Mice Brains May Be Too Different From Humans ’ To Be Accurate Research Model, Study Says
New research has found key differences between the cerebellum of mice and that of humans. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - October 28, 2019 Category: Pharmaceuticals Authors: Dana Dovey, Contributor Source Type: news
Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum
We present histological and molecular analyses of the developing human cerebellum from 30 days after conception to 9 months after birth. Differences in developmental patterns between humans and mice include spatiotemporal expansion of both ventricular and rhombic lip primary progenitor zones to include subventricular zones containing basal progenitors. The human rhombic lip persists longer through cerebellar development than in the mouse and undergoes morphological changes to form a progenitor pool in the posterior lobule, which is not seen in other organisms, not even in the nonhuman primate the macaque. Disruptions in hu...
Source: ScienceNOW - October 23, 2019 Category: Science Authors: Haldipur, P., Aldinger, K. A., Bernardo, S., Deng, M., Timms, A. E., Overman, L. M., Winter, C., Lisgo, S. N., Razavi, F., Silvestri, E., Manganaro, L., Adle-Biasette, H., Guilmiot, F., Russo, R., Kidron, D., Hof, P. R., Gerrelli, D., Lindsay, S. J., Doby Tags: Medicine, Diseases, Neuroscience r-articles Source Type: news
New Finding Challenges Old Notions About Dyslexia
THURSDAY, Oct. 10, 2019 -- The cerebellum does not affect reading ability in people with dyslexia, according to a new study that challenges a controversial theory.
The cerebellum is a brain structure traditionally involved in motor function. Some... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 10, 2019 Category: General Medicine Source Type: news
Cerebellar Surprises
Kamran Khodakhah, a researcher at the Albert Einstein College of Medicine, describes the cerebellum's newly described role in addictive and social behaviors. (Source: The Scientist)
Source: The Scientist - October 1, 2019 Category: Science Tags: Videos Source Type: news
The Cerebellum ’s Secrets: A Profile of Kamran Khodakhah
The Albert Einstein College of Medicine neuroscientist has revealed surprising functions of the brain region, such as its role in the brain ’s rewards circuits and in addiction. (Source: The Scientist)
Source: The Scientist - October 1, 2019 Category: Science Tags: Profile Source Type: news
Imaging Technique May Help Predict Stroke-Related Dementia
THURSDAY, Sept. 12, 2019 -- Diffusion tensor image segmentation technique (DSEG), which characterizes microstructural damage across the cerebellum, identifies damage in cerebral small vessel disease (SVD) and can predict dementia, according to a... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 12, 2019 Category: Pharmaceuticals Source Type: news
The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm - Ernst TM, Brol AE, Gratz M, Ritter C, Bingel U, Schlamann M, Maderwald S, Quick HH, Merz CJ, Timmann D.
Prediction errors are thought to drive associative fear learning. Surprisingly little is known about the possible contribution of the cerebellum. To address this question, healthy participants underwent a differential fear conditioning paradigm during 7T m... (Source: SafetyLit)
Source: SafetyLit - September 2, 2019 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Scientific Meeting » New Perspectives on Cerebellar Function: Implications for Mental Health
This NIMH-sponsored symposium will bring together experts in basic and translational neuroscience to discuss the state of the field and identify opportunities to advance our understanding of how the cerebellum contributes to cognition, emotion, and social behavior in both healthy and psychiatric populations. (Source: National Institute of Mental Health)
Source: National Institute of Mental Health - August 13, 2019 Category: Psychiatry Authors: National Institute of Mental Health Source Type: news
Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution
Spatial positions of cells in tissues strongly influence function, yet a high-throughput, genome-wide readout of gene expression with cellular resolution is lacking. We developed Slide-seq, a method for transferring RNA from tissue sections onto a surface covered in DNA-barcoded beads with known positions, allowing the locations of the RNA to be inferred by sequencing. Using Slide-seq, we localized cell types identified by single-cell RNA sequencing datasets within the cerebellum and hippocampus, characterized spatial gene expression patterns in the Purkinje layer of mouse cerebellum, and defined the temporal evolution of ...
Source: ScienceNOW - March 27, 2019 Category: Science Authors: Rodriques, S. G., Stickels, R. R., Goeva, A., Martin, C. A., Murray, E., Vanderburg, C. R., Welch, J., Chen, L. M., Chen, F., Macosko, E. Z. Tags: Genetics, Molecular Biology reports Source Type: news
Newly discovered role for climbing fibers: Conveying a sensory snapshot to the cerebellum
(Max Planck Florida Institute for Neuroscience) Though there is a wealth knowledge supporting the idea that sensory cues benefit motor learning, the precise brain circuitry and mechanisms tying these two together has been debated in recent years. Shedding new light on this topic, a paper in Neuron from the lab of Dr. Jason Christie at the Max Planck Florida Institute for Neuroscience, has revealed that a special input pathway into the cerebellum seems to hold the key to coding sensory information. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 27, 2019 Category: International Medicine & Public Health Source Type: news
Part of the brain may be 'dementia-proof'
A study by the University of Manchester found people who die from Alzheimer's produce proteins in the brain region known as the cerebellum - but not in five other key areas of the vital organ. (Source: the Mail online | Health)
Source: the Mail online | Health - February 11, 2019 Category: Consumer Health News Source Type: news
Cerebellum connects to brain ’s reward system
A study in mice found that the brain ’s cerebellum—known to play a role in motor coordination—also helps control the brain’s reward circuitry. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - February 5, 2019 Category: Consumer Health News Source Type: news
UCLA-led team uncovers critical new clues about what goes awry in brains of people with autism
This study gives a new critical clue in understanding what has gone awry in the brains of autism patients.”More than 24 million people worldwide are estimated to have autism. In developed countries, about 1.5 percent of children have been diagnosed with autism spectrum disorder as of 2017. The disorder affects communication and behavior, and is marked by problems in social communication and social interaction, and repetitive behaviors.“We need to understand how a panoply of genetic and environmental factors converges to cause autism,” Geschwind said. “RNA editing is an important piece of the autism puzzle that has ...
Source: UCLA Newsroom: Health Sciences - January 30, 2019 Category: Universities & Medical Training Source Type: news
BIDMC researchers ID, treat faulty brain circuitry underlying symptoms of schizophrenia
(Beth Israel Deaconess Medical Center) In a first-of-its-kind study, Beth Israel Deaconess Medical Center researchers determined the underlying anatomical cause of certain symptoms of schizophrenia, then ameliorated them with non-invasive brain stimulation. The scientists reported in the American Journal of Psychiatry that these symptoms arise from a breakdown in a network between the brain's prefrontal cortex and the cerebellum, and that non-invasive brain stimulation restored network function, which in turn improved schizophrenia's most debilitating symptoms. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 30, 2019 Category: International Medicine & Public Health Source Type: news
