. It has three clinical phases: intestinal, migratory, and muscular. Kuth root, also known as Costus (Saussurea lappa) roots, is used in many traditional medical systems all over the world to treat a variety of illnesses, such as dyspepsia, diarrhoea, vomiting, and inflammation. Current study assessed the therapeutic Potential of costus roots extract (CRE) tr...
Source: Cell Research - March 26, 2024 Category: Cytology Authors: Areej Jameel M Alghabban Lamiaa Bakr Aya A Elbatawy Afaf El Atrash Ehab Tousson Source Type: research
Development and validation of the Gastrointestinal Symptom Severity Scale in Spanish children and adolescents
Conclusions: The GSSS shows promising psychometric properties for assessing GS in neurotypical Spanish adolescents and children.What is Known:• To the best of our knowledge, instruments assessing the severity of gastrointestinal symptoms in children and adolescents are still too few.What is New:• The GSSS shows promising psychometric properties for assessing GS in neurotypical adolescents and children. The GSSS may help improve understanding of GS involvement in the gut-brain microbiota axis in children and adolescents. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - March 25, 2024 Category: Pediatrics Source Type: research
Evaluating the effectiveness and safety of various Tirzepatide dosages in the management of Type 2 diabetes mellitus: a network meta-analysis of randomized controlled trials
ConclusionTZP effectively lowers HbA1c and induces weight loss across its three doses for type 2 diabetes management. The higher dose (15 mg) significantly reduces fasting serum glucose, with increased adverse events observed at higher doses. Dose-specific patterns for adverse effects emphasize the need to balance therapeutic benefits and risks. Further research is crucial for refining clinical applications and understanding TZP’s role in DM2 management across doses. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - March 25, 2024 Category: Endocrinology Source Type: research
Efficacy, safety, and tolerability of xanomeline for schizophrenia spectrum disorders: a systematic review
CONCLUSION: KarXT offers an innovative non-D2 blocking approach, representing a promising treatment avenue for schizophrenia.PMID:38515004 | DOI:10.1080/14656566.2024.2334424 (Source: Expert Opinion on Pharmacotherapy)
Source: Expert Opinion on Pharmacotherapy - March 22, 2024 Category: Drugs & Pharmacology Authors: Alexia Leber Ranuk Ramachandra Felicia Ceban Angela T H Kwan Taeho Greg Rhee Jie Wu Bing Cao Muhammad Youshay Jawad Kayla M Teopiz Roger Ho Gia Han Le Diluk Ramachandra Roger S McIntyre Source Type: research
UPLC-Q-Exactive Orbitrap-MS and network pharmacology for deciphering the active compounds and mechanisms of stir-fried Raphani Semen in treating functional dyspepsia
CONCLUSION: SRS can treat FD through a variety of pathways, which provides a direction for the modern application of SRS in FD treatment.PMID:38517816 | DOI:10.3233/THC-231122 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Zhuang Miao Xinyue Yu Lizhen Zhang Liqiao Zhu Huagang Sheng Source Type: research
Efficacy, safety, and tolerability of xanomeline for schizophrenia spectrum disorders: a systematic review
CONCLUSION: KarXT offers an innovative non-D2 blocking approach, representing a promising treatment avenue for schizophrenia.PMID:38515004 | DOI:10.1080/14656566.2024.2334424 (Source: Expert Opinion on Pharmacotherapy)
Source: Expert Opinion on Pharmacotherapy - March 22, 2024 Category: Drugs & Pharmacology Authors: Alexia Leber Ranuk Ramachandra Felicia Ceban Angela T H Kwan Taeho Greg Rhee Jie Wu Bing Cao Muhammad Youshay Jawad Kayla M Teopiz Roger Ho Gia Han Le Diluk Ramachandra Roger S McIntyre Source Type: research
UPLC-Q-Exactive Orbitrap-MS and network pharmacology for deciphering the active compounds and mechanisms of stir-fried Raphani Semen in treating functional dyspepsia
CONCLUSION: SRS can treat FD through a variety of pathways, which provides a direction for the modern application of SRS in FD treatment.PMID:38517816 | DOI:10.3233/THC-231122 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Zhuang Miao Xinyue Yu Lizhen Zhang Liqiao Zhu Huagang Sheng Source Type: research
Efficacy, safety, and tolerability of xanomeline for schizophrenia spectrum disorders: a systematic review
CONCLUSION: KarXT offers an innovative non-D2 blocking approach, representing a promising treatment avenue for schizophrenia.PMID:38515004 | DOI:10.1080/14656566.2024.2334424 (Source: Expert Opinion on Pharmacotherapy)
Source: Expert Opinion on Pharmacotherapy - March 22, 2024 Category: Drugs & Pharmacology Authors: Alexia Leber Ranuk Ramachandra Felicia Ceban Angela T H Kwan Taeho Greg Rhee Jie Wu Bing Cao Muhammad Youshay Jawad Kayla M Teopiz Roger Ho Gia Han Le Diluk Ramachandra Roger S McIntyre Source Type: research
UPLC-Q-Exactive Orbitrap-MS and network pharmacology for deciphering the active compounds and mechanisms of stir-fried Raphani Semen in treating functional dyspepsia
CONCLUSION: SRS can treat FD through a variety of pathways, which provides a direction for the modern application of SRS in FD treatment.PMID:38517816 | DOI:10.3233/THC-231122 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Zhuang Miao Xinyue Yu Lizhen Zhang Liqiao Zhu Huagang Sheng Source Type: research
UPLC-Q-Exactive Orbitrap-MS and network pharmacology for deciphering the active compounds and mechanisms of stir-fried Raphani Semen in treating functional dyspepsia
CONCLUSION: SRS can treat FD through a variety of pathways, which provides a direction for the modern application of SRS in FD treatment.PMID:38517816 | DOI:10.3233/THC-231122 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Zhuang Miao Xinyue Yu Lizhen Zhang Liqiao Zhu Huagang Sheng Source Type: research
Utility of ultrasound in the diagnostic approach to lymphoma with splenic involvement
This study highlights the role of abdominal ultrasound as a useful technique in the non-invasive assessment of this entity, considering an appropriate clinical context and mainly after detecting multiple hypoechogenic splenic lesions in the US.PMID:38501803 | DOI:10.17235/reed.2024.10283/2024 (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - March 19, 2024 Category: Gastroenterology Authors: Roc ío Martínez Fernández Lidia Castillo G ázquez Mar ía Caldas Álvarez Leticia Gonz ález Moreno Cecilio Santander Vaquero Source Type: research
