Effects of Resveratrol Co-Administration on Celecoxib Disposition and
Pharmacokinetics in Healthy Volunteers
The objective of the current study was to investigate the effects of resveratrol
(RSV), a natural herbal remedy used as an adjacent anti-inflammatory supplement
on, the pharmacokinetics of celecoxib in healthy male volunteers. Twelve healthy
human participants were involved in two-period open-labeled trial. Celecoxib
(200 mg) was given as a single oral dose under fasting conditions as a
control phase. Afterward, RSV (500 mg) commenced as a single oral dose
for ten days as a treatment phase. Blood samples were collected during the
control and treatmen...
Source: Drug Research - November 7, 2023 Category: Drugs & Pharmacology Authors: Helal, Nagwa I. El-Khodary, Noha M. Omran, Gamal A. El-Masry, Soha M. Tags: Original Article Source Type: research
AI-driven Discovery of Celecoxib and Dexamethasone for Exploring their Mode of Action as Human Interleukin (IL-6) Inhibitors to Treat COVID-19-induced Cytokine Storm in Humans
CONCLUSION: The findings of this study have suggested the potential of the drugs studied to be utilized as antagonists for countering CRS in COVID-19 ailment. This study presents the studied drugs as promising candidates both for the clinical and pre-clinical treatment of COVID-19.PMID:37921134 | DOI:10.2174/0113816128260449231017091824 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 3, 2023 Category: Drugs & Pharmacology Authors: Israa M Shamkh Mahmoud Elkazzaz Enas S Radwan Jawayria Najeeb Md Tabish Rehman Mohamed F AlAjmi Moayad Shahwan Muhammad Sufyan Nouf Khaifa Alaqeel Ibrahim A Ibrahim Basit Jabbar Mohammad Shahbaz Khan Tomasz M Karpi ński Ishrat Rahman Abdullah Haikal Reem Source Type: research
AI-driven Discovery of Celecoxib and Dexamethasone for Exploring their Mode of Action as Human Interleukin (IL-6) Inhibitors to Treat COVID-19-induced Cytokine Storm in Humans
CONCLUSION: The findings of this study have suggested the potential of the drugs studied to be utilized as antagonists for countering CRS in COVID-19 ailment. This study presents the studied drugs as promising candidates both for the clinical and pre-clinical treatment of COVID-19.PMID:37921134 | DOI:10.2174/0113816128260449231017091824 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 3, 2023 Category: Drugs & Pharmacology Authors: Israa M Shamkh Mahmoud Elkazzaz Enas S Radwan Jawayria Najeeb Md Tabish Rehman Mohamed F AlAjmi Moayad Shahwan Muhammad Sufyan Nouf Khaifa Alaqeel Ibrahim A Ibrahim Basit Jabbar Mohammad Shahbaz Khan Tomasz M Karpi ński Ishrat Rahman Abdullah Haikal Reem Source Type: research
AI-driven Discovery of Celecoxib and Dexamethasone for Exploring their Mode of Action as Human Interleukin (IL-6) Inhibitors to Treat COVID-19-induced Cytokine Storm in Humans
CONCLUSION: The findings of this study have suggested the potential of the drugs studied to be utilized as antagonists for countering CRS in COVID-19 ailment. This study presents the studied drugs as promising candidates both for the clinical and pre-clinical treatment of COVID-19.PMID:37921134 | DOI:10.2174/0113816128260449231017091824 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 3, 2023 Category: Drugs & Pharmacology Authors: Israa M Shamkh Mahmoud Elkazzaz Enas S Radwan Jawayria Najeeb Md Tabish Rehman Mohamed F AlAjmi Moayad Shahwan Muhammad Sufyan Nouf Khaifa Alaqeel Ibrahim A Ibrahim Basit Jabbar Mohammad Shahbaz Khan Tomasz M Karpi ński Ishrat Rahman Abdullah Haikal Reem Source Type: research
Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model
This study aimed to evaluate the role of COX-1 and -2 on colonic mucosal integrity in an experimental colitis model. Colitis was induced in Wistar rats by intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (20 mg + 50% ethanol). The control group (sham group) received saline only. After 7, 14, or 28 days, colonic samples were removed, and macroscopic lesion scores, wet weight, myeloperoxidase activity, and transepithelial electrical resistance (TER) were determined. In other rat groups, colonic samples from the sham group and a 7th day post-colitis group were mounted in Üssing chambers with the luminal side...
Source: Braz J Med Biol Res - November 1, 2023 Category: Research Authors: H B Costa-Filho T M A L Sales S M Paula L A D Nicolau M L Queiroga A Havt P M G Soares A L R Barbosa M H L P Souza Source Type: research
Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model
This study aimed to evaluate the role of COX-1 and -2 on colonic mucosal integrity in an experimental colitis model. Colitis was induced in Wistar rats by intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (20 mg + 50% ethanol). The control group (sham group) received saline only. After 7, 14, or 28 days, colonic samples were removed, and macroscopic lesion scores, wet weight, myeloperoxidase activity, and transepithelial electrical resistance (TER) were determined. In other rat groups, colonic samples from the sham group and a 7th day post-colitis group were mounted in Üssing chambers with the luminal side...
Source: Brazilian Journal of Medical and Biological Research - November 1, 2023 Category: Research Authors: H B Costa-Filho T M A L Sales S M Paula L A D Nicolau M L Queiroga A Havt P M G Soares A L R Barbosa M H L P Souza Source Type: research
Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model
This study aimed to evaluate the role of COX-1 and -2 on colonic mucosal integrity in an experimental colitis model. Colitis was induced in Wistar rats by intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (20 mg + 50% ethanol). The control group (sham group) received saline only. After 7, 14, or 28 days, colonic samples were removed, and macroscopic lesion scores, wet weight, myeloperoxidase activity, and transepithelial electrical resistance (TER) were determined. In other rat groups, colonic samples from the sham group and a 7th day post-colitis group were mounted in Üssing chambers with the luminal side...
Source: Braz J Med Biol Res - November 1, 2023 Category: Research Authors: H B Costa-Filho T M A L Sales S M Paula L A D Nicolau M L Queiroga A Havt P M G Soares A L R Barbosa M H L P Souza Source Type: research
Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model
This study aimed to evaluate the role of COX-1 and -2 on colonic mucosal integrity in an experimental colitis model. Colitis was induced in Wistar rats by intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (20 mg + 50% ethanol). The control group (sham group) received saline only. After 7, 14, or 28 days, colonic samples were removed, and macroscopic lesion scores, wet weight, myeloperoxidase activity, and transepithelial electrical resistance (TER) were determined. In other rat groups, colonic samples from the sham group and a 7th day post-colitis group were mounted in Üssing chambers with the luminal side...
Source: Brazilian Journal of Medical and Biological Research - November 1, 2023 Category: Research Authors: H B Costa-Filho T M A L Sales S M Paula L A D Nicolau M L Queiroga A Havt P M G Soares A L R Barbosa M H L P Souza Source Type: research
Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model
This study aimed to evaluate the role of COX-1 and -2 on colonic mucosal integrity in an experimental colitis model. Colitis was induced in Wistar rats by intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (20 mg + 50% ethanol). The control group (sham group) received saline only. After 7, 14, or 28 days, colonic samples were removed, and macroscopic lesion scores, wet weight, myeloperoxidase activity, and transepithelial electrical resistance (TER) were determined. In other rat groups, colonic samples from the sham group and a 7th day post-colitis group were mounted in Üssing chambers with the luminal side...
Source: Braz J Med Biol Res - November 1, 2023 Category: Research Authors: H B Costa-Filho T M A L Sales S M Paula L A D Nicolau M L Queiroga A Havt P M G Soares A L R Barbosa M H L P Souza Source Type: research
Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model
This study aimed to evaluate the role of COX-1 and -2 on colonic mucosal integrity in an experimental colitis model. Colitis was induced in Wistar rats by intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (20 mg + 50% ethanol). The control group (sham group) received saline only. After 7, 14, or 28 days, colonic samples were removed, and macroscopic lesion scores, wet weight, myeloperoxidase activity, and transepithelial electrical resistance (TER) were determined. In other rat groups, colonic samples from the sham group and a 7th day post-colitis group were mounted in Üssing chambers with the luminal side...
Source: Brazilian Journal of Medical and Biological Research - November 1, 2023 Category: Research Authors: H B Costa-Filho T M A L Sales S M Paula L A D Nicolau M L Queiroga A Havt P M G Soares A L R Barbosa M H L P Souza Source Type: research
