Low-value chronic prescription of acid reducing medication among Dutch general practitioners: impact of a patient education intervention
CONCLUSION: Our educational intervention did not result in a change in the low-value chronic prescription of ARM; approximately half of the patients of the intervention and control still received low-value chronic ARM prescriptions. The absence of effect might be explained by selection bias of participating practices, awareness on the topic of chronic AMR prescriptions and the relative low proportion of low-value chronic ARM prescribing in the intervention as well as the control group compared to an assessment conducted two years prior.TRIAL REGISTRATION: 10/31/2023 NCT06108817.PMID:38575887 | DOI:10.1186/s12875-024-02351-...
Source: Primary Care - April 4, 2024 Category: Primary Care Authors: Joris L J M M üskens Simone A van Dulmen Karin Hek Gert P Westert Rudolf B Kool Source Type: research
Low-value chronic prescription of acid reducing medication among Dutch general practitioners: impact of a patient education intervention
Dyspepsia is a commonly encountered clinical condition in Dutch general practice, which is often treated through the prescription of acid-reducing medication (ARM). However, recent studies indicate that the ma... (Source: BMC Family Practice)
Source: BMC Family Practice - April 4, 2024 Category: Primary Care Authors: Joris L. J. M. M üskens, Simone A. van Dulmen, Karin Hek, Gert P. Westert and Rudolf B. Kool Tags: Research Source Type: research
Exploring The Diverse Therapeutic Potentials of Synthetic Analogues of Keto-terpenoids (+) Carvone: A Future Scaffold
CONCLUSION: S(+) carvone has a CNS depressive impact and possesses an anti-convulsant activity. According to the research parameters on both the enantiomers, R&S can block GABA binding sites. Therefore, it suggests that S(+) carvone may be the new moiety for anticonvulsant activity. It has been observed by various studies that the S(+) carvone is more powerful than R(-) carvone. Therefore, it can be concluded that S(+) Carvone can serve as a scaffold for anticonvulsant activity.PMID:38551059 | DOI:10.2174/0118715249278766240322054108 (Source: Molecular Medicine)
Source: Molecular Medicine - March 29, 2024 Category: Molecular Biology Authors: Snigdha Srivastava Reema Sinha Rahul Kaushik Rajan Kumar Kurmi Source Type: research
Abnormal functional connectivity of the reward circuit associated with early satiety in patients with postprandial distress syndrome
This study indicated that the altered FC of reward circuit regions may play a role in the pathophysiology of patients with PDS, and some of the aberrant NAc-based FC within the reward circuit were more related to the early satiety of patients with PDS. These findings improve our symptom-based understanding of the central pathophysiology of FD, lay the groundwork for an objective diagnosis of FD, and shed light on the precise prescription for treating FD based on symptoms.PMID:38552365 | DOI:10.1016/j.appet.2024.107317 (Source: Appetite)
Source: Appetite - March 29, 2024 Category: Nutrition Authors: Pan Zhang Yangke Mao Liangchao Gao Zilei Tian Ruirui Sun Yuqi He Peihong Ma Beihong Dou Yuan Chen Xiabing Zhang Zhaoxuan He Tao Yin Fang Zeng Source Type: research
Exploring The Diverse Therapeutic Potentials of Synthetic Analogues of Keto-terpenoids (+) Carvone: A Future Scaffold
CONCLUSION: S(+) carvone has a CNS depressive impact and possesses an anti-convulsant activity. According to the research parameters on both the enantiomers, R&S can block GABA binding sites. Therefore, it suggests that S(+) carvone may be the new moiety for anticonvulsant activity. It has been observed by various studies that the S(+) carvone is more powerful than R(-) carvone. Therefore, it can be concluded that S(+) Carvone can serve as a scaffold for anticonvulsant activity.PMID:38551059 | DOI:10.2174/0118715249278766240322054108 (Source: Molecular Medicine)
Source: Molecular Medicine - March 29, 2024 Category: Molecular Biology Authors: Snigdha Srivastava Reema Sinha Rahul Kaushik Rajan Kumar Kurmi Source Type: research
