Effects of Resveratrol Co-Administration on Celecoxib Disposition and Pharmacokinetics in Healthy Volunteers
The objective of the current study was to investigate the effects of resveratrol
(RSV), a natural herbal remedy used as an adjacent anti-inflammatory supplement
on, the pharmacokinetics of celecoxib in healthy male volunteers. Twelve healthy
human participants were involved in two-period open-labeled trial. Celecoxib
(200 mg) was given as a single oral dose under fasting conditions as a
control phase. Afterward, RSV (500 mg) commenced as a single oral dose
for ten days as a treatment phase. Blood samples were collected during the
control and treatment phases and analyzed using the validated High-performance
liquid chromatography (HPLC) method. RSV pre-exposure significantly increased
the area under the curve (AUC0–24), peak plasma concentration
(Cmax), absorption rate constant (ka), and prolongated half-life
(t1/2), along with a decrease in elimination rate
constant (ke). Meanwhile, the volume of distribution (Vd/F) and apparent
total body clearance (CL/F) were significantly decreased for celecoxib.
There was no significant change in the time it takes for celecoxib to reach the
maximum concentration (tmax) was observed. The obtained results
suggested the presence of a beneficial pharmacokinetic interaction between RSV
and celecoxib. Consequently, combining resveratrol as an herbal remedy and
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Source: Drug Research - Category: Drugs & Pharmacology Authors: Helal, Nagwa I. El-Khodary, Noha M. Omran, Gamal A. El-Masry, Soha M. Tags: Original Article Source Type: research
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