Capsules for the Diagnosis and Treatment of Gastrointestinal Motility Disorders- A Game Changer
AbstractPurpose of ReviewOver the last few decades, there have been remarkable strides in endoscopy and radiological imaging that have advanced gastroenterology. However, the management of neurogastroenterological disorders has lagged behind, in part handicapped by the use of catheter-based manometry that is both non-physiological and uncomfortable. The advent of capsule technology has been a game changer for both diagnostic and therapeutic applications.Recent FindingsHere, we discuss several capsule devices that are available or under investigation. There are three technologies that are FDA approved. Wireless motility cap...
Source: Current Gastroenterology Reports - April 17, 2024 Category: Gastroenterology Source Type: research
Differences Between Patients with Heartburn Refractory to Vonoprazan and Those Refractory to Proton Pump Inhibitors
ConclusionPatients with unproven GERD with vonoprazan-refractory heartburn demonstrated more symptoms, including not only GERD symptoms but also functional dyspepsia and irritable bowel syndrome symptoms, than those with PPI-refractory heartburn. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 15, 2024 Category: Gastroenterology Source Type: research
Cancers, Vol. 16, Pages 1476: Helicobacter pylori cagA, vacA, iceA and babA Genotypes from Peruvian Patients with Gastric Intestinal Metaplasia
This study was cross-sectional and included 158 H. pylori clinical isolates; each isolate corresponded to a different Peruvian patient, genotyped by polymerase chain reaction to detect cagA gene and EPIYA motifs, the vacA gene (alleles s1, s2, i1, i2, d1, d2, m1, m2 and subtypes s1a, s1b and s1c), the iceA gene (alleles 1 and 2), and the babA gene (allele 2). We observed that 38.6% presented with IM and that all clinical isolates were CagA positive. The EPIYA-ABC motif was predominant (68.4%), and we observed a high frequency for the vacA gene alleles s1 (94.9%), m1 (81.7%), i1 (63.9%), and d1 (70.9%). Strains with both ic...
Source: Cancers - April 12, 2024 Category: Cancer & Oncology Authors: Jes ús Guzmán Denis Castillo Anabel D. Gonz ález-Siccha Alejandro Bussalleu Alba A. Trespalacios-Rangel Andres G. Lescano Michel Sauvain Tags: Article Source Type: research
Fecal calprotectin levels in patients with non-celiac wheat sensitivity: a proof of concept
AbstractSome data suggest the existence of intestinal inflammation in patients with non-celiac wheat sensitivity (NCWS). We aimed to verify whether fecal calprotectin (FCP), a marker of intestinal inflammation, could be used to confirm this inflammatory status and to test its diagnostic performance in differentiating NCWS from irritable bowel syndrome/functional dyspepsia (IBS/FD). We conducted a multicenter study, comparing NCWS patients, diagnosed by a double-blind placebo-controlled wheat challenge, with IBS/FD subjects. In the retrospective phase, FCP values were analyzed to define the prevalence of its positivity an...
Source: Internal and Emergency Medicine - April 12, 2024 Category: Emergency Medicine Source Type: research
Different Food Preferences in Patients with Gastrointestinal Disorders
Conclusions Patients with FD had a negative preference for foods, particularly fatty foods, independent of the severity of GI symptoms.PMID:38599865 | DOI:10.2169/internalmedicine.3433-24 (Source: Internal Medicine)
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Ryo Katsumata Tomoka Kaburagi Takayuki Hosokawa Noriaki Manabe Manabu Ishii Katsunori Ishii Tomohiro Tanikawa Noriyo Urata Maki Ayaki Ken Nishino Takahisa Murao Mitsuhiko Suehiro Minoru Fujita Miwa Kawanaka Ken Haruma Hirofumi Kawamoto Toshihiro Takao Tom Source Type: research
Predictors of Toxicity in a Randomized Study of Consolidation Chemoradiation Versus Observation After First Line Chemotherapy in Advanced Gall Bladder Cancers
CONCLUSIONS: Consolidation CTRT is tolerable in those with PTV1 volume less than 800 cc.PMID:38590716 | PMC:PMC10999813 | DOI:10.1016/j.adro.2024.101468 (Source: Adv Data)
Source: Adv Data - April 9, 2024 Category: Epidemiology Authors: Sushma Agrawal Anshika Gupta Vishwas Kapoor Rahul Rahul Ashish Singh Prabhakar Mishra Rajan Saxena Source Type: research
Electroacupuncture can Modify Stress, Low-Grade Inflammation in the Duodenum, and Damage to the Intestinal Barrier in Rats with Functional Dyspepsia through the CRF Signaling Pathway
CONCLUSION: EA has been shown to improve the stress state of FD rats, inhibit the activation of mast cells in the duodenum, and reduce low-grade inflammatory response and damage to the intestinal mucosal barrier. It is believed that EA achieves these effects by modulating the expression of CRF and its receptors in the brain-gut interaction pathway through the CRF signaling pathway. This provides a new approach to treating FD.PMID:38591200 | DOI:10.2174/0113862073306526240403063736 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 9, 2024 Category: Chemistry Authors: Tong Liu Haili Wang Jiayi Liu Ruirui Tan Lili Chen Xurong Liang Ailin Li Chenxi Qi Zhaohui Wang Source Type: research
Electroacupuncture can Modify Stress, Low-Grade Inflammation in the Duodenum, and Damage to the Intestinal Barrier in Rats with Functional Dyspepsia through the CRF Signaling Pathway
CONCLUSION: EA has been shown to improve the stress state of FD rats, inhibit the activation of mast cells in the duodenum, and reduce low-grade inflammatory response and damage to the intestinal mucosal barrier. It is believed that EA achieves these effects by modulating the expression of CRF and its receptors in the brain-gut interaction pathway through the CRF signaling pathway. This provides a new approach to treating FD.PMID:38591200 | DOI:10.2174/0113862073306526240403063736 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 9, 2024 Category: Chemistry Authors: Tong Liu Haili Wang Jiayi Liu Ruirui Tan Lili Chen Xurong Liang Ailin Li Chenxi Qi Zhaohui Wang Source Type: research
Electroacupuncture can Modify Stress, Low-Grade Inflammation in the Duodenum, and Damage to the Intestinal Barrier in Rats with Functional Dyspepsia through the CRF Signaling Pathway
CONCLUSION: EA has been shown to improve the stress state of FD rats, inhibit the activation of mast cells in the duodenum, and reduce low-grade inflammatory response and damage to the intestinal mucosal barrier. It is believed that EA achieves these effects by modulating the expression of CRF and its receptors in the brain-gut interaction pathway through the CRF signaling pathway. This provides a new approach to treating FD.PMID:38591200 | DOI:10.2174/0113862073306526240403063736 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 9, 2024 Category: Chemistry Authors: Tong Liu Haili Wang Jiayi Liu Ruirui Tan Lili Chen Xurong Liang Ailin Li Chenxi Qi Zhaohui Wang Source Type: research
Electroacupuncture can Modify Stress, Low-Grade Inflammation in the Duodenum, and Damage to the Intestinal Barrier in Rats with Functional Dyspepsia through the CRF Signaling Pathway
CONCLUSION: EA has been shown to improve the stress state of FD rats, inhibit the activation of mast cells in the duodenum, and reduce low-grade inflammatory response and damage to the intestinal mucosal barrier. It is believed that EA achieves these effects by modulating the expression of CRF and its receptors in the brain-gut interaction pathway through the CRF signaling pathway. This provides a new approach to treating FD.PMID:38591200 | DOI:10.2174/0113862073306526240403063736 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 9, 2024 Category: Chemistry Authors: Tong Liu Haili Wang Jiayi Liu Ruirui Tan Lili Chen Xurong Liang Ailin Li Chenxi Qi Zhaohui Wang Source Type: research
Electroacupuncture can Modify Stress, Low-Grade Inflammation in the Duodenum, and Damage to the Intestinal Barrier in Rats with Functional Dyspepsia through the CRF Signaling Pathway
CONCLUSION: EA has been shown to improve the stress state of FD rats, inhibit the activation of mast cells in the duodenum, and reduce low-grade inflammatory response and damage to the intestinal mucosal barrier. It is believed that EA achieves these effects by modulating the expression of CRF and its receptors in the brain-gut interaction pathway through the CRF signaling pathway. This provides a new approach to treating FD.PMID:38591200 | DOI:10.2174/0113862073306526240403063736 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 9, 2024 Category: Chemistry Authors: Tong Liu Haili Wang Jiayi Liu Ruirui Tan Lili Chen Xurong Liang Ailin Li Chenxi Qi Zhaohui Wang Source Type: research
Proton Pump Inhibitors and Kidney Disease: Fact or Fiction?
Am J Nephrol. 2024 Apr 6. doi: 10.1159/000538755. Online ahead of print.ABSTRACTBACKGROUND: Proton pump inhibitors (PPI) are commonly prescribed medications for dyspepsia and gastroesophageal reflux. There are concerns about their use in the development of chronic kidney disease (CKD).SUMMARY: The available published literature fails to support an association with PPI and the development of CKD. Placebo-controlled trials demonstrate no difference on the incidence of CKD between placebo and PPI. If one examines the data according to the Bradford Hill perspective incorporating temporal relationship, strength of association, ...
Source: American Journal of Nephrology - April 7, 2024 Category: Urology & Nephrology Authors: Matthew Ryan Weir Source Type: research
Proton Pump Inhibitors and Kidney Disease: Fact or Fiction?
Am J Nephrol. 2024 Apr 6. doi: 10.1159/000538755. Online ahead of print.ABSTRACTBACKGROUND: Proton pump inhibitors (PPI) are commonly prescribed medications for dyspepsia and gastroesophageal reflux. There are concerns about their use in the development of chronic kidney disease (CKD).SUMMARY: The available published literature fails to support an association with PPI and the development of CKD. Placebo-controlled trials demonstrate no difference on the incidence of CKD between placebo and PPI. If one examines the data according to the Bradford Hill perspective incorporating temporal relationship, strength of association, ...
Source: American Journal of Nephrology - April 7, 2024 Category: Urology & Nephrology Authors: Matthew Ryan Weir Source Type: research
