Assessing the Efficacy of Clotrimazole and Metronidazole Combined Treatment in Vaginitis: A Meta-Analysis
CONCLUSIONS: The combination of clotrimazole and metronidazole is an effective treatment option for mixed infectious vaginitis, thus warranting recommendation.PMID:37773671 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - September 29, 2023 Category: Complementary Medicine Authors: Yan Huang Cihui Shen Yanmin Shen Hongyin Cui Source Type: research
The effects of P-glycoprotein induction on ivermectin-induced behavioural alterations in zebrafish (Danio rerio) under varying diets
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep 7:109740. doi: 10.1016/j.cbpc.2023.109740. Online ahead of print.ABSTRACTThe neuroprotective effects of inducing the blood-brain barrier ATP-binding cassette protein transporter P-glycoprotein (P-gp) with clotrimazole (CTZ) in both fed and fasted zebrafish (Danio rerio) against the CNS-toxicant ivermectin (IVM, 22,23-dihydro avermectin B1a + 22,23-dihydro avermectin B1b) were examined. Zebrafish were administered 2 μmol/kg IVM intraperitoneally, and various behavioural assays (swimming performance, exploratory behaviour, olfactory responses, motor coordination, and escape...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 9, 2023 Category: Biochemistry Authors: Vinicius Cavicchioli Azevedo Christopher J Kennedy Source Type: research
The effects of P-glycoprotein induction on ivermectin-induced behavioural alterations in zebrafish (Danio rerio) under varying diets
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep 7:109740. doi: 10.1016/j.cbpc.2023.109740. Online ahead of print.ABSTRACTThe neuroprotective effects of inducing the blood-brain barrier ATP-binding cassette protein transporter P-glycoprotein (P-gp) with clotrimazole (CTZ) in both fed and fasted zebrafish (Danio rerio) against the CNS-toxicant ivermectin (IVM, 22,23-dihydro avermectin B1a + 22,23-dihydro avermectin B1b) were examined. Zebrafish were administered 2 μmol/kg IVM intraperitoneally, and various behavioural assays (swimming performance, exploratory behaviour, olfactory responses, motor coordination, and escape...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 9, 2023 Category: Biochemistry Authors: Vinicius Cavicchioli Azevedo Christopher J Kennedy Source Type: research
The effects of P-glycoprotein induction on ivermectin-induced behavioural alterations in zebrafish (Danio rerio) under varying diets
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep 7:109740. doi: 10.1016/j.cbpc.2023.109740. Online ahead of print.ABSTRACTThe neuroprotective effects of inducing the blood-brain barrier ATP-binding cassette protein transporter P-glycoprotein (P-gp) with clotrimazole (CTZ) in both fed and fasted zebrafish (Danio rerio) against the CNS-toxicant ivermectin (IVM, 22,23-dihydro avermectin B1a + 22,23-dihydro avermectin B1b) were examined. Zebrafish were administered 2 μmol/kg IVM intraperitoneally, and various behavioural assays (swimming performance, exploratory behaviour, olfactory responses, motor coordination, and escape...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 9, 2023 Category: Biochemistry Authors: Vinicius Cavicchioli Azevedo Christopher J Kennedy Source Type: research
The effects of P-glycoprotein induction on ivermectin-induced behavioural alterations in zebrafish (Danio rerio) under varying diets
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep 7:109740. doi: 10.1016/j.cbpc.2023.109740. Online ahead of print.ABSTRACTThe neuroprotective effects of inducing the blood-brain barrier ATP-binding cassette protein transporter P-glycoprotein (P-gp) with clotrimazole (CTZ) in both fed and fasted zebrafish (Danio rerio) against the CNS-toxicant ivermectin (IVM, 22,23-dihydro avermectin B1a + 22,23-dihydro avermectin B1b) were examined. Zebrafish were administered 2 μmol/kg IVM intraperitoneally, and various behavioural assays (swimming performance, exploratory behaviour, olfactory responses, motor coordination, and escape...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 9, 2023 Category: Biochemistry Authors: Vinicius Cavicchioli Azevedo Christopher J Kennedy Source Type: research
Tacrolimus and Cyclosporin Pharmacotherapy, Detection Methods, Cytochrome P450 Enzymes after Heart Transplantation
CONCLUSION: Polypharmacy based on tacrolimus or cyclosporine needs vigilant therapeutic drug monitoring due to the cytochrome P450 enzymes associated with biochemical variables in metabolic pathways. Further attention to polypharmacy should be given to circulate drugs that could hide pharmacokinetics interactions associated with infections, malignancies, chronic kidney disease, and rejection after organ transplantation.PMID:37496131 | DOI:10.2174/1871525721666230726150021 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - July 27, 2023 Category: Cardiology Authors: Zahra Tolou-Ghamari Source Type: research
Treatment of antimicrobial azole compounds via photolysis, electrochemical and photoelectrochemical oxidation: Degradation kinetics and transformation products
Environ Pollut. 2023 Jul 17:122220. doi: 10.1016/j.envpol.2023.122220. Online ahead of print.ABSTRACTThe degradation kinetics and transformation products of pharmaceutical azole drugs from Watch list (2020) (fluconazole, FCZ; miconazole, MCZ; clotrimazole, CTZ; and sulfamethoxazole, SMX) are examined individually and as a mixture in Milli-Q water and simulated wastewater (SWW) upon treatment with three different advanced oxidation processes: (i) photolysis (UV), (ii) electrochemical (eAOP), and (iii) photoelectrochemical (eAOP/UV). For individual pollutant degradation, UV was found to be significantly more effective for SM...
Source: Environmental Pollution - July 19, 2023 Category: Environmental Health Authors: Izba Ali Allisson Barros de Souza Deirdre Cabooter Steven De Laet Kwinten Van Eyck Raf Dewil Source Type: research
Treatment of antimicrobial azole compounds via photolysis, electrochemical and photoelectrochemical oxidation: Degradation kinetics and transformation products
Environ Pollut. 2023 Jul 17:122220. doi: 10.1016/j.envpol.2023.122220. Online ahead of print.ABSTRACTThe degradation kinetics and transformation products of pharmaceutical azole drugs from Watch list (2020) (fluconazole, FCZ; miconazole, MCZ; clotrimazole, CTZ; and sulfamethoxazole, SMX) are examined individually and as a mixture in Milli-Q water and simulated wastewater (SWW) upon treatment with three different advanced oxidation processes: (i) photolysis (UV), (ii) electrochemical (eAOP), and (iii) photoelectrochemical (eAOP/UV). For individual pollutant degradation, UV was found to be significantly more effective for SM...
Source: Environmental Pollution - July 19, 2023 Category: Environmental Health Authors: Izba Ali Allisson Barros de Souza Deirdre Cabooter Steven De Laet Kwinten Van Eyck Raf Dewil Source Type: research
Silver(I) complexes containing N-heterocyclic carbene azole drugs: Synthesis, characterization, cytotoxic activity, and their BSA interactions
J Inorg Biochem. 2023 Jun 23;246:112303. doi: 10.1016/j.jinorgbio.2023.112303. Online ahead of print.ABSTRACTCancer is one of the main public health problems globally, there is a public demand for better drugs. Rational strategies or approaches are used to improve the success of drug discovery. Our strategy was to the repurposing of well-known antifungal agents as potential anticancer drugs, such as Clotrimazole (CTZ) and Ketoconazole (KTZ). We prepared the respective iodide imidazolium salt L1: (CTZ-Me)I and L2: (KTZ-Me)I to be the intermediates toward the synthesis of its respective NHC ligand and achieve the respective ...
Source: Journal of Inorganic Biochemistry - July 6, 2023 Category: Biochemistry Authors: Camila Aparecida da Silva Dos Reis Cond é Ana Luiza de Andrade Querino Heveline Silva Maribel Navarro Source Type: research
Silver(I) complexes containing N-heterocyclic carbene azole drugs: Synthesis, characterization, cytotoxic activity, and their BSA interactions
J Inorg Biochem. 2023 Jun 23;246:112303. doi: 10.1016/j.jinorgbio.2023.112303. Online ahead of print.ABSTRACTCancer is one of the main public health problems globally, there is a public demand for better drugs. Rational strategies or approaches are used to improve the success of drug discovery. Our strategy was to the repurposing of well-known antifungal agents as potential anticancer drugs, such as Clotrimazole (CTZ) and Ketoconazole (KTZ). We prepared the respective iodide imidazolium salt L1: (CTZ-Me)I and L2: (KTZ-Me)I to be the intermediates toward the synthesis of its respective NHC ligand and achieve the respective ...
Source: Journal of Inorganic Biochemistry - July 6, 2023 Category: Biochemistry Authors: Camila Aparecida da Silva Dos Reis Cond é Ana Luiza de Andrade Querino Heveline Silva Maribel Navarro Source Type: research
