Identification and characterization of β-sitosterol target proteins.

Identification and characterization of β-sitosterol target proteins.
Bioorg Med Chem Lett. 2015 Mar 11;
Authors: Lomenick B, Shi H, Huang J, Chen C
Abstract
β-Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β-sitosterol that may underlie its beneficial effects.
PMID: 25804720 [PubMed - as supplied by publisher]

Source: Bioorganic and Medicinal Chemistry Letters - March 11, 2015 Category: Chemistry Authors: Lomenick B, Shi H, Huang J, Chen C Tags: Bioorg Med Chem Lett Source Type: research