Molecules, Vol. 26, Pages 7014: Leucosceptoside A from Devil ’s Claw Modulates Psoriasis-like Inflammation via Suppression of the PI3K/AKT Signaling Pathway in Keratinocytes
Molecules, Vol. 26, Pages 7014: Leucosceptoside A from Devil’s Claw Modulates Psoriasis-like Inflammation via Suppression of the PI3K/AKT Signaling Pathway in Keratinocytes Molecules doi: 10.3390/molecules26227014 Authors: Ivanka K. Koycheva Liliya V. Mihaylova Monika N. Todorova Zhivka P. Balcheva-Sivenova Kalina Alipieva Claudio Ferrante Giustino Orlando Milen I. Georgiev Psoriasis is a chronic inflammatory skin condition characterized by abnormal keratinocyte proliferation and differentiation that is accompanied with dysregulated immune response and abnormal vascularization. Devil’s claw (Harpa...
Source: Molecules - November 20, 2021 Category: Chemistry Authors: Ivanka K. Koycheva Liliya V. Mihaylova Monika N. Todorova Zhivka P. Balcheva-Sivenova Kalina Alipieva Claudio Ferrante Giustino Orlando Milen I. Georgiev Tags: Article Source Type: research

The Efficacy of < em > Harpagophytum procumbens < /em > (Teltonal) in Patients with Knee Osteoarthritis: A Randomized Active-Controlled Clinical Trial
CONCLUSION: Teltonal is an effective and safe treatment in patients with mild KOA in the short term. However, no significant superiority was shown in using Teltonal or meloxicam, in people who cannot take NSAIDs, it can be a good alternative, although difference in medication periods should be considered.PMID:34712343 | PMC:PMC8548091 | DOI:10.1155/2021/5596892 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 29, 2021 Category: Complementary Medicine Authors: Hamid Reza Farpour Najme Rajabi Bahareh Ebrahimi Source Type: research

The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells
Osteoarthritis (OA) is the most common form of arthritis, affecting millions of people worldwide and characterised by joint pain and inflammation. It is a complex disease involving inflammatory factors and aff... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - October 14, 2021 Category: Complementary Medicine Authors: Sybille Brochard, Julien Pontin, Benoit Bernay, Karim Boumediene, Thierry Conrozier and Catherine Baug é Tags: Research Source Type: research

In vitro antioxidant activity of crude extracts of Harpagophytum zeyheri and their anti-inflammatory and cytotoxicity activity compared with diclofenac
This study evaluated the in vitro antioxidant activity and comparison of anti-inflammatory and cytotoxic activity of Harpagopytum zeyheri with diclofenac. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - September 23, 2021 Category: Complementary Medicine Authors: Sibonokuhle F. Ncube, Lyndy J. McGaw, Emmanuel Mfotie Njoya, Hilton G. T. Ndagurwa, Peter J. Mundy and Samson Sibanda Tags: Research Source Type: research

Molecules, Vol. 26, Pages 5392: Phytochemical Analysis and Anti-Inflammatory and Anti-Osteoarthritic Bioactive Potential of Verbascum thapsus L. (Scrophulariaceae) Leaf Extract Evaluated in Two In Vitro Models of Inflammation and Osteoarthritis
In this study, we first analyzed the phenylethanoid glycosides profile and the total amount of polyphenols present in a leaf aqueous extract of Verbascum thapsus L. We then investigated the anti-inflammatory and anti-osteoarthritic bioactive potential of the extract in murine monocyte/macrophage-like cells (RAW 264.7) and in human chondrocyte cells (HC), by gene expression analysis of specifics inflammatory cytokines, pro-inflammatory enzymes and metalloproteases. Six phenylethanoid glycosides were identified and the total phenolic content was 124.0 ± 0.7 mg gallic acid equivalent (GAE)/g of extract. The biological invest...
Source: Molecules - September 5, 2021 Category: Chemistry Authors: Giovanna Calabrese Agata Zappal à Anna Dolcimascolo Rosaria Acquaviva Rosalba Parenti Giuseppe Antonio Malfa Tags: Article Source Type: research

IJERPH, Vol. 18, Pages 5538: Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens, Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial
lia Guadalupe-Grau Recreational running (RR) is becoming a popular way to increase physical activity for improving health, together with a higher incidence of knee injuries. The aim was to analyze the effect of a four-week supplementation with a mixture of Harpagophytum procumbens, Zingiber officinale and Bixa orellana on males, middle-aged, RR with an undiagnosed knee discomfort. A randomized triple-blind placebo-control trial was conducted among male RR aged 40–60 years suffering from self-declared knee discomfort after training. Participants were assigned to supplementation (2 g/day in 6 doses; n  =  13; inter...
Source: International Journal of Environmental Research and Public Health - May 22, 2021 Category: Environmental Health Authors: Marcela Gonz ález-Gross Carlos Quesada-Gonz ález Javier Rueda Manuel Sillero-Quintana Nicolas Issaly Angel Enrique D íaz Eva Gesteiro David Escobar-Toledo Rafael Torres-Peralta Marc Roller Amelia Guadalupe-Grau Tags: Article Source Type: research

Removal of lead(II) and chromium(VI) ions from synthetic wastewater by the roots of harpagophytum procumbens plant
Publication date: December 2020Source: Journal of Environmental Chemical Engineering, Volume 8, Issue 6Author(s): Ntaote David Shooto (Source: Journal of Environmental Chemical Engineering)
Source: Journal of Environmental Chemical Engineering - October 4, 2020 Category: Chemistry Source Type: research

Multielement Determination in Medicinal Plants and Herbal Medicines Containing Cynara scolymus L., Harpagophytum procumbens D.C., and Maytenus ilifolia (Mart.) ex Reiss from Brazil Using ICP OES.
Abstract Worldwide, medicinal plants and herbal medicines are widely consumed. The aim of this study was to determine macro- (Ca, K, Mg, Na, and P) and microelements (Al, As, Ba, Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Sb, Se, Si, Sn, Sr, V, and Zn) in medicinal plants and herbal medicines: "globe artichoke" - Cynara scolymus L., "devil's claw" - Harpagophytum procumbens D.C., and "espinheira santa" - Maytenus ilifolia (Mart) ex Reiss. Concentrations of 24 (essential and toxic potentially) elements in samples from Brazil were determined using a sequential optical emission spectrometer with inductively coupled ...
Source: Biological Trace Element Research - August 12, 2020 Category: Biology Authors: de Aragão Tannus C, de Souza Dias F, Santana FB, Dos Santos DCMB, Magalhães HIF, de Souza Dias F, de Freitas Santos Júnior A Tags: Biol Trace Elem Res Source Type: research

Toxicology studies of aqueous-alcohol extracts of Harpagophytum procumbens subsp. procumbens (Burch.) DC.Ex Meisn. (Pedaliaceae) in female and male rats
A variety of medicinal products prepared from secondary tubers of Harpagophytum procumbens subsp. procumbens (Burch.) DC.ex Meisn. (Devil ’s Claw) and H. zeyheri are marketed in Africa, Europe, the United States, ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - January 15, 2020 Category: Complementary Medicine Authors: Kirtan Joshi, Alan Parrish, Elizabeth A. Grunz-Borgmann, Mary Gerkovich and William R. Folk Tags: Research article Source Type: research

Harpagophytum procumbens Extract Ameliorates Allodynia and Modulates Oxidative and Antioxidant Stress Pathways in a Rat Model of Spinal Cord Injury
AbstractSpinal cord injury (SCI) is  a deliberating disorder with impairments in locomotor deficits and incapacitating sensory abnormalities.Harpagophytum procumbens (Hp) is a botanical widely used for treating inflammation and pain related to various inflammatory and musculoskeletal conditions. Using a modified rodent contusion model of SCI, we explored the effects of this botanical on locomotor function and responses to mechanical stimuli, and examined possible neurochemical changes associated with SCI-induced allodynia. Following spinal cord contusion at T10 level, Hp (300  mg/kg, p.o.) or vehicle (water) was administ...
Source: NeuroMolecular Medicine - January 2, 2020 Category: Neurology Source Type: research

Molecules, Vol. 24, Pages 2251: Quality Assessment of Commercial Spagyric Tinctures of Harpagophytum procumbens and Their Antioxidant Properties
eri Preparations from the dried tubers of Harpagophytum procumbens (Burch.) DC ex Meisn, commonly known as devil&amp;rsquo;s claw, are mainly used in modern medicine to relieve joint pain and inflammation in patients suffering from rheumatic and arthritic disorders. This paper describes for the first time the chemical profile of a commercial spagyric tincture (named 019) prepared from the roots of the plant. For comparison purposes, a commercial not-spagyric devil&amp;rsquo;s claw tincture (NST) was also analyzed. Chemical investigation of the content of specialized metabolites in the three samples indicated th...
Source: Molecules - June 16, 2019 Category: Chemistry Authors: Pinarosa Avato Maria Pia Argentieri Tags: Article Source Type: research

Harpagoside Content in Devil's Claw Extracts.
Authors: Kondamudi N, Turner MW, McDougal OM Abstract Devil's claw is a common ingredient in nutraceutical products for the treatment of inflammation due to arthritis. The secondary root extract of Harpagophymn piocumbens contains bioactive iridoid glycosides known as harpagosides. Recent scrutiny of the nutraceutical industry claims that products listing devil's claw on their labels should refer only to H. procumbens, while the closely related, and less expensive, H. zeyheri is not to be classified as devil's claw. .This assertion is in contrast to botanists who claim that either species of Harpagophytum ...
Source: Natural Product Communications - June 9, 2019 Category: Biochemistry Tags: Nat Prod Commun Source Type: research

Natural products and their (semi-)synthetic forms in treatment of migraine: History and current status.
CONCLUSIONS: The discovery of novel targets in migraine therapy has opened new horizons for compounds that have not been clinically tested or that previously failed in clinical trials as potential antimigraine drugs. Ginkgolide B, melatonin, histamine, oxytocin, various ribosomal peptide toxins, kavalactones, devil's claw-derived compounds, salvinorin A and petasin are among those agents that show considerable promise as novel drugs in migraine prevention and treatment. It is necessary to conduct more research to better understand their antimigraine action, to confirm their effectiveness and safety, and to introduce them i...
Source: Current Medicinal Chemistry - January 25, 2019 Category: Chemistry Authors: Tauchen J Tags: Curr Med Chem Source Type: research