Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice.
To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lithium Produces Mildly Positive Effects on Healthspan in Mice
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice.
To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 13, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Sweat Powered Battery for Wearable Medical Devices
Researchers at Nanyang Technological University in Singapore created a flexible battery that is powered by sweat. The device could provide a new way to energize medical wearables, some of which already use sweat to detect or monitor disease. The stretchable device incorporates silver flakes that clump together and generate a small electrical current in the presence of sweat.
Medical wearables are becoming increasingly ubiquitous. The ability to monitor vital signs or disease progression using such an unobtrusive and convenient technology has obvious advantages. However, in the interests of the environment, moving away f...
Source: Medgadget - August 25, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Source Type: blogs
This ECG Pattern Told the Story When the Patient Could Not
Submitted by Spencer Lord MD, written by Alex Bracey with edits by Meyers and SmithA patient presents as a transfer from an outside facility. On arrival, he appeared air hungry, volume overloaded, and agitated. EMS was not available for a history at the time and the patient was unable to provide any details regarding his circumstances. During the initial minutes of his resuscitation the following ECG was performed:This ECG is pathognomonic. What is it?Sinus bradycardia with first degree AV blockWide, bizarre QRS complexes with STE in V1 and aVRPeaked T waves in I, II, V4-V6QRS duration is nearly 200 ms.There is a lar...
Source: Dr. Smith's ECG Blog - July 2, 2021 Category: Cardiology Authors: Bracey Source Type: blogs
June 2021: Mounting Evidence Supports Ivermectin for COVID-19
Ivermectin has been proposed as a treatment for COVID-19 based on in vitro studies. It is currently FDA-approved for treating parasites (intestinal strongyloidiasis and onchocerciasis) but not approved for COVID-19, though a large body of evidence supports its use in inpatients and outpatients. (Antiviral Res. 2020;178:104787; https://bit.ly/3bpeTrm.)Mechanism of ActionIvermectin is an antiparasitic agent that binds directly and has high affinity to the glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of microfilaria. This causes the cell membrane to have increased permeability to chl...
Source: The Tox Cave - June 1, 2021 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Sticker on Skin Diagnoses Cystic Fibrosis in Real-time
Researchers at Northwestern University have developed a sticker that can measure chloride levels in sweat in real-time through a simple color change. The sticker is applied to the skin and wicks sweat inside itself through a set of microfluidic channels, where an onboard bioassay measures chloride levels, a marker of cystic fibrosis. The technology may end up simplifying cystic fibrosis diagnosis in newborns.
Cystic fibrosis is a genetic disease caused by a malfunctioning chloride channel in epithelial cells. It typically results in very thick mucus in the airways, leading to serious breathing issues and infections, and...
Source: Medgadget - April 6, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Source Type: blogs
March 2021: The Toxicity of Fire Smoke
A 54-year-old man was brought to the ED unresponsive by paramedics after his neighbors called 911 because they smelled smoke in his apartment. The patient was found unconscious in his living room, and a fire was burning in an adjoining room.His initial vital signs were a blood pressure of 115/80 mm Hg, a heart rate of 120 bpm, a respiratory rate of 30 bpm, an SPO2 of 94% on a nonrebreather, and a temperature of 98.9° F. The patient was unresponsive to verbal and physical stimuli but had spontaneous respirations. His nose and mouth were filled with soot, his lungs had trace wheezes, and his skin appeared flushed.What toxin...
Source: The Tox Cave - March 1, 2021 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Pass the Salt: Sodium ’s Role in Nerve Signaling and Stress on Blood Vessels
Most of the mouthwatering dishes in a Thanksgiving feast share a vital ingredient: salt! Though the words “salt” and “sodium” are often used interchangeably, table salt is actually a compound combining the elements sodium and chloride. Table salt is the most common form that sodium takes on Earth. Many other sodium compounds are also useful to us. For instance, you might use baking soda, also known as sodium bicarbonate, in preparing Thanksgiving treats. Sodium compounds are also used in soaps and cosmetics and in producing paper, glass, metals, medicines, and more.
The best-known sodium compound is table ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 25, 2020 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Cellular Processes Source Type: blogs
Earwax Sampling Device for Easy Cortisol Measurement
Researchers at University College London and King’s College London have developed a device that allows for easy earwax sampling, with the goal that the wax could be a convenient and reliable way to measure cortisol levels. The device can be used by a patient at home to obtain a sample of earwax and is less invasive and unpleasant than existing methods, such as syringing.
Cortisol levels change in patients with conditions such as depression, Addison’s disease, and Cushing syndrome, and so measuring someone’s cortisol levels could be useful in diagnosing and monitoring these diseases. However, cortisol level...
Source: Medgadget - November 5, 2020 Category: Medical Devices Authors: Conn Hastings Tags: ENT Medicine Psychiatry Source Type: blogs
Is dry shampoo bad for your hair and scalp? episode 223
Welcome to the Beauty Brains, a show where real cosmetic chemists answer your beauty product questions and give you an insider’s look at the cosmetic industry.
Hosts: Valerie George and Perry Romanowski.
On today’s show we’re going to answer questions about…
Whether you should get a cosmetic fridge?
If dry shampoo is bad for your hair and other hair questions
What is the lameller technique and how does it work?
Suggested listening:
Up First Podcast – American Police
This American Life – Episode 707
Beauty Science News
Is men’s skin care really poised for growth?
A third of people surveyed are practi...
Source: thebeautybrains.com - June 11, 2020 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast Source Type: blogs
Wait time between skincare products – is it necessary? episode 219
Welcome to the Beauty Brains, a show where real cosmetic chemists answer your beauty product questions and give you an insider’s look from scientists in the cosmetic industry.
On today’s show we’re going to be answering questions about…
Is the wait time necessary when you are applying acids?
How do you debate product safety with someone?
Do skin products with natural moisturizing factor work better?
Should you avoid glycerin and dimethicone in hair products?
And we’ll cover some beauty science news too.
Beauty Science news
What’s your stance on wearing masks?
Perry on Ecowell podcast
J&J lawsuits get ...
Source: thebeautybrains.com - May 4, 2020 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast Source Type: blogs
Wait time between skincare products – is it necessary? episode 219
Welcome to the Beauty Brains, a show where real cosmetic chemists answer your beauty product questions and give you an insider’s look from scientists in the cosmetic industry.
On today’s show we’re going to be answering questions about…
Is the wait time necessary when you are applying acids?
How do you debate product safety with someone?
Do skin products with natural moisturizing factor work better?
Should you avoid glycerin and dimethicone in hair products?
And we’ll cover some beauty science news too.
Beauty Science news
What’s your stance on wearing masks?
Perry on Ecowell podcast
J&J lawsuits get ...
Source: thebeautybrains.com - May 4, 2020 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast Source Type: blogs
Multi-Atom Bonding in Cheminformatics
ConclusionMulti-atom bonding appears in many areas of chemistry. The entrenched cheminformatics convention of two-atom bonding is inadequate when faced with chemistry's full repertoire. Multi-atom bonding offers a solution that can be implemented in a backward-compatible way. (Source: Depth-First)
Source: Depth-First - April 27, 2020 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Hydrogen Suppression in Molfiles
ConclusionThe assignment of hydrogen counts to hydrogen-suppressed molecules is an important and error-prone step when reading or writing molfiles. Contrary to first appearances, the molfile format imposes very specific rules in this regard. The error-free exchange of chemical structure information requires that all of these rules be followed. (Source: Depth-First)
Source: Depth-First - April 14, 2020 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Does Beverly Hills MD Brow Serum work and other beauty questions? episode 213
We have a lot of beauty questions to answer today, including:
What do we think of the Beverly Hills MD brow serum
Are lash tints safe?
Why do anti-aging ingredients affect skin color?
Why do dermatologists keep saying hyaluronic acid is pointless?
Perry and Valerie are under self imposed quarantine! But we’re still recording.
Beauty science news
Are cosmetics going to be more regulated?
The spokesperson from the EWG (who likes this new legislation by the way) said the following about the cosmetics industry. “…no category of consumer products is subject to less government oversight than cosmetics and o...
Source: thebeautybrains.com - March 19, 2020 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast Source Type: blogs
