Distinct mechanism of action for antitumoral neutral cyclometalated Pt(II)-complexes bearing antifungal imidazolyl-based drugs
J Inorg Biochem. 2021 Nov 11;226:111663. doi: 10.1016/j.jinorgbio.2021.111663. Online ahead of print.ABSTRACTThree neutral Pt(II) complexes containing 1-Methylimidazole and the antifungal imidazolyl drugs Clotrimazole and Bifonazole have been prepared. The general formula of the new derivatives is [Pt(κ2-(C^N)Cl(L)], where C^N stands for ppy = 2-phenylpyridinate, and L = 1-Methylimidazole (MeIm) for [Pt-MeIm]; L = Clotrimazole (CTZ) for [Pt-CTZ] and L = Bifonazole (BFZ) for [Pt-BFZ]). The complexes have been completely characterized in solution and the crystal structures of [Pt-BFZ] and [Pt-CTZ] have been resolved. Comple...
Source: Journal of Inorganic Biochemistry - November 21, 2021 Category: Biochemistry Authors: Natalia Fern ández-Pampín M ónica Vaquero Tania Gil Gustavo Espino Dar ío Fernández Bego ña García Natalia Busto Source Type: research
Distinct mechanism of action for antitumoral neutral cyclometalated Pt(II)-complexes bearing antifungal imidazolyl-based drugs
J Inorg Biochem. 2021 Nov 11;226:111663. doi: 10.1016/j.jinorgbio.2021.111663. Online ahead of print.ABSTRACTThree neutral Pt(II) complexes containing 1-Methylimidazole and the antifungal imidazolyl drugs Clotrimazole and Bifonazole have been prepared. The general formula of the new derivatives is [Pt(κ2-(C^N)Cl(L)], where C^N stands for ppy = 2-phenylpyridinate, and L = 1-Methylimidazole (MeIm) for [Pt-MeIm]; L = Clotrimazole (CTZ) for [Pt-CTZ] and L = Bifonazole (BFZ) for [Pt-BFZ]). The complexes have been completely characterized in solution and the crystal structures of [Pt-BFZ] and [Pt-CTZ] have been resolved. Comple...
Source: Journal of Inorganic Biochemistry - November 21, 2021 Category: Biochemistry Authors: Natalia Fern ández-Pampín M ónica Vaquero Tania Gil Gustavo Espino Dar ío Fernández Bego ña García Natalia Busto Source Type: research
Distinct mechanism of action for antitumoral neutral cyclometalated Pt(II)-complexes bearing antifungal imidazolyl-based drugs
J Inorg Biochem. 2021 Nov 11;226:111663. doi: 10.1016/j.jinorgbio.2021.111663. Online ahead of print.ABSTRACTThree neutral Pt(II) complexes containing 1-Methylimidazole and the antifungal imidazolyl drugs Clotrimazole and Bifonazole have been prepared. The general formula of the new derivatives is [Pt(κ2-(C^N)Cl(L)], where C^N stands for ppy = 2-phenylpyridinate, and L = 1-Methylimidazole (MeIm) for [Pt-MeIm]; L = Clotrimazole (CTZ) for [Pt-CTZ] and L = Bifonazole (BFZ) for [Pt-BFZ]). The complexes have been completely characterized in solution and the crystal structures of [Pt-BFZ] and [Pt-CTZ] have been resolved. Comple...
Source: Journal of Inorganic Biochemistry - November 21, 2021 Category: Biochemistry Authors: Natalia Fern ández-Pampín M ónica Vaquero Tania Gil Gustavo Espino Dar ío Fernández Bego ña García Natalia Busto Source Type: research
Fifteen-minute consultation: Vulval soreness in the prepubertal girl
Case scenario A general practitioner (GP) refers to your general paediatric outpatient clinic a 6-year old girl with an intermittently sore vulva with occasional discharge. Her mother noticed her ‘vagina’/genitalia has been slightly red, and there is intermittent minimal white discharge. Clotrimazole (Canestan), prescribed by her GP, has not made any difference. What are you going to do? In this article, we discuss the aetiology and initial assessment of vulval soreness and related symptoms in the prepubertal girl. The article does not include the differential diagnoses in the peripubertal and postpubertal adol...
Source: Archives of Disease in Childhood - Education and Practice - November 18, 2021 Category: Pediatrics Authors: Chanchlani, N., Hodes, D. Tags: Best practice and Fifteen Minute Consultations Best practice and Fifteen-minute consultations Source Type: research
Binder jetting 3D printing of challenging medicines: from low dose tablets to hydrophobic molecules
Eur J Pharm Biopharm. 2021 Nov 13:S0939-6411(21)00274-5. doi: 10.1016/j.ejpb.2021.11.001. Online ahead of print.ABSTRACTIncreasing access to additive manufacturing technologies utilising easily available desktop devices opened novel ways for formulation of personalized medicines. It is, however, challenging to propose a flexible and robust formulation platform which can be used for fabrication of tailored solid dosage forms composed of APIs with different properties (e.g., hydrophobicity) without extensive optimization. This manuscript presents a strategy for formulation of fast dissolving tablets using binder jetting (BJ)...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 17, 2021 Category: Drugs & Pharmacology Authors: Marta Kozakiewicz Karol P Nartowski Aleksandra Dominik Katarzyna Malec Anna M Go łkowska Adrianna Z łocińska Ma łgorzata Rusińska Patrycja Szymczyk-Zi ółkowska Grzegorz Zi ółkowski Agata G órniak Bo żena Karolewicz Source Type: research
Binder jetting 3D printing of challenging medicines: from low dose tablets to hydrophobic molecules
Eur J Pharm Biopharm. 2021 Nov 13:S0939-6411(21)00274-5. doi: 10.1016/j.ejpb.2021.11.001. Online ahead of print.ABSTRACTIncreasing access to additive manufacturing technologies utilising easily available desktop devices opened novel ways for formulation of personalized medicines. It is, however, challenging to propose a flexible and robust formulation platform which can be used for fabrication of tailored solid dosage forms composed of APIs with different properties (e.g., hydrophobicity) without extensive optimization. This manuscript presents a strategy for formulation of fast dissolving tablets using binder jetting (BJ)...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 17, 2021 Category: Drugs & Pharmacology Authors: Marta Kozakiewicz Karol P Nartowski Aleksandra Dominik Katarzyna Malec Anna M Go łkowska Adrianna Z łocińska Ma łgorzata Rusińska Patrycja Szymczyk-Zi ółkowska Grzegorz Zi ółkowski Agata G órniak Bo żena Karolewicz Source Type: research
The continued inappropriate use and overuse of combination topical clotrimazole-betamethasone
CONCLUSION: We strongly recommend clinicians use alternative treatments for rashes or refer to dermatologists.PMID:34755955 | DOI:10.5070/D327854686 (Source: Dermatol Online J)
Source: Dermatol Online J - November 10, 2021 Category: Dermatology Authors: Nicholas D Flint Jamie L W Rhoads Ryan Carlisle Meganne Ferrel Zachary H Hopkins Aaron M Secrest Source Type: research
The continued inappropriate use and overuse of combination topical clotrimazole-betamethasone
CONCLUSION: We strongly recommend clinicians use alternative treatments for rashes or refer to dermatologists.PMID:34755955 | DOI:10.5070/D327854686 (Source: Dermatol Online J)
Source: Dermatol Online J - November 10, 2021 Category: Dermatology Authors: Nicholas D Flint Jamie L W Rhoads Ryan Carlisle Meganne Ferrel Zachary H Hopkins Aaron M Secrest Source Type: research
The continued inappropriate use and overuse of combination topical clotrimazole-betamethasone
CONCLUSION: We strongly recommend clinicians use alternative treatments for rashes or refer to dermatologists.PMID:34755955 | DOI:10.5070/D327854686 (Source: Dermatol Online J)
Source: Dermatol Online J - November 10, 2021 Category: Dermatology Authors: Nicholas D Flint Jamie L W Rhoads Ryan Carlisle Meganne Ferrel Zachary H Hopkins Aaron M Secrest Source Type: research
The continued inappropriate use and overuse of combination topical clotrimazole-betamethasone
CONCLUSION: We strongly recommend clinicians use alternative treatments for rashes or refer to dermatologists.PMID:34755955 | DOI:10.5070/D327854686 (Source: Dermatol Online J)
Source: Dermatol Online J - November 10, 2021 Category: Dermatology Authors: Nicholas D Flint Jamie L W Rhoads Ryan Carlisle Meganne Ferrel Zachary H Hopkins Aaron M Secrest Source Type: research
The continued inappropriate use and overuse of combination topical clotrimazole-betamethasone
CONCLUSION: We strongly recommend clinicians use alternative treatments for rashes or refer to dermatologists.PMID:34755955 | DOI:10.5070/D327854686 (Source: Dermatol Online J)
Source: Dermatol Online J - November 10, 2021 Category: Dermatology Authors: Nicholas D Flint Jamie L W Rhoads Ryan Carlisle Meganne Ferrel Zachary H Hopkins Aaron M Secrest Source Type: research
The continued inappropriate use and overuse of combination topical clotrimazole-betamethasone
CONCLUSION: We strongly recommend clinicians use alternative treatments for rashes or refer to dermatologists.PMID:34755955 | DOI:10.5070/D327854686 (Source: Dermatol Online J)
Source: Dermatol Online J - November 10, 2021 Category: Dermatology Authors: Nicholas D Flint Jamie L W Rhoads Ryan Carlisle Meganne Ferrel Zachary H Hopkins Aaron M Secrest Source Type: research
The continued inappropriate use and overuse of combination topical clotrimazole-betamethasone
CONCLUSION: We strongly recommend clinicians use alternative treatments for rashes or refer to dermatologists.PMID:34755955 | DOI:10.5070/D327854686 (Source: Dermatol Online J)
Source: Dermatol Online J - November 10, 2021 Category: Dermatology Authors: Nicholas D Flint Jamie L W Rhoads Ryan Carlisle Meganne Ferrel Zachary H Hopkins Aaron M Secrest Source Type: research
The continued inappropriate use and overuse of combination topical clotrimazole-betamethasone
CONCLUSION: We strongly recommend clinicians use alternative treatments for rashes or refer to dermatologists.PMID:34755955 | DOI:10.5070/D327854686 (Source: Dermatol Online J)
Source: Dermatol Online J - November 10, 2021 Category: Dermatology Authors: Nicholas D Flint Jamie L W Rhoads Ryan Carlisle Meganne Ferrel Zachary H Hopkins Aaron M Secrest Source Type: research
The continued inappropriate use and overuse of combination topical clotrimazole-betamethasone
CONCLUSION: We strongly recommend clinicians use alternative treatments for rashes or refer to dermatologists.PMID:34755955 | DOI:10.5070/D327854686 (Source: Dermatol Online J)
Source: Dermatol Online J - November 10, 2021 Category: Dermatology Authors: Nicholas D Flint Jamie L W Rhoads Ryan Carlisle Meganne Ferrel Zachary H Hopkins Aaron M Secrest Source Type: research
