Pharmacokinetics of harpagoside in horses after intragastric administration of a Devil's claw (Harpagophytum procumbens) extract
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - September 22, 2018 Category: Veterinary Research Authors: Sonja
Axmann
,
Karin
Hummel
,
Katharina
N öbauer
,
Ebrahim
Razzazi‐Fazeli
,
Karin
Zitterl‐Eglseer Source Type: research
Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine in Pain Reduction and Functional Capacity in Osteoarthritis Patients.
Authors: Puigdellivol J, Comellas Berenger C, Pérez Fernández MÁ, Cowalinsky Millán JM, Carreras Vidal C, Gil Gil I, Martínez Pagán J, Ruiz Nieto B, Jiménez Gómez F, Comas Figuerola FX, Aguilar Hernández ME
Abstract
This observational, open, multicenter clinical trial with a single treatment group aimed to evaluate the effectiveness of a dietary supplement whose main ingredients are hydrolyzed gelatin, chondroitin sulfate, glucosamine sulfate, and devil's claw and bamboo extracts for pain reduction and improvement of functional capacities in patients with osteoarthritis (OA) of the knee and/or hip...
Source: Journal of Dietary Supplements - April 29, 2018 Category: Nutrition Tags: J Diet Suppl Source Type: research
Use of Innovative (Micro)Extraction Techniques to Characterise Harpagophytum procumbens Root and its Commercial Food Supplements
Phytochemical Analysis, EarlyView. (Source: Phytochemical Analysis)
Source: Phytochemical Analysis - November 16, 2017 Category: Biochemistry Source Type: research
Use of Innovative (Micro)Extraction Techniques to Characterise Harpagophytum procumbens Root and its Commercial Food Supplements
ConclusionAll commercial samples respected the European Pharmacopoeia monograph for this plant material, showing a harpagoside content ≥ 1.2%. Copyright © 2017 John Wiley & Sons, Ltd.
Determination of harpagoside and a wide phenolic pattern in H. procumbens root and commercial food supplements, dispersive liquid–liquid microextraction (DLLME), ultrasound‐assisted DLLME, sugaring‐out liquid–liquid extraction, and MAE were tested and compared following HPLC‐PDA analysis. (Source: Phytochemical Analysis)
Source: Phytochemical Analysis - November 1, 2017 Category: Biochemistry Authors: Alina Diuzheva, Simone Carradori, Vasil Andruch, Marcello Locatelli, Elisa De Luca, Matteo Tiecco, Raimondo Germani, Luigi Menghini, Alessio Nocentini, Paola Gratteri, Cristina Campestre Tags: Research Article Source Type: research
Drug-Herb Interactions in the Elderly Patient with IBD: a Growing Concern
Opinion statementInflammatory bowel disease (IBD), which includes conditions such as Crohn ’s disease and ulcerative colitis, is becoming more prevalent with the elderly being the fastest growing group. Parallel to this, there is an increasing interest in the use of complementary and alternative medicine (CAM). Nearly half of patients with IBD have used CAM at one time. The elderly pati ents, however, are burdened by comorbid conditions, polypharmacy, and altered functional status. With increasing use of complementary and alternative medicine in our elderly patients with IBD, it is vital for the provider to provide couns...
Source: Current Treatment Options in Gastroenterology - September 16, 2017 Category: Gastroenterology Source Type: research
Oral herbal medicines marketed in Brazil for the treatment of osteoarthritis: A systematic review and meta ‐analysis
This study guides managers of the Brazilian public health system and prescribers in decision‐making regarding the use of these herbal medicines for OA. Copyright © 2017 John Wiley & Sons, Ltd. (Source: Phytotherapy Research)
Source: Phytotherapy Research - September 1, 2017 Category: Biochemistry Authors: Mariana Del Grossi Moura, Luciane Cruz Lopes, Maique Weber Biavatti, Sean Alexander Kennedy, Maria Carolina Oliveira e Silva, Marcus Tolentino Silva, Cristiane C ássia Bergamaschi Tags: Review Source Type: research
Natural or plant products for the treatment of neurological disorders: current knowledge.
This article updates on the current knowledge of promising natural products used in neurological disorders.
PMID: 28699506 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 10, 2017 Category: Drugs & Pharmacology Authors: Parvez MK Tags: Curr Drug Metab Source Type: research
A Rosa canina – Urtica dioica – Harpagophytum procumbens/zeyheri Combination Significantly Reduces Gonarthritis Symptoms in a Randomized, Placebo-Controlled Double-Blind Study
This study demonstrates excellent efficacy for MA212 in gonarthritis patients. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - June 14, 2017 Category: Drugs & Pharmacology Authors: Mor é, Margret Gruenwald, Joerg Pohl, Ute Uebelhack, Ralf Tags: Original Papers Source Type: research
Review of Anti-Inflammatory Herbal Medicines.
Authors: Ghasemian M, Owlia S, Owlia MB
Abstract
Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies. Curcuma longa, Zingiber officinale, Rosmarinus officinalis, Borago officinalis, evening primrose, and Devil's claw are some of the introd...
Source: Advances in Pharmacological Sciences - June 3, 2016 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research
Anti-osteoporotic activity of harpagide by regulation of bone formation in osteoblast cell culture and ovariectomy-induced bone loss mouse models
Conclusion Taken together, the present study demonstrates that harpagide has a potential for prevention of bone loss in OVX mice by regulating the stimulation of osteoblast differentiation and the suppression of osteoclast formation. Therefore, these findings suggest that harpagide might serve as a bioactive compound derived from H. procumbens var. sublobatum for improvement of age-dependent bone destruction disease. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 12, 2016 Category: Drugs & Pharmacology Source Type: research
Herbal Medicine for Low Back Pain: A Cochrane Review
Conclusions. Additional well-designed large trials are needed to test these herbal medicines against standard treatments. In general, the completeness of reporting in these trials was poor. Trialists should refer to the CONSORT statement extension for reporting trials of herbal medicine interventions.
Level of Evidence: N/A (Source: Spine)
Source: Spine - January 1, 2016 Category: Orthopaedics Tags: Cochrane Collaboration Source Type: research
Africa’s Indigenous Fruit Trees: A Blessing in Decline
Fruits native to the African continent offer nutrients that often come up short in local diets, and they grow on trees that provide a range of ecosystem services. But deforestation is threatening Africa’s indigenous fruit trees. Now researchers and local farmers are partnering to ensure the trees have a future.© Ake Mamo/ICRAF
Grafted bush mango seedlings await planting. According to the World Agroforestry Centre, bush mango has been identified by farmers in Cameroon and Nigeria as their highest priority for domesticating indigenous fruit trees. © Charlie Pye-Smith/ICRAF
At a...
Source: EHP Research - December 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News December 2015 Source Type: research
Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.
CONCLUSIONS: In the present study, we have successfully developed a highly reproducible system to evaluate CYP3A4 inhibition in small intestines by natural medicines.
PMID: 26626238 [PubMed - in process] (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - November 1, 2015 Category: Drugs & Pharmacology Authors: Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K Tags: J Pharm Pharm Sci Source Type: research
Molecules, Vol. 20, Pages 16758-16769: Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats
This study was designed to investigate whether the HO/CO pathway is involved in the analgesic response of H. procumbens in carrageenan-induced hyperalgesia in rats. Mechanical allodynia and thermal hyperalgesia were evaluated by using von Frey filaments and the plantar test, respectively. The results of our experiments showed that pretreatment with the HO inhibitor ZnPP IX significantly decreased the antihyperalgesic effect produced by H. procumbens (800 mg/kg, i.p.) in carrageenan-injected rats. Consistently, the pretreatment with hemin, a HO-1 substrate, or CORM-3, a CO releasing molecule, before a low dose of H. procum...
Source: Molecules - September 15, 2015 Category: Chemistry Authors: Carmela ParentiGiuseppina AricòSantina ChiechioGiulia Di BenedettoRosalba ParentiGiovanna Scoto Tags: Article Source Type: research
Inhibitory effects of harpagoside on TNF-α-induced pro-inflammatory adipokine expression through PPAR-γ activation in 3T3-L1 adipocytes.
Abstract
Obesity is closely associated with increased production of pro-inflammatory adipokines, including interleukin (IL)-6, plasminogen activator inhibitor (PAI)-1, and adipose-tissue-derived monocyte chemoattractant protein (MCP)-1, which contribute to chronic and low-grade inflammation in adipose tissue. Harpagoside, a major iridoid glycoside present in devil's claw, has been reported to show anti-inflammatory activities by suppression of lipopolysaccharide (LPS)-induced production of inflammatory cytokines in murine macrophages. The present study is aimed to investigate the effects of harpagoside on ...
Source: Cytokine - June 3, 2015 Category: Molecular Biology Authors: Kim TK, Park KS Tags: Cytokine Source Type: research
