Clotrimazole ameliorates chronic mild stress-induced depressive-like behavior in rats; crosstalk between the HPA, NLRP3 inflammasome, and Wnt/ β-catenin pathways
Int Immunopharmacol. 2023 Dec 15;127:111354. doi: 10.1016/j.intimp.2023.111354. Online ahead of print.ABSTRACTDepression is a major emotional disorder that has a detrimental effect on quality of life. The chronic mild stress (CMS)-depression model was adopted in rats to evaluate the neurotherapeutic effect of Clotrimazole (CLO) and investigate the possible mechanisms of its antidepressant action via its impact on the hypothalamic pituitary adrenal (HPA) axis and the stress hormone, cortisol. It was found that azole antifungals affect steroidogenesis and the HPA axis. Behavioral, histopathological, inflammatory, and apoptot...
Source: International Immunopharmacology - December 16, 2023 Category: Allergy & Immunology Authors: Sylvia F Fawzi Haidy E Michel Esther T Menze Mariane G Tadros Mina Y George Source Type: research
Ivermectin Toxicokinetics in Rainbow Trout (Oncorhynchus mykiss) following P-glycoprotein Induction
Arch Environ Contam Toxicol. 2023 Dec 16. doi: 10.1007/s00244-023-01045-7. Online ahead of print.ABSTRACTAlterations in ivermectin (IVM, 22,23-dihydro avermectin B1a+22,23-dihydro avermectin B1b) toxicokinetics following P-glycoprotein (P-gp) induction by clotrimazole (CTZ) were examined in rainbow trout (Oncorhynchus mykiss) to assess the potential importance of P-gp activity levels in xenobiotic distribution and kinetics in fish. Control and fish pretreated with CTZ (30 µmol/kg) were administered 175 µg/kg 3H-IVM into the caudal vasculature. At various time points (0.25, 0.5, 1, 3, 24, 48, 96, and 168 h) following inje...
Source: Archives of Environmental Contamination and Toxicology - December 16, 2023 Category: Environmental Health Authors: Vinicius Cavicchioli Azevedo Christina U Johnston Christopher J Kennedy Source Type: research
Ivermectin Toxicokinetics in Rainbow Trout (Oncorhynchus mykiss) following P-glycoprotein Induction
Arch Environ Contam Toxicol. 2023 Dec 16. doi: 10.1007/s00244-023-01045-7. Online ahead of print.ABSTRACTAlterations in ivermectin (IVM, 22,23-dihydro avermectin B1a+22,23-dihydro avermectin B1b) toxicokinetics following P-glycoprotein (P-gp) induction by clotrimazole (CTZ) were examined in rainbow trout (Oncorhynchus mykiss) to assess the potential importance of P-gp activity levels in xenobiotic distribution and kinetics in fish. Control and fish pretreated with CTZ (30 µmol/kg) were administered 175 µg/kg 3H-IVM into the caudal vasculature. At various time points (0.25, 0.5, 1, 3, 24, 48, 96, and 168 h) following inje...
Source: Archives of Environmental Contamination and Toxicology - December 16, 2023 Category: Environmental Health Authors: Vinicius Cavicchioli Azevedo Christina U Johnston Christopher J Kennedy Source Type: research
Comparative study of drug release from electrospun nanofibers loaded with clotrimazole via two different approaches using a fully automated sequential injection system
Talanta. 2023 Nov 21;269:125415. doi: 10.1016/j.talanta.2023.125415. Online ahead of print.ABSTRACTThe development of new drug delivery platforms including the use of nanotechnology has been found of great interest in recent years. Two different loading approaches of the model antimycotic drug clotrimazole into the nanofibrous polycaprolactone and polydioxanone structures including electrospinning of a drug-polymer blend and impregnation of nanofibers with drug have been tested. The final amount of clotrimazole in the nanofibrous materials was determined by HPLC analysis and Raman spectroscopy. The electrospinning of blend...
Source: Talanta - November 25, 2023 Category: Chemistry Authors: Martina H áková Ukamaka Modebelu Jakub Erben Ludmila Matysov á Dalibor Šatínský Franti šek Švec Hana Sklen ářová Source Type: research
Comparative study of drug release from electrospun nanofibers loaded with clotrimazole via two different approaches using a fully automated sequential injection system
Talanta. 2023 Nov 21;269:125415. doi: 10.1016/j.talanta.2023.125415. Online ahead of print.ABSTRACTThe development of new drug delivery platforms including the use of nanotechnology has been found of great interest in recent years. Two different loading approaches of the model antimycotic drug clotrimazole into the nanofibrous polycaprolactone and polydioxanone structures including electrospinning of a drug-polymer blend and impregnation of nanofibers with drug have been tested. The final amount of clotrimazole in the nanofibrous materials was determined by HPLC analysis and Raman spectroscopy. The electrospinning of blend...
Source: Talanta - November 25, 2023 Category: Chemistry Authors: Martina H áková Ukamaka Modebelu Jakub Erben Ludmila Matysov á Dalibor Šatínský Franti šek Švec Hana Sklen ářová Source Type: research
A comprehensively validated IVRT method reliably discriminates sameness and differences between several topical clotrimazole creams
Eur J Pharm Sci. 2023 Nov 20:106649. doi: 10.1016/j.ejps.2023.106649. Online ahead of print.ABSTRACTIn vitro release testing (IVRT) has gained increasing acceptance for use as a biowaiver for topical products intended for local action. Whereas the United States Food and Drug Administration (US FDA) has issued product specific guidances (PSGs) recommending IVRT for several products, the PSG for clotrimazole cream does not include an IVRT option. However, an important requirement to include supplemental selectivity in the validation process as described in the recent FDA draft guidance on IVRT studies for topical drug produc...
Source: European Journal of Pharmaceutical Sciences - November 22, 2023 Category: Drugs & Pharmacology Authors: Hannah Wellington Seeprarani Rath Isadore Kanfer Source Type: research
A comprehensively validated IVRT method reliably discriminates sameness and differences between several topical clotrimazole creams
Eur J Pharm Sci. 2023 Nov 20:106649. doi: 10.1016/j.ejps.2023.106649. Online ahead of print.ABSTRACTIn vitro release testing (IVRT) has gained increasing acceptance for use as a biowaiver for topical products intended for local action. Whereas the United States Food and Drug Administration (US FDA) has issued product specific guidances (PSGs) recommending IVRT for several products, the PSG for clotrimazole cream does not include an IVRT option. However, an important requirement to include supplemental selectivity in the validation process as described in the recent FDA draft guidance on IVRT studies for topical drug produc...
Source: European Journal of Pharmaceutical Sciences - November 22, 2023 Category: Drugs & Pharmacology Authors: Hannah Wellington Seeprarani Rath Isadore Kanfer Source Type: research
Molecules, Vol. 28, Pages 7453: Antimicrobial Activity of Manganese(I) Tricarbonyl Complexes Bearing 1,2,3-Triazole Ligands
Conclusions. Due to the increased problem of antibiotic resistance and a lack of new antibacterial drugs with no toxicity, these results are exciting and show that these types of complexes can be an avenue to pursue in the future. (Source: Molecules)
Source: Molecules - November 6, 2023 Category: Chemistry Authors: Sofia Fri ães C ândida Trigueiros Clara S. B. Gomes Alexandra R. Fernandes Oscar A. Lenis-Rojas Marta Martins Beatriz Royo Tags: Article Source Type: research
Proposal for priority emerging pollutants in the Nakdong river, Korea: Application of EU watch list mechanisms
Environ Pollut. 2023 Oct 31:122838. doi: 10.1016/j.envpol.2023.122838. Online ahead of print.ABSTRACTThe Nakdong River, the longest in Korea, has received numerous pollutants from heavily industrialized and densely populated areas while being used as a drinking water source. A number of research have reported occurrences of emerging pollutants (EPs) in the river. The results requested efficient monitoring and systematic management strategies such as EU watch list under Water Framework Directive. The aim of this study is to propose a watch list through preliminary monitoring of the river and risk-based prioritization approa...
Source: Environmental Pollution - November 2, 2023 Category: Environmental Health Authors: Sangyoon Lee Younghoon Choi Daeho Kang Junho Jeon Source Type: research
Proposal for priority emerging pollutants in the Nakdong river, Korea: Application of EU watch list mechanisms
Environ Pollut. 2023 Oct 31:122838. doi: 10.1016/j.envpol.2023.122838. Online ahead of print.ABSTRACTThe Nakdong River, the longest in Korea, has received numerous pollutants from heavily industrialized and densely populated areas while being used as a drinking water source. A number of research have reported occurrences of emerging pollutants (EPs) in the river. The results requested efficient monitoring and systematic management strategies such as EU watch list under Water Framework Directive. The aim of this study is to propose a watch list through preliminary monitoring of the river and risk-based prioritization approa...
Source: Environmental Pollution - November 2, 2023 Category: Environmental Health Authors: Sangyoon Lee Younghoon Choi Daeho Kang Junho Jeon Source Type: research
Molecules, Vol. 28, Pages 7308: Evaluation of Encapsulation Potential of Selected Star-Hyperbranched Polyglycidol Architectures: Predictive Molecular Dynamics Simulations and Experimental Validation
This study demonstrates an MD approach to model drying of systems comprising either hydrophilic tinidazole or hydrophobic clotrimazole drugs with amphiphilic hyperbranched copolyethers. The simulated drying protocol was critical for elucidating drug encapsulation and binding mechanisms. Experimentally, two polymers were synthesized and shown to encapsulate clotrimazole with up to 83% efficiency, guided by interactions with the hydrophobic core observed in simulations. In contrast, tinidazole is associated with surface regions, indicating capacity differences between drug types. Overall, this work highlights MD simulation o...
Source: Molecules - October 28, 2023 Category: Chemistry Authors: Mateusz Gosecki Malgorzata Urbaniak Nuno Martinho Monika Gosecka Mire Zloh Tags: Article Source Type: research
Assessing the Efficacy of Clotrimazole and Metronidazole Combined Treatment in Vaginitis: A Meta-Analysis
CONCLUSIONS: The combination of clotrimazole and metronidazole is an effective treatment option for mixed infectious vaginitis, thus warranting recommendation.PMID:37773671 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - September 29, 2023 Category: Complementary Medicine Authors: Yan Huang Cihui Shen Yanmin Shen Hongyin Cui Source Type: research
Assessing the Efficacy of Clotrimazole and Metronidazole Combined Treatment in Vaginitis: A Meta-Analysis
CONCLUSIONS: The combination of clotrimazole and metronidazole is an effective treatment option for mixed infectious vaginitis, thus warranting recommendation.PMID:37773671 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - September 29, 2023 Category: Complementary Medicine Authors: Yan Huang Cihui Shen Yanmin Shen Hongyin Cui Source Type: research
Assessing the Efficacy of Clotrimazole and Metronidazole Combined Treatment in Vaginitis: A Meta-Analysis
CONCLUSIONS: The combination of clotrimazole and metronidazole is an effective treatment option for mixed infectious vaginitis, thus warranting recommendation.PMID:37773671 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - September 29, 2023 Category: Complementary Medicine Authors: Yan Huang Cihui Shen Yanmin Shen Hongyin Cui Source Type: research
Assessing the Efficacy of Clotrimazole and Metronidazole Combined Treatment in Vaginitis: A Meta-Analysis
CONCLUSIONS: The combination of clotrimazole and metronidazole is an effective treatment option for mixed infectious vaginitis, thus warranting recommendation.PMID:37773671 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - September 29, 2023 Category: Complementary Medicine Authors: Yan Huang Cihui Shen Yanmin Shen Hongyin Cui Source Type: research
