Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction
J Diet Suppl. 2024 Jan 5:1-15. doi: 10.1080/19390211.2023.2284982. Online ahead of print.ABSTRACTOsteoarthritis (OA) is an age-related degenerative joint disease with a great impact on patients' well-being and quality of life. This is an observational, open, single-arm multicenter study aimed to evaluate the effectiveness of a nutritional supplement in patients with knee and/or hip OA. A total of 186 patients were recruited from Spanish centers and received a supplement containing hydrolyzed collagen (3000 mg), chondroitin sulfate (800 mg), glucosamine sulfate (700 mg), turmeric extract (250 mg) and devil's claw (150 mg), ...
Source: Journal of Dietary Supplements - January 5, 2024 Category: Nutrition Authors: Jordi Puigdell ívol Grifell Carme Comellas Berenguer Gilbert Steinbacher Tomislav Kranjcec Pedro Álvarez Díaz Antoni L ópez Pujol Asunci ón Acosta Pereira Maximiliano S ánchez Martos Jos é Reyes Fernández Velázquez Miguel Ángel Esparza Pagán V Source Type: research
Ethyl Acetate Fraction of Harpagophytum procumbens Prevents Oxidative Stress In Vitro and Amphetamine-Induced Alterations in Mice Behavior
Neurochem Res. 2023 Jan 17. doi: 10.1007/s11064-022-03846-z. Online ahead of print.ABSTRACTMicroglial activation has been associated to the physiopathology of neurodegenerative diseases, such as schizophrenia, and can occur during inflammation and oxidative stress. Pharmacological treatment is associated with severe side effects, and studies for use of plant extracts may offer alternatives with lower toxicity. Harpagophytum procumbens (HP) is a plant known for its anti-inflammatory properties. In the present study, we characterized the ethyl acetate fraction of HP (EAF HP) by ESI-ToF-MS and investigated the effects EAF HP ...
Source: Neurochemical Research - January 17, 2023 Category: Neuroscience Authors: Valtieri Bortoluzzi Lima Altevir Rossato Viana Daniel Santos Narieli Felipetto Nat ália Fernandes Mezzomo Adriana Maria Zago Erico Marlon Moraes Flores Alencar Kolinski Machado Alexandre Krause Luis Ricardo Peroza Larissa Finger Schaffer Luciana Maria Fo Source Type: research
Ethyl Acetate Fraction of Harpagophytum procumbens Prevents Oxidative Stress In Vitro and Amphetamine-Induced Alterations in Mice Behavior
Neurochem Res. 2023 Jan 17. doi: 10.1007/s11064-022-03846-z. Online ahead of print.ABSTRACTMicroglial activation has been associated to the physiopathology of neurodegenerative diseases, such as schizophrenia, and can occur during inflammation and oxidative stress. Pharmacological treatment is associated with severe side effects, and studies for use of plant extracts may offer alternatives with lower toxicity. Harpagophytum procumbens (HP) is a plant known for its anti-inflammatory properties. In the present study, we characterized the ethyl acetate fraction of HP (EAF HP) by ESI-ToF-MS and investigated the effects EAF HP ...
Source: Cell Research - January 17, 2023 Category: Cytology Authors: Valtieri Bortoluzzi Lima Altevir Rossato Viana Daniel Santos Narieli Felipetto Nat ália Fernandes Mezzomo Adriana Maria Zago Erico Marlon Moraes Flores Alencar Kolinski Machado Alexandre Krause Luis Ricardo Peroza Larissa Finger Schaffer Luciana Maria Fo Source Type: research
Ethyl Acetate Fraction of Harpagophytum procumbens Prevents Oxidative Stress In Vitro and Amphetamine-Induced Alterations in Mice Behavior
Neurochem Res. 2023 Jan 17. doi: 10.1007/s11064-022-03846-z. Online ahead of print.ABSTRACTMicroglial activation has been associated to the physiopathology of neurodegenerative diseases, such as schizophrenia, and can occur during inflammation and oxidative stress. Pharmacological treatment is associated with severe side effects, and studies for use of plant extracts may offer alternatives with lower toxicity. Harpagophytum procumbens (HP) is a plant known for its anti-inflammatory properties. In the present study, we characterized the ethyl acetate fraction of HP (EAF HP) by ESI-ToF-MS and investigated the effects EAF HP ...
Source: Neurochemical Research - January 17, 2023 Category: Neuroscience Authors: Valtieri Bortoluzzi Lima Altevir Rossato Viana Daniel Santos Narieli Felipetto Nat ália Fernandes Mezzomo Adriana Maria Zago Erico Marlon Moraes Flores Alencar Kolinski Machado Alexandre Krause Luis Ricardo Peroza Larissa Finger Schaffer Luciana Maria Fo Source Type: research
Ethyl Acetate Fraction of Harpagophytum procumbens Prevents Oxidative Stress In Vitro and Amphetamine-Induced Alterations in Mice Behavior
Neurochem Res. 2023 Jan 17. doi: 10.1007/s11064-022-03846-z. Online ahead of print.ABSTRACTMicroglial activation has been associated to the physiopathology of neurodegenerative diseases, such as schizophrenia, and can occur during inflammation and oxidative stress. Pharmacological treatment is associated with severe side effects, and studies for use of plant extracts may offer alternatives with lower toxicity. Harpagophytum procumbens (HP) is a plant known for its anti-inflammatory properties. In the present study, we characterized the ethyl acetate fraction of HP (EAF HP) by ESI-ToF-MS and investigated the effects EAF HP ...
Source: Cell Research - January 17, 2023 Category: Cytology Authors: Valtieri Bortoluzzi Lima Altevir Rossato Viana Daniel Santos Narieli Felipetto Nat ália Fernandes Mezzomo Adriana Maria Zago Erico Marlon Moraes Flores Alencar Kolinski Machado Alexandre Krause Luis Ricardo Peroza Larissa Finger Schaffer Luciana Maria Fo Source Type: research
Ethyl Acetate Fraction of Harpagophytum procumbens Prevents Oxidative Stress In Vitro and Amphetamine-Induced Alterations in Mice Behavior
Neurochem Res. 2023 Jan 17. doi: 10.1007/s11064-022-03846-z. Online ahead of print.ABSTRACTMicroglial activation has been associated to the physiopathology of neurodegenerative diseases, such as schizophrenia, and can occur during inflammation and oxidative stress. Pharmacological treatment is associated with severe side effects, and studies for use of plant extracts may offer alternatives with lower toxicity. Harpagophytum procumbens (HP) is a plant known for its anti-inflammatory properties. In the present study, we characterized the ethyl acetate fraction of HP (EAF HP) by ESI-ToF-MS and investigated the effects EAF HP ...
Source: Neurochemical Research - January 17, 2023 Category: Neuroscience Authors: Valtieri Bortoluzzi Lima Altevir Rossato Viana Daniel Santos Narieli Felipetto Nat ália Fernandes Mezzomo Adriana Maria Zago Erico Marlon Moraes Flores Alencar Kolinski Machado Alexandre Krause Luis Ricardo Peroza Larissa Finger Schaffer Luciana Maria Fo Source Type: research
Ethyl Acetate Fraction of Harpagophytum procumbens Prevents Oxidative Stress In Vitro and Amphetamine-Induced Alterations in Mice Behavior
Neurochem Res. 2023 Jan 17. doi: 10.1007/s11064-022-03846-z. Online ahead of print.ABSTRACTMicroglial activation has been associated to the physiopathology of neurodegenerative diseases, such as schizophrenia, and can occur during inflammation and oxidative stress. Pharmacological treatment is associated with severe side effects, and studies for use of plant extracts may offer alternatives with lower toxicity. Harpagophytum procumbens (HP) is a plant known for its anti-inflammatory properties. In the present study, we characterized the ethyl acetate fraction of HP (EAF HP) by ESI-ToF-MS and investigated the effects EAF HP ...
Source: Neurochemical Research - January 17, 2023 Category: Neuroscience Authors: Valtieri Bortoluzzi Lima Altevir Rossato Viana Daniel Santos Narieli Felipetto Nat ália Fernandes Mezzomo Adriana Maria Zago Erico Marlon Moraes Flores Alencar Kolinski Machado Alexandre Krause Luis Ricardo Peroza Larissa Finger Schaffer Luciana Maria Fo Source Type: research
The Nutraceuticals as Modern Key to Achieve Erythrocyte Oxidative Stress Fighting in Osteoarthritis
Curr Issues Mol Biol. 2022 Aug 5;44(8):3481-3495. doi: 10.3390/cimb44080240.ABSTRACTOsteoarthritis (OA), the most common joint disease, shows an increasing prevalence in the aging population in industrialized countries. OA is characterized by low-grade chronic inflammation, which causes degeneration of all joint tissues, such as articular cartilage, subchondral bone, and synovial membrane, leading to pain and loss of functionality. Erythrocytes, the most abundant blood cells, have as their primary function oxygen transport, which induces reactive oxygen species (ROS) production. For this reason, the erythrocytes have sever...
Source: Current Issues in Molecular Biology - August 25, 2022 Category: Molecular Biology Authors: Alessia Mariano Irene Bigioni Francesco Misiti Luigi Fattorini Anna Scotto d'Abusco Angelo Rodio Source Type: research
The Nutraceuticals as Modern Key to Achieve Erythrocyte Oxidative Stress Fighting in Osteoarthritis
Curr Issues Mol Biol. 2022 Aug 5;44(8):3481-3495. doi: 10.3390/cimb44080240.ABSTRACTOsteoarthritis (OA), the most common joint disease, shows an increasing prevalence in the aging population in industrialized countries. OA is characterized by low-grade chronic inflammation, which causes degeneration of all joint tissues, such as articular cartilage, subchondral bone, and synovial membrane, leading to pain and loss of functionality. Erythrocytes, the most abundant blood cells, have as their primary function oxygen transport, which induces reactive oxygen species (ROS) production. For this reason, the erythrocytes have sever...
Source: Current Issues in Molecular Biology - August 25, 2022 Category: Molecular Biology Authors: Alessia Mariano Irene Bigioni Francesco Misiti Luigi Fattorini Anna Scotto d'Abusco Angelo Rodio Source Type: research
The Nutraceuticals as Modern Key to Achieve Erythrocyte Oxidative Stress Fighting in Osteoarthritis
Curr Issues Mol Biol. 2022 Aug 5;44(8):3481-3495. doi: 10.3390/cimb44080240.ABSTRACTOsteoarthritis (OA), the most common joint disease, shows an increasing prevalence in the aging population in industrialized countries. OA is characterized by low-grade chronic inflammation, which causes degeneration of all joint tissues, such as articular cartilage, subchondral bone, and synovial membrane, leading to pain and loss of functionality. Erythrocytes, the most abundant blood cells, have as their primary function oxygen transport, which induces reactive oxygen species (ROS) production. For this reason, the erythrocytes have sever...
Source: Current Issues in Molecular Biology - August 25, 2022 Category: Molecular Biology Authors: Alessia Mariano Irene Bigioni Francesco Misiti Luigi Fattorini Anna Scotto d'Abusco Angelo Rodio Source Type: research
The Nutraceuticals as Modern Key to Achieve Erythrocyte Oxidative Stress Fighting in Osteoarthritis
Curr Issues Mol Biol. 2022 Aug 5;44(8):3481-3495. doi: 10.3390/cimb44080240.ABSTRACTOsteoarthritis (OA), the most common joint disease, shows an increasing prevalence in the aging population in industrialized countries. OA is characterized by low-grade chronic inflammation, which causes degeneration of all joint tissues, such as articular cartilage, subchondral bone, and synovial membrane, leading to pain and loss of functionality. Erythrocytes, the most abundant blood cells, have as their primary function oxygen transport, which induces reactive oxygen species (ROS) production. For this reason, the erythrocytes have sever...
Source: Current Issues in Molecular Biology - August 25, 2022 Category: Molecular Biology Authors: Alessia Mariano Irene Bigioni Francesco Misiti Luigi Fattorini Anna Scotto d'Abusco Angelo Rodio Source Type: research
The Nutraceuticals as Modern Key to Achieve Erythrocyte Oxidative Stress Fighting in Osteoarthritis
Curr Issues Mol Biol. 2022 Aug 5;44(8):3481-3495. doi: 10.3390/cimb44080240.ABSTRACTOsteoarthritis (OA), the most common joint disease, shows an increasing prevalence in the aging population in industrialized countries. OA is characterized by low-grade chronic inflammation, which causes degeneration of all joint tissues, such as articular cartilage, subchondral bone, and synovial membrane, leading to pain and loss of functionality. Erythrocytes, the most abundant blood cells, have as their primary function oxygen transport, which induces reactive oxygen species (ROS) production. For this reason, the erythrocytes have sever...
Source: Current Issues in Molecular Biology - August 25, 2022 Category: Molecular Biology Authors: Alessia Mariano Irene Bigioni Francesco Misiti Luigi Fattorini Anna Scotto d'Abusco Angelo Rodio Source Type: research
The Nutraceuticals as Modern Key to Achieve Erythrocyte Oxidative Stress Fighting in Osteoarthritis
Curr Issues Mol Biol. 2022 Aug 5;44(8):3481-3495. doi: 10.3390/cimb44080240.ABSTRACTOsteoarthritis (OA), the most common joint disease, shows an increasing prevalence in the aging population in industrialized countries. OA is characterized by low-grade chronic inflammation, which causes degeneration of all joint tissues, such as articular cartilage, subchondral bone, and synovial membrane, leading to pain and loss of functionality. Erythrocytes, the most abundant blood cells, have as their primary function oxygen transport, which induces reactive oxygen species (ROS) production. For this reason, the erythrocytes have sever...
Source: Current Issues in Molecular Biology - August 25, 2022 Category: Molecular Biology Authors: Alessia Mariano Irene Bigioni Francesco Misiti Luigi Fattorini Anna Scotto d'Abusco Angelo Rodio Source Type: research