Cellular Senescence as an Important Cause of Non-Healing Wounds in Diabetes
One of the many unpleasant complications produced by type 1 and type 2 diabetes is a much reduced ability to heal wounds, leading to ulcers and non-healing injuries. Following the discovery of the importance of senescent cells to degenerative aging, it was found that senescent cell accumulation is important in the pathology of both type 1 and type 2 diabetes. Senescent cells secrete a mix of molecules that provoke chronic inflammation, destructively remodel nearby tissue, and encourage other cells to become senescent, among other outcomes. This signaling, when present for the long term, is harmful to tissue function. Thera...
Source: Fight Aging! - October 27, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
THCB Spotlights: Jon Bloom, Podimetrics
By MATTHEW HOLT
This is a fun conversation with Jon Bloom, the CEO of Podimetrics. It’s one of a number of competitors trying to help prevent foot ulcers among people with diabetes. Some use socks, others use insoles, but Podimetrics’ approach is to use a pad which looks like a weight scale and can tell whether a patient might be developing a foot ulcer and is therefore at risk for amputation. Last week Podimetrics and Kaiser Permanente released a study that showed their service showed great success in reducing hospitalization, ER visits and foot amputations. But Bloom thinks that there’s much more to ...
Source: The Health Care Blog - October 19, 2020 Category: Consumer Health News Authors: matthew holt Tags: Featured Health Tech Matthew Holt THCB Spotlights Diabetes care Jon Bloom podimetrics VA Source Type: blogs
Is There a COVID-Related Wound?
A variety of skin lesions have been described with Coronavirus infection, also called COVID-19 or SARS-CoV-2, and this post explores whether there is a link between COVID and wounds. Understanding of this disease is still in the early stages, and it is unclear whether these skin lesions are the result of comorbidities or coinfection with other agents, or whether COVID-19 is actually responsible. A search of the world literature reveals the following skin issues with COVID:
Acral erythema (redness and swelling of the hands and feet) with vesicles and pustules. This is similar to chilblains – a condition associated with...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - September 21, 2020 Category: Geriatrics Authors: Jeffrey M Levine Tags: Featured Medical Articles Geriatric Medicine Long-Term Care Pressure Injuries & Wound Care bedsore bedsores coronavirus COVID COVID-19 decubiti decubitus ulcer end-of-life care eschar geriatrics gerontology Improving Medical Source Type: blogs
Wearable Ozone Therapy Device for Chronic Wound Treatment
Researchers at Purdue University have developed a wearable device that can administer antibacterial ozone gas to chronic wounds to help disinfect them. The technology could allow people to disinfect chronic wounds at home, and would be helpful in cases where wounds have been colonized by drug-resistant bacteria and aren’t responding to antibiotic therapy.
Approximately 6 million patients in the U.S. have a chronic wound. This includes many patients with diabetes who develop foot ulcers. These wounds can have a significant impact on quality of life, mobility, and the ability to work. In many cases, chronic wounds can...
Source: Medgadget - September 8, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Plastic Surgery Vascular Surgery Source Type: blogs
Health in 2 Point 00, Episode 145 | Amwell, OneDrop, Outset Medical & Podimetrics
Today on Health in 2 Point 00, Jess asks me about the big news that Google Cloud has entered into a partnership with Amwell and invested $100 million into the company—looks like their IPO is really a thing! OneDrop gets $98.7 million in a partnership with Bayer, following at $40 million partnership last November, in a funding and development agreement. Outset Medical files their S1 and is going to go public, looking for $100 million for their portable dialysis system, and finally Podimetrics raises another $8 million for their foot ulcer detection platform for diabetics. —Matthew Holt (Source: The Health Care Blog)
Source: The Health Care Blog - August 25, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health in 2 Point 00 Health Tech Jessica DaMassa Matthew Holt AmWell google cloud OneDrop Outset Medical podimetrics Source Type: blogs
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
HIF-1 and Age-Related Impairment of Neovascularization in Regeneration
Hypoxia inducible factor 1 (HIF-1) is known to be important in skin aging, involved in the regulation of numerous processes relevant to the maintenance and structure of skin tissue. One of these is the growth of blood vessels that is required for regeneration to take place following injury. The dysfunction of HIF-1 signaling and consequent dysfunction in blood vessel regrowth is a feature of the varieties of non-healing wounds that are observed in older people. The open access paper here reviews what is known of HIF-1 in this context.
Oxygen is key to many processes of life and is involved in all stages of wound h...
Source: Fight Aging! - March 6, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Psychology Around the Net: February 8, 2020
This article offers tips for those struggling with severe health anxiety.
The Environmental Burden of Generation Z: Kids today are terrified, anxious and depressed about climate change. In this article, the author discusses why this is so: “As climate change continues unabated, parents, teachers and medical professionals across the country find themselves face-to-face with a quandary: How do you raise a generation to look toward the future with hope when all around them swirls a message of apparent hopelessness?”
Students Shouldn’t Have to Choose Between Groceries and Therapy: In this article, the author expresses ho...
Source: World of Psychology - February 8, 2020 Category: Psychiatry & Psychology Authors: Traci Pedersen Tags: Anxiety and Panic Children and Teens College Depression Disorders General Green and Environment Mental Health and Wellness OCD Policy and Advocacy Professional Psychiatry Psychology Psychology Around the Net Psychotherapy Stu Source Type: blogs
Scientists 3D Print Vascularized Artificial Skin
Researchers from Rensselaer Polytechnic Institute have developed a new method to 3D print living skin with built-in blood vessels. This living skin construct is cultured in vitro and develops into an interconnected microvascular network underneath a layered barrier of skin cells. in tests on mice, the grafts connect with the animals’ vascular network and become perfused within four weeks after transplantation. This exciting development may one day provide new, more functional skin grafts for patients.
Current artificial skin grafts can fall off due to their lack of integration with the host cells. One of the major...
Source: Medgadget - November 4, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Dermatology Materials Medicine Plastic Surgery Rehab Vascular Surgery Source Type: blogs
Bruin Biometrics Is on a Mission to End Pressure Ulcers: Interview with CEO Martin Burns
Earlier this year, Medgadget reported on the FDA’s clearance of the SEM Scanner, a device created by Los Angeles-based Bruin Biometrics (BBI). The SEM Scanner is a wireless, handheld device that detects changes in sub-epidermal moisture as an indicator of risk for developing a pressure ulcer. Moisture can indicate the presence of localized edema and tissue fluid-related inflammation well before visual and tactile tests that represent the diagnostic standard of care today. To learn more about the challenges of pressure ulcers, their impact on the healthcare system, and how the SEM Scanner is making an impact improving...
Source: Medgadget - October 28, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Critical Care Exclusive Medicine Plastic Surgery Vascular Surgery Source Type: blogs
8 Nootropics to Stimulate Your Brain This Fall
You're reading 8 Nootropics to Stimulate Your Brain This Fall, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles.
Nootropics is a term coined by Dr. Corneliu E. Giurgea
to describe a class of drugs, supplements, and other synthetic and naturally
occurring compounds that improve cognitive function in our brains. They’re
often called “smart drugs,” as they can help us think faster and more
efficiently.
Although used by pretty much everyone, these nootropic supplements are especially
popular among younger and olde...
Source: PickTheBrain | Motivation and Self Improvement - September 26, 2019 Category: Consumer Health News Authors: Nadav Dakner Tags: featured health and fitness self improvement nootropics pickthebrain Source Type: blogs
From Chernobyl To Mars: The Future Of Radiation Protection
In the minutes after block 4 of the nuclear power
plant in Chernobyl exploded, no one knew that they are experiencing a disaster
that never happened anywhere before on planet Earth. The public health,
environmental, and even the socio-political consequences were disastrous and we
can still experience the negative impacts. That’s why we posed the question of
what public health authorities, as well as individuals, can do to mitigate the
consequences of radiation exposure, and what digital technologies are available
for radiation detection. In this respect, after our investigations, it even
turned out that it would be benef...
Source: The Medical Futurist - June 29, 2019 Category: Information Technology Authors: nora Tags: Future of Medicine Space Medicine astronautics chernobyl disaster fiction Health Healthcare Innovation mars nuclear power plant public health radiation radiation exposure radiation protection technology Source Type: blogs
Is it SAFE to be grain-free?
Listen to critics of the Wheat Belly lifestyle and you’d think that, by banishing all things wheat and grains from your life, you will be excommunicated from your church, tossed out of your club, ostracized by friends and family, and suffer dire health consequences like heart disease and colon cancer. After all, they say that you are eliminating an entire food group and will be crippled by lack of fiber and nutrients. Worse, our focus on increasing our intake of fats and oils will get you a heart attack, three stents, or bypass surgery and you’ll be obliged to take Lipitor and Repatha for a lifetime.
First of a...
Source: Wheat Belly Blog - June 25, 2019 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle grain-free Weight Loss Source Type: blogs
Fight Aging! Newsletter, June 3rd 2019
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing.
Altered Intercellular Communication
It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - June 2, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
