Statin-related neurocognitive disorder: a real-world pharmacovigilance study based on the FDA adverse event reporting system
CONCLUSIONS: This study suggests a significant association between the NCDE and statins, including atorvastatin, simvastatin, and pravastatin. The intensity of the association increased with age.PMID:38275183 | DOI:10.1080/17512433.2024.2311875 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - January 26, 2024 Category: Drugs & Pharmacology Authors: Min Xiao Li Li Weiwei Zhu Fengbo Wu Bin Wu Source Type: research
Efficacy of Dyslipidemia Control by Combination Therapy with Rosuvastatin 10 Mg and Ezetimibe 10 Mg Compared with Rosuvastatin 20 Mg Monotherapy in Patients with Chronic Coronary Syndromes: A Randomized, Single-blind Controlled Trial
CONCLUSION: Group A's LDL-c reduction effect and target achievement proportion (Rosuvastatin 10mg + Ezetimibe 10 mg) were significantly higher than Group B's (Rosuvastatin 20 mg). Both medication therapies were safe in patients, and the increased dose of monotherapy showed more side effects than the combination therapy.PMID:38275031 | DOI:10.2174/0118715257274373231211060714 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 26, 2024 Category: Cardiology Authors: An Viet Tran Bao Lam Thai Tran Nghia Minh Bui Anh Tan To Le Diem Thi Nguyen Son Kim Tran Toan Hoang Ngo Source Type: research
Enhancing osteogenic differentiation of dental pulp stem cells through rosuvastatin loaded niosomes optimized by Box-Behnken design and modified by hyaluronan: a novel strategy for improved efficiency
Bone tissue engineering necessitates a stem cell source capable of osteoblast differentiation and mineralized matrix production. Dental pulp stem cells (DPSCs), a subtype of mesenchymal stem cells from human t... (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - January 26, 2024 Category: Biotechnology Authors: Zaynab Sadeghi Ghadi, Amin Asadi, Younes Pilehvar, Mozhgan Abasi and Pedram Ebrahimnejad Tags: Research Source Type: research
Genetic Determinants of Response to Statins in Cardiovascular Diseases
Curr Cardiol Rev. 2024 Jan 9. doi: 10.2174/011573403X267793231220114042. Online ahead of print.ABSTRACTDespite extensive efforts to identify patients with cardiovascular disease (CVD) who could most benefit from the treatment approach, patients vary in their benefit from therapy and propensity for adverse drug events. Genetic variability in individual responses to drugs (pharmacogenetics) is considered an essential determinant in responding to a drug. Thus, understanding these pharmacogenomic relationships has led to a substantial focus on mechanisms of disease and drug response. In turn, understanding the genomic and mole...
Source: Current Cardiology Reviews - January 11, 2024 Category: Cardiology Authors: Ghazaleh Ghorbannezhad Shima Mehrabadi Negar Golampour-Shamkani Amirhossein Barjasteh Poorya Etesamizadeh Mohammad Tayyebi Majid Khazaei Seyed Mahdi Hassanian Gordon A Ferns Amir Avan Source Type: research
Triple-layered platform utilizing electrospun nanofibers and 3D-printed sodium alginate-based hydrogel for effective topical treatment of rheumatoid arthritis
Int J Biol Macromol. 2024 Jan 4:129195. doi: 10.1016/j.ijbiomac.2023.129195. Online ahead of print.ABSTRACTRheumatoid arthritis (RA), an autoimmune disease impacting the joints, significantly diminishes the quality of life for patients. Conventional treatments predominantly rely on oral or injectable formulations, underscoring the crucial need for an effective topical remedy. The present study reports a novel triple-layered transdermal platform for efficient RA treatment. The patches are based on an electrospun/electrosprayed diclofenac (DIC)-conjugated polyvinyl alcohol (PVA) nanofibers/nanoparticles (NFs/NPs) composite l...
Source: International Journal of Biological Macromolecules - January 6, 2024 Category: Biochemistry Authors: Hend A Elshabrawy Ahmed S Abo Dena Ibrahim M El-Sherbiny Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Atherosclerosis)
Source: Atherosclerosis - January 4, 2024 Category: Cardiology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Atherosclerosis)
Source: Atherosclerosis - January 4, 2024 Category: Cardiology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | DOI:10.4093/dmj.2022.0402 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Comparative Efficacy of Rosuvastatin Monotherapy and Rosuvastatin/Ezetimibe Combination Therapy on Insulin Sensitivity and Vascular Inflammatory Response in Patients with Type 2 Diabetes Mellitus
CONCLUSION: Although rosuvastatin/ezetimibe combination therapy had a greater LDL-C reduction effect than rosuvastatin monotherapy, it had no additional effects on insulin sensitivity and vascular inflammatory response. Further studies are needed on the effect of long-term treatment with ezetimibe on insulin sensitivity and vascular inflammatory response.PMID:38173371 | PMC:PMC10850282 | DOI:10.4093/dmj.2022.0402 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Ji Hye Han Kyong Hye Joung Jun Choul Lee Ok Soon Kim Sorim Choung Ji Min Kim Yea Eun Kang Hyon-Seung Yi Ju Hee Lee Bon Jeong Ku Hyun Jin Kim Source Type: research
Uptake of Fluorescein via a pH-Dependent Monocarboxylate Transporter by Human Kidney 2 (HK-2) Cells
Biol Pharm Bull. 2024;47(1):79-87. doi: 10.1248/bpb.b23-00570.ABSTRACTHerein, we investigated whether a fluorescent probe for an organic anion transporter (OAT), fluorescein (FLS), could be accumulated by human kidney 2 (HK-2) cells derived from human kidney proximal tubular epithelia. HK-2 cells took up FLS in a pH-dependent and concentration-dependent manner. FLS accumulation by HK-2 cells was inhibited by monocarboxylic acids, ibuprofen, rosuvastatin, and indoleacetic acid but not by typical substrates for OATs. A typical protonophore, carbonyl cyanide p-trichloromethoxyphenylhydrazone completely abolished FLS accumulat...
Source: Biological and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takaharu Takiguchi Kazuaki Sugio Masayuki Masuda Shotaro Sasaki Seiji Miyauchi Source Type: research
Uptake of Fluorescein via a pH-Dependent Monocarboxylate Transporter by Human Kidney 2 (HK-2) Cells
Biol Pharm Bull. 2024;47(1):79-87. doi: 10.1248/bpb.b23-00570.ABSTRACTHerein, we investigated whether a fluorescent probe for an organic anion transporter (OAT), fluorescein (FLS), could be accumulated by human kidney 2 (HK-2) cells derived from human kidney proximal tubular epithelia. HK-2 cells took up FLS in a pH-dependent and concentration-dependent manner. FLS accumulation by HK-2 cells was inhibited by monocarboxylic acids, ibuprofen, rosuvastatin, and indoleacetic acid but not by typical substrates for OATs. A typical protonophore, carbonyl cyanide p-trichloromethoxyphenylhydrazone completely abolished FLS accumulat...
Source: Biological and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takaharu Takiguchi Kazuaki Sugio Masayuki Masuda Shotaro Sasaki Seiji Miyauchi Source Type: research
Uptake of Fluorescein via a pH-Dependent Monocarboxylate Transporter by Human Kidney 2 (HK-2) Cells
Biol Pharm Bull. 2024;47(1):79-87. doi: 10.1248/bpb.b23-00570.ABSTRACTHerein, we investigated whether a fluorescent probe for an organic anion transporter (OAT), fluorescein (FLS), could be accumulated by human kidney 2 (HK-2) cells derived from human kidney proximal tubular epithelia. HK-2 cells took up FLS in a pH-dependent and concentration-dependent manner. FLS accumulation by HK-2 cells was inhibited by monocarboxylic acids, ibuprofen, rosuvastatin, and indoleacetic acid but not by typical substrates for OATs. A typical protonophore, carbonyl cyanide p-trichloromethoxyphenylhydrazone completely abolished FLS accumulat...
Source: Biological and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Takaharu Takiguchi Kazuaki Sugio Masayuki Masuda Shotaro Sasaki Seiji Miyauchi Source Type: research
