Systemic Hypertension Induced by Harpagophytum procumbens (devil's claw): A Case Report
(Source: The Journal of Clinical Hypertension)
Source: The Journal of Clinical Hypertension - June 1, 2015 Category: Cardiology Authors: Cesare Cuspidi, Carla Sala, Marijana Tadic, Guido Grassi, Giuseppe Mancia Tags: Case Report Source Type: research
Identification and characterization of β-sitosterol target proteins.
Abstract
β-Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β-sitosterol that may underlie its beneficial effects.
PMID: 25804720 [PubMed - as supplied by publisher] (Source: Bioorganic and Medicinal Chemistry Letters)
Source: Bioorganic and Medicinal Chemistry Letters - March 11, 2015 Category: Chemistry Authors: Lomenick B, Shi H, Huang J, Chen C Tags: Bioorg Med Chem Lett Source Type: research
Herbal medicine for low-back pain.
CONCLUSIONS: C. frutescens (Cayenne) reduces pain more than placebo. Although H. procumbens, S. alba, S. officinale L., S. chilensis, and lavender essential oil also seem to reduce pain more than placebo, evidence for these substances was of moderate quality at best. Additional well-designed large trials are needed to test these herbal medicines against standard treatments. In general, the completeness of reporting in these trials was poor. Trialists should refer to the CONSORT statement extension for reporting trials of herbal medicine interventions.
PMID: 25536022 [PubMed - as supplied by publisher] (Source: Coch...
Source: Cochrane Database of Systematic Reviews - December 23, 2014 Category: Journals (General) Authors: Oltean H, Robbins C, van Tulder MW, Berman BM, Bombardier C, Gagnier JJ Tags: Cochrane Database Syst Rev Source Type: research
Alteration of anti‐inflammatory activity of Harpagophytum procumbens (devil's claw) extract after external metabolic activation with S9 mix
Conclusions Cytokines inhibitory activity of DC was not affected after its external metabolic activation. However, the amount of harpagoside and caffeic acid derivates was decreased. Other components of the extract might have contributed to its anti‐inflammatory effect. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 31, 2014 Category: Drugs & Pharmacology Authors: Katarina Hostanska, Joerg Melzer, Matthias Rostock, Andy Suter, Reinhard Saller Tags: RESEARCH PAPER Source Type: research
Kynurenic acid content in anti-rheumatic herbs.
Conclusion: These findings indicate that the use of herbal preparations containing a high level of KYNA can be considered as a supplementary measure in rheumatoid arthritis therapy, as well as in rheumatic diseases prevention.
PMID: 24364456 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - December 19, 2013 Category: Environmental Health Authors: Zgrajka W, Turska M, Rajtar G, Majdan M, Parada-Turska J Tags: Ann Agric Environ Med Source Type: research
Harpagophytum procumbens Prevents Oxidative Stress and Loss of Cell Viability In Vitro.
Abstract
Harpagophytum procumbens, popularly known as devil's claw, is a plant commonly used in the treatment of diseases of inflammatory origin. The anti-inflammatory effects of H. procumbens have been studied; however, the mechanism of action is not elucidated. It is known that excess of reactive oxygen and nitrogen species may contribute to increasing tissue damage due to inflammation. In the present study, we examined the effects of H. procumbens infusion, crude extract and fractions on lipid peroxidation (brain homogenates) induced by different pro-oxidants (Fe(2+) or sodium nitroprusside) and the eff...
Source: Neurochemical Research - August 28, 2013 Category: Neuroscience Authors: Schaffer LF, Peroza LR, Boligon AA, Athayde ML, Alves SH, Fachinetto R, Wagner C Tags: Neurochem Res Source Type: research
Mechanisms of Herb-Induced Nephrotoxicity.
Abstract
Herbal therapies gained much popularity among the general public, but compared to therapies approved by official authorities, toxicological studies are frequently not available for them. Hence, there may be inherent risks and the kidneys may be especially vulnerable to toxic effects. Herbs may induce nephrotoxicity by induction of apoptosis. High oxalate contents in Star fruit (Averrhoa carambola L.) may induce acute nephropathy. Triptolide from Thunder God Vine (Triperygium wilfordii Hook) is a diterpenoid epoxide with induces reactive oxygen species and nephrotubular apoptosis. Cranberry juice i...
Source: Current Medicinal Chemistry - April 12, 2013 Category: Chemistry Authors: Allard T, Wenner T, Greten HJ, Efferth T Tags: Curr Med Chem Source Type: research
