Elucidating the antifungal activity and mechanism of action of bioactive phytochemicals against fungal dermatitis isolates
AbstractDermatophytosis has been the most common cause of superficial fungal infections which invade the keratinized tissues of body such as nail, hair, and skin, respectively. Although these infections are treatable and many commercial drugs are available that can be applied topically (clotrimazole, fluconazole, itraconazole, miconazole, voriconazole) on the infected areas but they have very low efficacy and has high probability of relapse. To increase the efficacy of treatment, the patient receives supplementary oral medicines for prolong duration that leads to hepatotoxicity. Previously, it has been reported that some w...
Source: Archives of Dermatological Research - November 27, 2022 Category: Dermatology Source Type: research

Clotrimazole-based hybrid structures of pyrazole and benzimidazole: synthesis, antifungal evaluation and computational studies
AbstractSome new N-substituted hetero aromatic compounds, derived from clotrimazole, were synthesized. In this regard, imidazole ring of clotrimazole was replaced by pyrazole (Series A; P1-P4) and benzimidazole moieties (Series B; P5-P8). All new compounds were evaluated against different species of fungi using broth microdilution method as recommended by clinical and laboratory standard institute (CLSI). Their cytotoxicity was assessed against MRC-5 as normal human fibroblasts cell line using MTT method. To augury the binding mode of the synthesized compounds against cytochrome P450 lanosterol 14 α-demethylase, molecular...
Source: Medicinal Chemistry Research - October 25, 2022 Category: Chemistry Source Type: research

Comparison between the Efficacy of < em > Nigella sativa < /em > -Honey and Clotrimazole on Vulvovaginal Candidiasis: A Randomized Clinical Trial
CONCLUSION: The results of this study show that the N. sativa-honey significantly improves the symptoms of VVC; thus, the application of N. sativa-honey can be considered as a complementary therapy in the treatment of VVC. This trial is registered with IRCT20190711044176N1.PMID:36276860 | PMC:PMC9586731 | DOI:10.1155/2022/1739729 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 24, 2022 Category: Complementary Medicine Authors: Masoumeh Norouzi Allahleh Korabi Seyedeh Tahereh Mirmolaei Malihe Tabarrai Seyedeh Mojgan Ghalandarpoor-Attar Seyede Nargess Sadati Lamardi Shima Haghani Source Type: research

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole
Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted t...
Source: Annales Pharmaceutiques Francaises - October 17, 2022 Category: Drugs & Pharmacology Authors: Arshin Nemati Homa Rezaei Kader Poturcu Jalal Hanaee Abolghasem Jouyban Hongkun Zhao Elaheh Rahimpour Source Type: research

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole
Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted t...
Source: Annales Pharmaceutiques Francaises - October 17, 2022 Category: Drugs & Pharmacology Authors: Arshin Nemati Homa Rezaei Kader Poturcu Jalal Hanaee Abolghasem Jouyban Hongkun Zhao Elaheh Rahimpour Source Type: research

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole
Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted t...
Source: Annales Pharmaceutiques Francaises - October 17, 2022 Category: Drugs & Pharmacology Authors: Arshin Nemati Homa Rezaei Kader Poturcu Jalal Hanaee Abolghasem Jouyban Hongkun Zhao Elaheh Rahimpour Source Type: research

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole
Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted t...
Source: Annales Pharmaceutiques Francaises - October 17, 2022 Category: Drugs & Pharmacology Authors: Arshin Nemati Homa Rezaei Kader Poturcu Jalal Hanaee Abolghasem Jouyban Hongkun Zhao Elaheh Rahimpour Source Type: research

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole
Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted t...
Source: Annales Pharmaceutiques Francaises - October 17, 2022 Category: Drugs & Pharmacology Authors: Arshin Nemati Homa Rezaei Kader Poturcu Jalal Hanaee Abolghasem Jouyban Hongkun Zhao Elaheh Rahimpour Source Type: research

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole
Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted t...
Source: Annales Pharmaceutiques Francaises - October 17, 2022 Category: Drugs & Pharmacology Authors: Arshin Nemati Homa Rezaei Kader Poturcu Jalal Hanaee Abolghasem Jouyban Hongkun Zhao Elaheh Rahimpour Source Type: research

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole
Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted t...
Source: Annales Pharmaceutiques Francaises - October 17, 2022 Category: Drugs & Pharmacology Authors: Arshin Nemati Homa Rezaei Kader Poturcu Jalal Hanaee Abolghasem Jouyban Hongkun Zhao Elaheh Rahimpour Source Type: research

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole
Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted t...
Source: Annales Pharmaceutiques Francaises - October 17, 2022 Category: Drugs & Pharmacology Authors: Arshin Nemati Homa Rezaei Kader Poturcu Jalal Hanaee Abolghasem Jouyban Hongkun Zhao Elaheh Rahimpour Source Type: research

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole
Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted t...
Source: Annales Pharmaceutiques Francaises - October 17, 2022 Category: Drugs & Pharmacology Authors: Arshin Nemati Homa Rezaei Kader Poturcu Jalal Hanaee Abolghasem Jouyban Hongkun Zhao Elaheh Rahimpour Source Type: research

Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole
Ann Pharm Fr. 2022 Oct 14:S0003-4509(22)00142-0. doi: 10.1016/j.pharma.2022.10.001. Online ahead of print.ABSTRACTHerein, the solubility study of clotrimazole was performed in a propylene glycol + water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol + water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol + water and fitted t...
Source: Annales Pharmaceutiques Francaises - October 17, 2022 Category: Drugs & Pharmacology Authors: Arshin Nemati Homa Rezaei Kader Poturcu Jalal Hanaee Abolghasem Jouyban Hongkun Zhao Elaheh Rahimpour Source Type: research