Results from a Preliminary Human Trial of Nicotinamide Riboside Supplementation
What sort of evidence would it take to challenge my assessment of the data to date that methods of raising NAD+ levels with age, such as nicotinamide riboside supplementation, are not worth pursuing as a major area of focus in research and development? Given the history of work in this area of metabolism, mostly that relating directly to sirtuins and their manipulation, one has to be a little skeptical. Initially promising (and overhyped) results in mice went essentially nowhere, or turned out to make the condition of obesity a little less harmful, while showing little evidence of utility for healthy individuals.
To...
Source: Fight Aging! - March 29, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Results from a Preliminary Human Trial of Nicotinomide Riboside Supplementation
What sort of evidence would it take to challenge my assessment of the data to date that methods of raising NAD+ levels with age, such as nicotinomide riboside supplementation, are not worth pursuing as a major area of focus in research and development? Given the history of work in this area of metabolism, mostly that relating directly to sirtuins and their manipulation, one has to be a little skeptical. Initially promising (and overhyped) results in mice went essentially nowhere, or turned out to make the condition of obesity a little less harmful, while showing little evidence of utility for healthy individuals.
To...
Source: Fight Aging! - March 29, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Tropical Travel Trouble 006 Watery Diarrhoea
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 006
Our medical student who caught shigella on a Nepalese elective has a thirst for adventure. They plan to help at a Bangladesh refugee camp but the latest CDC report states there have been some cases of cholera. They’ve done a little bit of reading and want your help to teach them all about cholera and how they may prepare and best serve their new community.
Questions:
Q1. What is cholera and how is it transmitted?
Answer and interpreta...
Source: Life in the Fast Lane - March 27, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine cholera diarrhoea john snow ORS rice water diarrhoea watery diarrhoea Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Funtabulously Frivolous Friday Five 216
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blogJust when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 216. Question 1Where was this photo taken and what is the significance of this “Trauma Room 1”? By Jpotter1138 – Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=27892379+ Reveal the Funtabulous Answerexpand(document.getElementB...
Source: Life in the Fast Lane - December 1, 2017 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five aspirin Baxter burns Charles Frederic Gerhardt Charles Frederick morris saint Charles Rufus Baxter Jack Ruby JFK John Connally john f kennedy Lee Harvey Oswald Lewis Macken occam's razor parkland formula Source Type: blogs
No advantage of Sodium Bicarbonate and Acetyl cysteine in Preventing Contrast Nephropathy
Steven D. Weisbord et al in NEJM published the results of Prevention of Serious Adverse Events Following Angiography(PRESERVE) trial which was done compare intravenous sodium bicarbonate with intravenous sodium chloride and oral acetylcysteine with oral placebo for the prevention of major adverse outcomes and acute kidney injury in a large population of high-risk patients undergoing coronary or noncoronary angiography.Among patients at high risk for renal complications who were undergoing angiography, there wasno benefit of intravenous sodium bicarbonate over intravenous sodium chloride or of oral acetylcysteine over ...
Source: Sumer's Radiology Site - November 27, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs
To start a cosmetic lab you need Lab Supplies
Here’s the next article in our series about starting a cosmetic lab. Here is the basic equipment you’ll need.
Containers
Weighing equipment
Mixers
Heating & Cooling equipment
Lab supplies
Testing equipment
See the link above for more information about starting a cosmetic lab. In this post we will cover the topic of lab supplies.
What lab supplies you need
Once you have your containers, mixers, weighing stuff, and temperature control equipment, there are still a few more things to get for completing your cosmetic lab setup. While this isn’t an exhaustive list, here are some things that I’ve...
Source: thebeautybrains.com - October 5, 2017 Category: Consumer Health News Authors: Perry Romanowski Tags: Formulating Resources Source Type: blogs
First U.S. Physicians to Save Lives & Limbs with New DABRA Laser Technology: Interview with CEO of Ra Medical Systems
More than 200 million people worldwide, including approximately 8.5 million Americans, suffer from Peripheral Artery Disease (PAD). In the U.S. and Europe, PAD is responsible for around 240,000 amputations every year. Nearly a quarter of patients die within 30 days and almost half within a year of their limb amputation. With the number of diabetic patients increasing annually, a group at high risk for arterial blockages, safer, faster, more effective, and less expensive treatment options have never been as important. DABRA is an innovative new technology from Ra Medical Systems that can combat the growing number of diab...
Source: Medgadget - September 25, 2017 Category: Medical Devices Authors: Alice Ferng Tags: Exclusive Vascular Surgery Source Type: blogs
Food trends through the years: A mixed bag for heart health?
Remember when packaged foods emblazoned with the words “fat free” seemed to be everywhere? Then came labels boasting “zero grams of trans fat.” “Sugar free” and “low sodium” claims soon joined the chorus. These days, gluten-free foods are all the rage.
For the most part, food industry trends have echoed the nutritional mantras of the time and were designed to improve our health — especially cardiovascular health. But just how successful have these efforts been?
“It’s a mixed picture, but over all, I think we’re going in a good direction,” says Dr. Walter Willett, professor in nutrition and epidemi...
Source: Harvard Health Blog - September 6, 2017 Category: Consumer Health News Authors: Julie Corliss Tags: Diet and Weight Loss Health Healthy Eating Heart Health Source Type: blogs
Sinus rhythm with a new wide complex QRS
This is another case written by Pendell Meyers, a G2 at Stony Brook. As I mentioned before, Pendell will be helping to edit and write the blog.CaseA middle aged female with type 2 diabetes presented to her endocrinologist for a regularly scheduled follow up appointment for diabetes management. Her history included ischemic cardiomyopathy (CM) with placement of an AICD, CAD s/p CABG, and recent elective LAD stent complicated by ischemic colitis requiring hemicolectomy and colostomy.During the appointment she complained of several days of off and on dizziness and bilateral leg weakness, and she also told the endocrinolo...
Source: Dr. Smith's ECG Blog - August 28, 2017 Category: Cardiology Authors: Pendell Source Type: blogs
Is bee venom a good anti-aging ingredient? Episode 163
Is bee venom a good anti-aging ingredient?
Monika asks…Korean Bee Venom essence but it does seem to work. My question is the bee venom really magic or is there something else that removes the spots?
RS: Thanks Monika…this gives me the perfect excuse time to remind listeners to go back to Episode 105 and listen to the story about how Perry got stung in the eye by a bee. If nothing else, just go the webpage and check out the picture of his face. It’s horrific. I’m not kidding. But let’s put my personal revulsion aside and try to figure out why this product seemed to work on Monika’s acne.
PR: We found a study pub...
Source: thebeautybrains.com - August 24, 2017 Category: Consumer Health News Authors: Randy Schueller Tags: Podcast Source Type: blogs
Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines
JacsInverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines: A new catalyst system capable of selective chloride functionalization in the Pd-catalyzed amination of 3,2- and 5,2- Br/Cl-pyridines is reported. A reaction optimization strategy employing ligand parametrization led to the identification of 1,1 ′-bis[bis(dimethylamino)phosphino]ferrocene “DMAPF”, a readily available yet previously unutilized diphosphine, as a uniquely effective ligand for this transformation. (Source: Organometallic Current)
Source: Organometallic Current - August 1, 2017 Category: Chemistry Tags: Arylation Pd Catalyzed Source Type: blogs
Biosynthesis of Complex Indole Alkaloids: Elucidation of the Concise Pathway of Okaramines
AngewchemBiosynthesis of Complex Indole Alkaloids: Elucidation of the Concise Pathway of Okaramines: The okaramines are a class of complex indole alkaloids isolated from Penicillium and Aspergillus species. Their potent insecticidal activity arises from selectively activating glutamate ‐gated chloride... (Source: Organometallic Current)
Source: Organometallic Current - July 12, 2017 Category: Chemistry Tags: Alkaloids Biosynthesis Source Type: blogs
Lethal Poison Used in Syria
The Syrian government recently used what is believed to be sarin on civilians, killing 80 people and injuring many more. (CNN. April 20, 2017; http://cnn.it/2oXX47G.) The use of a nerve agent was confirmed by the Turkish government after examining several bodies during autopsy.Sarin was first developed by the Germans as a pesticide in 1938, and is one of the G-series nerve agents that includes tabun, soman, and cyclosarin. Sarin was also used in a terrorist attack in the Tokyo subway in 1995, killing 12 people. (TIME. March 20, 2015; http://ti.me/2oY3F1Y.) Sarin is an organophosphorus compound similar to what is...
Source: The Tox Cave - June 1, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Death by Poison
Poison has been used for many purposes since humans have existed, often for assassination or assassination attempts. Some of those make the news, the most recent being the assassination of Kim Jong-nam, the half-brother of North Korean leader Kim Jong-un.Authorities identified the nerve agent VX on his face, and video corroborated two women wiping a substance on his face before his collapse and death. VX is the most potent nerve agent, and was developed in the United States in the 1950s during the Cold War. It is an acetylcholinesterase inhibitor, and exerts its effects like organophosphate insecticides. Victims develop...
Source: The Tox Cave - May 1, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
